Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT04962815Recruiting
Study to collect brainwave data for ICU delirium
This study tests how well a special brain-monitor (EEG) can be used to assess delirium in people in the ICU. It may help improve delirium detection and monitoring in critically ill patients.
Stanford, CaliforniaAges 18 years+ - NCT04965545Recruiting
Tests for diagnosing Wilson disease using special lab findings
This trial is for people who already have a genetic diagnosis of Wilson disease. It looks at whether specific lab tests and a physical eye finding can help confirm and support the diagnosis.
Hangzhou, ZhejiangAges 6–65 - NCT04964206Recruiting
Epidural pain relief in labor and baby brain development
This trial studies how epidural pain relief during vaginal labor may affect a child’s early brain and development. It’s for first-time, term pregnancies where you plan a vaginal birth.
Beijing, Beijing MunicipalityAges 18–35 - NCT04965064RecruitingPhase 2
Neratinib plus capecitabine for HER2-negative breast cancer brain mets
This study tests whether neratinib plus capecitabine can slow or shrink breast cancer that has spread to the brain. It is for people whose cancer shows an “overactive HER2 signal” on a specific tumor test, even though their cancer is labeled HER2-negative.
Rochester, New YorkAges 18 years+ - NCT04967274Recruiting
Study testing how the spinal cord controls movement after injury
This trial studies how nerve pathways in the spinal cord help control movements in people with spinal cord injury. It may help researchers better understand movement control and could lead to improved rehab strategies.
ZurichAges 18–80 - NCT04969042RecruitingPhase 1
Closed-loop spinal cord stimulation for spinal cord injury rehab
This Phase 1 study tests a computer-controlled spinal cord stimulation system to help people with spinal cord injuries during rehabilitation. It is mainly looking at safety and whether the device can be used during follow-up visits and training.
Beijing, Beijing MunicipalityAges 18–70 - NCT04971850Recruiting
Sleep study for children with possible breathing sleep problems
This trial looks at sleep-related breathing problems (“sleep-disordered breathing”) in children and young adults and how they may affect thinking and memory using sleep study testing plus neurocognitive (thinking) assessments. It may help doctors better understand symptoms and identify who could benefit from treatment.
ParisAges 1–20 - NCT04971564Recruiting
Blood inflammation test study in sudden brain oxygen loss
This trial looks at blood “inflammation-related” biomarkers to understand what happens early after certain sudden brain events. It may help doctors predict outcomes and tailor treatment for people like those with stroke types that sometimes need a clot-removal procedure.
Paris, Île-de-France RegionAges 18 years+ - NCT04972760RecruitingPhase 3
Baricitinib for active dermatomyositis in adults
This trial studies whether baricitinib can improve symptoms and test results in adults with active dermatomyositis (a muscle and skin inflammation disease). It’s for people whose disease is still active despite prior treatment or who have been recently diagnosed.
ParisAges 18–64 - NCT04972071Recruiting
Using a heart-related fainting risk score in emergency care
This trial helps emergency departments use a simple risk score to guide care for adults who faint. It looks at whether using these recommended steps improves how syncope (fainting) is assessed and managed in the ER.
Calgary, AlbertaAges 18 years+ - NCT04974138RecruitingPhase 4
Preventing first stroke in people with high-risk blood pressure
This trial tests whether a study medicine regimen can help prevent a first stroke in people with hard-to-control “high homocysteine” risk factors linked to a specific gene type. You may qualify if you have certain blood pressure levels, a specific MTHFR gene result, and related blood test findings.
Bengbu, AnhuiAges 45–74 - NCT04973579Recruiting
Stent plus heart surgery for high risk carotid patients
This trial looks at whether doing carotid artery stenting at the same time as heart surgery is safe and effective for people at high risk of stroke around the time of surgery. It targets people with significant carotid narrowing who also need heart surgery for specific heart problems.
KrakowAges 18 years+ - NCT04974151RecruitingPhase 4
Prevention trial for stroke risk in people with high blood pressure
This trial tests an approach to prevent first-time stroke and heart problems in people with high blood pressure who also have a specific genetic test result (MTHFR 677 TT). It may help by lowering risk before a first stroke happens.
Bengbu, AnhuiAges 45–74 - NCT04975646Recruiting
Goal-setting tool for upper-arm spasticity treatment
This study looks at whether a structured goal-setting approach helps measure and improve treatment for stiff, tight upper-arm muscles after a stroke. It tests how well patients’ (or caregivers’) goals can be tracked when receiving or considering botulinum toxin (BTX-A).
LjubljanaAges 18 years+ - NCT04978857Recruiting
Virtual reality for people with minimal consciousness
This study tests whether guided virtual reality (“VR”) and other senses-based stimulation can help patients in a state of minimal consciousness become more aware. It focuses on whether the experience is safe and tolerable, with the goal of supporting awakening.
AngersAges 18 years+ - NCT04977375RecruitingPhase 1/Phase 2
Anti–PD-1 treatment plus focused radiation for recurrent glioblastoma
This trial tests a cancer-immunotherapy medicine (an anti–PD-1 antibody, similar to pembrolizumab) combined with precisely targeted radiation to treat glioblastoma that has come back or progressed. It may help your immune system recognize and attack the tumor while the radiation targets the cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT04978571Recruiting
Electrical nerve stimulation for long-lasting concussion symptoms
This study tests whether a device that delivers gentle electrical signals to nerves through the skin can help children and teens with concussion symptoms that have lasted at least 3 months. You may be asked to attend clinic visits for the nerve stimulation setup if you meet the safety and scheduling requirements.
Orange, CaliforniaAges 11–18 - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT04981184Recruiting
Testing muscle signals to predict walking recovery after stroke
This study looks at surface muscle electrical signals (from electrodes on the skin) to understand and predict how well your balance and walking may improve after a first stroke. You might benefit by learning more about your recovery and by helping researchers find better ways to track progress.
KaunasAges 18–89 - NCT04982562Recruiting
7-tesla MRI for symptoms after a mild concussion
This study checks whether a stronger MRI scan (7-tesla) can help diagnose and better understand ongoing symptoms after a mild concussion. You would be scanned about 7 days after your injury to compare results with typical care.
PoitiersAges 20–72 - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT04986683Recruiting
MRI study to reduce brain deficits after pediatric epilepsy surgery
This study uses special MRI pictures to better plan epilepsy surgery and help lower the chance of new brain problems after surgery. It includes children and teens with drug-resistant focal epilepsy who are having a two-stage surgery with brain surface electrodes.
Detroit, MichiganAges 3–19 - NCT04987814Recruiting
Testing a skin-sensor scan to detect muscle loss
This study uses a high-detail sensor placed on the skin to look for signs of sarcopenia, or age-related muscle loss. The goal is to see whether the scan can help diagnose sarcopenia more accurately.
Ivry-sur-SeineAges 75 years+ - NCT04986891Recruiting
Study chemotherapy nerve damage in people with no or stable symptoms
This study looks at chemotherapy-related nerve damage (often felt as numbness, tingling, or pain) and why it happens and should matter. You may be eligible if you had a normal nerve check before chemotherapy started, or if your nerve symptoms are stable after finishing treatment.
MonzaAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.