Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05849038RecruitingPhase 2
Treating inflammation to improve depression in HIV
This Phase 2 study looks at whether lowering inflammation can help improve depression symptoms in adults living with HIV. You may be able to join if your HIV is well controlled and you are currently experiencing major depression (or a certain type of bipolar depression).
Atlanta, GeorgiaAges 18–65 - NCT05849285Recruiting
Testing a program to support adults with lifelong care needs
This study tests a “Transitional and Lifelong Care” program for adults who had a disability since childhood, and includes their main caregiver or support person. It aims to see how this type of care support may improve experiences and support over time.
London, OntarioAges 21 years+ - NCT05849597RecruitingPhase 3
Dexmedetomidine to prevent delirium after open-heart surgery
This trial tests whether a sedating medicine called dexmedetomidine can reduce the risk of “delirium” (sudden confusion) in the intensive care unit after open-heart surgery. If you’re having certain heart operations, it may help protect your thinking and alertness during recovery.
KamenitzAges 18 years+ - NCT05849896Recruiting
Tests how muscle-monitor signals work after stroke rehab
This study checks how well a device’s surface muscle signals (recorded on the skin) match what happens during post-stroke rehabilitation tasks. It may help improve how rehab progress is measured, using information from both healthy participants and people after a first stroke.
LuganoAges 18–99 - NCT05895019Recruiting
Propofol’s effects on brain function in Parkinson’s surgery
This study tests how propofol, a common anesthesia medicine, affects brain activity in people with Parkinson’s disease during planned surgery. It also compares them with people without Parkinson’s during similar non-brain, non-heart surgery.
Beijing, Beijing MunicipalityAges 18–80 - NCT05850247RecruitingPhase 2
Study brain inflammation in carotid artery narrowing after stroke or TIA
This Phase 2 study looks at a protein called ficolin-2 and whether it relates to brain inflammation after a short stroke-like event or eye blood vessel blockage caused by narrowed carotid arteries. If you recently had symptoms from the carotid artery and meet imaging and health criteria, you may be offered study-related assessments to better understand the cause and help future treatment decisions.
BronAges 18 years+ - NCT06029075Recruiting
Brain stimulation for nerve pain after spinal injury
This study tests whether a gentle electrical current applied to the scalp can help relieve nerve pain that continues after an injury to the spinal cord, arm or leg amputation, or brain injury. Participants will continue their usual pain medications during the trial.
Houston, TexasAges 18–75 - NCT05875116Recruiting
Virtual reality therapy for arm weakness after stroke
This trial tests whether virtual reality training plus a specific arm-movement approach helps people regain function after a stroke. It focuses on improving arm weakness on one side of the body during the early months after leaving the hospital.
Mexico CityAges 35–70 - NCT05957679Recruiting
Check how well an MRI test shows spinal tumor surgery challenges
This study looks at an MRI-type scan (called MRE) to measure stiffness and “adhesion” around spinal cord tumor surgery. It may help doctors plan surgery better by predicting what the tumor area will feel like and how it may stick to nearby tissues.
Shenyang, LiaoningAges 18–80 - NCT05851287Recruiting
Eye and health check study for adults 65 and older
This study enrolls people age 65+ to get regular eye and general health checkups. It may help doctors understand what eye problems are developing and how to catch them earlier.
Guangzhou, GuangdongAges 65 years+ - NCT05851989Recruiting
Studying outcomes after burst brain blood vessel aneurysms
This study looks at what happens over time after a burst brain blood vessel aneurysm that caused bleeding around the brain. Your care team may use the study results to better predict outcomes and guide treatment for people like you.
AmsterdamAges 18 years+ - NCT05851508RecruitingPhase 3
Steroid ear injections for vertigo in one-ear Ménière’s
This Phase 3 study compares injections of steroid medicine into the ear versus a dummy (placebo) injection to see if it reduces vertigo attacks in people with Ménière’s disease. It may help by improving balance symptoms and reducing how often attacks happen.
