Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06628206RecruitingPhase 1
Testing LPX-TI641 for rheumatoid and psoriatic arthritis
This trial tests a new drug, LPX-TI641, to see if it is safe and how it works in the body for people with rheumatoid arthritis or psoriatic arthritis. It may be an option if you have active joint swelling and pain despite standard treatments.
AmmanAges 18 years+ - NCT06629376RecruitingPhase 1
Testing a new gout drug for safety and effect on uric acid
This trial tests an experimental drug, SSS11, to see if it is safe and how it affects uric acid levels in people with gout and high uric acid. You may not take other gout medicines during the study.
ShanghaiAges 18–65 - NCT06630715Recruiting
Comparing Upadacitinib for Psoriatic and Rheumatoid Arthritis
This study tests whether the medication upadacitinib (Rinvoq) works similarly for psoriatic arthritis and rheumatoid arthritis. Participants will have ultrasound imaging to track joint inflammation while taking upadacitinib.
Legnano, MilanoAges 18 years+ - NCT06630975Recruiting
Knee alignment surgery comparison for children
This trial compares two surgical methods to correct knee alignment in children whose bones are still growing. It will help doctors know which approach works better and is safer.
AsyutAges 2–18 - NCT06631053Recruiting
Exercise program for 30 days of leg muscle disuse
This study looks at how a specific exercise program affects your muscles after a period of not using them (simulated by a leg brace). You'll wear a brace on one leg for 30 days and do certain exercises to see if they help prevent muscle loss.
Lexington, KentuckyAges 35–45 - NCT06632535Recruiting
Group visits and chiropractic care for older adults with chronic spine pain
This study tests whether group medical visits combined with chiropractic care can help older adults with chronic neck or back pain. If you join, you'll receive chiropractic treatments and attend group visits to learn pain management strategies.
Boston, MassachusettsAges 65 years+ - NCT06632639Recruiting
Wedged insoles with ankle straps for knee pain and bow legs
This trial tests whether special shoe inserts (wedged insoles) combined with ankle straps can reduce pain and improve knee alignment in people with mild bow legs and inner knee pain. It aims to help those who have not had knee surgery and can walk without help.
GizaAges 20–60 - NCT06634654Recruiting
AI-guided knee replacement study
This trial tests whether using artificial intelligence can improve recovery from total knee replacement by tailoring care to your body's needs. It may help people with severe knee arthritis who have not had major knee surgery before.
Rome, ItalyAges 18 years+ - NCT06637592Recruiting
Taping for heel pain in football players
This study compares two types of foot taping (windlass and calcaneal) to see which better relieves heel pain in football players with plantar fasciitis. It aims to help players return to sport more quickly.
Lahore, Punjab ProvinceAges 18 years+ - NCT06640309RecruitingPhase 2
Nicotinamide for rheumatoid arthritis: a clinical trial
This trial tests if taking a vitamin B3 supplement (nicotinamide) can improve outcomes for people with rheumatoid arthritis. Researchers want to see if adding this over-the-counter vitamin to your usual arthritis medicines helps reduce disease activity.
CairoAges 18–65 - NCT06640764Recruiting
Study of Medacta SMS hip stem for hip replacement
This study tests a specific hip implant (the Medacta SMS stem) for people needing a total hip replacement. It aims to see how well the implant works for patients with hip pain or disability from arthritis, injury, or other hip conditions.
Saint-JeanAges 18–85 - NCT06641895RecruitingEarly Phase 1
Testing BBM-D101 gene therapy for Duchenne muscular dystrophy
This early-phase study tests a new gene therapy called BBM-D101 for boys with Duchenne muscular dystrophy (DMD). The goal is to see if it is safe and helps improve muscle function in young boys.
Shanghai, Shanghai MunicipalityAges 4–8 - NCT06642207Recruiting
Comparing two biologic drugs for ankylosing spondylitis
This study compares two types of biologic drugs (IL-17 inhibitors vs. anti-TNF drugs) in people with ankylosing spondylitis (a form of arthritis affecting the spine) who have already tried standard treatments. The goal is to see which drug works better for controlling symptoms.
SohagAges 16–60 - NCT06642870Recruiting
Self-management programme for rare rheumatic conditions
This trial is developing a self-management programme for people with rare rheumatic conditions like lupus, vasculitis, myositis, or Sjogren syndrome. It aims to help participants better manage their condition and improve their quality of life.
BristolAges 18 years+ - NCT06643845Recruiting
Can medical treatments delay or avoid knee replacement?
This trial tests whether a combination of non-surgical treatments can help people with knee osteoarthritis avoid or delay total knee replacement surgery. It may be an option if you are considering knee replacement but want to explore medical alternatives first.
AmiensAges 18–90 - NCT06644729Recruiting
Shoulder surgery long-term study
This study looks at how patients who had rotator cuff repair surgery between 2010 and 2014 are doing now, including their shoulder function and x-ray results. It helps doctors understand long-term outcomes and when more surgery like reverse shoulder replacement may be needed.
OsloAges 18–95 - NCT06645899Recruiting
Italian database for parathyroid conditions
This study is creating a database of people with hypoparathyroidism or pseudohypoparathyroidism in Italy. It may help researchers learn more about these conditions and improve future care.
AlessandriaAges Any age - NCT06647069RecruitingPhase 1
Testing a new drug for lupus and rheumatoid arthritis
This study tests an investigational drug called SAR448501/DR-0201 in people with active lupus or rheumatoid arthritis who have not responded well to standard treatments. The goal is to see if the drug is safe and helps control disease activity.
Brisbane, QueenslandAges 18–75 - NCT06647134Recruiting
Understanding how immunotherapy side effects affect daily life
This study is for people whose immunotherapy (a type of cancer treatment) caused joint pain, swelling, or muscle stiffness. Researchers want to talk to you about how these side effects have affected your life, so they can better understand and help others in the future.
Houston, TexasAges 18 years+ - NCT06647225Recruiting
AI screening for hip dysplasia in babies
This trial tests whether an artificial intelligence tool can help doctors more accurately diagnose hip dysplasia in babies using ultrasound images. It might help your baby get a faster and more precise diagnosis if they are already being checked for a hip problem.
Parkville, VictoriaAges 4 weeks–5 months - NCT06649136RecruitingPhase 4
Maximizing methotrexate therapy for active rheumatoid arthritis
This trial tests whether increasing your methotrexate dose or switching from pills to injections can better control active rheumatoid arthritis. It's for people already taking a stable, moderate dose of methotrexate but still having joint swelling and symptoms.
Vienna, State of ViennaAges 18–99 - NCT06650228Recruiting
Heart risks and healthy habits in ankylosing spondylitis
This study looks at how heart health risks and healthy lifestyle habits (like diet, exercise, and not smoking) relate to people with ankylosing spondylitis. It may help you understand how to better manage your overall health.
KırşehirAges 18–65 - NCT06650631Recruiting
Heat treatment for knee pain from arthritis
This study tests if a heat treatment device can help reduce knee pain caused by arthritis. It involves people with moderate pain who can walk without help and have a recent knee X-ray.
Gravesano, SwitzerlandAges 19–69 - NCT06652061Recruiting
AI model to predict bone density from X-ray
This trial is testing an artificial intelligence (AI) model that uses X-ray images to predict bone density. If you have X-rays and a bone density scan, the AI may help doctors screen for osteoporosis without extra tests.
DhakaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.