Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07580222Recruiting
Using Mobile Technology to Track Knee Arthritis Health
This study uses smartphone or tablet technology to measure how your knee osteoarthritis (wear-and-tear arthritis) changes over time. You'll be helping researchers understand how well a previous arthritis treatment works by tracking your knee health at home.
Palo Alto, CaliforniaAges 30 years+ - NCT07580495Recruiting
Collagen Membrane to Preserve Jaw Bone After Tooth Extraction
This study tests whether a collagen membrane (a thin, natural material) placed after a tooth extraction helps preserve the jaw bone. Keeping bone healthy can make future tooth replacement easier and more successful.
Pittsburgh, PennsylvaniaAges 18–80 - NCT07580716RecruitingPhase 2
Knee Injection Treatment for Moderate Osteoarthritis
This study tests a new cell-based injection (Allocetra) directly into the knee joint for people with moderate osteoarthritis who haven't benefited from other treatments. The goal is to reduce pain and improve knee function.
Longwood, FloridaAges 64 years+ - NCT07581717Recruiting
Hip Socket Surgery Imaging Study for Children
This study uses MRI scans before and after hip socket surgery to measure how the surgery changes the shape and size of the hip joint. It helps doctors understand which surgical technique works best for children with hip dysplasia (a condition where the hip socket doesn't fully cover the thighbone).
IstanbulAges 2–18 - NCT07582510Recruiting
Telehealth vs. In-Person Physical Therapy for Golfer's Elbow
This study compares doing physical therapy exercises at home with video guidance versus attending in-person sessions for medial epicondylitis (golfer's elbow). The goal is to see which approach helps reduce pain and improve function better.
Banhā, BenhaAges 18–60 - NCT07583498Recruiting
Treating Muscle Stiffness After Spinal Cord Injury With Oxygen Therapy
This study tests whether brief periods of low oxygen (called acute intermittent hypoxia) can reduce muscle stiffness and tightness that develops after a spinal cord injury. Researchers believe this approach may help improve arm and hand function.
Chicago, IllinoisAges 18 years+ - NCT07585045Recruiting
Magnesium Supplements for Fibromyalgia Not Helped by Standard Drugs
This study tests whether taking magnesium by mouth can reduce fibromyalgia pain in people whose symptoms don't improve with common medications like amitriptyline, duloxetine, or pregabalin. Magnesium is a mineral that may help relax muscles and ease pain.
Lahore, Punjab ProvinceAges 18–65 - NCT07585305Recruiting
Blood Flow Restriction Training for Knee Pain in Athletes
This study compares two types of exercise—resistance training and cycling—both using a special technique that temporarily reduces blood flow to your leg muscles. The goal is to see which approach works better for reducing knee pain and improving strength in athletes with patellofemoral pain (pain around or behind the kneecap).
IslamabadAges 18–40 - NCT07588087Recruiting
Shoulder Release Therapy for Frozen Shoulder Pain
This study tests whether adding a specific muscle-release technique to shoulder exercises helps reduce pain and improve movement in frozen shoulder (adhesive capsulitis). Frozen shoulder causes stiffness and pain that limits arm movement; this trial explores whether combining two physical therapy methods works better than standard care.
Islamabad, Punjab ProvinceAges 35–70 - NCT07588555Recruiting
Two surgical approaches for lumbar spine narrowing
This trial compares two slightly different surgical techniques for treating lumbar spinal stenosis (a narrowing of the spinal canal that causes leg pain). Both procedures fuse one level of your spine to relieve pain, but use slightly different approaches through the side of the spine.
Guangzhou, GuangdongAges 40–70 - NCT07590050Recruiting
Catgut Embedding for Lower Back Pain and Blood Stasis
This trial tests catgut embedding (a traditional acupuncture technique using absorbable material) to treat chronic lower back pain caused by spine wear-and-tear, particularly for patients whose condition matches a traditional medicine pattern called 'blood stasis.' The goal is to see if this approach relieves pain and improves movement.
Ho Chi Minh City, Ho Chi Minh CityAges 18–65 - NCT07595718Recruiting
AI Study of Disease Patterns and Health Data
This research uses artificial intelligence to analyze health information from adults to better understand and predict when major diseases like diabetes, heart disease, and cancer might develop. Your participation could help scientists discover new patterns that improve early detection.
