Invasive Mechanical Ventilation clinical trials

Improving communication in the ICU for patients, families, and staff

This study looks at how doctors, nurses, and other healthcare team members talk with patients and their families in the intensive care unit (ICU). It aims to improve understanding and support for everyone involved.

Exercises to help breathing during ventilator weaning

This study tests whether specific neck and breathing muscle exercises during ventilator weaning can help people breathe more effectively and safely come off the ventilator. It may help patients who have already had trouble with prior weaning attempts.

Using ECMO to help you breathe, sit up, and come off a ventilator

This trial tests whether a heart-lung machine called venovenous ECMO can help people with severe breathing failure get less sedated, get extubated (have the breathing tube removed), and start moving. It’s for certain adults who are on a ventilator for a short time and have specific oxygenation problems.

Help deciding when to remove a breathing tube

This trial studies a decision-support tool that helps ICU teams decide when it’s safe to try removing (extubating) a breathing tube. It may help reduce delays or avoidable re-intubation by guiding the timing of a low-support breathing trial (SBT).

Study for people on a breathing machine after spine trauma

This trial studies how care is given to people who have a traumatic injury to the spine and need a breathing machine. It may help improve treatment and recovery for people who are ventilated after injury, including those with or without spinal cord damage.

Brain monitoring during breathing therapy in critically ill patients

This study looks at how a breathing machine setting (called PEEP) affects blood flow in the brain. If you or your loved one is in the ICU with a serious brain injury and is on a breathing machine, this trial could help doctors understand how to make breathing therapy safer for the brain.

Tested a muscle-relaxing treatment for severe low-oxygen breathing

This study tests whether partially relaxing the breathing-related muscles can help people with severe low oxygen while they are on a breathing machine. It may improve how well the lungs work by changing the way the muscles affect breathing.

Cooling fever in ventilated people with septic shock

This study tests whether external cooling can safely lower very high fever in people who are on a breathing machine for septic shock. It may help improve outcomes by controlling fever while they are treated for the infection causing their illness.

Music therapy for adults on breathing machines in the ICU

This trial tests whether music therapy can improve comfort and recovery for adults who need a breathing machine (mechanical ventilation) in the ICU for at least 48 hours. It may help with stress, mood, and other ICU-related symptoms while you are in critical care.

Study of breathing muscle and lung changes during transplant planning

This trial studies how the diaphragm (your main breathing muscle) and lung/airway tissue behave in people who are being supported until they can get a lung transplant. The results may help doctors better understand breathing failure and improve transplant care.

Ultrasound of the diaphragm during breathing machine weaning

This study uses ultrasound to look at how well your diaphragm (the main breathing muscle) is working while you are on a breathing machine. The goal is to see if this can help doctors predict when you can safely breathe on your own and leave the ventilator sooner.

Comparing breathing support methods in the heart ICU

This study compares different ways to support breathing in patients who need a ventilator in the cardiac intensive care unit. It aims to find the best approach for people with certain heart conditions, like cardiogenic shock or heart failure.

Ventilation strategies in obese patients during laparoscopic surgery

This study tests different ways of using a breathing machine (ventilator) during laparoscopic surgery in people with obesity. The goal is to find a safer and more effective ventilation method for this group.

Effects of Inspiratory Muscle Training and Positive Expiratory Pressure on Mechanically Ventilated Restrictive Lung Disease Patients

Testing a new lung imaging method in ICU patients

This study tests whether a special imaging technique called EIT (electrical impedance tomography) combined with a safe contrast injection can measure blood flow in the lungs of patients on breathing machines. If it works, it could help doctors better manage critically ill patients.

Comparing Two Sedation Drugs for ICU Patients on Breathing Support

This study compares two medications (ciprofol and propofol) used to keep ICU patients calm and comfortable while they receive non-invasive breathing support, such as oxygen masks or tubes that help them breathe without a breathing tube in their windpipe. Researchers want to see which drug works better and is safer.

Predicting response to breathing support in COPD

This study looks at whether nighttime breathing problems can predict long-term success with a non-invasive breathing machine in people with COPD who have high carbon dioxide levels in their blood. The goal is to help doctors decide who will benefit most from this therapy.

Hyperoxia effects on brain blood flow in ICU patients

This trial studies how giving extra oxygen (hyperoxia) affects blood flow in the brain for patients on a breathing machine in the intensive care unit. The goal is to see if short bursts of higher oxygen levels are safe and how they change brain activity.

Lung opening procedure safety in children on breathing machines

This trial tests a lung opening procedure (alveolar recruitment maneuver) in children on a breathing machine to see if it's safe and helpful. It compares how well the procedure works with different machine settings.

BPAP breathing support for severe asthma attacks in children

This study tests whether a special breathing mask (BPAP) can help children ages 5–17 who come to the emergency room with severe asthma attacks. The mask gently pushes air into the lungs to help them breathe more easily.

Electrical impedance guided ventilator settings for breathing failure

This trial tests whether using electrical impedance tomography (EIT), a safe and non-invasive monitoring technique, helps doctors set the ventilator better for patients with low oxygen levels. It may improve your breathing support during mechanical ventilation.

Lung medication with different oxygen levels for premature babies

This study tests a lung medication called pulmonary surfactant, given with different oxygen levels, to help very premature babies (born before 32 weeks) who have breathing difficulties. The goal is to see which oxygen level works best with non-invasive breathing support.

Ventilator Pressure Levels During Surfactant Therapy in Preterm Infants

This study tests whether different pressure levels used during a minimally invasive surfactant procedure (MIST)—a way to deliver lung-coating medicine without a breathing tube—affect how well preterm infants' lungs inflate. Researchers hope to find the best pressure settings to help babies breathe more easily.

Ventilator settings to protect lungs during high-risk surgery

This study compares two ways of setting the ventilator during surgery to reduce lung complications. Researchers will test whether using a lower 'driving pressure' (a setting on the breathing machine) helps protect the lungs better than usual care. It is for adults having high-risk surgeries under general anesthesia with a breathing tube.