Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT04302116Recruiting
Vigabatrin plus high-dose steroid versus vigabatrin alone
This trial tests whether adding a high-dose steroid (prednisolone) to vigabatrin works better than vigabatrin alone for infants with infantile spasms. It may help reduce seizures and improve early development, but your child’s prior treatments and health conditions must fit the study rules.
Ratchathewi, BangkokAges 2 months–1.2 years - NCT04303325RecruitingPhase 4
Esketamine after breast surgery for depression and gut changes
This trial studies whether esketamine given around the time of breast cancer surgery can improve depression and change gut bacteria. It also monitors your sleep/deep anesthesia level (with a simple monitoring number).
Shenyang, LiaoningAges 18–65 - NCT04306432Recruiting
Check how cognitive tests change after brain tumor radiation
This trial studies how radiation therapy affects thinking and memory in adults with certain brain tumors. It may help doctors understand which patients are more likely to have cognitive side effects and how to measure them over time.
Copenhagen, Capital RegionAges 18–100 - NCT04310098Recruiting
CADASIL registry for confirmed patients and mutation carriers
This study builds a group “registry” of people affected by CADASIL (a genetic brain blood-vessel condition) and people who carry the NOTCH3 mutation, even if they have no symptoms. It helps researchers learn more about the condition over time and compare experiences between patients, carriers, and healthy relatives or controls.
Fuzhou, FujianAges 18–85 - NCT04310644Recruiting
Study of nerve and connective-tissue symptoms in EDS and autonomic issues
This study collects information about how the body’s automatic nerves (autonomic nerves) affect symptoms like fast heart rate on standing, fatigue, and related conditions in people with Ehlers-Danlos syndrome. It also enrolls healthy volunteers to compare results, which may help doctors understand these conditions better and improve care.
Aachen, North Rhine-WestphaliaAges 18–80 - NCT04310241Recruiting
Test eye alignment and vision changes in lazy eye patients
This study looks at vision problems in children with lazy eye (amblyopia) and eye misalignment (strabismus), and whether they improve with treatment. It may help researchers understand what visual changes to expect and which patients respond best.
Cleveland, OhioAges 6 months–90 years - NCT04309487Recruiting
Check shunt blockage using ShuntCheck versus a scan
This study tests whether a device called ShuntCheck can accurately tell if a VP (ventriculoperitoneal) shunt is blocked in people with normal pressure hydrocephalus. If it works well, it may help doctors find shunt problems faster and more safely.
Tampa, FloridaAges 40 years+ - NCT04312399Recruiting
Hormone treatment study for Alzheimer risk in postmenopausal women
This study looks at whether hormone treatment can help prevent or slow Alzheimer’s disease in women who have gone through menopause. It may help by testing a hormone-based approach in a carefully selected group.
GhentAges 40–65 - NCT04312269Recruiting
Brain stimulation plus memory practice to improve stroke arm recovery
This trial tests whether a combined therapy—MyoCI plus memory “reactivation”—can improve arm movement recovery after stroke. It’s meant for people with ongoing arm weakness at least 6 months after their first stroke.
Chicago, IllinoisAges 21–100 - NCT04318119Recruiting
Brain scan registry for small blood vessel disease
This study is a registry that collects information and brain scan findings from adults with possible small vessel disease. It may help doctors better understand how this condition looks on scans and what it is linked to.
Fuzhou, FujianAges 18–100 - NCT04321512Recruiting
Blood test study for people with heart or stroke problems
This study looks at a type of white blood cell (monocytes) in blood to understand differences in people with certain heart attacks, stable heart disease, or ischemic stroke. It may help researchers learn why these conditions happen and how the immune system may be involved.
Farmington, ConnecticutAges 18 years+ - NCT04322734Recruiting
Blood tests study immune and metabolism markers in neurodevelopment
This study looks for biological “signals” in blood—related to the immune system and metabolism—to better understand conditions like autism and other brain or development-related disorders. It may help researchers find markers that could guide future diagnosis or treatment.
