Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05066503Recruiting
Nutrition treatment for confusion in hospitalized older adults
This study tests whether a nutritional therapy can help older adults in the hospital who have confusion (delirium) or are at risk during serious infections. It aims to see if nutrition changes outcomes for mental status while you’re being treated for infection.
Little Rock, ArkansasAges 60 years+ - NCT05066633RecruitingPhase 3
Metoprolol added to standard care to prevent heart muscle damage
This trial tests whether adding metoprolol (a beta-blocker) to usual care can prevent or slow cardiomyopathy (heart muscle weakness) in people with Duchenne muscular dystrophy (DMD). It also checks for safety, especially effects on heart rate and rhythm.
Gdansk, Pomeranian VoivodeshipAges 8–17 - NCT05068791RecruitingEarly Phase 1
Psilocybin-assisted treatment for long-term body pain
This early trial studies whether psilocybin, given in a supported setting, can reduce long-term widespread musculoskeletal pain (including fibromyalgia-like symptoms). You would be monitored closely and need someone to take you home after the medicine session.
Birmingham, AlabamaAges 25–65 - NCT05066763Recruiting
Surveys for people with Parkinson’s and their care partners
This trial is for people with Parkinson’s disease, their care partners, and health professionals who work with people with Parkinson’s. The Parkinson’s Foundation will contact you to collect survey information and may invite you to future research opportunities.
Miami, FloridaAges 18 years+ - NCT05067348RecruitingPhase 2
Tocilizumab for generalized myasthenia gravis symptoms
This trial tests whether tocilizumab can improve symptoms and safety in people with generalized myasthenia gravis (MG) who already take standard MG treatments. It may help if your weakness is still significant despite current therapy.
Beijing, Beijing MunicipalityAges 18–80 - NCT05067179Recruiting
ALS patient data and tissue study
This study collects information from people diagnosed with ALS and, if applicable, studies ALS tissue samples. It aims to improve understanding of ALS using patient records and donated materials, which may help future treatments.
Chicago, IllinoisAges 18–90 - NCT05067998Recruiting
Natural medicine and vitamin IV study for overall health
This study looks at whether natural medicine, vitamin IV fluids, and supplements can help people maintain good health. There don’t appear to be specific eligibility limits listed, so many people may be able to join, but you’d still need screening by the study team.
Dover, DelawareAges 21–80 - NCT05069428RecruitingPhase 4
Ramelteon to reduce confusion in ICU patients
This trial tests whether ramelteon, a sleep medicine, can reduce delirium—a sudden confusion problem—in people in the intensive care unit (ICU). If you qualify, it may help you (or your loved one) stay clearer and more comfortable during ICU treatment.
Nashville, TennesseeAges 18 years+ - NCT05070013Recruiting
Brain stimulation to improve sleep in people with Parkinson’s disease
This study tests an adaptive brain stimulation device to help restore better sleep in people with Parkinson’s disease. You may be eligible if your Parkinson’s motor symptoms are severe despite best medical treatment and you are already being considered for a specific deep brain stimulation surgery.
Omaha, NebraskaAges 18–80 - NCT05072691Recruiting
Tests spinal fluid proteins to predict multiple sclerosis outlook
This study checks specific proteins in spinal fluid to see whether they can predict how multiple sclerosis (or related symptoms like optic neuritis) may go over time. It may help doctors better estimate prognosis using results from tests you may already be having.
BrusselsAges 18 years+ - NCT05072483Recruiting
Study of CADASIL’s natural course using blood tests and MRI
This study follows people with CADASIL (a genetic brain blood-vessel condition) to learn how it progresses over time. It uses blood and possibly tissue samples and brain MRI scans to better understand changes in the brain.
Bethesda, MarylandAges 18–100 - NCT05074901Recruiting
Using a health app in France with virtual support
This trial tests whether a digital health app (with “virtual agents,” like guided prompts/support) can improve people’s health outcomes. You may help the study by using the app and completing its questionnaires.
