Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT03286868Recruiting
Tested knee replacement alignment during knee surgery
This study looks at how a specific computer/measurement approach (“Verasense”) helps position the knee during total knee replacement for people with knee arthritis. It may help improve how the new knee fits and aligns as you recover.
Halifax, Nova ScotiaAges 21–80 - NCT04711551Recruiting
Monitoring patients after regenerative treatments for joint or tendon pain
This trial follows people who receive “regenerative medicine” treatments (orthobiologics) for joint or tendon problems, like osteoarthritis or tendon pain. The goal is to study whether clinical check-ins and lab/biologic measurements can help monitor how patients are doing after treatment.
Milan, ItaliaAges 6 years+ - NCT06487741Recruiting
Stretching at home for fibromyalgia pain relief
This study tests whether a simple home stretching program can help relieve fibromyalgia symptoms. You would be asked to do stretches at home and report how you feel.
AalborgAges 18–60 - NCT07394673Recruiting
Nerve block for pain after shoulder surgery
This trial tests a new ultrasound-guided nerve block for pain relief after shoulder surgery. It aims to improve comfort and reduce the need for pain medications.
BursaAges 18–65 - NCT07395128RecruitingPhase 1
Artery Treatment for Plantar Fasciitis
This study tests a new, minimally invasive procedure to treat stubborn heel pain caused by plantar fasciitis. Small particles are injected into a specific artery in the foot to reduce blood flow and inflammation, which may relieve pain without surgery.
Libertyville, IllinoisAges 25–80 - NCT07391605RecruitingPhase 2
Descartes-08 for treatment-resistant myositis
This trial tests a new treatment called Descartes-08 for people with dermatomyositis or antisynthetase syndrome whose disease hasn't responded well to standard therapies. It aims to see if this treatment can help control muscle and skin symptoms.
Orange, CaliforniaAges 18 years+ - NCT07393373Enrolling by invitationPhase 2
Long-term study of infigratinib in children with hypochondroplasia
This study is for children with hypochondroplasia who already completed the ACCEL 2/3 trial. It tests the long-term safety and effects of the study drug infigratinib, and gives continued access to the treatment.
Oakland, CaliforniaAges 3–18 - NCT07396051Recruiting
Exercise program for frail older adults after back fusion surgery
This trial tests whether a special exercise program after lower back fusion surgery can help prevent complications in older adults who are frail. If you are 75 or older and having your first small back fusion, this rehab might help you recover better.
Beijing, Beijing MunicipalityAges 75 years+ - NCT07397884Recruiting
Bone loss and stress markers in implant gum disease
This study looks at markers of bone damage and stress in people with gum disease around dental implants (peri-implantitis). It aims to understand how the body responds, which could help improve treatment.
Keçiören, AnkaraAges 18–65 - NCT07394582Recruiting
Pre-surgery optimization for hip or knee replacement
This trial tests a program to improve your health before hip or knee replacement surgery. It aims to help you recover better and reduce risks.
Innsbruck, TyrolAges 18–99 - NCT07396233Recruiting
Knee Osteoarthritis Therapy: Diagonal Movement Patterns
This trial tests a type of physical therapy called proprioceptive neuromuscular facilitation for people with knee osteoarthritis. It may help reduce pain and improve how well your knee works.
Karachi, SindhAges 40–60 - NCT07389096RecruitingPhase 4
Pain relief without opioids for teens having spine surgery
This trial tests if a drug combination that avoids opioids can safely control pain during and after scoliosis surgery in teenagers. It aims to reduce opioid side effects and improve recovery.
Port SaidAges 8–18 - NCT07391410Recruiting
A registry study for bone metastases
This study is creating a registry to track information about people with bone metastases (cancer that has spread to the bones) who need treatment for symptoms. It may help researchers learn more about these conditions.
Basking Ridge, New JerseyAges 22 years+ - NCT07397806Recruiting
Home-based leg trainer for knee osteoarthritis
This study tests a home exercise device designed to improve leg control and reduce pain in people with knee osteoarthritis. You may be eligible if you have knee pain and are between 40 and 85 years old.
Vail, ColoradoAges 40–85 - NCT07396077Recruiting
Pre-op health boost for elderly spine surgery patients
This trial tests if a 6-week prehabilitation program (exercise and nutrition) before spine surgery helps elderly patients recover better. It is for people 75 or older with long-term lower back problems who need spinal fusion surgery.
Beijing, Beijing MunicipalityAges 75 years+ - NCT07390851Recruiting
Magnesium with lidocaine for jaw and neck muscle trigger points
This trial tests whether adding magnesium to lidocaine makes trigger point injections more effective for jaw, face, or upper shoulder pain. The results will be measured by pain scales and muscle activity tests.
Giza, Giza GovernorateAges 18–70 - NCT07395427Enrolling by invitation
Body awareness therapy for knee osteoarthritis
This study compares a movement therapy called Basic Body Awareness Therapy to usual care for people with knee osteoarthritis. It aims to see if this therapy can improve pain, movement, and quality of life.
Ankara, AnkaraAges 40–74 - NCT07389681Recruiting
Bone loss repair: Masquelet technique vs transport nails
This study compares two surgical techniques for rebuilding bone in the lower leg or thigh after significant bone loss. If you need this type of surgery, you may be able to join and help doctors learn which method works best.
BordeauxAges 18 years+ - NCT07389343Recruiting
Semi-rigid foot insole for flat feet without pain
This study tests whether a semi-rigid shoe insert can help young adults with flexible flat feet that are not painful. If you have flat feet but not constant pain, this trial may help improve foot function.
GizaAges 18–35 - NCT07391488Enrolling by invitation
Lumbopelvic rhythm & posture in scoliosis
This study looks at how the way your lower back and pelvis move together affects your balance, daily activities, and quality of life if you have scoliosis. It aims to find better ways to help you move and feel better.
Ankara, ÇorumAges 10–18 - NCT06829875Recruiting
Access to muscle and joint therapy services
This study looks at how quickly people get appointments for muscle and joint problems. It includes patients waiting for foot therapy, occupational therapy, or physical therapy.
Cardiff, WalesAges 18 years+ - NCT06807853Recruiting
Tracking movement with a smartwatch for spine arthritis
This study uses a smartwatch to track your movement and give you exercise advice. It aims to help people with axial spondyloarthritis stay active and manage their condition.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT06817616Recruiting
Rotator cuff repair with stem cells for large shoulder tears
This trial tests whether adding umbilical cord stem cells to standard arthroscopic rotator cuff repair helps heal large or massive tears better. It may be an option if you have had shoulder pain for at least three months and other treatments haven't worked.
Seoul, KoreaAges 19 years+ - NCT06833489Recruiting
Using genetic testing to find answers for rare muscle diseases
This study looks at leftover muscle tissue from people who have had genetic testing for rare muscle diseases but didn't get a clear diagnosis. The goal is to use newer genetic analysis to find the cause of their disease.
MarseilleAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.