Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06366724RecruitingPhase 2
Life Improvement Trial for ME/CFS
This trial tests a new treatment for ME/CFS (chronic fatigue syndrome) that includes symptoms like dizziness when standing. It uses a smartphone app to track your progress and aims to see if the treatment can improve your daily life.
Boston, MassachusettsAges 18–70 - NCT06366815Recruiting
A study of Duchenne muscular dystrophy in boys who no longer walk
This study is for boys with Duchenne muscular dystrophy who can no longer walk. It aims to describe how the condition changes over time once walking is lost, without testing any new treatments.
Bosisio Parini, LcAges 8–35 - NCT06367855RecruitingPhase 4
Dexamethasone before spine surgery for pain control
This study tests whether giving a single dose of the steroid dexamethasone before minimally invasive spine surgery can help reduce pain and inflammation afterward. It is for people aged 50–80 who are having surgery on 1 or 2 levels of their lower back and have not had spine surgery before.
Pathum Thani, Changwat Pathum ThaniAges 50–80 - NCT06368154Recruiting
Studying early markers for brittle bones in newborns
This trial looks for tiny particles in the blood that might help doctors detect bone weakness in premature babies. It aims to find early signs of metabolic bone disease, which could lead to better care.
Changsha, HunanAges birth–3 days - NCT06368492Recruiting
Psilocybin for fibromyalgia pain
This trial tests whether psilocybin, a substance found in certain mushrooms, can help reduce pain in people with fibromyalgia. You would receive the drug and be monitored closely to see if it improves your pain levels.
Maastricht, LimburgAges 18–65 - NCT06370312Recruiting
Biomarkers for thumb osteoarthritis surgery
This study looks at joint fluid and tissue samples from people with thumb base osteoarthritis who are already scheduled for a surgery called trapeziectomy. The goal is to find markers that might help better understand the disease and improve treatment.
Malmö, Skåne CountyAges 25 years+ - NCT06374342Recruiting
Bone substitutes study after surgery follow-up
This study follows patients who receive a Teknimed bone substitute during surgery for bone defects. It collects data on how well these bone fillers work in real-world use.
Mainvilliers, Eure et LoirAges 18 years+ - NCT06374719Recruiting
TNNT1 myopathy natural history study
This study follows people with a rare genetic muscle condition called TNNT1 myopathy over time. Researchers will track how the disease progresses to better understand it and help plan future treatments.
Gordonville, PennsylvaniaAges Any age - NCT06376149Recruiting
Making Mindfulness Matter for Kids with JIA
This study tests a program called Making Mindfulness Matter (M3) for children with JIA. It is an online program that helps children and their caregivers learn mindfulness skills to manage pain and stress from arthritis.
Hamilton, OntarioAges 4–12 - NCT06379243Recruiting
Predicting future spinal fractures after osteoporosis treatment
This study is testing a new way to predict if your spine might break again after you have treatment for a fracture caused by osteoporosis. If you have a recent spinal fracture from weak bones and are getting a cement injection (PVP or PKP), researchers want to check your information to see how well their risk model works for people like you.
Guangzhou, GuangdongAges 50–90 - NCT06379646Recruiting
YTS109 cell therapy for autoimmune disease
This study tests a new cell therapy (YTS109) for people with autoimmune diseases like lupus or Sjogren's syndrome that have not improved or keep coming back after standard treatments. It aims to see if the treatment can help control the disease.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06379997Recruiting
Oral supplement vs. shoulder injection for rotator cuff pain
This trial compares taking an oral supplement versus getting hyaluronic acid injections for ongoing shoulder pain due to a partial rotator cuff tear. It aims to see which treatment works better for improving movement and reducing pain without surgery.
Roma, RMAges 30–80 - NCT06380530Recruiting
Computer-assisted surgical planning for limb deformity correction
This trial tests a new computer-assisted planning method to help surgeons better correct bone deformities in the arms or legs. It may lead to more precise surgeries and faster recovery.
Bologna, BOAges 2–40 - NCT06383936Recruiting
Knee replacement for active sports lovers
This study tests a new knee replacement designed for active people ages 40 to 65 who used to play sports but had to stop due to knee pain. It aims to see if the implant helps you return to your favorite activities.
BolognaAges 40–65 - NCT06384430Recruiting
Shoulder impingement tests and ultrasound in diagnosis
This study looks at how certain shoulder tests and ultrasound images relate to each other in people with shoulder impingement (a common cause of shoulder pain). It aims to improve diagnosis and understand which tests work best.
MuğlaAges 18–70 - NCT06385574Recruiting
Tech-based rehab for rheumatic hand pain
This study tests a technology-based rehab program (like apps or computer exercises) to help people with rheumatic diseases that affect their hands. It aims to improve hand function and reduce pain.
Antalya, KonyaaltıAges 18–64 - NCT06387524Recruiting
Eccentric exercises for knee pain in women
This trial studies if special leg exercises can improve walking in women with pain behind the kneecap. It may help if you have had knee pain for at least 2 months and it hurts during activities like stairs or sitting for a long time.
Rawalpindi, Punjab ProvinceAges 18–35 - NCT06387654Recruiting
Collection of skin samples for immune-related skin diseases
This study collects skin samples and medical information from people with skin conditions caused by their immune system. It helps researchers better understand these diseases and develop new treatments.
ToulouseAges 6–99 - NCT06388603Recruiting
Bioactive glass for diabetic foot bone infection in the forefoot
This trial tests a special glass material (bioactive glass S53P4) placed into the bone after surgery to treat a diabetic foot infection in the forefoot. It may help heal the infection better than standard care.
Monfalcone, GoriziaAges 18–100 - NCT06388811Recruiting
Turkish version of a knee pain questionnaire study
This study tests a Turkish questionnaire for early knee osteoarthritis. It may help doctors better identify and treat early knee pain.
IstanbulAges 18 years+ - NCT06388993Recruiting
Comparing Two Bone Marrow Collection Methods for Hip Surgery
This study compares two methods of collecting bone marrow from the hip during hip arthroscopy. It aims to find which method works better for treating bone cysts or avascular necrosis.
Columbus, OhioAges 18–50 - NCT06389435Recruiting
Robotic vs. conventional knee replacement study
This trial compares robotic-assisted knee replacement surgery to the standard, conventional method. It aims to see if the robotic technique leads to better outcomes for patients getting a total knee replacement.
StockholmAges 18 years+ - NCT06389539Recruiting
Probiotic supplement study for bone health in older adults
This study tests whether a daily probiotic supplement can help prevent bone loss in adults aged 60 and older. It is designed for people who have chosen not to take standard osteoporosis medications.
Roslindale, MassachusettsAges 60 years+ - NCT06391554Recruiting
Education and exercise for hip osteoarthritis
This study compares the effects of adding exercise to an education program for people with hip osteoarthritis. It aims to see if exercise improves pain, function, and hip joint health (measured by MRI) more than education alone.
Aarhus CAges 45 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.