BordeauxAges 18 years+ - NCT05077579Recruiting
Alzheimer’s scan study for people with higher body weight
This study uses brain scans (MRI and two special PET scans) to see how Alzheimer’s-related changes show up in people who are overweight or obese, with different blood-sugar and insulin patterns. It may help researchers understand whether body weight and metabolism affect early Alzheimer’s markers in the brain.
St Louis, MissouriAges 40–60 - NCT05077618Recruiting
Teeth bacteria study in seniors with and without Alzheimer’s
This study looks at the bacteria in the mouth (periodontal microbiota) to see whether they differ between seniors with Alzheimer’s disease and seniors without it. You may be asked for a sample from your gums/teeth and background health information.
Nice, CHU de NICEAges 18–90 - NCT05081713Recruiting
Rehab-based study for walking recovery after a first stroke
This study looks at how therapy and movement training may help people regain walking and compensate after their first stroke. You may be eligible if you are in the early weeks after stroke and are currently in inpatient rehabilitation, with medical clearance to safely participate in exercise.
Indianapolis, IndianaAges 18–85 - NCT05085704Recruiting
Brain scans to study metabolism in healthy and diabetic people
This study uses MRI brain scans at different strengths to measure how the brain uses energy (metabolism) in health and in people with genetically confirmed G1D. It may help researchers understand brain energy changes related to metabolic disease and diabetes.
New York, New YorkAges 16–80 - NCT05082181Recruiting
Phone group support for adults with epilepsy and depression
This study tests whether telephone-based group support helps adults with epilepsy who also have elevated depressive symptoms. Sessions are recorded, and you’ll join by phone in English or Spanish.
New York, New YorkAges 18–99 - NCT05085210Recruiting
Brain stimulation to improve parts of lost vision
This study tests whether a noninvasive brain stimulation treatment (tRNS) plus visual training can improve visual field problems after a stroke. It may help some people regain better visual perception in the area they lost.
Boston, MassachusettsAges 18–80 - NCT05088187Recruiting
Study of thinking and quality of life after thyroid surgery
This study looks at how thyroid surgery affects thinking (cognition) and day-to-day quality of life. It may help patients and doctors understand what to expect and how to support people after surgery.
StockholmAges 18 years+ - NCT05089604RecruitingPhase 4
Compare two tacrolimus forms to reduce tremors after liver transplant
This study compares immediate-release versus extended-release tacrolimus (an anti-rejection medicine) to see if one form causes fewer tremors after a first liver transplant. It may help you and your care team choose the best form if tremors are a problem while your body adjusts after transplant.
Vancouver, British ColumbiaAges 18 years+ - NCT05092685RecruitingPhase 1/Phase 2
Gene therapy trial for children with OTC ammonia build-up
This early-phase study tests an AAV gene therapy meant to reduce ammonia levels in children with ornithine transcarbamylase (OTC) deficiency. It’s designed to slow or stop ammonia-related harm, while also carefully monitoring safety for years.
LondonAges birth–16 years - NCT05090943Recruiting
Adult tic disorder registry for patients in France
This study is a registry, meaning it collects information about adults with tic disorders over time. It may help researchers better understand tic disorders and improve future care.
Clermont-FerrandAges 18 years+ - NCT05092191RecruitingPhase 2
Cannabis pill study for MS-related muscle stiffness
This Phase 2 trial tests whether cannabis can reduce muscle stiffness (spasticity) in people with multiple sclerosis. You may be able to participate if your stiffness is not improving with your current treatments.
Montreal, QuebecAges 21 years+ - NCT05095740Recruiting
Testing brain stimulation for laryngeal dystonia symptoms
This study tests whether a noninvasive brain stimulation treatment (referred to as neuromodulation, such as rTMS) can improve symptoms of laryngeal dystonia. It’s meant to see if stimulating certain brain areas can reduce how severely your voice/throat problem affects you.
Boston, MassachusettsAges 21–85
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.