Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06776965Recruiting
Ultra-processed foods and rheumatic disease study
This study explores how eating ultra-processed foods affects people with chronic rheumatic diseases like rheumatoid arthritis, spondyloarthritis, or osteoarthritis. It aims to understand if diet plays a role in symptom management.
LyonAges 18 years+ - NCT06778343Recruiting
Biomarkers study for inflammatory rheumatic diseases
This study is looking for people with ankylosing spondylitis, rheumatoid arthritis, or lupus to help find biomarkers that may make diagnosis easier. If you have one of these conditions and haven't tried biologic therapies, you may be able to join.
LisbonAges 18–65 - NCT06778447Recruiting
Disc injection for chronic low back pain
This study tests whether injecting a special disc material (nucleus pulposus allograft) into the damaged discs of your lower back can safely reduce pain and improve function. It's for people with long-term, moderate to severe low back pain from disc disease that hasn't gotten better with other treatments.
Napa, CaliforniaAges 22–85 - NCT06779123Recruiting
Vagus nerve stimulation for rheumatoid arthritis
This trial tests a non-invasive device that stimulates a nerve in your ear to see if it can reduce rheumatoid arthritis symptoms. It is for people whose RA has not responded well to at least one biologic or targeted DMARD.
Lund, Skåne CountyAges 18 years+ - NCT06780293RecruitingPhase 2
Laser acupuncture for dry eye and Sjogren's dry eye
This study tests if laser acupuncture can help people with dry eye symptoms, including those with Sjogren's syndrome, which causes dryness in the eyes and mouth. It may be a good fit if you have dry eye or Sjogren's and meet the age and eye test requirements.
Taipei, TaiwanAges 20–75 - NCT06781060Recruiting
Nerve stimulation for sciatic nerve injury in children
This trial tests if electrical nerve stimulation can help children aged 3 to 19 who have nerve damage in the leg caused by an injection. The goal is to improve nerve healing and leg function.
Multan, Punjab ProvinceAges 3–19 - NCT06781463Recruiting
Knee arthritis treatment registry
This study tracks patients with knee arthritis who undergo a procedure called genicular artery embolization (GAE), a minimally invasive option for those not ready for or not eligible for knee replacement. The goal is to see how well GAE works for pain relief.
Chicago, IllinoisAges 18 years+ - NCT06781580Recruiting
Ergonomic program for competitive esports players
This study tests an ergonomic protocol designed to help competitive esports athletes avoid injuries and stay comfortable during long gaming sessions. It focuses on PC gamers who use a mouse and keyboard and are already on a team.
Las Vegas, NevadaAges 18 years+ - NCT06782191Recruiting
Arthroscopic treatments for jaw joint disc displacement
This trial tests two types of jaw joint surgery for people with a displaced disc that still moves. It compares a simpler procedure (flushing the joint) with a more involved one (surgical repair) to see which helps more with pain and jaw function.
HuddingeAges 18 years+ - NCT06782178Recruiting
Comparing two jaw joint procedures for limited mouth opening
This study compares two minimally invasive procedures (arthroscopy using a tiny camera vs. arthrocentesis using a needle to flush the joint) to see which works better for people with a displaced jaw disc that limits mouth opening. It might help you if simple treatments haven't worked.
HuddingeAges 18 years+ - NCT06782347Recruiting
Study on SilverSneakers benefits for seniors with osteoarthritis
This study looks at whether offering the free SilverSneakers exercise program helps seniors with hip or knee osteoarthritis feel better and stay active. It is for people who have not used SilverSneakers before.
Hershey, PennsylvaniaAges 65 years+ - NCT06782464Recruiting
Freezing nerves for shoulder pain after stroke or brain injury
This trial tests if freezing certain nerves in the upper arm (cryoneurolysis) works as well as standard care for reducing shoulder pain and muscle tightness after a stroke or brain injury. It aims to improve function and ease caregiving tasks.
