Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06392711RecruitingPhase 1
Stem cell therapy for dry mouth not from radiation
This trial tests a new treatment using special cells (mesenchymal stromal cells) from your own bone marrow to help with dry mouth that is not caused by radiation. The goal is to see if it can increase saliva production and improve quality of life.
Madison, WisconsinAges 18–90 - NCT06394089Recruiting
Spine surgery study for stenosis with mild slippage
This study tests a minimally invasive spine surgery (unilateral biportal endoscopy) to see if it works well for people with lumbar spinal stenosis who also have a mild vertebra slippage (spondylolisthesis). The goal is to improve leg symptoms like pain or numbness when walking.
Beijing, Beijing MunicipalityAges 50–80 - NCT06394310Recruiting
Dry needling for leg tightness in MS
This study tests whether dry needling (a therapy using thin needles to release muscle tightness) can help reduce leg stiffness and improve walking in people with multiple sclerosis. If you have leg spasticity and can walk with some help, this trial may be a good fit.
Kansas City, KansasAges 18–64 - NCT06395506Recruiting
Exercise and creatine for breast cancer survivors
This trial tests if adding creatine supplements to a virtual exercise program helps breast cancer survivors recover after chemotherapy. Participants will attend online exercise sessions three times a week and take creatine by mouth.
Galveston, TexasAges 18–75 - NCT06397677Recruiting
Study of Progressive RA Interstitial Lung Disease
This study is looking at people with rheumatoid arthritis (RA) who also have interstitial lung disease (ILD), a condition that causes scarring in the lungs. It aims to understand how the disease changes over time by using imaging and blood tests, without providing any new treatments right now.
San Francisco, CaliforniaAges 18–90 - NCT06398574Recruiting
Dry needling for shoulder muscle function
This study tests if dry needling (using thin needles on trigger points) can change how the shoulder muscles work. It aims to help people with long-term shoulder pain or healthy people understand muscle responses.
Alcalá de Henares, MadridAges 18–70 - NCT06401811Recruiting
Turkish swallowing questionnaire study for Sjögren's syndrome
This study tests a Turkish version of a swallowing questionnaire (EAT-10) to see if it is reliable and accurate for people with primary Sjögren's syndrome. Taking part could help doctors better understand and track swallowing problems in this condition.
AnkaraAges 18 years+ - NCT06402942Recruiting
Game-based occupational therapy for teens with Duchenne
This trial tests a fun, game-based occupational therapy program for teens with Duchenne muscular dystrophy. It aims to help you build skills and stay engaged through activities you can do at home on a computer or tablet.
AnkaraAges 13–18 - NCT06406452Recruiting
Resorbable airway splint trial for severe tracheobronchomalacia in children
This trial tests a new bioresorbable airway splint for babies and young children with severe tracheobronchomalacia (a weak, collapsing windpipe). It aims to help them breathe without a machine or tracheostomy and avoid major surgery.
Ann Arbor, MichiganAges 1 week–3 years - NCT06407817Recruiting
Comparing two gentle techniques for frozen shoulder
This study compares two gentle physical therapy techniques (Spencer and Reverse Distraction) to see which better improves mobility in people with frozen shoulder. The goal is to help you regain more pain-free movement in your daily activities.
Lahore, Punjab ProvinceAges 40–60 - NCT06409442Recruiting
Support and vibration for shoulder impingement
This study tests two non-invasive treatments—corrective external support (like special tape) and regional vibration—for people with subacromial impingement syndrome, a common cause of shoulder pain. It aims to see if these treatments can reduce pain and improve shoulder function.
Izmir, BalçovaAges 18 years+ - NCT06409962Recruiting
New school program for childhood obesity and prediabetes
This study tests a new program to help children with obesity, focusing on those with slightly higher blood sugar (prediabetes). It takes place at a school and requires both parent and child consent.
CórdobaAges 6–16 - NCT06410976Recruiting
Study of hypochondroplasia in children
This study is for children with hypochondroplasia, a condition that causes short stature. It will look at how the condition changes over time and aims to better understand it, with the goal of finding new treatments.
Oakland, CaliforniaAges 2.5 years–16 years - NCT06410833RecruitingPhase 4
Combination therapy for resistant Sjögren's in children
This trial tests a combination of two medicines, rituximab then belimumab, for children and teens with Sjögren's syndrome that hasn't improved with other treatments. The goal is to see if this two-step approach can better control symptoms like joint pain, skin rashes, and blood problems.
Beijing, Beijing MunicipalityAges 5–18 - NCT06411197Recruiting
Walking and muscle pain in healthy adults
This study looks at how people walk and how muscles in the legs may feel sore. It is for healthy adults to understand normal movement patterns.
Aalborg, North DenmarkAges 18–45 - NCT06413914Recruiting
CBT for long-term pain in rheumatic disease
This trial tests if cognitive behavioral therapy (a type of talk therapy that helps change pain-related thoughts and behaviors) can reduce long-term pain in people with rheumatic diseases. It also validates a new questionnaire (AE-FS) about how pain affects daily life.
OsloAges 18 years+ - NCT06414473RecruitingPhase 1/Phase 2
CBD for knee osteoarthritis pain
This study tests whether a CBD (cannabidiol) product can help reduce pain and improve daily life for people with knee osteoarthritis. If you have moderate to severe knee pain and haven't used cannabis recently, you may be able to join.
Gainesville, FloridaAges 40–75 - NCT06415591Recruiting
Nerve stimulation for fibromyalgia in veterans
This trial tests whether a mild ear nerve stimulation device can reduce pain for veterans with fibromyalgia. It also looks at how the brain changes with treatment using MRI scans for some participants.
Decatur, GeorgiaAges 18 years+ - NCT06415890Recruiting
4-7-8 breathing for shoulder pain after gallbladder surgery
This study tests whether a simple breathing technique (called 4-7-8 breathing) can help reduce shoulder pain and improve breathing after gallbladder removal surgery. It may be a good fit if you are having planned laparoscopic gallbladder surgery and staying overnight in the hospital.
HatayAges 18 years+ - NCT06416761Recruiting
Genetics and kidney disease progression study
This study looks at how genetics affect the progression of kidney diseases. Joining may help researchers understand your condition better and find better treatments.
MilanAges 18 years+ - NCT06417502Recruiting
China pediatric rheumatic disease registry study
This study collects information from children with rheumatic and immune system diseases in China to better understand these conditions. By participating, you help researchers learn more about how to diagnose and treat these diseases.
Beijing, Beijing MunicipalityAges Up to 18 years - NCT06417138Recruiting
Comparing rheumatoid arthritis treatments in Saudi Arabia
This study compares different drugs used to treat rheumatoid arthritis in Saudi Arabia. If you have rheumatoid arthritis and have been treated for at least a year, this study may help doctors learn which medicines work best.
Jeddah, Mecca RegionAges 18 years+ - NCT06424158Recruiting
Massage therapy after upper or lower back surgery
This study tests if massage therapy can help children recover after their first back surgery (thoracic or lumbar fusion). It's for kids who can talk and don't have certain health problems like chronic pain or bleeding disorders.
Fort Worth, TexasAges 7–19 - NCT06424743Recruiting
Strength training volume for women with fibromyalgia
This study tests whether different amounts of strength training (resistance exercise) help women with fibromyalgia feel better. It compares three different workout volumes to see which one women prefer and which works best for their symptoms.
Natal, Rio Grande do NorteAges 18–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.