Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05836831RecruitingPhase 4
Tranexamic acid for sudden brain bleeding after stroke
This trial studies whether tranexamic acid (a medicine that helps blood clot) can improve outcomes after a spontaneous (not caused by injury) brain bleed. It is designed for adults who arrive soon after stroke symptoms start and meet several safety and timing requirements.
Guntur, Andhra PradeshAges 18–99 - NCT05836610RecruitingPhase 4
Testing hydrocortisone dosing during newborn cooling
This Phase 4 trial studies the best way to give hydrocortisone (a steroid medicine) to newborns who are being cooled for a specific kind of birth-related lack of oxygen. It’s for babies who have low blood pressure during cooling, aiming to improve their stability while they receive standard treatment.
Budapest, Pest CountyAges Up to 3 days - NCT05836987RecruitingPhase 3
Smartwatch monitoring trial to guide blood thinner use for AF
This study tests whether continuous heart-rhythm monitoring with a smartwatch can better guide treatment for atrial fibrillation (AF) while you stay on a blood thinner. The goal is to improve safety and reduce stroke risk by catching AF patterns more closely.
Phoenix, ArizonaAges 22–85 - NCT05837091RecruitingPhase 4
Low-dose sodium oxybate for idiopathic hypersomnia sleepiness
This trial tests whether low-dose sodium oxybate can improve symptoms in adults with idiopathic hypersomnia, a condition that causes excessive sleepiness. You’d likely be asked to pause this standard treatment briefly while baseline testing is completed, and you’d use reliable contraception during and after the study drug.
Phoenix, ArizonaAges 18–65 - NCT05837676Recruiting
Problem-solving training for concussion symptoms
This trial tests whether a structured problem-solving skill program can improve mood and thinking symptoms after a concussion. It may help Veterans who have had concussion symptoms for several months and are currently feeling psychological distress.
Buffalo, New YorkAges 18 years+ - NCT05838547Recruiting
PET-MR scan study for narrowing in the carotid artery
This study tests how well a special PET-MR scan can help evaluate carotid artery plaque in people who have significant narrowing but no symptoms. It may help researchers better understand disease activity to guide treatment decisions like medication alone or medication plus surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT05839379Recruiting
Targeted therapy study for children and young adults with brain tumors
This trial studies a targeted medicine approach for high-grade glioma (a fast-growing brain tumor) and some diffuse midline tumors, including DIPG. It may help by matching treatment to tumor biology using tumor testing done before or around starting standard therapy.
Aurora, ColoradoAges 1–39 - NCT05839418Recruiting
Registry study for people with status epilepticus
This study records information about people who are in the hospital with status epilepticus (prolonged seizure activity) to better understand care for refractory cases. If you qualify, your team may collect your clinical details during your hospital stay rather than giving a new treatment as part of the study.
LinzAges 18 years+ - NCT05842551Recruiting
Prism glasses and brain stimulation after stroke
This trial studies whether prism lenses and a mild brain-stimulation treatment can help people who have stroke-related “neglect,” where they don’t notice one side of the body or space. If you qualify, the goal is to see if these treatments improve attention and daily functioning after a recent ischemic stroke.
Bari, BaAges 18–90 - NCT05843084Recruiting
7-Tesla brain scans to map networks for Parkinson’s DBS
This study uses a very strong MRI (7-tesla) to analyze how parts of the brain connect in people with Parkinson’s who already have deep brain stimulation (DBS). It may help researchers better understand DBS and how it works in the brain.
Amsterdam, North HollandAges 18 years+ - NCT05843552Recruiting
Blood test using small vesicles in Gaucher disease
This study looks for tiny particles in blood (called extracellular vesicles) that may help identify Gaucher disease and could guide future treatments. It also studies people who have Gaucher gene carrier status but do not have the disease, using careful genetic testing.
Minneapolis, MinnesotaAges 18–80 - NCT05843253RecruitingPhase 2
Ribociclib plus everolimus or temozolomide for certain brain tumors
This Phase 2 study tests ribociclib with either everolimus or temozolomide, depending on the specific brain tumor type. It may help slow tumor growth in children and young adults whose tumor has specific genetic changes and who have had recent standard radiation therapy.
