Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05821075RecruitingPhase 1/Phase 2
Prednisolone vs Cerebrolysin for sudden facial weakness
This early-stage study compares two medicines—prednisolone and cerebrolysin—to see which works better for Bell’s palsy (sudden one-sided facial weakness with no clear cause). You may be asked to take one of the study treatments and be followed to measure how well facial movement improves.
GizaAges 18–60 - NCT05822258Recruiting
Tracking freezing while walking in Parkinson’s using motion sensors
This study tests motion-sensor devices (small inertial measurement units) to detect moments when walking suddenly “freezes” in Parkinson’s disease. If you have freezing episodes, it may help researchers measure them more accurately and support better monitoring.
Rennes, Brittany RegionAges 18 years+ - NCT05821972RecruitingPhase 4
Breathing-mist medicines for cleft palate surgery pain control
This trial tests whether a breathing mist of two medicines (dexmedetomidine plus ketamine) works better than dexmedetomidine alone during cleft palate repair surgery. It may help improve comfort and safety around anesthesia for eligible patients.
AsyutAges 1–4 - NCT05821959RecruitingPhase 1/Phase 2
Gene therapy for hearing loss caused by otoferlin gene changes
This early-stage study tests a one-time gene therapy to help patients with profound hearing loss linked to otoferlin gene mutations. It may help hearing by delivering a working version of the otoferlin gene to the inner ear, followed by long-term monitoring.
San Francisco, CaliforniaAges Any age - NCT05822362RecruitingPhase 2
CBD for People with Early Memory Trouble Risk
This Phase 2 study tests whether CBD (a cannabis-derived product) can improve thinking and memory in people who are at risk for Alzheimer’s disease. You would be followed for about 24 weeks with memory/thinking check-ins and require a study partner to help with certain assessments.
Aurora, ColoradoAges 55–85 - NCT05822388Recruiting
Deep brain stimulation and memory changes in Parkinson’s
This study looks at whether deep brain stimulation (a surgical treatment for Parkinson’s disease) affects thinking and memory over time. It compares Parkinson’s participants to people without Parkinson’s to better understand what changes happen with treatment.
Charleston, South CarolinaAges 18 years+ - NCT05822908RecruitingPhase 1/Phase 2
Study drug VO659 for SCA1, SCA3, and Huntington disease
This early-phase study tests whether VO659 is safe and how the body processes it in people with certain genetic movement disorders (SCA1, SCA3, or Huntington disease). It may help researchers learn the right dose and whether the drug can be given safely.
CopenhagenAges 25–60 - NCT05823454Recruiting
Testing brain-connection changes during propofol sedation
This study looks at how the brain network connects during propofol sedation in people with long-lasting disorders of consciousness. It may help doctors understand brain function in these conditions and improve how care is guided during procedures.
BeijingAges 18–65 - NCT05824169RecruitingPhase 1/Phase 2
Gene therapy for babies with severe spinal muscular atrophy
This early-stage study tests whether a one-time gene therapy can safely improve outcomes for babies with the most severe type of spinal muscular atrophy (SMA type 1). It focuses on safety and early signs of benefit, and participation requires specific genetic and health criteria.
BeijingAges birth–6 months - NCT05825027Recruiting
Sorting out risk in children with a recent concussion
This study looks at how to identify which children are at higher risk after a concussion and how they should be monitored. It may help doctors choose safer, more personalized follow-up care after a recent head injury.
Durham, North CarolinaAges 11–17 - NCT05826548Recruiting
Telerehabilitation program for memory, Parkinson’s, and stroke needs
This trial studies a home-based exercise and training program delivered by telerehabilitation (remote care) for people with mild cognitive impairment, Parkinson’s disease, or stroke. It may help improve day-to-day thinking and movement skills by supporting you with structured practice from home.
Lido, VeneziaAges 18–85 - NCT05829668Recruiting
Behavior plan study for children with Cornelia de Lange syndrome
This study tests a structured behavior assessment and treatment program for children with Cornelia de Lange syndrome who have challenging behaviors. It may help reduce self-injury, aggression, and disruptive behavior through a plan families can carry out.
