Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,837 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)65
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Chronic Pain37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,837 total
- NCT06356766Recruiting
Home-based rehab for hand tendon injuries via video calls
This trial tests if doing hand therapy exercises at home through video calls (telerehabilitation) works as well as in-person therapy for people who had surgery for a specific type of tendon injury in the finger.
IstanbulAges 18–55 - NCT06354790Recruiting
LAMA2-related dystrophy natural history study in children
This study follows children with LAMA2-related muscular dystrophy to learn how the condition changes over time. It does not test a new treatment, but helps researchers understand the disease better.
GarchesAges 2–15 - NCT06231758RecruitingPhase 3
Metformin for knee osteoarthritis: a phase 3 trial
This study tests whether metformin, a common diabetes medication, can help reduce pain and improve knee function in people with knee osteoarthritis. It may offer a new treatment option for those with moderate knee OA.
Damietta, New DamiettaAges 30–60 - NCT06347991Recruiting
Chiropractic self-care app study for back pain in Alberta
This study tests an app called SelfBack that helps chiropractic patients manage their own long-term low back pain. You will use your smartphone to receive personalized exercises and tips. It may help you take control of your back pain between chiropractic visits.
Edmonton, AlbertaAges 18 years+ - NCT07473141Recruiting
Measuring walking problems with wearable sensors
This trial uses small wearable sensors to measure how you walk while you are in the hospital. It can help doctors better understand and treat walking difficulties.
Milan, ItalyAges 18–80 - NCT06981741RecruitingPhase 1/Phase 2
Stem cell treatment for knee cartilage damage
This trial tests whether a new stem cell treatment, given during a surgical procedure, can help repair damaged cartilage in the knee. It is for people with moderate to severe knee pain and a specific size of cartilage injury.
AltenburgAges 18–60 - NCT06320496Recruiting
Can a physical activity recovery stay help your child?
This study is for children age 8 to 18 who have a long-term health condition (like a chronic illness, rare disease, or disability) and are in a program to help them start being active again. The trial will check if a special exercise recovery stay helps them get stronger and feel better.
NancyAges 8–18 - NCT06322654Recruiting
Comparing two types of robotic rehab for spinal muscular atrophy
This study compares two robot-assisted rehabilitation programs to see which one helps children and young adults with spinal muscular atrophy (SMA) improve their movement and function better. You may join if you have SMA (types 1-4), are up to 21 years old, and are already receiving medication for SMA.
PoznanAges Up to 21 years - NCT07377669Enrolling by invitation
Partial knee replacement plus ACL repair study
This study tests a combination surgery: repairing the torn ACL at the same time as replacing only the damaged part of your knee. It's designed for active people with arthritis in one knee compartment and a fully torn ACL.
BolognaAges 18–75 - NCT06987019Recruiting
Testing balance in people with one-sided below-knee amputation
This study tests a new way to measure balance in people who have a below-knee amputation on one leg. It uses special sensors to see how well the legs work together during movement, which could help improve prosthetic fit and rehabilitation.
New York, New YorkAges 18 years+ - NCT06309433Recruiting
Bone density after different knee replacement designs
This study looks at how bone density around a new knee replacement changes over time, comparing two different types of knee implants. It may help your surgeon choose the best option for you.
Bologna, ItaliaAges 45 years+ - NCT07240961Recruiting
Nerve block for pain after hip replacement
This study tests whether a nerve block injection in the back (called an erector spinae plane block) can provide better pain relief after a first-time hip replacement. It may help reduce the need for strong painkillers.
ManoubaAges 18–85 - NCT06254794Recruiting
Blood flow restriction rehab after Achilles tendon repair
This study tests whether adding blood flow restriction (BFR) to standard physical therapy helps people recover better after Achilles tendon repair surgery. You may be a good fit if you had a PARS or open repair and plan to rehab at a Methodist Hospital.
Houston, TexasAges 18 years+ - NCT06244511Recruiting
Balance Exercises for Chronic Ankle Instability
This study compares two types of balance exercises (standing on one leg vs. standing on both legs) to see which works better for people with long-term ankle instability. If you have chronic ankle weakness after a sprain at least 6 months ago, this trial may help improve your balance and confidence.
IstanbulAges 18–50 - NCT06238960Recruiting
Home-based physical therapy after hip replacement
This trial tests whether doing physical therapy at home using video calls works as well as in-person therapy after a hip replacement. You would continue your rehab with the same team, but from home.
Bologna, ItaliaAges 50–80 - NCT07735949Recruiting
Daily footwear and leg health in hemophilia knee replacement
This study looks at how the shoes you wear every day affect your leg health and movement. It involves adults with hemophilia who are about to have their first total knee replacement and are willing to participate in a pre-surgery exercise program.
Istanbul, IstanbulAges 18–35 - NCT07736456Enrolling by invitation
Exercise program for teens with mild to moderate scoliosis
This study tests a 16-week corrective exercise program for adolescents with idiopathic scoliosis. It aims to see if these exercises can improve spinal curves and posture without surgery or bracing.
Pristina, KosovoAges 10–18 - NCT07252219Recruiting
How ankle muscle fatigue affects balance in unstable ankles
This study looks at how getting your ankle muscles tired changes your ability to sense force and control movement. It compares people with chronic ankle instability to healthy volunteers to find better ways to prevent re-injury.
LjubljanaAges 18–45 - NCT06999460Recruiting
Shoulder block for pain relief during shoulder surgery
This trial tests if a nerve block near the shoulder blade can reduce pain before, during, and after shoulder surgery. It may help patients need less pain medicine and feel more comfortable.
Zagazig, EgyptAges 21–65 - NCT06181097Recruiting
Negative pressure wound therapy after knee or hip replacement
This study tests whether using a special bandage that applies gentle suction (negative pressure wound therapy) after knee or hip replacement helps incisions heal better. It may reduce wound complications and improve recovery.
Hong KongAges 50 years+ - NCT07287215Recruiting
Motor imagery and daily function in diplegic cerebral palsy
This study tests whether imagining movements (motor imagery) can help improve everyday skills like walking and playing in children with diplegic cerebral palsy. It compares the effects of motor imagery training with standard physical therapy.
BingoelAges 5–18 - NCT06171204Recruiting
Knee arthritis treatment with your own cells
This trial tests a treatment using your own cells (stromal vascular fraction) to repair knee joint damage and reduce pain. It may help people with knee arthritis, tendon injuries, or persistent knee pain.
Ghent, Oost-VlaanderenAges 18–90 - NCT06153940Recruiting
Study of three hip implants after surgery
This study is testing three different hip implants (Everglade Stem, World Cup, and World Liner) to see how well they work in people needing a hip replacement. It aims to help patients with hip arthritis or other joint damage get back to their daily activities.
Cleveland, OhioAges 18–75 - NCT07089888RecruitingPhase 3
Dotinurad vs allopurinol for gout with lumps
This trial is testing a new gout medication, dotinurad, compared to the standard treatment allopurinol for people with tophaceous gout (gout that causes hard lumps). It aims to see if dotinurad is better at reducing uric acid and shrinking those lumps.
Birmingham, AlabamaAges 18–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,837 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,953 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.