Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07424352Recruiting
Rotational exercise for knee osteoarthritis
This study tests a special rotational exercise device to see if it can improve knee function and reduce pain in people with knee osteoarthritis. It involves supervised sessions at the university and may help you move better without surgery.
Aurora, ColoradoAges 40–70 - NCT07424638Recruiting
Nerve blocks for shoulder pain after lung surgery
This trial compares two types of nerve blocks to prevent shoulder pain after lung cancer surgery. If you are having open-lung surgery for lung cancer, you may be able to join.
CairoAges 18–65 - NCT07424716Recruiting
Bone healing with platelet-rich fibrin after cyst removal
This trial tests whether a natural blood concentrate (PRF) helps jawbone heal better after removing a dental cyst. It may improve recovery and reduce the need for additional bone grafting.
Sanaa, Sanaa GovernorateAges 18–80 - NCT07424742Recruiting
Toothless upper jaw implant study without bone grafts
This trial tests a way to place dental implants in the upper jaw where bone is thin (4-6 mm height) without needing a bone graft. It uses special self-tapping implants to lift the sinus floor gently through the implant site.
Sanaa, Sanaa GovernorateAges 18–80 - NCT07425613Recruiting
Neck movement before and after disc surgery
This study looks at how neck movement control changes after a common surgery (ACDF) for a damaged disc. It compares people having surgery with those who have neck pain but are not having surgery, to understand how the neck moves before and after treatment.
LjubljanaAges 18–65 - NCT07425652Recruiting
Physiotherapy methods for fibromyalgia pain
This study tests different physiotherapy techniques to help women with fibromyalgia manage pain and improve daily function. It compares several hands-on therapies to find the most effective approach.
AnkaraAges 18–65 - NCT07426991Recruiting
Multiple sclerosis, thinking, sleep, and tiredness study
This study looks at how multiple sclerosis (MS) affects your thinking, sleep, and tiredness. It compares people with MS who have at least mild fatigue to people without MS who also have sleep problems, to understand these issues better.
DüsseldorfAges 18–79 - NCT07427368Recruiting
Shockwave vs Ozone Injection for Tennis Elbow
This study compares two treatments for tennis elbow (lateral epicondylitis) that hasn't gotten better with simple care: one uses sound waves (ESWT) and the other uses a small injection of ozone gas. The goal is to see which works better for pain and function.
AnkaraAges 18–65 - NCT07428902Recruiting
French method with or without brace for clubfoot
This study compares two ways to treat clubfoot in babies: one using the French method alone, and the other adding a brace. It aims to see which approach helps better without surgery.
Lahore, Punjab ProvinceAges 1 day–1 year - NCT07428928Recruiting
Play-based hand therapy for cerebral palsy children
This trial tests whether playful hand and nerve exercises can improve grip strength and hand use in children with cerebral palsy. It may help children who have trouble with fine motor tasks.
Lahore, Punjab ProvinceAges 6–12 - NCT07429240RecruitingPhase 1/Phase 2
Gene editing trial for Duchenne muscular dystrophy (ages 2-7)
This trial tests a new gene editing treatment called PBGENE-DMD for boys with Duchenne muscular dystrophy (DMD) whose genetic mutation falls within a specific range of the dystrophin gene (exons 45-55). The goal is to see if it is safe and can help improve muscle function.
Little Rock, ArkansasAges 2–7 - NCT07429188Recruiting
Study of upper-limb assistive device users
This study looks at how well upper-limb assistive devices (like robotic arms) work for people who use them and for their caregivers. You and your caregiver can help by sharing your experiences in video interviews.
PerpignanAges 18 years+ - NCT07429916RecruitingEarly Phase 1
Ketamine for shoulder pain after weight loss surgery
This trial tests if a single dose of ketamine, given during surgery, can reduce common shoulder pain after laparoscopic gastric sleeve surgery. If you are having this weight-loss procedure and meet the weight and health criteria, this study may help improve your recovery.
IrbidAges 18–60 - NCT07431632Recruiting
Nerve freezing vs. epidural for pain after pectus excavatum repair
This study compares two ways to manage pain after pectus excavatum surgery: freezing the nerves during surgery (cryoanalgesia) versus an epidural block. The goal is to see which method provides better pain relief with fewer side effects.
São Paulo, São PauloAges 13 years+ - NCT07433335RecruitingPhase 1
First study of sr-878 for rheumatoid arthritis safety
This study tests a new investigational drug called SR-878 for people with rheumatoid arthritis. It aims to see if the drug is safe and tolerable. You may join if you are between 18 and 60, have RA for at least 3 months, and take a stable dose of methotrexate.
TbilisiAges 18–60 - NCT07434011Recruiting
Smartphone exercise program for knee osteoarthritis
This study tests if an artificial intelligence-powered smartphone app can help people with knee osteoarthritis do exercises at home that reduce pain and improve function.
Madrid, MadridAges 45 years+ - NCT07438652Recruiting
Mediterranean vs paleo diet for rheumatoid arthritis
This 12-week study compares two diets (Mediterranean and paleo) to see which one better helps rheumatoid arthritis symptoms, muscle health, and quality of life. It is for adults aged 40 to 60 who have been diagnosed with rheumatoid arthritis.
Cairo, Al-ManialAges 40–60 - NCT07439575Recruiting
Wound closure methods in hip and knee replacement
This study compares different ways of closing the wound after hip or knee replacement surgery. It looks at which methods heal best with fewer problems.
Istanbul, IstanbulAges 30 years+ - NCT07439679Recruiting
Anxiety Before Double Jaw Surgery and Your Recovery
This trial studies how anxiety before double jaw surgery affects your body during surgery and your recovery (pain, swelling, and ability to open your mouth). Researchers will use a simple anxiety questionnaire to see if feeling anxious changes your surgical experience.
IstanbulAges 18 years+ - NCT07440862Recruiting
Pelvic floor exercises and belt for pubic pain in pregnancy
This trial tests if pelvic floor exercises and a support belt work better than either alone for symphysis pubis dysfunction, a condition that causes pain in the front of the pelvis during pregnancy.
Daska KalanAges 25–40 - NCT07442773Recruiting
Support for partners and family caregivers of frail RA patients
This trial tests a support program for people who care for a loved one with rheumatoid arthritis. The program aims to reduce the burden on caregivers and help them feel more supported.
Glostrup Municipality, Capital RegionAges 18 years+ - NCT07443956Recruiting
Biologic and anti-obesity drug combo for psoriatic arthritis
This study tests whether adding a weight-loss medication (tirzepatide) to a biologic (ixekizumab) helps people with psoriatic arthritis and overweight or obesity. You will need to have biopsies of joint tissue and fat to see how the treatment affects inflammation.
Birmingham, EnglandAges 18–75 - NCT07445516Recruiting
Bite adjustment for TMD: long-term follow-up
This trial follows up with people who previously had a dental bite adjustment (occlusal equilibration) for TMD (jaw or face muscle/joint pain). It compares their long-term results with a group that received a 'sham' (fake) procedure.
Santiago de Compostela, A CoruñaAges 18–85 - NCT07446517Recruiting
Laser therapy for knee or heel pain in young athletes
This study tests if low-level laser therapy can help teenagers with Osgood-Schlatter knee pain or Sever heel pain. It aims to reduce pain from sports, so you can keep playing.
Gdansk, PomeranianAges 10–17
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.