Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06814821Recruiting
Web-based rehabilitation after wrist surgery for osteoarthritis
This study tests a web-based rehabilitation program after certain wrist surgeries for osteoarthritis. It aims to help you recover better at home after your operation.
StockholmAges 18 years+ - NCT06805396RecruitingPhase 2
Adding palliative care support during radiation for bone cancer pain
This study tests whether adding a palliative care team early while you receive radiation for bone metastases can improve your quality of life and reduce symptoms.
AmersfoortAges Any age - NCT06812481Recruiting
Anticholinergic drugs and bone health in rheumatoid arthritis
This study looks at whether a type of medication (anticholinergic drugs) used for other conditions affects bone health in people with rheumatoid arthritis. It will help doctors understand if these drugs increase the risk of osteoporosis (weak bones) and if they should be avoided.
BalıkesirAges 18 years+ - NCT06809998RecruitingPhase 1/Phase 2
Steroid injection in non-surgical knee before knee replacement
This study tests whether a single steroid injection in the healthy knee (the one not being replaced) can reduce pain and improve recovery after total knee replacement. It may help people who have arthritis in both knees but are only having one replaced now.
Toronto, OntarioAges 18 years+ - NCT06813352Recruiting
Using facial expressions to recognize pain in fibromyalgia
This study uses artificial intelligence to look at facial expressions and other body signals to help recognize pain in people with fibromyalgia. It may lead to better ways to measure and treat pain.
Belo Horizonte, Minas GeraisAges 18–65 - NCT06803914Recruiting
Returning to sports after hip replacement
This study looks at how people move and return to sports after total hip replacement surgery. If you are an active person planning to have a hip replacement, this trial may help understand your recovery.
MérignacAges 18–65 - NCT06807866RecruitingPhase 4
Duloxetine for pain after hip replacement surgery
This trial tests if duloxetine, a medication that helps with nerve pain, can reduce pain after hip replacement surgery. It may help patients who are having a first-time total hip replacement.
Miami, FloridaAges 18 years+ - NCT04846959Recruiting
Pregnancy outcomes study for people exposed to risankizumab
This study looks at pregnancy outcomes in people who took risankizumab during pregnancy (or shortly before getting pregnant). It compares them with pregnancies exposed to similar biologic medicines, to better understand risks and what to expect.
Morrisville, North CarolinaAges Any age - NCT06801119RecruitingPhase 1
HN2301 for autoimmune diseases study
This trial tests a new mRNA treatment called HN2301 for people with autoimmune diseases like lupus, scleroderma, or rheumatoid arthritis. It aims to see if the treatment is safe and helps control the disease.
Hefei, AnhuiAges 18–69 - NCT06798623RecruitingPhase 1
ACL repair with stem cells from your own knee fat
This trial tests whether adding stem cells from your knee fat pad to a standard ACL reconstruction helps you heal better. It is for Houston Methodist patients who can do physical therapy there and meet basic health requirements.
Houston, TexasAges 18 years+ - NCT06795152Recruiting
Rare GSD Natural History Study
This study follows people with rare types of glycogen storage disease (GSD) over time to learn more about how the disease progresses. It does not test a new treatment but will collect information to help future research.
Durham, North CarolinaAges birth–90 years - NCT06797492Recruiting
Virtual Reality for Shoulder Problems
This trial tests whether virtual reality (a computer-made, 3D environment) can help people with shoulder problems recover better. You would use a VR headset for exercises, and the study will see if it improves your shoulder movement or pain.
Roma, ItalyAges 18–75 - NCT06794294RecruitingPhase 1/Phase 2
Stem cell therapy for chronic shoulder pain from partial rotator cuff tear
This trial tests whether a single injection of stem cells from donated umbilical cord tissue can help people with a partial rotator cuff tear that hasn't healed with standard treatments like physical therapy or injections. If you have had shoulder pain for at least 3 months and a partial tear confirmed by MRI or ultrasound, you may be eligible.
Seoul, KoreaAges 19 years+ - NCT06801574Recruiting
Comparing pain relief methods for back surgery
This trial compares three different ways to manage pain during and after back surgery (lumbar fixation). The goal is to find which approach provides better pain relief and recovery.
ErzurumAges 18–65 - NCT06802120Recruiting
Osteopathic care after lower back surgery
This trial tests whether osteopathic treatments can help reduce pain and improve daily life after spinal fusion surgery. It is for people who still have ongoing mechanical back pain four weeks after surgery.
ParisAges 18–75 - NCT06798116Enrolling by invitation
Gum disease treatment with platelet-rich fibrin and albumin gel
This study tests a new treatment for severe gum disease. It combines a natural blood product (platelet-rich fibrin) with a special albumin gel to help repair bone defects around teeth. The goal is to see if this mixture helps the bone grow back better than standard treatment.
Al MansurahAges 25–55 - NCT06797050Recruiting
Robot helper story for children with movement challenges
This study tests whether interacting with a robot helper named Nao can help children with movement difficulties learn new skills. The robot tells a story and guides activities to improve motor and thinking abilities.
Bosisio Parini, LeccoAges 7–16 - NCT06090357Recruiting
How footplant changes after foot and ankle surgery
This study uses special pressure mats to measure how your foot pushes against the ground before and after surgery. It helps doctors learn how surgeries change your walking and balance.
BolognaAges 18–75 - NCT06506201Recruiting
Hip replacement methods and leg length difference
This study compares two ways to perform hip replacement to see which one helps reduce leg length differences after surgery. The findings could help people with severe arthritis get better alignment and feel more comfortable.
BolognaAges 50–80 - NCT05871216Recruiting
Study of joint instability in people with loose joints
This trial is testing how to assess and manage joint instability in people who have unusually loose (hypermobile) joints. If you have moderate to severe loose joints, you may be able to join after screening checks like movement tests and health history.
BolognaAges 18–60 - NCT06791044Recruiting
Vitamin D and bone health in neurological patients
This trial looks at how vitamin D levels relate to bone strength and daily function in people with neurological disorders. If you have a neurological condition or are healthy, you may join to help understand how vitamin D affects bone health.
Nea Liosia, AthensAges 20–85 - NCT06788990RecruitingPhase 2/Phase 3
Study of ficerafusp alfa with pembrolizumab for advanced head and neck cancer
This study tests a new drug called ficerafusp alfa (BCA101) combined with the immunotherapy pembrolizumab for people with advanced head and neck cancer that has not been treated before. The goal is to see if adding ficerafusp alfa helps shrink tumors better than pembrolizumab alone.
Birmingham, AlabamaAges 18 years+ - NCT06782490RecruitingPhase 2
Testing a new drug for MS muscle stiffness
This study tests an investigational drug (BMS-986368) to see if it helps reduce muscle stiffness and spasms caused by multiple sclerosis. It may be an option if you have had spasticity for at least 6 months and are not currently using other treatments that cannot be paused.
Birmingham, AlabamaAges 18–70 - NCT06783114RecruitingPhase 2/Phase 3
Testing a new Botox-like injection for arm stiffness after stroke
This study tests an investigational botulinum toxin injection (YY001) to reduce muscle stiffness in the arm after a stroke. It may help you move your arm more easily and improve daily tasks.
Hefei, AnhuiAges 18–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.