Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT07409103RecruitingPhase 2
Testing ELV001 for active rheumatoid arthritis
This study tests a new medication, ELV001, for people with active rheumatoid arthritis who haven't improved enough with methotrexate and a TNF inhibitor. The goal is to see if different doses of ELV001 are safe and can help reduce joint pain and swelling.
Gilbert, ArizonaAges 18–75 - NCT07414745RecruitingPhase 3
Study of a bone graft for two-level lower back fusion
This trial tests a special material (rhBMP-2) placed inside a cage to help two nearby vertebrae in the lower back fuse together. It is for patients whose disc problems or deformity have not improved after at least 3 months of other treatments, and who have significant pain and limited function.
Kobe, HyōgoAges 18–80 - NCT07408726Recruiting
Two screw types for stabilizing recent spine fractures
This study compares two ways of doing a minimally invasive back surgery to stabilize a recent spine fracture. It looks at whether using screws that can be angled in one direction versus all directions gives better results.
Innsbruck, TyrolAges 60 years+ - NCT07409818Recruiting
Shoulder calcific tendinitis treatment study
This trial tests a new way to classify calcium deposits in the shoulder tendon using MRI, which may help doctors choose the best treatment. It is for people who are having surgery for this condition.
Istanbul, ZeytinburnuAges Any age - NCT07409142Recruiting
BetterLife FSHD health and research platform
This study creates a patient-driven health and research platform for people with FSHD. It aims to collect information to better understand the condition and improve future research and care.
Randolph, MassachusettsAges 1 year+ - NCT07412821Enrolling by invitationPhase 1
Study of ASA-001 for ADSS1 deficiency muscle disease
This trial tests a drug called ASA-001 (adenylosuccinic acid) for people with a rare genetic muscle disease caused by ADSS1 deficiency. The goal is to see if it is safe and helps muscle function.
Los Angeles, CaliforniaAges 18 years+ - NCT07415967Recruiting
Dual-task exercise for rotator cuff shoulder pain
This study tests an exercise program that combines shoulder movements with mental tasks (like counting or naming things) to improve pain and function. It is for people with ongoing shoulder pain from common rotator cuff problems.
IstanbulAges 18–65 - NCT07410650Enrolling by invitation
Shoulder replacement that spares a key muscle
This study is testing a shoulder replacement surgery that avoids cutting a key muscle (the subscapularis). It may help patients recover shoulder function more quickly with less pain.
Salt Lake City, UtahAges 18–90 - NCT07413302Recruiting
Predicting recovery after back surgery for leg weakness
This study looks at which factors before surgery help predict how well leg weakness improves after a single-level microdiskectomy (minimally invasive back surgery for a slipped disk). It may help you understand what to expect if you are having this procedure.
KavalaAges 18 years+ - NCT07411625Recruiting
Pre-surgery exercise program for ACL injury patients
This trial tests whether doing special exercises before ACL surgery (called prehabilitation) helps you recover better after the operation. It's for people who have a first-time ACL tear and are scheduled for reconstruction surgery using a tendon from their own body.
NantesAges 18 years+ - NCT07415837Recruiting
Studying a molecule in muscle diseases and healthy people
This study looks at a molecule called miR-1 in the blood to see if it can help understand muscle diseases. Researchers will compare levels in people with certain muscle conditions and in healthy volunteers.
Clermont-FerrandAges 2 years+ - NCT07414017Recruiting
Virtual reality exercise for older adults with low back pain
This study tests if using virtual reality during exercise helps older adults with long-term low back pain. You'll do exercises while focusing your attention in different ways, and researchers will see which method works best for reducing pain and improving movement.
Center, Kirşehi̇rAges 65–80 - NCT07412782Recruiting
REMS bone scan study for children with bone conditions
This study uses a new ultrasound technology called REMS to check bone health in children aged 5 to 18 who have conditions that weaken bones. It may help find low bone density without radiation.
Florence, TuscanyAges 5–18 - NCT02719314Recruiting
Study bone loss from steroid use in people with inflammatory disease
This study looks at how steroid medicines (called glucocorticoids) affect bone strength in people with long-term inflammatory rheumatic conditions or psoriasis. It may help improve how doctors check and manage osteoporosis risk and bone metabolism over time.
BerlinAges 18 years+ - NCT05525039Recruiting
Vibration plus supplement trial for weak muscles and nerves
This trial studies whether a vibration treatment combined with an HMB supplement can improve weak muscle quality and reduce early nerve-to-muscle connection problems. It is mainly for older adults who already have signs of low muscle strength or function.
Hong KongAges 60 years+ - NCT06813040Recruiting
TMS therapy for jaw and face pain
This trial tests if repetitive transcranial magnetic stimulation (a non-invasive brain stimulation technique) can reduce long-lasting jaw and face pain caused by temporomandibular disorders. It might help people who have had pain for over six months and rate their pain as high.
CoimbraAges 18 years+ - NCT06587906Recruiting
Complications after skull base tumor surgery
This study looks at how often problems happen after surgery to remove skull base tumors. It may help doctors better understand and reduce risks for future patients.
BeijingAges 18 years+ - NCT06825650Recruiting
Turkish adaptation of a pain questionnaire
This study aims to adapt a questionnaire about pain into Turkish and check if it works well. Researchers want to see if the questions are understandable and reliable for people with certain types of pain.
Ankara, AltındağAges 18 years+ - NCT07403084Recruiting
Study of NEMOST V2 implant for children with scoliosis
This study looks at how well the NEMOST V2 implant works to straighten the spine in children with scoliosis that is getting worse despite other treatments. It may help kids whose spine curve is severe and needs surgery.
Nice, Provence-Alpes-Côte d'Azur RegionAges 5–17 - NCT07403188Recruiting
Long-Term Follow-Up Study for KYV-101 Participants
This long-term follow-up study checks on the health and safety of people who have already received the experimental cell therapy KYV-101 in a previous clinical trial. It is a way for them to be monitored over time without any additional treatments.
Denver, ColoradoAges 18 years+ - NCT07405983Recruiting
New study of a thumb joint replacement for arthritis
This study tests a new implant (TOUCH® CMC) for people with thumb arthritis. It aims to see if the implant relieves pain and improves function.
Aurora, ColoradoAges 22 years+ - NCT07398417RecruitingPhase 3
Testing esreboxetine for fibromyalgia relief
This study tests a medicine called esreboxetine to see if it helps people with fibromyalgia. First, everyone gets the medicine, then some may switch to a placebo to see if the medicine keeps working better than no treatment.
Glendale, ArizonaAges 18 years+ - NCT07406035RecruitingPhase 2
Study of TQH3906 for active psoriatic arthritis
This trial tests an experimental oral medication called TQH3906 for people with active psoriatic arthritis (PsA), a condition that causes joint pain, swelling, and skin psoriasis. The study aims to see if TQH3906 is safe and effective in reducing arthritis symptoms.
Bozhou, AnhuiAges 18–70 - NCT07400146RecruitingPhase 4
Numbing medicine for pain relief in laparoscopic surgery
This trial tests if numbing medicine (bupivacaine with epinephrine) placed over the diaphragm during laparoscopic surgery can reduce shoulder and other pain. It may help patients undergoing gynecologic laparoscopy recover more comfortably.
Los Angeles, CaliforniaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.