Baltimore, MarylandAges 3–15 - NCT05830305Recruiting
Phone app coaching after brain bleed to help blood pressure
This trial tests a mobile health app (WeRISE) to help people who survived an intracerebral hemorrhage (a type of brain bleed) monitor health and manage blood pressure after discharge. It may help you reduce the risk of problems related to high or unstable blood pressure.
Hong KongAges 18–85 - NCT05830877Recruiting
Acupuncture study for long-term trouble sleeping
This trial tests whether acupuncture can improve chronic insomnia, meaning ongoing difficulty falling asleep or staying asleep. You may be asked to complete questionnaires and sleep testing to see how your sleep and stress signals change.
Hangzhou, ZhejiangAges 18–70 - NCT05831631Recruiting
Study immune cells in brain tumors during neurosurgery
This study looks at different immune cells in the blood and inside brain tumors. It includes adults who have a malignant brain tumor and need a neurosurgery procedure, such as surgery, stereotactic biopsy, or radiosurgery, to help doctors better understand the immune response.
Milan, MilanAges 18 years+ - NCT05832515RecruitingPhase 1
Stem cell transplant for multiple sclerosis with MS-prep chemotherapy
This early-phase study tests a stem cell transplant procedure for people with multiple sclerosis whose usual MS medicines have not worked or can’t be tolerated. The goal is to see if this approach can help control MS activity and progression, while checking for safety.
Saint PetersburgAges 18–65 - NCT05832567Recruiting
Study of hidden and open placebo effects in stroke recovery
This study looks at how “open” (told) and “hidden” (not told) placebo effects may change arm recovery after a long-term stroke. You would do recovery-related assessments and likely receive brain-stimulation or related procedures to test these effects.
Cambridge, MassachusettsAges 18 years+ - NCT05832762Recruiting
Clot-buster procedure for blocked neck artery stroke
This trial studies whether an emergency clot-removal procedure through the blood vessels (endovascular treatment) helps people who have a stroke caused by a blocked internal carotid artery in the neck. It compares outcomes in patients treated urgently when imaging shows the blockage is likely the main cause.
Montpellier, FanceAges 18 years+ - NCT05833321Recruiting
Testing a way to detect low muscle in women with certain cancers
This study looks at whether doctors can spot “low muscle” (sarcopenia) in everyday clinic care for people with ovarian or endometrial cancer who are planning to start chemotherapy. It may help your care team identify muscle loss early and potentially support better treatment planning.
Chambéry, SavoieAges 18 years+ - NCT05833932Recruiting
Registry study of Suhexiang Pill after recent stroke
This study tracks people who had an ischemic stroke (a type of stroke caused by blocked blood flow) within the last week and received Suhexiang Pill. It aims to see how outcomes and follow-up go in real-world use, which may help doctors understand who might benefit and how to monitor patients.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05834855RecruitingPhase 3
Rituximab versus ocrelizumab for relapsing multiple sclerosis
This Phase 3 trial compares two similar immune therapies—rituximab and ocrelizumab—to see if rituximab works about as well for relapsing multiple sclerosis. It may help you and researchers understand which option is equally effective and safe for preventing relapses and disease activity.
AmsterdamAges 18 years+ - NCT05835622Recruiting
Home walking brace study to improve quality of life in MS
This study tests whether using a home “walking exoskeleton” brace can improve quality of life for people with relapsing-remitting multiple sclerosis who have moderate walking problems. You would use the device at home, and the study team will check your walking safety and comfort during and after training.
Saint-Genis-Laval, Auvergne-Rhône-AlpesAges 18 years+ - NCT05835674Recruiting
Early brain screening and therapy planning for babies at CP risk
This trial aims to find and support babies who are at risk of cerebral palsy (CP) as early as possible. It checks specific early signs and brain or health risk factors, then helps determine whether early intervention might improve outcomes.
AalborgAges 3 months–1 year - NCT05835973Recruiting
Study of sleep changes in people with inflammatory bowel disease
This study looks at how sleep patterns change in adults with inflammatory bowel disease (IBD) who are currently in remission. It may help researchers understand sleep issues in IBD and identify ways to improve care during symptom-free periods.
Clermont-FerrandAges 18–65
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.