Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,837 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)65
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Chronic Pain37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,837 total
- NCT07337772Recruiting
Comparing corticosteroid doses in knee replacement pain relief injection
This study compares different doses of a corticosteroid (an anti-inflammatory medicine) injected into the knee during total knee replacement surgery. The goal is to see which dose provides the best pain relief after surgery. It is for people having their first knee replacement due to osteoarthritis.
Fuzhou, FujianAges 18–100 - NCT04876781Recruiting
Track safety of Xeljanz XR in Korea
This study collects real-world safety information about Xeljanz XR after it has been approved. It includes people with certain immune-related joint diseases and checks for side effects in everyday use.
SeoulAges 18 years+ - NCT06172569Recruiting
Study of a new hip replacement system
This study is testing a new hip replacement system (Spartan, World Cup, and World Liner) in people who need their first hip replacement due to arthritis or similar conditions. It aims to see how well the implant works and how safe it is over time.
Cleveland, OhioAges 18–75 - NCT07028476Recruiting
New care for possible ACL tear using automated laxity test
This trial is testing a new approach to care for people with a possible torn ACL (the ligament in your knee). It uses a special exam to measure knee looseness automatically, and the goal is to give you a faster path to the right treatment.
AngersAges 18 years+ - NCT06308965Recruiting
Does blood vessel-sparing hip replacement improve recovery?
This study compares two different surgical techniques for total hip replacement using an anterior approach. The goal is to see if saving the small blood vessels around the hip during surgery leads to a better recovery for patients.
Genk, LimburgAges 18 years+ - NCT07031778RecruitingEarly Phase 1
Topical simvastatin to help jawbone healing after wisdom tooth removal
This study tests whether a simvastatin (a common cholesterol medicine) applied directly to the tooth socket after wisdom tooth removal can help your jawbone heal faster. If you need a lower wisdom tooth taken out and are generally healthy, you may be able to join.
Granada, GranadaAges 18–40 - NCT07031791Recruiting
Picturing daily tasks to assess arm use after injury
This study uses pictures to evaluate how often you use your arm for everyday tasks and whether you avoid using it, which can help understand recovery after a suspected brachial plexus or similar nerve injury.
AngersAges 18 years+ - NCT06643104Recruiting
Testing a 3D scan method for scoliosis in teens
This study tests a new 3D imaging method to assess scoliosis by comparing back height difference and trunk rotation angle. It aims to find a simpler way to measure spinal curves in teenagers with adolescent idiopathic scoliosis.
HangzhouAges 10–18 - NCT07032675Recruiting
Nasal cartilage reshaping trial for better breathing
This trial tests a low-temperature radiofrequency device to remodel nasal cartilage during surgery, aiming to improve nasal airflow. It is for adults undergoing nose surgery for function or appearance.
Indianapolis, IndianaAges 18 years+ - NCT07719452Enrolling by invitation
Strengthening exercise for chronic low back pain
This study tests if adding a specific low back strengthening exercise to standard physical therapy helps people with long-lasting low back pain. It is for Tricare beneficiaries who have had back pain for at least 3 months without leg pain.
Fort Sam Houston, TexasAges 18–65 - NCT07237867Recruiting
Nerve stimulation for knee pain in athletes
This study tests if a mild electrical current to a nerve in the groin area can improve thigh muscle strength in athletes with long-standing jumper's knee (patellar tendinopathy). The goal is to see if this treatment can help reduce pain and improve function.
Barcelona, BarcelonaAges 18–40 - NCT06288256Recruiting
Spine surgery study: genes, thinking, and pain
This study is for people getting planned spine surgery. It looks at how your genes and thinking skills might affect your pain and use of pain medicine after surgery.
New York, New YorkAges 18 years+ - NCT06896240Recruiting
Fiber smoothie trial for knee replacement patients
This trial tests if drinking a special fiber smoothie for 2 weeks before knee revision surgery can reduce inflammation and improve recovery. It is for people who are scheduled for knee replacement and have certain chronic health conditions.
New York, New YorkAges 40–80 - NCT06102954Recruiting
Safe-tech: a falls prevention program for older adults
This trial tests a multi-part program to help older adults living in the community reduce their risk of falling. It combines education, exercise, and technology to help you stay safe on your feet.
SingaporeAges 60–95 - NCT06533865RecruitingPhase 3
Romosozumab and estrogen for bone loss from missed periods
This study tests whether a bone-building medication (romosozumab) combined with estrogen replacement therapy can improve bone density in young women with hypothalamic amenorrhea (missing periods due to low energy or stress). It aims to find a better treatment for low bone density caused by this condition.
Boston, MassachusettsAges 14–30 - NCT06143306RecruitingPhase 4
Adding a second numbing shot for shoulder replacement pain
This study tests whether adding an extra numbing shot (pectoserratus block) to the standard shoulder block reduces pain after total shoulder replacement. It may help you recover more comfortably and use fewer pain medicines.
Minneapolis, MinnesotaAges 18–85 - NCT07041242Recruiting
ACL reconstruction outcomes in older vs. younger adults
This study compares how well a specific type of ACL knee surgery works in people over 50 versus those under 30. It looks at results and problems after surgery to see if the technique is safe and effective for older patients.
Bologna, BolognaAges 18 years+ - NCT06645847Recruiting
Ketone drink for walking and strength in older adults
This study tests whether a special ketone drink can help older adults who are starting to feel frail (slower walking, less energy). You would be assigned to one of several groups, and researchers will check if the drink improves your strength and daily function.
Novato, CaliforniaAges 65 years+ - NCT06646029Recruiting
Splint for Finger Stiffness Study
This study tests whether a special splint (called a relative motion orthosis) can help improve how straight you can straighten a finger that has been injured. It focuses on people with stiffness in the middle finger joint.
New York, New YorkAges 18–80 - NCT07731269Enrolling by invitation
Kinesiology taping for acute low back pain
This study tests if kinesiology tape (a special stretchy tape placed on the skin) can help relieve pain and improve movement in people with sudden, short-term low back pain. It may be an option if your pain just started and you haven't had long-term back issues.
IstanbulAges 18–50 - NCT07142174Recruiting
New implant for neck pain and nerve compression
This trial tests a new type of implant that is placed in the back of your neck to help open up space for nerves and improve spine alignment. It may help people with pain, numbness, or weakness from a pinched nerve or spinal cord compression caused by wear-and-tear changes.
RiyadhAges 18 years+ - NCT07678749Enrolling by invitation
Closed sinus lift with bone graft and a natural supplement scaffold
This trial tests whether adding a natural supplement (apigenin) to a bone graft scaffold helps improve bone healing during a closed sinus lift procedure. It may be an option for people who need extra bone in their upper jaw before getting dental implants.
CairoAges 18–50 - NCT07139938Recruiting
Spinal decompression without implants for lumbar stenosis
This trial tests whether removing pressure on spinal nerves alone, without any hardware, can help fix spine balance and reduce pain in people with lumbar stenosis. It is for those who have had leg pain or trouble walking for at least 3 months and plan to have surgery without implants.
MoscowAges 18 years+ - NCT05916235Recruiting
Laser light treatment for jaw pain from TMJ disorder
This trial tests whether a specific type of light therapy (called photobiomodulation/laser) can reduce pain from temporomandibular disorder (TMJ) affecting the jaw muscles. If you have jaw muscle pain for at least 3 months, the study will compare your symptoms while you follow the treatment and diary requirements.
Gainesville, FloridaAges 18–99
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,837 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,953 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.