Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06961578Recruiting
Comparing surgery and collar for odontoid fractures in older adults
This trial is comparing two treatments for a specific type of neck fracture (odontoid fracture) in people over 70: wearing a rigid neck collar versus having surgery. The goal is to see which approach leads to better recovery and quality of life.
Munich, BavariaAges 70 years+ - NCT06953284Enrolling by invitation
Tape or electrical stimulation for ankle stiffness in CP
This trial compares kinesiotaping (a special stretchy tape) to functional electrical stimulation (mild electrical pulses to muscles) for treating equinus deformity (walking on tiptoes) in children with cerebral palsy. It aims to see which method helps improve ankle movement and walking better.
TantaAges 4–10 - NCT06962306RecruitingPhase 4
Pain relief study for children having cleft palate surgery
This trial tests different ways to manage pain after cleft palate repair in young children. The goal is to find which approach works best to lower pain and improve recovery.
Durham, North CarolinaAges 6 months–4 years - NCT06953258Enrolling by invitation
Lengthening muscle exercises for older adults' function
This study tests whether a special type of exercise (eccentric training, which focuses on lengthening your muscles) can improve your ability to move and balance. It is designed for healthy older adults who are not already doing strength training.
NantesAges 60–80 - NCT06953375Recruiting
Electrical stimulation for faster recovery after knee replacement
This study tests if adding a gentle electrical stimulation (called NMES) to standard physical therapy helps people recover strength faster after knee replacement surgery. It is for patients who go to specific UCHealth or Intermountain Health therapy clinics after their first total knee replacement.
Aurora, ColoradoAges 18 years+ - NCT06960564Recruiting
Hyaluronic acid injection for knee osteoarthritis
This study tests whether a hyaluronic acid injection (a natural lubricant for joints) can reduce inflammation markers in the knee for people with osteoarthritis. It may be a good option if you have moderate knee pain that hasn't improved with other treatments.
IstanbulAges 45–75 - NCT06960343Recruiting
Shoulder repair with fat tissue for better healing
This trial tests whether adding a small amount of your own fat tissue to standard shoulder surgery helps the torn tendons heal better and last longer. It is for people with a full-thickness tear of the supraspinatus and infraspinatus tendons that needs arthroscopic repair.
Milan, ItalyAges 18 years+ - NCT06956664Recruiting
Exercise after steroid injection for herniated disc
This study tests whether adding a structured exercise program after a steroid injection for a herniated disc in the lower back helps reduce pain and improve function better than the injection alone. You may be eligible if you recently had the injection but still have significant pain.
ÇankırıAges 18–70 - NCT06956027Recruiting
Ultrasound study of Dupuytren's disease nodules
This study uses ultrasound to look at Dupuytren's disease nodules and track changes over 6 months. It may help doctors understand which nodules are active and need treatment.
Leuven, Vlaams-BrabantAges Any age - NCT06957444Enrolling by invitation
Allergic skin reactions and scar appearance after joint replacement
This study looks at how often patients have an allergic skin reaction to the stitches used after knee or hip replacement, and how their scar looks. If you are having a first-time replacement, you may be able to join.
Morgantown, West VirginiaAges 18–80 - NCT06677359Recruiting
Creatine and exercise for older adults
This study tests whether a creatine supplement, taken with or without a gentle exercise program, can help older adults stay stronger and more independent. It's designed for people aged 75 and older who can still walk.
Pamplona, NavarreAges 75 years+ - NCT05714007RecruitingPhase 4
Iron infusion for anemia after spinal deformity surgery
This trial looks at whether a specific iron infusion (ferric derisomaltose) can help treat anemia after spinal deformity surgery. You may be eligible if your blood counts show anemia soon after surgery and it’s likely due to iron deficiency.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06942819Enrolling by invitation
MRI study of VersaWrap nerve protector after back surgery
This trial uses MRI scans to see how well a nerve protector called VersaWrap works after one-level lumbar decompression surgery. It may help understand if the device helps nerves heal better.
Austin, TexasAges 18–65 - NCT06942689RecruitingPhase 4
Finding the best dose of numbing medicine for knee surgery pain
This trial tests different amounts of a long-lasting numbing medicine (liposomal bupivacaine) injected near the nerve in your thigh to see which volume works best for controlling pain after knee surgery. If you qualify, you may receive better pain relief and need fewer opioids.
Nanjing, JiangsuAges 18–85 - NCT06951477Recruiting
Gut health and knee replacement revision study
This study looks at how the bacteria in your gut might affect recovery after a second knee replacement surgery. Researchers want to learn more about the connection between gut health and surgical outcomes.
London, OntarioAges Any age - NCT06947746Recruiting
Studying stem cells for rheumatoid arthritis knee pain
This trial tests if stem cells can improve pain and swelling in the knee for people with rheumatoid arthritis that hasn't responded well to standard treatments. It's for those who still have significant knee symptoms despite taking medications.
ShanghaiAges 18–65 - NCT06948903Recruiting
Fibromyalgia, brain sensitivity and thinking
This study looks at how the brain's pain sensitivity (central sensitization) relates to memory and thinking problems in people with fibromyalgia. Participating could help doctors understand and treat these symptoms better.
Istanbul, UskudarAges 18–65 - NCT06946316Recruiting
Dairy or plant drinks for stronger bones with exercise
This trial compares dairy and plant-based drinks to see which is better for bone health when you also do resistance training. If you are a postmenopausal woman or a man 50 or older, you may join to help find out which drink helps bones most.
Saskatoon, SaskatchewanAges Any age - NCT06946199RecruitingPhase 1
Study of Cizutamig for Hard-to-Treat Rheumatoid Arthritis
This trial tests an experimental drug called cizutamig for people with rheumatoid arthritis that hasn't responded to other treatments. It aims to see if a new approach can help control the disease in patients who still have active inflammation despite trying other advanced therapies.
Wuhan, HubeiAges 18–75 - NCT06946329Enrolling by invitation
Water exercise for knee pain in obese men
This study tests whether a supervised water exercise program (called WATERinMOTION) can reduce knee pain and improve movement in obese men with knee osteoarthritis. It may help if you are looking for a gentle, joint-friendly way to manage your knee pain.
Zahedan, Sistan and BaluchestanAges 45–65 - NCT06948500Recruiting
Virtual reality exercise program for fibromyalgia pain
This study tests whether a virtual reality exercise program that changes how you see your own movements can help reduce pain and improve function in people with fibromyalgia. You would do the exercises at home using a headset, and researchers will check if this approach works better than standard exercise.
Valencia, Valencia-valènciaAges 18–80 - NCT06945198Recruiting
Long-term sports activity after ankle surgery for chronic instability
This study follows patients for years after ankle surgery to see how well they return to sports. It compares two surgical techniques for chronic ankle instability caused by old sprains.
LyonAges 18 years+ - NCT06946368Recruiting
Exparel for pain after knee replacement
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Cleveland, OhioAges Any age - NCT06946641RecruitingPhase 1
Testing QLS12010 safety in healthy adults and people with eczema
This trial tests a new drug, QLS12010, to see if it is safe and how it works in healthy volunteers and in people with moderate to severe atopic dermatitis (eczema). It may offer a new treatment option for those whose eczema has not improved with topical creams.
BeijingAges 18–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.