Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07615491Recruiting
Safety and effectiveness study of spinal implants and bone materials
This study tracks how well spinal implants (Titania systems) and bone-filling materials (BONEGRAFT) work after surgery and whether patients experience any problems. Researchers will follow patients after cervical or lower spine surgery to confirm these devices are safe and effective in real-world use.
IzmirAges 18 years+ - NCT07616401Recruiting
Bone-Strengthening Drugs and Biomarkers in Postmenopausal Osteoporosis
This study tests two injectable medications (romosozumab and abaloparatide) that help strengthen bones in women after menopause. Researchers will also look at blood markers to understand why some women respond better to treatment than others.
Miano, LombardyAges 50 years+ - NCT07618403Recruiting
Physical Therapy for Knee Arthritis
This study tests whether a structured physical therapy program helps knee arthritis pain and function. Researchers will also look at how your expectations about treatment affect your results.
Ankara, YenimahalleAges 50 years+ - NCT07620834Recruiting
AI-Guided Bone Density Screening for High-Risk Adults
This study tests whether artificial intelligence can help identify people at risk for weak bones (osteoporosis) using chest X-rays. If you qualify, you'll be randomly assigned to either standard screening or AI-enhanced screening to see which approach works better.
ChanghuaAges 40–80 - NCT07621679Recruiting
Walking Program to Prevent Falls and Fractures in Older Adults
This study tests whether a specialized walking and balance program helps people aged 70+ with weak bones reduce their risk of falls and fractures. The program is designed to improve strength, balance, and confidence in daily movement.
Montreal, QuebecAges 70 years+ - NCT07624136Recruiting
Kinesio Taping for Shoulder Flexibility and Range of Motion
This study tests whether a special athletic tape (Kinesio tape) applied to your lower back and shoulder area can improve flexibility and reduce shoulder pain in people with chronic shoulder impingement syndrome—a condition where shoulder structures get pinched, causing long-term pain and stiffness.
Ankara, AltindagAges 20–40 - NCT07625150Recruiting
PET/MRI Imaging Study of Kneecap Joint Osteoarthritis
This research study uses advanced imaging (PET and MRI scans) to better understand osteoarthritis in the front of the knee, where the kneecap meets the thighbone. You'll help researchers learn how to detect and track this condition earlier.
San Francisco, CaliforniaAges 18 years+ - NCT07626346Recruiting
Pain relief medication added to shoulder surgery nerve block
This trial tests whether adding a medication called dexmedetomidine to a numbing injection around shoulder nerves can improve pain control after laparoscopic shoulder surgery. The goal is to see if this combination works better than the numbing medication alone.
CairoAges 18–65 - NCT07627282Recruiting
Understanding spine care evolution and patient outcomes
This study follows patients visiting a spine surgery department to better understand how care is provided and how patients do over time. It helps doctors improve treatment for spine problems like degeneration, deformity, injury, infection, or tumors.
BordeauxAges 18 years+ - NCT07627542Recruiting
Smartphone use and neck posture in arthritis patients
This study looks at how much time people with rheumatoid arthritis or ankylosing spondylitis spend on smartphones and how it affects their neck posture, balance, and disability. Understanding this connection may help doctors give better advice about phone use and neck health.
Konya, MeramAges 18–65 - NCT07628335Recruiting
Gong's Mobilization Techniques for Frozen Shoulder
This trial tests whether a specific hands-on physical therapy technique called Gong's mobilization, with or without an additional method called Nielasher, can help restore movement and reduce pain in frozen shoulder. Frozen shoulder is a condition where the shoulder becomes stiff and painful, limiting your ability to move your arm.
Lahore, Punjab ProvinceAges 40–60 - NCT07629141Recruiting
Muscle Position and Dry Needling for Neck Pain
This study tests whether the position of your neck muscle affects how well dry needling (inserting thin needles into tight muscle knots) relieves chronic neck pain. Dry needling may help reduce pain by relaxing tense muscles.
Alcalá de Henares, MadridAges 18–80 - NCT07630337Recruiting
Cryotherapy to reduce pain medication after knee replacement
This study tests whether applying cold therapy (cryotherapy) after knee replacement surgery helps patients need fewer opioid pain medications than standard care alone. If cryotherapy works, it could help you manage pain more safely after surgery.
