Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,837 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)65
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Chronic Pain37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,837 total
- NCT06216756Recruiting
Frozen cartilage transplant for knee cartilage defects
This trial tests a frozen cartilage transplant (called an osteochondral allograft) for people with painful knee cartilage defects. It aims to see if this procedure can help relieve pain and improve knee function.
Phoenix, ArizonaAges 12–60 - NCT06480955Recruiting
Freezing bone tumors to cure them: a registry study
This trial is studying the use of a freezing treatment called cryoablation to completely destroy bone tumors that have spread from other cancers. It is for people who have only a few tumors or whose tumors are mostly stable, and who are healthy enough to undergo the procedure.
BordeauxAges 18 years+ - NCT07727161Recruiting
3D printing to plan spine fracture surgery
This trial uses 3D-printed models to help surgeons plan operations for broken bones in the mid or lower back. It aims to make surgery more precise and safer.
Ústí nad LabemAges Any age - NCT06029764Recruiting
Extended fusion for spinal disc vacuum signs
This trial tests a surgery that fuses one extra spinal disc to treat a 'vacuum sign' (air pockets in the disc) that hasn't caused symptoms yet. It aims to prevent future problems in people with lumbar disc disease who need fusion surgery.
Beijing, Beijing MunicipalityAges 18–60 - NCT06456489RecruitingPhase 3
Pulse steroids for hard-to-treat rheumatoid arthritis
This trial tests whether a high-dose steroid injection can help people with rheumatoid arthritis that hasn't improved with other treatments. If you have RA that's not well controlled, this may be an option for you.
CairoAges 20–65 - NCT07727551Recruiting
Nerve block before knee replacement for better recovery
This trial tests if a nerve block given a few weeks before knee replacement surgery can improve pain and function after the operation. It is designed for people who have certain risk factors that might make recovery harder.
BrusselsAges 18–60 - NCT07727408Recruiting
New technique for early childhood scoliosis correction
This study tests a new way of treating early-onset scoliosis in young children without needing surgery at first. It aims to correct the spine curve using a special technique, which might help avoid more invasive treatments later.
Asyut, Asyut GovernorateAges 1–10 - NCT05801185Enrolling by invitation
Studying muscle changes after leg unloading in healthy young adults
This trial looks at how human muscle cells change when one leg is not used for a short time. It may help us understand muscle loss and how to prevent it.
Huddinge, Stockholm CountyAges 18–40 - NCT06448325Recruiting
Hip replacement fracture risk prediction
This study looks at past hip replacement patients to develop a score that predicts who might have another fracture later. It may help doctors prevent future breaks.
Milan, ItaliaAges 60 years+ - NCT06451874Recruiting
Exercise for older veterans with memory and walking concerns
This study tests whether personalized exercise programs can help older veterans who walk slowly and have mild memory or thinking concerns. The goal is to improve your physical and mental function.
Boston, MassachusettsAges 65 years+ - NCT06418217Recruiting
Exercise and education for lateral hip pain
This study tests whether exercise and patient education can help people with long-term lateral hip pain (pain on the outside of the hip). If you've had hip pain for over 6 months and an MRI confirms the cause, you may be able to join.
Horsens, HorsensAges 18–75 - NCT06434441Recruiting
Skull vs hip bone graft for upper jaw
This trial compares two ways to rebuild a narrow upper jaw bone: using a bone block from your skull (calvarial) versus one from your hip (iliac crest). It may help if you need more bone for future dental implants.
CairoAges 20–55 - NCT06414005RecruitingPhase 2/Phase 3
TPX-115 injection for partial-thickness rotator cuff tear
This trial tests an injection called TPX-115 for people with a partial-thickness rotator cuff tear (a shoulder tendon injury that doesn't go all the way through). It may help reduce pain and improve movement if you've had shoulder problems for more than 3 months despite other treatments.
Seongnam-si, Gyeonggi-doAges 19 years+ - NCT06268704RecruitingPhase 4
Comparing two types of steroid injections for sacroiliac joint pain
This study compares two types of steroid medication used in injections for sacroiliac joint pain. It aims to see if one type works better than the other, helping patients with low back or buttocks pain find relief.
Albuquerque, New MexicoAges 18–99 - NCT06389240Enrolling by invitation
Early weight bearing for shinbone fractures
This study tests whether starting to put weight on your leg early after surgery helps people with a certain type of shinbone fracture heal better. If you qualify, you'll receive standard surgery and then be assigned to either an early or a delayed weight bearing schedule.
Salt Lake City, UtahAges 18–65 - NCT07675304RecruitingEarly Phase 1
Mesotherapy for chronic low back pain study
This trial tests whether injecting a natural substance (collagen) into the lower back can safely reduce chronic pain. It may help people with pain that hasn't spread to the legs.
WarsawAges 18–65 - NCT06383377Recruiting
New bone graft for tooth extraction and implant
This study tests a new bone graft material called Wishbone HA used after tooth extraction to prepare for a dental implant. It is for people who need a tooth pulled and have healthy gums and good bone support.
Louvain-la-Neuve, Brabant WallonAges 18–80 - NCT07502209Recruiting
Two types of nerve treatment for chronic shoulder pain
This study compares two methods of treating chronic shoulder pain by using a needle to deliver a special type of electrical pulse to a nerve in the shoulder. The goal is to find which method provides better pain relief for people with shoulder pain from a rotator cuff problem.
AnkaraAges 40–80 - NCT06567665Recruiting
Leucine supplement for muscle building in older men
This study tests if taking a leucine supplement (an amino acid found in protein) can help older men build muscle more effectively. You may be eligible if you are a healthy, non-smoking man between 65 and 75 who does not currently do weight training.
Nottingham, NottinghamshireAges 65–75 - NCT06374654Enrolling by invitation
Home vs. formal physical therapy for new Achilles tendon pain
This study compares doing a home exercise program with going to formal physical therapy for people who have recently developed pain in the middle of the Achilles tendon (the thick cord in the back of the ankle). The goal is to see which approach works better for reducing pain and improving function.
Boston, MassachusettsAges 18 years+ - NCT07468734Recruiting
Shock wave vs. physical therapy for knee arthritis
This study compares two treatments for chronic knee osteoarthritis: shock wave therapy and traditional physical therapy. The goal is to see which one helps reduce pain and improve function better.
CairoAges 40 years+ - NCT06373341Recruiting
Virtual reality rehab for arm and hand after ICU stay
This study tests whether using virtual reality (VR) games can help you regain movement and strength in your arms and hands after a long hospital stay in the ICU. It is designed for people who live in the Frisian region of the Netherlands and can understand Dutch.
Leeuwarden, Provincie FrieslandAges 18 years+ - NCT06365892Recruiting
Open-label placebo for pain after scoliosis surgery
This trial tests whether taking a placebo pill that you know is a placebo (open-label placebo) can help reduce pain after spinal fusion surgery for scoliosis. It compares the placebo to standard care in adolescents aged 11-17.
San Francisco, CaliforniaAges 10–18 - NCT06365112RecruitingEarly Phase 1
Endoscopic surgery for hip socket fractures
This trial tests a minimally invasive, endoscopic (camera-guided) surgery to fix fractures of the hip socket (acetabulum). It may help people with this type of hip fracture recover with less pain and shorter hospital stays.
TampereAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,837 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,953 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.