Seoul, Seoul Special CityAges 30–60 - NCT07597850RecruitingPhase 2
TCM formula versus HMB supplement for muscle strength in older adults
This study compares a traditional Chinese medicine formula with HMB (a muscle-building supplement) to see which helps preserve muscle strength and bone health in adults aged 65 and older who are starting to show signs of frailty. Both treatments aim to help you stay stronger and more active as you age.
TaipeiAges 65 years+ - NCT07598474Recruiting
Pregabalin and Movement Therapy for Knee Osteoarthritis Pain
This trial tests whether a nerve pain medication called pregabalin, applied through ultrasound waves to your knee, combined with gentle movement exercises, can reduce pain in advanced knee osteoarthritis. You'll attend 16 treatment sessions over 4 weeks to see if this combination helps.
Faisalābad, Punjab ProvinceAges 40–60 - NCT07600229Recruiting
Barefoot Walking vs. Standard Care for Heel Pain
This study compares barefoot walking to standard conservative care (like stretching and supportive shoes) for plantar fasciitis—a common cause of heel pain. Researchers want to see if walking barefoot helps reduce pain and improve function in people with persistent heel discomfort.
Carlow, Carlow CountyAges 18–70 - NCT07602595Recruiting
Understanding pain after childhood rheumatic disease or surgery
This study helps researchers learn how young adults (ages 14–26) who had rheumatic disease or orthopedic surgery as children experience pain over time. By understanding your story, the study may help doctors better support others facing similar challenges.
Cincinnati, OhioAges 14–26 - NCT07603674Recruiting
Personalized Primary Care for Muscle and Joint Pain
This trial tests whether tailoring musculoskeletal pain treatment to each patient's unique needs in primary care works better than standard care. You'll work with your regular doctor to find the approach that works best for your specific pain.
StockholmAges 18 years+ - NCT07603973Recruiting
Smartphone App to Help Manage Knee Osteoarthritis
This study tests whether a smartphone app that provides information and self-management tools helps people with knee osteoarthritis feel better and manage their condition. You would use the app at home to learn exercises, track symptoms, and get support.
Oslo, OsloAges 50 years+ - NCT07608432RecruitingPhase 3
Testing a New DMD Treatment Given Every 4 Weeks
This study tests whether a new medicine called zeleciment rostudirsen can help ambulatory (walking) males with Duchenne muscular dystrophy (DMD). The medicine is given as an intravenous infusion (through a vein) every 4 weeks and works by helping the body produce a protective muscle protein.
Hillsborough, North CarolinaAges 4–18 - NCT07608809Recruiting
Blood Flow Restriction Training vs. Pilates for Shoulder Pain
This study compares two exercise approaches—one using special wraps to limit blood flow during exercise, and standard Pilates—to treat shoulder impingement syndrome (a common condition causing shoulder pain with overhead movements). The goal is to see which method works better at reducing pain and improving shoulder function.
RāshidAges 4 months–1.1 years - NCT07609329Recruiting
Nutritional Support Before Sarcoma Surgery
This study tests whether special nutritional supplements given before surgery for bone or soft tissue sarcoma (a type of cancer) can help your body heal better and recover faster. You'll take oral supplements for at least a week before your planned surgery.
BrnoAges Any age - NCT07609394Recruiting
Duchenne and Becker Muscular Dystrophy Health Records Study
This study collects electronic health records (medical information already in your doctor's computer system) from people with Duchenne or Becker muscular dystrophy, or female carriers of these conditions. Researchers will use this data to better understand the diseases and improve care over time.
Little Rock, ArkansasAges Any age - NCT07611747RecruitingPhase 4
Ultrasound Screening to Prevent Heart Disease in Rheumatic Patients
This study tests whether using ultrasound to look at arteries in the neck can help prevent heart attacks and strokes in people with inflammatory joint diseases like rheumatoid arthritis or lupus. Researchers will use the results to guide treatment decisions.
Alicante, AlicanteAges 50 years+ - NCT07614945Recruiting
Reflexology for Pain and Sleep in Fibromyalgia
This study tests whether reflexology—a massage technique applied to specific points on the feet and hands—can help reduce pain and improve sleep in women with fibromyalgia. Fibromyalgia causes widespread muscle pain and sleep problems, and this trial explores whether reflexology might offer relief.
Al Mansurah, Dakahlia GovernorateAges 18–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.