Aurora, ColoradoAges 1–39 - NCT05845255Recruiting
Test wearable monitoring for epilepsy quality of life and safety
This study tests a wearable device that records seizure-related information to understand how epilepsy affects daily life and safety. It may help your care team better track seizures in real-world settings and understand quality-of-life changes.
KorkAges 12–65 - NCT05845047Recruiting
Telemedicine speech therapy for stroke-related language problems
This trial tests a home-based (telemedicine) therapy that uses focused brain “engagement” exercises to help improve language after a stroke. It is meant for adults with stroke-related aphasia (language difficulty) and checks whether you can participate reliably with the tasks.
Baltimore, MarylandAges 18–99 - NCT05845541Recruiting
Meditation and body feedback for mood after stroke
This study tests whether guided meditation and biofeedback can improve anxiety, depression, and quality of life for people recovering in inpatient rehab after a recent stroke. It may help you feel better emotionally and cope more easily during recovery.
Toronto, OntarioAges 18 years+ - NCT05847010Recruiting
Study program to prevent postoperative delirium in older adults
This study adds an extra scientific program to help prevent confusion (“delirium”) after surgery in older adults. If you were already planned to join the main prevention program, this may help improve how care is delivered and how outcomes are measured.
BerlinAges 70 years+ - NCT05846490RecruitingPhase 4
Sleep apnea treatment to improve blood pressure in kidney disease
This study tests whether treating obstructive sleep apnea can help control blood pressure in people with chronic kidney disease. If your sleep apnea is not currently being treated, participation may help your care team see whether safer breathing at night improves blood pressure control.
São PauloAges 18 years+ - NCT05847192Recruiting
Testing brain-signal networks in Alzheimer’s with hallucinations
This study looks at “tau” (a brain protein) and brain-signal patterns in people with Alzheimer’s disease who have psychotic symptoms like hallucinations or delusions. It may help researchers understand what’s happening in the brain and how to better target these symptoms.
Manhasset, New YorkAges 65–85 - NCT05847426Recruiting
Testing early hearing support using brain scans in babies
This study helps improve early hearing care by using a simple brain scan test (fNIRS) in babies with permanent hearing loss. It compares different early intervention approaches and aims to find better ways to support hearing development early on.
East Melbourne, VictoriaAges 24 years+ - NCT05847699Recruiting
MRI study of stroke brain changes after decompression surgery
This study looks at how MRI findings match what doctors see in brain tissue after treatment for a type of severe stroke. It may help researchers better understand which brain changes happen early and how decompressive surgery affects them.
ParisAges 18 years+ - NCT05847985Recruiting
Noninvasive brain stimulation for thinking and language issues
This study tests whether a noninvasive brain stimulation treatment can improve sentence understanding in people with Parkinson’s disease–related mild cognitive impairment or mild cognitive impairment from Lewy body disease. It also compares results with healthy volunteers who do not have Lewy body or other memory/brain disorders.
BrnoAges 60–80 - NCT05848297Recruiting
Robotic ultrasound monitoring for severe traumatic brain injury
This trial tests whether a robotic system using a bedside ultrasound test (TCD) can safely monitor brain blood flow in adults with severe traumatic brain injury soon after the injury. It may help the care team track changes earlier and adjust treatment sooner.
Davis, CaliforniaAges 18 years+ - NCT05848271Recruiting
Natural history study for people with HPDL gene changes
This study follows people who have an HPDL gene change to better understand how symptoms and health progress over time. It may help clinicians learn more about the condition and plan future treatments.
San Diego, CaliforniaAges Any age - NCT05849467RecruitingPhase 1
Testing how the brain absorbs anti–CD8 therapy in nervous system disease
This Phase 1 study tests a small drug (called an anti–CD8+ T cell minibody) to see how much reaches the brain. It may help researchers understand how to deliver similar treatments for multiple sclerosis, progressive multifocal leukoencephalopathy (PML), or other brain inflammation when the brain’s protective barrier is “open.”
Bethesda, MarylandAges 18–120
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.