LuxembourgAges 18 years+ - NCT06782529RecruitingPhase 4
Knee injection study for patients with obesity and arthritis
This study tests if steroid injections for knee arthritis work in people with obesity. It may help you manage pain and avoid surgery.
Jacksonville, FloridaAges 55–85 - NCT06786936Recruiting
Study of IL-17 in depression with psoriasis
This study explores whether a protein called IL-17 might link skin/joint inflammation with depressive symptoms. If you have psoriasis or psoriatic arthritis and are starting a specific biologic (secukinumab, bimekizumab, or ixekizumab), this could help understand how treatment affects your mood.
Glasgow, ScotlandAges 18–74 - NCT06787417RecruitingPhase 4
Knee alignment study for total knee replacement
This study compares two different surgical techniques for total knee replacement to see which one leads to better knee movement and function. If you need a knee replacement due to arthritis, this trial may help find the best approach for your surgery.
Hamilton, OntarioAges 18 years+ - NCT06788860Recruiting
Needle knife release for trigger finger
This trial tests if using a needle knife guided by ultrasound can help release a locked or painful trigger finger. It's for people who have had symptoms for at least 3 months and haven't gotten better with other treatments like splinting or exercises.
Al Mansurah, Dakahlia GovernorateAges 18 years+ - NCT06788847Recruiting
Ultrasound-guided needle knife for Dupuytren's contracture
This trial tests a less invasive procedure using a needle-knife guided by ultrasound to treat Dupuytren's contracture, which causes fingers to curl. It may be an option if you haven't had prior treatment on the same hand and are in otherwise good health.
Al Mansurah, Dakahlia GovernorateAges 18 years+ - NCT06789029RecruitingPhase 4
Dexamethasone and numbing medicine for children's spine surgery
This study tests whether giving a common anti-inflammatory medicine (dexamethasone) in a different way or using a different strength of numbing medicine can reduce pain and swelling during and after spine surgery in children. It's for kids aged 11–17 who are having surgery for a curved spine that started without a known cause.
PoznanAges 10–18 - NCT06790225Recruiting
A study on a gut hormone and bone health
This trial looks at how a natural gut hormone (GIP) affects bone remodeling in healthy people. If you are healthy, you may help us understand how this hormone works on bone cells.
EsbjergAges 18–40 - NCT06791226Recruiting
Testing FAPI PET/CT for eye socket tumors
This study tests whether a new type of PET/CT scan (FAPI) can provide better images of tumors in the eye socket than the standard FDG scan. If you have a suspected or newly diagnosed orbital tumor, joining could help doctors see your tumor more clearly.
Beijing, Beijing MunicipalityAges 3–80 - NCT06793982RecruitingPhase 4
PRP vs Corticosteroids for Hip Osteoarthritis Pain
This study compares two types of hip injections—platelet-rich plasma (PRP) and corticosteroids—to see which works better for hip osteoarthritis pain. It may help you if you are considering an injection for your hip pain.
Baltimore, MarylandAges 21–80 - NCT06794008RecruitingPhase 2
CAR-T cell therapy for hard-to-treat autoimmune diseases
This trial tests a new treatment using your own immune cells (called CAR-T cells) designed to target and attack cells that cause autoimmune diseases. It is for people with lupus, Sjögren's syndrome, inflammatory myopathy, scleroderma, Behcet's disease, ANCA-associated vasculitis, IgG4-related disease, antiphospholipid syndrome, or thrombotic thrombocytopenic purpura who have not improved with standard therapies.
Beijing, Beijing MunicipalityAges 18–65 - NCT06795152Recruiting
Rare GSD Natural History Study
This study follows people with rare types of glycogen storage disease (GSD) over time to learn more about how the disease progresses. It does not test a new treatment but will collect information to help future research.
Durham, North CarolinaAges birth–90 years - NCT06795932Recruiting
Testing a new nerve stimulation device for frozen shoulder
This study tests if a non-invasive device that stimulates nerves can help treat frozen shoulder (adhesive capsulitis). If you are an adult with frozen shoulder and are in generally good health, you may be able to join to see if this device works.
Saguenay, QuebecAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.