Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,406 recruiting studies in this area right now.
By phase
- Not applicable9,736
- Phase 2785
- Phase 1578
- Phase 3537
- Phase 4343
- Phase 1/Phase 2304
- Phase 2/Phase 3123
Top conditions
- Stroke839
- Parkinson Disease429
- Multiple Sclerosis344
- Alzheimer Disease340
- Dementia227
- Ischemic Stroke201
- Epilepsy197
- Obstructive Sleep Apnea156
- Spinal Cord Injuries154
- Insomnia152
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke137
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Migraine114
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris114
- Mayo Clinic98
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University71
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California681
- Massachusetts298
- New York292
- Florida273
- Texas269
- Maryland248
- Arizona214
- Alabama209
- Illinois190
- Pennsylvania175
Recruiting studies12,404 total
- NCT07793396Recruiting
Eslicarbazepine study for adults with partial-onset seizures
This study tests a medication called eslicarbazepine for adults who have partial-onset seizures. It may help people who are newly diagnosed or who have not had good results with two common seizure medicines, carbamazepine or oxcarbazepine.
Lahore, Punjab ProvinceAges 18 years+ - NCT06818877Recruiting
Brain-powered virtual reality game for arm training in kids with cerebral palsy
This study uses a virtual reality game controlled by brain activity to help children with cerebral palsy improve arm and hand movement. It also includes typically developing children to see how the game works for everyone.
Omaha, NebraskaAges 6–17 - NCT07392229RecruitingPhase 2
Zanubrutinib for Anti-MAG Neuropathy
This trial tests whether the oral drug zanubrutinib can help people with anti-MAG antibody polyneuropathy, a nerve condition often linked to certain blood cancers. It aims to improve nerve symptoms by targeting the immune cells responsible.
Milan, MilanAges 18 years+ - NCT06680830RecruitingPhase 2
Testing NEU-411 for early Parkinson's with LRRK2 gene change
This trial tests an experimental drug called NEU-411 for people with early Parkinson's disease who have a specific genetic change (LRRK2). It aims to see if the drug can slow the disease progression.
Sun City, ArizonaAges 40–80 - NCT07428629Recruiting
Insomnia treatment trial for people with ulcerative colitis
This trial tests whether a sleep-focused therapy can help people with active ulcerative colitis who also have trouble sleeping. It aims to improve both sleep and UC symptoms.
Lebanon, New HampshireAges 18 years+ - NCT07719608Recruiting
MySalvia system for resistant migraine
This trial tests a device called MySalvia that is implanted in the head to reduce migraine attacks. It is for people whose migraines have not improved with at least three different preventive treatments.
Newnan, GeorgiaAges 22–84 - NCT06735833Recruiting
Testing embolization for chronic migraines
This study tests a procedure called MMA embolization (blocking a small artery in the head) to see if it can reduce migraine attacks in people with chronic, hard-to-treat migraines.
Walnut Creek, CaliforniaAges 18–65 - NCT07451769Recruiting
Testing a new drug target for migraine relief
This trial tests a substance that activates adrenomedullin receptors, which may be a new way to treat migraines. It may help people who have migraines without aura and aren't on preventive migraine medications.
Glostrup MunicipalityAges 18–65 - NCT07070089Recruiting
Stent implant for severe heartbeat-synchronized ear ringing
This trial tests whether placing a small mesh tube (stent) in a narrowed brain vein can stop severe, pulse-synchronous tinnitus—a whooshing sound that matches your heartbeat. It is for people whose tinnitus is very bothersome and has not improved with other treatments.
Ottawa, CanadaAges 18–80 - NCT07111065RecruitingPhase 2
Fatty Acid Supplement for Dermatomyositis
This study tests whether taking a fatty acid supplement (omega-3) for 6 months can help reduce disease activity in people with dermatomyositis. Participants will also receive dietary coaching and have regular check-ups at the NIH to monitor their progress.
Bethesda, MarylandAges 18–60 - NCT06642246Recruiting
Sleep Help for Kids with High Blood Pressure
This study tests whether helping teens with high blood pressure get more sleep can lower their blood pressure. It offers a sleep-focused program and checks if it helps within a few months.
