Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05009394Recruiting
Surgery options for long-term pain after limb amputation
This trial studies different surgical approaches to reduce persistent pain in the leftover part of an amputated limb. You may be able to join if your post-amputation pain has lasted more than a year and your pain level stays high despite stable pain treatments and prosthesis use.
Chicago, IllinoisAges 18 years+ - NCT05009771Recruiting
Testing a pain-control method after C-section
This study looks at how to better manage pain after a C-section using spinal anesthesia and either a patient-controlled IV pain pump or a specific pain medicine (naldebaein). You may be able to join if you’re scheduled for a C-section at 37–40 weeks and can take the usual pain medicines.
New Taipei City, TaiwanAges 20–40 - NCT05009992RecruitingPhase 2
Drug combination for diffuse midline gliomas in children and young adults
This Phase 2 trial studies whether a combination of medicines (including ONC201/related study drugs) can better treat diffuse midline gliomas, a type of brain/spinal cord tumor that often affects the midline. You may qualify if your tumor diagnosis is confirmed and your treatment timing (before radiation, after radiation, or at recurrence) matches one of the study groups.
Birmingham, AlabamaAges 2–39 - NCT05010031RecruitingPhase 2
Lower-dose radiation for metastatic cancer with an ATM mutation
This trial tests whether giving a lower dose of radiation can help control metastatic tumors that carry a specific genetic change in the ATM gene. It may reduce side effects by using less radiation, while still aiming to keep the tumor under control.
Basking Ridge, New JerseyAges 18 years+ - NCT05010148RecruitingPhase 3
IV lidocaine after spinal fusion to reduce delirium and pain
This trial tests whether giving lidocaine through a vein after elective spinal fusion surgery can help prevent confusion (delirium) and reduce pain. It may help people recover more comfortably and think more clearly after surgery.
San Francisco, CaliforniaAges 60 years+ - NCT05010603Recruiting
Studies families to understand late-onset Alzheimer’s
This study focuses on people with late-onset Alzheimer’s (and some similar memory diseases) and uses a close family “informant” to share what they’ve noticed. It may help researchers learn more about these conditions and how they progress in families.
Washington D.C., District of ColumbiaAges 55 years+ - NCT05010265Recruiting
Learning how to detect hidden awareness using brain signals
This study explores an ethical approach to detecting “covert consciousness,” meaning a person may be aware even if they cannot show it clearly. It involves people connected to patients with disorders of consciousness, including caregivers and specialists, and uses information related to MRI or EEG brain testing done for clinical care.
Boston, MassachusettsAges 18 years+ - NCT05010902Recruiting
Pregnancy and MS study for people 18 and older
This study follows people with multiple sclerosis (MS) or a related condition to learn how pregnancy affects MS. You may be asked to complete health questionnaires and get MRI scans, which can help researchers understand what changes during pregnancy.
BerlinAges 18–50 - NCT05011877Recruiting
Study for sleep testing after sudden breathing trouble
This trial studies people who unexpectedly end up in the hospital or emergency room because of a sudden worsening in breathing that leads to too much carbon dioxide. It may help doctors understand whether sleep-related breathing issues contribute and how to better prevent repeat episodes.
Toronto, OntarioAges 18 years+ - NCT05012475Recruiting
Test whether video games help arm movement in Rett syndrome
This trial looks at whether computer gaming can improve how well you can use your arms to control game actions in Rett syndrome. It checks whether the gaming tasks can be done safely based on your arm movement range.
Washington D.C., District of ColumbiaAges 4–60 - NCT05013892RecruitingPhase 2
Whole-brain radiation with a targeted drug plan for brain mets
This Phase 2 study tests a treatment plan that combines whole-brain radiation therapy with an additional approach to help people with brain metastases. It aims to improve outcomes while also tracking brain function and memory over time.
Boston, MassachusettsAges 18 years+ - NCT05013736Recruiting
Study to test recovery in babies with brain injury
This study looks at how well babies recover after certain types of brain injuries that happen around birth, such as stroke, bleeding, or lack of oxygen. You might join if your baby fits the specific age range and has a confirmed injury on brain imaging.
