Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05048212RecruitingPhase 2
Nivolumab, ipilimumab, and cabozantinib for kidney cancer brain spread
This Phase 2 study tests how well nivolumab plus ipilimumab, along with cabozantinib, treats untreated or worsening kidney cancer that has spread to the brain. It may help shrink brain tumors and slow the disease when standard local brain treatments aren’t the right option.
Houston, TexasAges 18 years+ - NCT05048680Recruiting
Breathing low-oxygen training to support brain blood flow in seniors
This study tests whether brief “low-oxygen” conditioning can improve blood flow to the brain and overall cerebrovascular (brain blood vessel) health in older adults. It may help people who are generally less active, as long as they have no major medical or safety barriers for the training.
La Tronche, Auvergne-Rhône-AlpesAges 60–80 - NCT05048862Recruiting
Brain scan and tests for neuromuscular conditions
This study compares people with neuromuscular disorders to healthy people using questionnaires and brain/neurological tests. It may help researchers understand how these conditions affect the brain and nervous system.
TaipeiAges 20 years+ - NCT05049148Recruiting
Study platelets in brain and spinal tumors
This study looks at how blood “platelets” may be involved in brain or spinal (medullary) tumors by testing tumor tissue taken during surgery or biopsy. It may help researchers understand disease biology and guide future treatments.
ParisAges 18 years+ - NCT05049057RecruitingPhase 2
Testing a nerve-blocking shot for recent mild TBI
This Phase 2 study tests a medication that blocks a pain signal (a CGRP receptor antibody) in people who recently had a mild traumatic brain injury (mTBI) and are also dealing with post-traumatic headache (PTH). The goal is to see if it can reduce symptoms and improve recovery after the injury.
Fort Bragg, North CarolinaAges 18–50 - NCT05051072Recruiting
MRI study in adults with trigeminal neuralgia pain
This study uses a special MRI scan to look at how the trigeminal nerve system is working in people with essential trigeminal neuralgia (face pain) and whether there is nerve involvement. You may be asked to get MRI scans while resting, which can help doctors better understand the cause and guide future treatments.
ParisAges 18 years+ - NCT05050383Recruiting
Study testing obstruction patterns to guide CPAP alternatives
This study looks at how breathing passages narrow during sleep to better understand obstruction patterns. It may help people who are being considered for alternatives to CPAP (a common breathing device) for sleep-disordered breathing.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05051254Recruiting
Breathing muscle testing in children with breathing muscle weakness
This study looks at how hard it is for children to breathe and how their breathing muscles work, using specific breathing-related tests. It may help doctors better understand breathing problems and choose care more effectively.
ParisAges birth–17 years - NCT05050864Recruiting
Stent versus brain-surgery options for idiopathic pressure
This study compares two treatment approaches for idiopathic intracranial hypertension (high pressure in the brain) that has not improved with usual medical treatment. It may help doctors learn which option works better and is safer for people with specific scan and eye findings.
Paris, ParisAges 18 years+ - NCT05050929RecruitingPhase 2
Targeted radiation for brain metastases using rapid imaging
This Phase 2 study tests a quicker, more targeted way to give radiation to brain metastases. It aims to treat tumors while using regular scans to check how well the treatment controls disease and how you feel.
Abbotsford British Columbia, British ColumbiaAges 18–100 - NCT05051618Recruiting
Exercise program for depression in people with multiple sclerosis
This trial studies whether a structured exercise program can help reduce symptoms of major depressive disorder in people who also have multiple sclerosis. You’ll complete questionnaires, wear an activity sensor, and do exercise testing while being assigned to the study program.
Chicago, IllinoisAges 18–64 - NCT05052736Recruiting
Noninvasive brain/nerve stimulation for early CRPS type I
This trial studies a noninvasive stimulation treatment to help people with early-stage complex regional pain syndrome (CRPS) type I. It may help calm nerve-related pain, especially soon after symptoms begin.