Philadelphia, PennsylvaniaAges 13–18 - NCT06819592RecruitingPhase 3
Preventing early lung infections after severe brain injury
This study tests whether giving an antibiotic (ceftriaxone) early after a severe brain injury can prevent lung infections caused by the breathing machine (ventilator). It is for adults in the ICU who recently started on a ventilator due to a brain emergency.
Canberra, Australian Capital TerritoryAges 18 years+ - NCT07137442Recruiting
Tic study: comparing tics and functional tics with brain tests
This study uses EEG and EMG tests to tell the difference between tics and functional tics. You may help doctors better understand and diagnose these conditions.
Bethesda, MarylandAges 18–80 - NCT07633470RecruitingPhase 4
Zunveyl for Alzheimer's disease symptoms and caregiver support
This study tests a medication called Zunveyl to see if it helps reduce behavioral and neuropsychiatric symptoms in people with mild-to-moderate Alzheimer's disease, and whether it reduces stress on family caregivers. You would need a confirmed Alzheimer's diagnosis supported by a blood test, and a dedicated caregiver who can attend visits and report on your symptoms.
Orange, CaliforniaAges 50 years+ - NCT06925542RecruitingPhase 1
Study of CTX112 for adults with autoimmune disease
This trial tests an experimental cell therapy called CTX112 for people with lupus, scleroderma, or inflammatory myositis that hasn't responded well to standard treatments. The goal is to see if it's safe and if it can help control the disease.
La Jolla, CaliforniaAges 18–70 - NCT07246941RecruitingPhase 1
Safety of RG6496 in Huntington's disease
This is an early-phase study testing a new drug (RG6496) for people with Huntington's disease. The study will check the drug's safety and how the body processes it, and it requires two doses given about 6 months apart.
Ciudad Autonoma Bs AsAges 25–65 - NCT07192042Recruiting
Testing a device to check sleep breathing in schizophrenia
This trial uses a non-wearable device to assess sleep-disordered breathing in people with schizophrenia who are hospitalized. It aims to understand if this easy method can help monitor sleep issues.
New Taipei CityAges 20–70 - NCT07067463RecruitingPhase 3
Testing orelabrutinib for primary progressive MS
This trial tests a daily pill called orelabrutinib to see if it can slow disability progression in people with primary progressive multiple sclerosis (PPMS). It may be an option for patients whose symptoms have been getting worse over the past two years.
Pheonix, ArizonaAges 18–60 - NCT06914609RecruitingPhase 3
Study of ION582 for people with Angelman syndrome
This trial tests a new medicine called ION582 for people with Angelman syndrome. It aims to see if it can help with symptoms and is given as a lumbar puncture (spinal tap). You may be able to join if you have a genetic diagnosis of Angelman syndrome and are between 2 and 50 years old.
Los Angeles, CaliforniaAges 2–50 - NCT07367100Recruiting
Testing a new clot-removal catheter for stroke
This study tests a special catheter (a thin tube) designed to remove blood clots from large arteries in the brain during a stroke. The goal is to see if it is safe and effective at restoring blood flow.
EdegemAges 18–90 - NCT07149428Enrolling by invitation
Deep study of smell loss causes using brain scans
This study uses brain imaging and electrical recordings to understand the brain's role in smell loss from any cause—like COVID, sinus problems, or chemotherapy. You may be eligible if you have any degree of smell loss lasting under a year.
Bethesda, MarylandAges 18–99 - NCT07191873RecruitingPhase 4
Tirzepatide for treating high pressure in the brain
This trial tests if tirzepatide can help lower the pressure inside your skull caused by a condition called Idiopathic Intracranial Hypertension. It's designed for people with a BMI of 30 or higher who have swelling of the optic nerve.
Durham, North CarolinaAges 18–60 - NCT06655883RecruitingPhase 3
Testing suvorexant for insomnia in people with opioid use disorder
This study tests whether the sleep medication suvorexant (Belsomra) can help people with opioid use disorder who also have trouble sleeping. If you are stable on medication for opioid use disorder and have not used opioids in the last month, this trial may be an option for you.
Garden Grove, CaliforniaAges 18–70 - NCT07099053Recruiting
Brain scan study for aging adults in Baltimore
This study uses a special brain scan (amyloid PET) to look at brain changes in healthy older adults. It may help researchers learn more about aging and memory loss.
Baltimore, MarylandAges 55–110
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,406 recruiting neurology studies from the U.S. registry right now, out of 19,187 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.