Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05450978Recruiting
Study drug levels in epilepsy meds during pregnancy and breastfeeding
This study measures how much epilepsy medicine (lamotrigine, levetiracetam, or oxcarbazepine) your body absorbs during pregnancy and breastfeeding. It may help doctors better understand dosing and safety during these times.
Pittsburgh, PennsylvaniaAges 18–45 - NCT05451251RecruitingPhase 1
Deep brain stimulation for severe trigeminal nerve pain
This trial tests whether deep brain stimulation can reduce intense facial pain from trigeminal neuralgia when medicines and prior procedures have not helped. You may be eligible if you’re an adult with a specific MRI finding near the trigeminal nerve pathway.
Sherbrooke, QuebecAges 18 years+ - NCT05452005RecruitingPhase 1
PET scan with a new tracer for lung cancer brain metastases
This Phase 1 study tests whether a specialized PET scan tracer can “light up” metastatic non-small cell lung cancer in the brain. If you join, you’ll get brain MRI and PET/CT scans and you’ll continue with your planned cancer treatments and follow-up imaging.
Sacramento, CaliforniaAges 18 years+ - NCT05451524Recruiting
Preventing insomnia in teens with family history
This study aims to prevent insomnia in young people who already have mild sleep problems and have a parent with a history of insomnia. You may qualify if your sleep symptoms happen occasionally, but you do not have a diagnosed sleep disorder or certain other mental health or medical issues.
Shatin, NTAges 15–24 - NCT05452031Recruiting
Sleep program for people with dementia and their caregiver
This study tests a “dyadic” sleep health approach, meaning it works with both you and your caregiver together. It aims to improve sleep when dementia is causing frequent sleep problems, and to see whether a caregiver-involved plan helps both of you.
La Jolla, CaliforniaAges 18 years+ - NCT05452694Recruiting
Personalized pain relief after back fusion surgery
This trial tests a personalized plan to manage pain after lumbar (lower back) fusion and decompression surgery. It may help reduce difficult pain while guiding safe use of opioids around the time of surgery.
Pittsburgh, PennsylvaniaAges 18–99 - NCT05453019Recruiting
Cochlear implants and changes in tinnitus symptoms
This study looks at whether a cochlear implant affects tinnitus (ringing in the ears) and related symptoms. It compares people who had tinnitus before surgery with people who did not.
Beijing, FranceAges 16–90 - NCT05453877Recruiting
Brain scan and health data study using a long-term cohort
This study uses existing health records and then collects or uses brain imaging (CT or MRI) along with basic health measurements. It may help researchers learn patterns in brain images that relate to health or disease risk in people from the Kailuan group.
Beijing, Beijing MunicipalityAges 18–90 - NCT05454124Recruiting
Study of brain-eye learning changes in macular degeneration
This study looks at how the eye’s “central vision” area and connected brain learning/adjustment work in people with advanced macular degeneration. You may be asked to do vision testing using special eye-scanning equipment and follow study procedures that could help researchers better understand the disease.
Birmingham, AlabamaAges 18–89 - NCT05454527Recruiting
Biobank study follow-up for adults with inflammatory muscle disease
This study follows adults who have (or are being evaluated for) inflammatory muscle conditions to collect health data and genetic test information. It may help researchers better understand these diseases and improve future care.
ParisAges 18 years+ - NCT05456503RecruitingPhase 3
PET scan study of tau buildup in memory and brain disorders
This Phase 3 study uses a PET/CT scan to measure whether a brain protein called tau (and related disease patterns) builds up in different dementia conditions. The goal is to better match which disorders have which brain changes and how they progress.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05458323Recruiting
Vision testing and glasses change to improve thinking
This study checks whether better distance and near vision (through eye exams and correct glasses) can improve thinking and memory. You may be randomly assigned to receive eye care, and your ability to see and think will be measured.
