Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 11,934 recruiting studies in this area right now.
By phase
- Not applicable9,337
- Phase 2764
- Phase 1555
- Phase 3514
- Phase 4340
- Phase 1/Phase 2299
- Phase 2/Phase 3125
Top conditions
- Stroke797
- Parkinson Disease395
- Alzheimer Disease337
- Multiple Sclerosis330
- Dementia224
- Epilepsy192
- Ischemic Stroke190
- Insomnia159
- Traumatic Brain Injury151
- Obstructive Sleep Apnea142
- Spinal Cord Injuries142
- Acute Ischemic Stroke139
- Sarcopenia135
- Mild Cognitive Impairment126
- Cerebral Palsy119
- Pain Management113
- Migraine107
- Fibromyalgia105
Leading sponsors
- Beijing Tiantan Hospital124
- Assistance Publique - Hôpitaux de Paris109
- Riphah International University105
- Mayo Clinic98
- VA Office of Research and Development92
- Xuanwu Hospital, Beijing89
- Hospices Civils de Lyon77
- Johns Hopkins University69
- University of Minnesota63
- Washington University School of Medicine63
Where studies are running
- California655
- Massachusetts304
- New York295
- Florida267
- Texas267
- Maryland248
- Arizona209
- Alabama205
- Illinois183
- Pennsylvania175
Recruiting studies11,934 total
- NCT07558876Recruiting
Upper limb training with vibration therapy after stroke
This trial tests whether combining task-oriented exercises with focal vibration (gentle vibrating stimulation) can help improve arm and hand function and feeling in people who've had a stroke. The vibration aims to help your brain better sense where your hand is and what it's touching.
SeoulAges 20 years+ - NCT07378644RecruitingPhase 2/Phase 3
Testing SKY-0515 for Huntington's disease
This trial tests a new drug called SKY-0515 in people with Huntington's disease. The goal is to see if it can safely improve symptoms or slow the disease down.
Englewood, ColoradoAges 25 years+ - NCT06126224RecruitingPhase 3
Testing KarXT for Alzheimer's-related psychosis
This clinical trial tests an investigational oral medication called KarXT for treating psychosis (hallucinations or delusions) in people with Alzheimer's disease. The study aims to see if the drug can safely reduce these symptoms.
Chandler, ArizonaAges 55–90 - NCT07237308RecruitingPhase 4
Two blood thinners compared for stroke with atrial fibrillation
This study tests whether a common blood thinner (apixaban) alone is as safe and effective as combining it with another drug (clopidogrel) to prevent future strokes in people who have both atrial fibrillation and narrowing in the arteries leading to the brain. It aims to find the best way to reduce stroke risk while minimizing bleeding.
SeoulAges 19 years+ - NCT07721467RecruitingPhase 2
Cognitive training with psilocybin for brain flexibility
This study tests whether combining a brain-training program with a psychedelic drug called psilocybin can boost the brain's ability to change and adapt. It may help improve thinking and memory.
Baltimore, MarylandAges 65–120 - NCT07871071Recruiting
Brain-computer interface communication device for ALS
This trial tests a brain-computer interface (BCI) device that lets people with ALS communicate using brain signals, without needing to move. It may help those who have difficulty speaking or using eye-gaze devices.
Santa Barbara, CaliforniaAges 18 years+ - NCT05147701RecruitingPhase 1
Testing stem cell treatment for NAION safety
This Phase 1 study tests whether lab-made stem cells taken from donated umbilical cord are safe for people with NAION. It mainly looks for side effects and safety rather than proving the treatment works.
Naples, FloridaAges Any age - NCT07226726RecruitingPhase 1
Stem cell exosome treatment for congenital myasthenic syndrome
This trial tests a treatment made from stem cell exosomes (tiny particles that may help repair cells) for people with congenital myasthenic syndrome, a muscle-weakening condition. It aims to see if this treatment is safe and could improve symptoms.
Naples, FloridaAges 18 years+ - NCT05152394RecruitingPhase 1
Testing cord stem cell exosome treatment for Parkinson’s safety
This Phase 1 study tests whether a treatment made from donated umbilical cord “exosomes” is safe in people with Parkinson’s disease. It mainly looks at side effects and safety, and could help guide future treatments if it proves tolerable.
Naples, FloridaAges Any age - NCT07210515RecruitingPhase 3
Testing Ambros Therapy for Early CRPS
This trial tests if an intravenous medicine called AMBTX-01 (neridronate) can help people with early-stage Complex Regional Pain Syndrome (CRPS) type 1. It focuses on those whose affected limb feels warm, looks red, and is swollen.
