Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,837 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)65
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Chronic Pain37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,837 total
- NCT03588975RecruitingPhase 3
MACI transplant for knee cartilage defects in ages 10 to 17
This Phase 3 study tests whether a cartilage repair transplant called MACI (a lab-made cartilage-like tissue) can improve symptoms in young people with knee cartilage damage. It compares a surgery approach chosen for each person, aiming to reduce pain and improve knee function.
Palo Alto, CaliforniaAges 10–17 - NCT03594344Recruiting
Extra hyperbaric oxygen after leg amputation wounds heal
This study tests whether giving extra treatments with hyperbaric (pressure) oxygen after a leg amputation can improve healing or recovery. It’s meant for people whose amputation happened due to long-lasting infection or poor blood flow and who can attend follow-up visits.
OsloAges 18–90 - NCT03643926Recruiting
Arthroscopic vs open surgery for ankle instability
This trial compares two surgical approaches to treat ongoing ankle “giving way” or instability. It aims to find which method works better for people whose ankle instability has lasted at least several months.
Belo Horizonte, Minas GeraisAges 18–65 - NCT03663790Recruiting
Gait retraining for knee osteoarthritis movement patterns
This trial tests whether a structured walking retraining program can improve how your leg moves if you have knee osteoarthritis. It may help reduce strain on your lower body during walking by changing walking technique.
Manassas, VirginiaAges 18–80 - NCT03675087Recruiting
Testing how exercise affects symptoms in ME/CFS
This trial studies how people with ME/CFS respond to an exercise test. It may help researchers understand what kind of exercise response is typical and how it relates to symptoms.
MadridAges 18–65 - NCT03699228Recruiting
Low-dose chest CT study for adults in China
This study is looking at people ages 30 to 90 who are willing to get a low-dose chest CT scan. It may help researchers improve how health data is collected and understood from scans.
Wuhu, AnhuiAges 30–90 - NCT03696134Recruiting
Study of musculoskeletal health, frailty, pain, and disability
This study looks at musculoskeletal health and wellbeing in adults, especially people who are frail or at risk of developing frailty-related problems like pain or limited ability to move. It may help researchers understand what puts people at risk and what could improve comfort and function.
NottinghamAges 18 years+ - NCT03698149Recruiting
Brain-signal training for hand and speech control after disability
This study tests whether recording brain signals can help people regain better control of movements in the arms and help with speech. It may be an option for people with significant disability from certain nerve and brain conditions who can safely take part in brain-monitoring procedures.
San Francisco, CaliforniaAges 21 years+ - NCT03707288Recruiting
Exercise study for neck and low back pain in medical students
This study looks at neck and low back pain in medical students and asks participants to follow a set exercise plan for a period of time. It may help researchers understand what kind of exercise support could improve symptoms in students.
Kingston, KingstonAges Any age - NCT03711773Recruiting
Low-impact exercise classes for joint pain
This study tests a gentle, low-impact exercise program to improve pain and function for adults with knee, ankle, and/or hip pain. You’ll also attend dietitian and behavioral health classes as part of standard care while you participate.
Columbia, MissouriAges 18 years+ - NCT03716128Recruiting
Testing bone hormone changes in people with kidney problems
This study checks how kidney disease affects bone health by measuring hormones like PTH and related blood markers. It may help doctors better diagnose bone problems that can occur with poor kidney function.
HerlevAges 18 years+ - NCT03718403RecruitingPhase 4
Theophylline trial for pseudohypoparathyroidism
This Phase 4 study tests whether the medicine theophylline can help people with pseudohypoparathyroidism type 1A or 1B. It may be considered if you’re trying to improve how your body uses parathyroid hormone and manage related calcium levels.
Boston, MassachusettsAges 5–21 - NCT03718637RecruitingPhase 4
Bioinductive implant for tennis elbow that therapy didn’t fix
This trial tests a special implant placed in the elbow to improve healing in people with tennis elbow (lateral epicondylitis) when physical therapy and other non-surgical treatments haven’t worked. If you qualify, you may receive the implant to see if it helps reduce pain and improve elbow function.
Detroit, MichiganAges 18 years+ - NCT03722537Recruiting
Test of cartilage graft surgery for thumb arthritis pain
This trial looks at using a donated cartilage-and-bone graft during surgery for thumb “basal joint” arthritis. It may help reduce pain and improve thumb function if you are planning surgery for this condition.
New York, New YorkAges 18 years+ - NCT03728478RecruitingPhase 3
Step-up and step-down treatment for newly diagnosed arthritis
This Phase 3 study tests whether children with early juvenile idiopathic arthritis do better by starting with one treatment approach and adjusting (stepping up or stepping down) based on how their arthritis responds. It may help find the safest, most effective long-term plan for controlling symptoms with fewer side effects.
Genova, GEAges 2–17 - NCT03749538Recruiting
Brain stimulation test for autoimmune muscle weakness
This trial tests whether a noninvasive brain stimulation technique (through the scalp) can improve muscle weakness in people with certain autoimmune muscle diseases. It may help by changing brain signals that affect how muscles work.
São PauloAges 18–80 - NCT03753412Recruiting
Rehab program for adults after ICU recovery on ECMO
This trial looks at a recovery and rehabilitation approach for adults who were very sick and needed a machine called ECMO to support breathing and heart function. It may help people regain strength and function after a severe ICU illness.
LondonAges 18 years+ - NCT03755193RecruitingPhase 2
Testing another osteoporosis medicine after 2 years of denosumab
This study looks at how well and how safely another osteoporosis medicine works for people who have already taken denosumab for 2 years. It may help find the best next step to strengthen bones and lower fracture risk after denosumab.
Matsumoto, NaganoAges 20–120 - NCT03759717Recruiting
Study of skull base tumors using tumor tissue
This study aims to learn more about skull base tumors by examining tumor tissue from surgery. It may help doctors better understand these tumors and improve future care.
Pittsburgh, PennsylvaniaAges Any age - NCT03759522RecruitingPhase 1
PET brain scan for inflammation in MS, fibromyalgia, or CFS
This early-stage study tests an imaging medicine ([F-18]DPA-714) that can help researchers see inflammation in the brain and nervous system. It may help doctors better understand how “inflammation signals” differ across conditions like multiple sclerosis, fibromyalgia, and chronic fatigue syndrome.
Birmingham, AlabamaAges 18–65 - NCT03768271Recruiting
Study of early psoriatic arthritis for better diagnosis and care
This study follows people with a first episode of peripheral (hand/foot/arm/leg) arthritis that seems to be psoriatic arthritis. It aims to improve understanding of early disease and may help guide more personalized care over time.
CréteilAges 18–65 - NCT03771105RecruitingEarly Phase 1
Study how phosphate handling affects healthy aging
This early study looks at how the body’s handling of phosphate may affect aging and bone health. It is meant for people with certain rare genetic conditions that change phosphate levels, to better understand their biology and responses to study tests.
New Haven, ConnecticutAges 13 years+ - NCT03770702RecruitingPhase 3
Testing blood pressure pills and statins for rheumatoid arthritis
This trial studies whether taking a cholesterol-lowering medicine (a statin) and a blood pressure medicine (an ARB) can better control rheumatoid arthritis activity. It may help people whose rheumatoid symptoms are not fully controlled with standard care.
TantaAges 18–65 - NCT03770923RecruitingPhase 3
Testing medicines for rheumatoid arthritis activity
This trial studies whether certain medicines can improve how active rheumatoid arthritis is. If you have rheumatoid arthritis and do not have significant liver or kidney problems, you may be able to join.
TantaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,837 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,953 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.