Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT06832046Recruiting
Intranasal fentanyl for pain in pediatric emergencies
This study looks back at children who already received fentanyl nasal spray for pain in the emergency department. It aims to see how well this method worked for treating sudden pain in children.
StrasbourgAges 1–17 - NCT06832852Recruiting
Comparing cost-effective care for muscle and joint pain
This study compares different models of care to find the most cost-effective way to treat common muscle and joint problems (like back, neck, knee, or shoulder pain). It looks at which approach works best for patients with persistent pain to guide future treatment decisions.
Québec, QuebecAges 18–65 - NCT06831214Recruiting
Bone growth with collagen membrane graft for jaw atrophy
This trial studies a new technique to help build up bone in the upper jaw (maxilla) that has become thin. It uses a special membrane and graft material to encourage bone growth, which may help people who need dental implants.
CairoAges 18–60 - NCT06388811Recruiting
Turkish version of a knee pain questionnaire study
This study tests a Turkish questionnaire for early knee osteoarthritis. It may help doctors better identify and treat early knee pain.
IstanbulAges 18 years+ - NCT06579599Recruiting
Preventing surgical issues with a doctor-nurse team
This study tests whether a new team approach—where doctors and nurses work closely together in the operating room—can help prevent problems during orthopedic surgery. If you are having surgery for a bone or joint issue at this hospital, you may be able to join.
Yiwu, ZhejiangAges 18–70 - NCT06833749RecruitingPhase 2
Testing KBP-336 for knee osteoarthritis with obesity
This study tests an experimental medicine called KBP-336 for people with both obesity and knee osteoarthritis who still have significant knee pain despite standard treatments. It aims to see if KBP-336 can reduce pain and improve function.
BrnoAges 45 years+ - NCT07383740Recruiting
Reliability of a gentle bike test for hip or knee osteoarthritis
This study checks whether a simple, low-effort bike test gives consistent results for people with hip or knee osteoarthritis. It helps doctors understand how well this test can measure your fitness without pushing you too hard.
GothenburgAges 30 years+ - NCT07380906Recruiting
Knee artery embolization for knee arthritis registry
This trial is testing a procedure called genicular artery embolization (GAE) to treat knee osteoarthritis. If your knee pain hasn't improved with standard treatments like medicine, this study may be a way to try something new.
Libertyville, IllinoisAges 18 years+ - NCT07388966Recruiting
Measuring limb movement in achondroplasia and hypochondroplasia
This study is tracking how people with achondroplasia or hypochondroplasia move their limbs in daily life using a small wearable device. The information will help doctors better understand these conditions and may lead to better care.
LiègeAges 2–65 - NCT07384104Enrolling by invitationPhase 1
Comparing a new bone drug (SAL023) to Evenity in healthy volunteers
This trial tests a new medicine called SAL023 to see how it compares to an approved drug (Evenity) in healthy people. It looks at how the body processes the drug, safety, and immune response. You must be healthy, within a certain age and weight range, and not have any bone or heart problems.
Hefei, AnhuiAges 18–45 - NCT07388017Recruiting
Using infrared cameras to spot bone or joint infections in children
This study tests if a special camera that detects heat (infrared thermography) can help doctors quickly identify bone or joint infections in children. If successful, it could lead to faster, painless diagnosis without extra blood tests or scans.
Sheffield, South YorkshireAges birth–15 years - NCT07385443Recruiting
Spanish registry for myotonic dystrophy type 1
This registry collects information from people with myotonic dystrophy type 1 (DM1) to better understand the condition and improve care. Anyone with a confirmed genetic diagnosis can join.
Multiple Locations, AndalusiaAges Any age - NCT07388407Recruiting
Genetics of leflunomide for rheumatoid arthritis
This study looks at how your genes might affect how well leflunomide works for rheumatoid arthritis. It is for Pakistani adults who are starting or recently started leflunomide, and will help doctors understand who might respond best.
Islamabad, Punjab ProvinceAges 20–65 - NCT07388290Enrolling by invitation
Moving inner knee cartilage back into place for a root tear
This study looks at whether moving a torn inner knee cartilage back into place helps reduce the amount it sticks out. It is for people with a specific type of tear (Type 2) on MRI, whose cartilage has shifted by 3 to 6 millimeters.
West Vail, ColoradoAges 18–65 - NCT07386587Enrolling by invitationPhase 3
Methotrexate plus etanercept for juvenile arthritis
This study compares methotrexate alone versus methotrexate combined with etanercept to see which works better for children with polyarticular juvenile idiopathic arthritis. The goal is to help children achieve low disease activity quickly.
Lahore, Punjab ProvinceAges 2–16 - NCT07383558Recruiting
Adding nerve treatment for chronic heel pain
This trial tests if adding a nerve treatment (pulsed radiofrequency of the sural nerve) to standard care helps people with long-lasting heel pain. It may reduce pain and improve function.
AnkaraAges 18–65 - NCT07384689Recruiting
Study of leg tissue in non-traumatic amputation patients
This study looks at the tissue environment in the legs of patients who need amputation due to non-traumatic causes, like poor blood flow or infection. Understanding the tissue better might help improve healing for future patients.
Aarhus NAges 18 years+ - NCT07382830Recruiting
Visual feedback exercises after lower back surgery
This trial tests if a special exercise program that uses visual feedback helps people recover better after surgery for a herniated disc in the lower back. It may improve your recovery and reduce pain.
AntalyaAges 18–65 - NCT07384754Recruiting
Foot exercises to improve balance and walking in older adults
This study tests whether doing simple foot exercises can improve balance and walking in older adults. It may help you feel steadier and move more easily.
Bloomington, IndianaAges 45 years+ - NCT07386548Recruiting
Biologic injection for low back disc problems
This study tests if an injection can help people with a herniated disc in the lower back who have not gotten better with other treatments and are already planning surgery. It aims to see if the injection can reduce symptoms and possibly avoid or improve surgery outcomes.
Manhattan, New YorkAges 18 years+ - NCT07385677Recruiting
Comparing a new approach to usual care for lateral elbow pain
This trial tests if a new way of thinking about the nerves and layers in your arm (called TINLL) works better than usual therapy for people with pain on the outside of their elbow. It may help you get better faster.
South Burlington, VermontAges 18 years+ - NCT07379801Recruiting
Ballet dancers with scoliosis: A study on bone health and exercise
This study looks at how scoliosis affects the bones and muscles of young female ballet dancers during puberty. It also tests whether a special exercise program can help. Eligible dancers will be followed for a year.
HaifaAges 11–16 - NCT07381296Recruiting
Studying rheumatoid arthritis flare-ups
This study looks at what causes disease flares in people with rheumatoid arthritis. Researchers will track participants to find predictors of flare-ups, which could help manage the disease better.
Sohag, Sohag GovernorateAges 18 years+ - NCT07381621Recruiting
Comparing sugar water vs. numbing shots for knee arthritis
This study compares two different types of knee injections for people with knee osteoarthritis. One injection uses a simple sugar solution (dextrose), and the other uses a standard numbing medication (local anesthetic). The goal is to see which works better for reducing pain and improving knee function.
Ankara, AltindagAges 40–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.