Leiden, South HollandAges 18–100 - NCT05852418Recruiting
Registry study of devices, medicines, and care in ALS and SMA
This study collects information in a registry about assistive devices, medicines, and healthcare support for people with long-term neurological conditions like ALS and SMA. It may help researchers understand what treatments and supports are used and how they relate to patients’ needs over time.
BerlinAges 18 years+ - NCT05853796Recruiting
Studying stroke warning signs in young adults
This observational study follows people ages 18–50 who had a first TIA (“mini-stroke”) or an acute ischemic stroke to better understand what happens after the event. It may help improve future care by tracking symptoms, imaging findings, and recovery over time.
Nijmegen, GelderlandAges 18–50 - NCT05853952Recruiting
Non-invasive brain stimulation to aid stroke rehab
This trial tests whether a non-invasive brain stimulation device used alongside stroke rehabilitation can improve recovery after stroke. It may help people regain function during a phase when stroke effects have stabilized but recovery is still possible.
Las Palmas de Gran Canaria, Las PalmasAges 18 years+ - NCT05854160Recruiting
Brain stimulation study during epilepsy surgery evaluation
This trial studies how stimulating the brain changes communication between parts of the brain involved in emotion and memory. You may be able to join if you are already having epilepsy surgery and doctors will place specific brain electrodes as part of your evaluation.
Birmingham, AlabamaAges 18 years+ - NCT05854524Recruiting
Exercise program to protect the brain in Parkinson’s disease
This trial studies whether doing regular moderate aerobic exercise can help protect the brain in people with Parkinson’s disease. It also includes people without Parkinson’s to compare exercise effects, using fitness and safety screening to keep everyone safe.
Las Vegas, NevadaAges 30–85 - NCT05854927Recruiting
MRI test for suspected giant cell arteritis
This study checks whether different MRI scanning details can better help doctors diagnose giant cell arteritis. If you’re being sent for an injected MRI because GCA is suspected, your scan results may help improve how future diagnoses are made.
ParisAges 18 years+ - NCT05855252Recruiting
Study on monitoring and outcomes after moderate to severe head injury
This observational study follows adults with moderate to severe traumatic brain injury to understand care and outcomes. It collects information from the first 48 hours in the ICU and may help improve how clinicians monitor and treat patients in the critical early period.
Kogarah, New South WalesAges 18 years+ - NCT05855421Recruiting
Ear acupuncture sessions for moderate depression during COVID
This trial tests whether auricular (ear) acupuncture can safely improve symptoms of moderate depression during the COVID period. You may be able to join if you’re an adult with moderate depression and can attend the study sessions.
Palhoça, Santa CatarinaAges 18–50 - NCT05855369RecruitingPhase 2/Phase 3
Smell training plus brain stimulation for long COVID smell loss
This study tests whether a combination of smell training and a type of nerve stimulation can improve persistent smell problems after COVID. It is meant for people who had normal smell before COVID and still struggle with smell changes months later.
Charleston, South CarolinaAges 18–65 - NCT05855603Recruiting
Pacemaker versus nerve ablation for fainting due to slow heart rate
This trial studies treatments for a type of fainting caused by the body’s reflex slowing the heart. It compares a permanent pacemaker with a procedure called cardiac nerve ablation to see which helps prevent fainting and improves quality of life.
Sant Joan d'Alacant, AlicanteAges 40 years+ - NCT05858060Recruiting
Osmotic treatment for severe bleeding around the brain
This trial looks at an “osmotic therapy” (a treatment meant to pull fluid away from swelling areas) for adults with severe bleeding around the brain caused by a burst aneurysm. It may help reduce dangerous swelling or complications, but your eligibility depends on your stability and lab results.
Beijing, Beijing MunicipalityAges 18–85 - NCT05858996RecruitingPhase 2
Testing a pain care guideline for older adults with dementia
This trial tests a clinical guideline to improve how pain is identified and managed. It may help if you or your loved one has dementia and ongoing pain, with a focus on better pain care in nursing homes.
Baltimore, MarylandAges 60 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.