Buenos Aires, Buenos AiresAges 18 years+ - NCT07630389Recruiting
Remote monitoring for childhood myotonic dystrophy
This study uses video calls and online assessments to track how myotonic dystrophy (a muscle-weakening condition) affects children over time. Researchers will also look at genetic factors to better understand the disease and improve care.
Rochester, New YorkAges birth–17 years - NCT07632846RecruitingPhase 2
Roflumilast as add-on treatment for active rheumatoid arthritis
This study tests whether adding roflumilast, a new medication, to your current rheumatoid arthritis treatment can help reduce joint inflammation and improve your symptoms. You would take it alongside methotrexate, a common RA medication you may already be using.
Al MansurahAges 18–60 - NCT07632872RecruitingPhase 2
Adding Desloratadine to Rheumatoid Arthritis Treatment
This study tests whether desloratadine, an allergy medication, can help reduce rheumatoid arthritis symptoms when added to your current treatments. Researchers want to see if it reduces joint swelling and pain alongside your existing therapy.
Al MansurahAges 18–60 - NCT07633587Recruiting
Cancer Survival Study After Heart Inflammation from Immunotherapy
This research tracks outcomes for cancer patients who developed heart inflammation (myocarditis) while receiving immune checkpoint inhibitor therapy. By studying survival patterns, researchers hope to better understand how to manage this serious side effect and improve care for future patients.
ParisAges Any age - NCT07633730Recruiting
Nerve Block for Back Pain in Ankylosing Spondylitis
This study tests whether a nerve-blocking injection in the back muscles can relieve persistent back pain in people with ankylosing spondylitis (a condition causing spine inflammation and stiffness). The injection targets specific nerves to reduce pain while your current disease treatment continues.
Istanbul, PendikAges 18–65 - NCT07634224Recruiting
Energy Transfer Therapy for Tennis Elbow Pain
This study tests whether a special energy-based therapy (called capacitive and resistive energy transfer) can reduce pain and improve function in people with tennis elbow—a common overuse injury of the outer elbow. You'll receive this non-invasive treatment and have your progress tracked over time.
Gaziantep, GaziantepAges 18–65 - NCT07637084Recruiting
Light therapy for chronic pain and fatigue in Ehlers-Danlos Syndrome
This trial tests whether a non-invasive light therapy called photobiomodulation can reduce chronic pain and fatigue in people with hypermobile Ehlers-Danlos Syndrome (hEDS), a genetic condition affecting connective tissue. The light is applied to the skin and may help cells produce energy and reduce inflammation.
Boulogne-Billancourt, Île-de-France RegionAges 18 years+ - NCT07637682Recruiting
Percutaneous Neurostimulation for Knee Osteoarthritis Pain
This trial tests a minimally invasive nerve-stimulation treatment for moderate to severe knee osteoarthritis pain in adults who have not found relief with standard treatments. The procedure uses small needles to deliver electrical stimulation near nerves to reduce pain.
TantaAges 18 years+ - NCT07638319RecruitingEarly Phase 1
Bone filler to preserve jawbone after tooth extraction
This early-stage trial tests a bone filler material (Neocement Inject P) placed in the socket after tooth removal to help preserve jawbone volume. This may help if you need a dental implant later.
Caparica, Monte Da CaparicaAges 18 years+ - NCT07639944Recruiting
REN Device Study for Jaw Pain and Headaches
This study tests whether a treatment called REN can help reduce headaches and jaw pain caused by temporomandibular disorders (TMD). You would use the REN device at home on your smartphone or tablet over several months.
Ridgeland, MississippiAges 12 years+ - NCT07640425RecruitingPhase 1/Phase 2
Testing a new collagenase injection for Dupuytren's contracture
This study tests whether a new injectable enzyme called CNT201 can safely and effectively treat Dupuytren's contracture—a condition where fingers curl and can't straighten. The injection aims to break down the thick tissue cords causing the problem, without surgery.
Kippa-Ring, QueenslandAges 18–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.