Phoenix, ArizonaAges 18 years+ - NCT07673627RecruitingPhase 2
Testing empasiprubart for generalized myasthenia gravis
This trial tests a new drug called empasiprubart for people with generalized myasthenia gravis (gMG) who have a certain antibody (AChR-Ab). It is given as a monthly IV infusion (into a vein) and aims to improve muscle weakness and daily functioning.
Carlsbad, CaliforniaAges 18 years+ - NCT07227779RecruitingPhase 2
B-PaLMZ for TB meningitis in people with HIV
This trial tests a combination of TB medicines (B-PaLMZ) for people with HIV who have their first episode of TB meningitis. It aims to find a better treatment option.
KampalaAges 18 years+ - NCT06095284Enrolling by invitation
Antiseizure drug use in nursing homes before and after COVID-19
This study looks at how antiseizure medications are prescribed to long-term nursing home residents and how those prescriptions changed during the COVID-19 pandemic. It helps understand if prescribing patterns affected residents' health.
Richmond, VirginiaAges 21 years+ - NCT03819608Recruiting
Brain stimulation and rehab after mild concussion with PTSD or cognitive issues
This trial studies whether brain stimulation plus targeted brain rehabilitation can improve symptoms after a mild concussion (mTBI). You may be invited if your concussion happened at least 3 months ago and your symptoms are affecting thinking or mood, with or without PTSD.
Chicago, IllinoisAges 18–80 - NCT07855341RecruitingPhase 4
Nerve block study for hip replacement pain relief
This study tests two different amounts of a numbing medicine injected around the hip nerves before hip replacement surgery, to see if adding a steroid helps reduce pain after surgery. It aims to improve pain control and recovery.
Cairo, Cairo GovernorateAges 50–70 - NCT05493722RecruitingEarly Phase 1
Adjusting deep brain stimulator settings for hard-to-control seizures
This early-phase study tests whether changing your deep brain stimulator settings can improve seizure control in people whose epilepsy is not helped by usual treatments. It is mainly for patients who already have the stimulator placed.
Minneapolis, MinnesotaAges 18 years+ - NCT05980949RecruitingPhase 3
Long-term safety study of KarXT for Alzheimer's psychosis
This trial tests the long-term safety of an investigational drug called KarXT for people with psychosis caused by Alzheimer's disease. It is for those who have already completed a previous KarXT study and want to continue treatment.
Homewood, AlabamaAges 55–90 - NCT07423975RecruitingPhase 2
Testing anakinra to improve recovery after stroke treatment
This study tests a medicine called anakinra (usually used for inflammation) to see if it helps improve recovery after a stroke caused by a blocked artery that was successfully opened with a procedure. It aims to reduce brain damage and improve outcomes for patients who still have significant symptoms after treatment.
Beijing, Beijing MunicipalityAges 18–80 - NCT05492188Recruiting
Testing training and skin reflex changes for nerve pain after SCI
This study looks at how a training program affects skin reflexes and nerve pain in people with spinal cord injury (SCI). It may help researchers find better ways to manage nerve pain by changing how the body responds to touch and training.
Charleston, South CarolinaAges 18 years+ - NCT07467356RecruitingPhase 3
Nerve blocks for easier positioning before hip surgery
This study compares two different numbing injections (nerve blocks) to see which one helps you get into position more easily for spinal anesthesia before hip surgery. The goal is to make the procedure less painful and more comfortable.
Banhā, ElqalyoubeaAges 18 years+ - NCT07242638RecruitingPhase 2
Abrocitinib for skin and hair loss in Down syndrome
This study tests if the pill abrocitinib can help people with Down syndrome who have atopic dermatitis (eczema) or alopecia areata (patchy hair loss). The goal is to see if it improves their skin or hair with manageable side effects.
New York, New YorkAges 12 years+ - NCT07857733RecruitingPhase 3
Extended treatment study for complex regional pain syndrome
This study gives an extended course of neridronate infusions to people who completed the earlier AMBTX-01-301 trial, to see if longer treatment safely keeps easing their chronic pain and other symptoms of complex regional pain syndrome (a long-lasting pain condition, often after an injury).
Phoenix, ArizonaAges 18 years+ - NCT06920004RecruitingPhase 3
Testing empasiprubart vs IVIg for chronic CIDP
This study tests an investigational drug called empasiprubart against standard IVIg in adults with CIDP. The goal is to see if it is safer and more effective for people who still have symptoms despite IVIg therapy.
Birmingham, AlabamaAges 18 years+ - NCT00029965Recruiting
Natural history of inherited metabolic storage disorders
This study follows people with certain inherited metabolic conditions (like GM1 or GM2 gangliosidosis, sialidosis, or galactosialidosis) to learn more about how these diseases progress over time. Participating may help researchers understand the conditions better, which could improve future care.
Bethesda, MarylandAges 1 day–100 years
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 11,934 recruiting neurology studies from the U.S. registry right now, out of 18,325 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.