Hyderabad, TelanganaAges 60 years+ - NCT05459090Recruiting
Study of how brain “brakes” work in drug-resistant temporal epilepsy
This study looks at how the brain’s natural “braking” system works in people with drug-resistant temporal lobe epilepsy. It may help researchers better understand the condition in order to improve future treatments.
Pozzilli, IserniaAges Any age - NCT05458947Recruiting
Physical therapy wound treatments for spinal cord injury sores
This study tests different physical therapy approaches to help heal pressure sores on the sacrum or ischium in people with a spinal cord injury. You may be able to join if you’re already in inpatient rehabilitation and your wound severity score fits the study criteria.
Charlotte, North CarolinaAges 18 years+ - NCT05459597Recruiting
Testing seizure medicine in older adults
This trial studies how seizure (epilepsy) medicines work in people age 65 and older. If you have epilepsy and are already taking seizure medication, you may be able to join to help researchers learn what to expect from these treatments in older adults.
Jinan, ShandongAges 65–100 - NCT05459935Recruiting
Light treatment for enlarged tonsils in children
This trial studies whether a light-based treatment (called photobiomodulation) can help children with very enlarged tonsils. It may improve breathing and sleep symptoms, and you’d have before-and-after checkups, including sleep testing.
Edmonton, AlbertaAges 6–12 - NCT05460793Recruiting
Surgery timing trial for brain bleeding after a stroke
This trial looks at whether starting brain surgery within 8 hours after a type of stroke called intracerebral hemorrhage (bleeding in the brain) can improve outcomes. It’s for adults with a certain amount and location of bleeding and without common causes like an aneurysm or malformation.
AmsterdamAges 18 years+ - NCT05460143Recruiting
Optical brain scanning to study memory and thinking
This study uses brain “optical” and possibly MRI scans to understand how thinking and memory work in people with Lewy body dementia, Alzheimer’s disease, or mild memory problems. It may help researchers find better ways to measure brain changes and cognition over time.
CambridgeAges 18 years+ - NCT05460507RecruitingPhase 1
Re-treating brain tumor with radioactive liposome after prior dose
This Phase 1 trial tests whether a radioactive treatment delivered in tiny fat “packets” is safe and tolerable when given again to people whose glioma (brain tumor) came back after a previous similar treatment. It also looks at how well this re-treatment works in carefully selected patients.
San Antonio, TexasAges 18 years+ - NCT05461092RecruitingEarly Phase 1
Nerve blocks to improve pain control after spinal fusion
This early-stage study tests whether a regional nerve block can improve pain control and recovery for older adults having elective lumbar spinal fusion. If you qualify, you may receive a special pain-control injection during surgery to reduce opioid needs and improve recovery comfort.
Iowa City, IowaAges 65 years+ - NCT05461898Recruiting
Rehabilitation program for adults with Guillain-Barré syndrome
This trial studies whether an inpatient rehabilitation program can help people with Guillain-Barré syndrome. It may be useful if you need structured therapy and support during recovery.
Vila Nova de GaiaAges 18 years+ - NCT05462106RecruitingPhase 1/Phase 2
ACI-24.060 study for early Alzheimer’s in adults and Down syndrome
This Phase 1/2 study tests an Alzheimer’s treatment called ACI-24.060 to see if it affects the disease in people with early Alzheimer’s changes. It includes two groups: older adults with early symptoms and people with Down syndrome who also show Alzheimer’s-related changes on brain scans.
Phoenix, ArizonaAges 35–85 - NCT05464251Recruiting
Review study for spinal infection diagnosis and outcomes
This study reviews medical records of people with certain spine infections, including infections of the spine bones, the discs, and the space around the spinal cord. It may help doctors better understand these conditions and how they are diagnosed and followed over time.
Lexington, KentuckyAges 18 years+ - NCT05464992Recruiting
PET/MRI scan study using a special brain MRI technique
This trial studies whether a special type of MRI during a PET/MRI scan (called CEST) can help doctors better evaluate brain tumors and tumor return after treatment. It may improve how well scans show where disease is before surgery or when tumors come back.
StrasbourgAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.