Las Palmas de Gran Canaria, Palmas, LasAges 18 years+ - NCT05056740Recruiting
Inflammatory markers for CNS autoimmune disease diagnosis
This trial studies whether certain inflammatory biomarkers in blood and spinal fluid can help diagnose autoimmune diseases affecting the brain and spinal cord. It may help people who are undergoing testing for white matter lesions.
NiceAges Any age - NCT05059158Recruiting
Study how the brain clears amyloid in Alzheimer’s
This trial studies how the brain removes amyloid-β, a protein linked to Alzheimer’s disease. It may help researchers understand what’s happening in people with mild memory impairment or Alzheimer’s, and guide better treatments in the future.
München, BavariaAges 50–85 - NCT05060614Recruiting
Testing spinal fluid in people with acute hip fractures
This study checks spinal fluid to learn more about delirium (confusion that comes on suddenly) in people with a recent hip fracture. The results may help doctors better understand and treat delirium after hip surgery or injury.
Oslo, OtherAges Any age - NCT05061953Recruiting
Eye-tracking test software study in adults with multiple sclerosis
This study checks how well new eye-tracking software can measure eye movements in people with multiple sclerosis. It may help researchers track changes in how the nervous system works using a simple camera-based eye test.
Montreal, QuebecAges 18 years+ - NCT05061329Recruiting
Learn how the nose’s microbes relate to health and disease
This study explores the tiny living organisms (microbes) in your nose and how they may be linked to health problems. It may help researchers better understand disease triggers and potential new prevention or treatment ideas.
Holstebro, Central JutlandAges 18 years+ - NCT05063955Recruiting
Study muscle changes in people with heart failure
This study looks at the reasons for age-related muscle loss (sarcopenia) in people with heart failure. It may help researchers understand what is causing muscle weakness and how it could be treated in the future.
Aarhus NAges 18–90 - NCT05064280RecruitingPhase 2
Pembrolizumab plus lenvatinib for brain metastases from solid tumors
This Phase 2 trial studies whether combining pembrolizumab with lenvatinib can shrink or control brain metastases in people with triple-negative breast cancer, lung cancer, or other solid tumors. It focuses on patients who have measurable brain lesions that can be followed on MRI.
Houston, TexasAges 18 years+ - NCT05065151Recruiting
Studying motivation in Parkinson’s using brain stimulation recordings
This study looks at what drives motivation in people with Parkinson’s disease (or dystonia) by using recordings from an implanted brain stimulation device. It may help researchers understand brain signals behind motivation and improve future treatments.
San Francisco, CaliforniaAges 18 years+ - NCT05065060Recruiting
Parkinson study tracking health online and long-term
This study aims to better understand Parkinson’s disease over time by collecting health information online. You may join if you have Parkinson’s, or if you don’t, to compare changes and help researchers find useful markers.
San Francisco, CaliforniaAges 18 years+ - NCT05065450Recruiting
Testing whether brain stimulation improves memory in epilepsy
This trial looks at ways to improve memory by targeting specific deep brain areas in people with epilepsy. You may be eligible if you are already scheduled for long-term video monitoring with implanted depth electrodes in the memory-related regions (amygdala, hippocampus, and nearby areas).
St Louis, MissouriAges 18–75 - NCT05066178Recruiting
Speech therapy for children with autism who speak very little
This study tests a speech treatment plan for children on the autism spectrum who currently speak very little. It aims to improve speech clarity and ability to repeat sounds, but only if the child’s home language environment and participation needs fit the study rules.
Boston, MassachusettsAges 5–18 - NCT05066347Recruiting
Remote heart monitoring after fainting discharge from the ER
This trial studies whether remote heart monitoring after an ER visit for fainting (syncope) can help identify dangerous heart problems. You may be enrolled only if your fainting episode seems medium- to high-risk and you’re being sent home from the ER.
Ottawa, OntarioAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.