Madison, WisconsinAges birth–2 years - NCT05013944Recruiting
Join a patient registry to support future research
This trial is a “patient registry,” which collects health information over time to help researchers plan and run future studies. It may help by contributing your experience so new treatments can be tested more effectively.
Arlington Heights, IllinoisAges 18 years+ - NCT05017142Recruiting
Pediatric brain inflammation registry for Swiss patients
This study is a registry that collects health information from children and teens in Switzerland diagnosed with certain inflammatory brain and spinal cord conditions. It helps researchers understand these illnesses better over time and may guide future treatments.
Aarau, Canton of AargauAges Up to 36 years - NCT05018819RecruitingPhase 1
IV stem cell treatment for cerebral palsy safety
This trial tests whether an IV infusion of lab-grown stem cells from donated umbilical cord is safe for people with cerebral palsy. It mainly focuses on side effects and safety rather than proving it works.
St John'sAges Any age - NCT05018793RecruitingPhase 1
Testing stem cell injections for spinal cord injury safety
This early study tests whether two types of stem cells—made from your own fat cells versus from donated umbilical-cord cells—are safe when injected into the fluid around the spinal cord. It may help researchers find safer cell-based options for people with spinal cord injury.
St John'sAges Any age - NCT05020002Recruiting
Checking RNA markers in blood and muscle in muscle disease
This study looks for tiny RNA “signals” in blood (and sometimes urine) and compares them with muscle samples in people with myotonic dystrophy (DM1 or DM2) and healthy controls. The goal is to find biomarkers that may help track the disease over time.
Boston, MassachusettsAges 5 years+ - NCT05019625Recruiting
Study samples for biomarkers in myotonic dystrophy
This study collects blood and, for some people, muscle tissue to look for signs (biomarkers) that can help track and better understand myotonic dystrophy. You may help by providing samples and basic muscle function testing, depending on your age and condition type.
Boston, MassachusettsAges 5 years+ - NCT05020106Recruiting
Tests Alzheimer’s core blood/brain markers to set diagnostic cutoffs
This study checks Alzheimer’s “core biomarkers” to find the best cut-off values for diagnosing Alzheimer’s disease and related conditions. It may help doctors more accurately tell Alzheimer’s, mild cognitive changes, and other causes of memory problems apart.
Beijing, Beijing MunicipalityAges 55–75 - NCT05019885RecruitingPhase 2
IV ketamine for hard-to-treat epilepsy in adults
This Phase 2 study tests whether a low dose of IV ketamine can reduce seizures in adults with drug-resistant epilepsy. It may help people whose seizures continue despite trying at least two appropriate seizure medicines.
New York, New YorkAges 18 years+ - NCT05020626Recruiting
Uses brain MRI data to study Alzheimer’s disease diagnosis
This study uses brain MRI images to better understand how a protein called tau spreads in Alzheimer’s disease and related conditions. If you’re 55 or older and had an MRI close to your diagnosis, you may be eligible.
Hong Kong, ShatinAges 55 years+ - NCT05021198Recruiting
Study for people diagnosed with cerebral venous thrombosis
This study is for people who have been diagnosed with cerebral venous thrombosis (a blood clot in the brain’s venous system) at specific hospitals. It looks back at cases from 2014 to 2023 to learn from real-world patients.
LørenskogAges Any age - NCT05022940Recruiting
Track recovery and participation after adult brain injury rehab
This study follows adults with traumatic brain injury (TBI) during and after rehabilitation, to better understand how recovery and daily participation change over time. It may help improve rehab programs for people like you in the future.
Montreal, QuebecAges 17 years+ - NCT05023005Recruiting
Strain-Counterstrain therapy for piriformis muscle pain
This trial tests a hands-on physical therapy technique called “strain-counterstrain” to reduce pain from the piriformis muscle. It may help people whose pain is coming from that specific muscle rather than the low back.
Loma Linda, CaliforniaAges 18–65
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.