Phoenix, ArizonaAges Up to 18 years - NCT04330287Recruiting
Study of heart health in adults aging with HIV
This study looks at how aging affects heart health in people who have HIV. It may help researchers find better ways to prevent or monitor heart problems over time.
Essen, NordrheinwestfalenAges 18 years+ - NCT04330651Recruiting
Extra-support machine for heart patients after surgery
This study looks at using an external life-support machine after heart surgery. It may help patients who need temporary extra support while the heart and body recover.
FlorenceAges 18–80 - NCT04330963Recruiting
Cohort study of causes of daytime sleepiness and sleepiness disorders
This study follows people with frequent daytime sleepiness (sometimes from narcolepsy or hypersomnia) and compares them with matched healthy people, including some with sleep apnea. The goal is to better understand what causes sleepiness and to improve how these conditions are recognized and measured.
BernAges 10–70 - NCT04331392Recruiting
Online memory training for people with recent brain injury
This trial tests an online memory program for people with a recent traumatic brain injury (TBI) to help with thinking and memory. It may be useful if your injury is recent and you can safely do MRI scanning.
Toronto, OntarioAges 18–55 - NCT04335994Recruiting
Home sleep testing for people with memory trouble
This study looks at how well home sleep apnea testing works for people with cognitive impairment (memory/thinking problems) to help improve outcomes. You may be asked to do a home sleep test (and possibly an in-lab test) and will involve a caregiver if needed.
Toronto, OntarioAges Any age - NCT04334031Recruiting
Hospital follow-up study for immune-related disease
This is a study that follows people with an immune-related illness at Lille University Hospital to better understand their care needs over time. By collecting information regularly, the study may help improve how future patients are monitored and treated.
LilleAges 18 years+ - NCT04336579Recruiting
Breathing exercises during knee replacement care
This study tests whether practicing diaphragmatic (belly/chest-breathing) exercises during total knee replacement with a nerve pain catheter is helpful for comfort or recovery. You may qualify if you are having knee replacement and have the specific type of nerve catheter, and you’re willing to learn and follow the breathing routine.
Los Angeles, CaliforniaAges 50–90 - NCT04339699Recruiting
PFO closure comparison trial for cryptogenic stroke
This trial studies ways to close a patent foramen ovale (PFO) to help prevent another stroke in people whose prior stroke had an unknown cause. If you qualify, you may receive one of the PFO closure approaches the study is comparing.
Tucson, ArizonaAges 18–60 - NCT04341155RecruitingPhase 2
Dexamethasone treatment for brain toxoplasmosis in people with HIV
This Phase 2 trial studies whether dexamethasone (a strong anti-inflammatory steroid) helps treat brain toxoplasmosis in adults with HIV. It looks at people who have symptoms and brain scan findings that fit cerebral toxoplasmosis and who have not already taken dexamethasone for more than a few days.
Bandung, West JavaAges 18 years+ - NCT04343157RecruitingPhase 2
Image-guided focused radiation to protect thinking in brain metastases
This Phase 2 trial tests a brain radiation technique that aims to treat up to a few brain metastases while sparing areas important for thinking and memory. It may help people keep cognitive abilities better than with more brain-wide radiation approaches.
San Diego, CaliforniaAges 18 years+ - NCT04344262Recruiting
Testing a small dose muscle relaxant during general anesthesia
This trial studies whether a small dose of a muscle-relaxing medicine works safely for people having surgery under general anesthesia. You might be a candidate if you fit the age and surgical setup, and you don’t have certain health problems or medication issues.
Al MansurahAges 20–50 - NCT04347785Recruiting
Study nerve effects after carotid surgery done with local anesthesia
This trial looks at what factors predict new or worsening nerve symptoms after a carotid endarterectomy (a surgery to clear plaque in the neck artery) when done with regional anesthesia. It may help doctors better anticipate and prevent neurologic problems during this procedure.
PortoAges 18–100
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.