Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,407 recruiting studies in this area right now.
By phase
- Not applicable9,742
- Phase 2782
- Phase 1577
- Phase 3534
- Phase 4342
- Phase 1/Phase 2307
- Phase 2/Phase 3123
Top conditions
- Stroke843
- Parkinson Disease429
- Alzheimer Disease342
- Multiple Sclerosis342
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea156
- Spinal Cord Injuries153
- Insomnia152
- Sarcopenia150
- Traumatic Brain Injury150
- Acute Ischemic Stroke138
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Migraine114
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California680
- Massachusetts299
- New York292
- Florida274
- Texas267
- Maryland246
- Arizona213
- Alabama209
- Illinois189
- Pennsylvania177
Recruiting studies12,405 total
- NCT06880991Recruiting
Study on visible tumors in neurofibromatosis type 1
This study talks with people who have NF1 (and caregivers of children with NF1) about how visible tumors affect them. The goal is to create questionnaires that measure these concerns, which could lead to better support and treatments.
Bethesda, MarylandAges 5–120 - NCT06404242Recruiting
Plaque features predict repeat stroke after middle cerebral artery blockage
This study looks at people who recently had a stroke caused by hardening of the arteries in the middle cerebral artery, a major blood vessel in the brain. The researchers use special MRI scans to see if the plaque (the fatty buildup) can predict whether another stroke might happen.
Ho Chi Minh City, Ho Chi Minh CityAges 45–100 - NCT03600779Recruiting
Advanced MRI scan for multiple sclerosis
This study uses a special MRI scan to look at brain damage caused by multiple sclerosis (MS). It may help doctors better understand the disease and could lead to better treatments.
Marseille, PACAAges 18–45 - NCT07749586RecruitingPhase 1/Phase 2
Study of ARV-6723 alone or with pembrolizumab for advanced solid tumors
This trial tests an experimental drug called ARV-6723, alone or with another drug called pembrolizumab, for people with advanced solid tumors that have not responded to other treatments. The goal is to see if these combinations can help shrink tumors or slow their growth.
Huntersville, North CarolinaAges 18 years+ - NCT07750626Recruiting
Vibration and ShotBlocker for injection pain in children
This study tests two methods to reduce pain and fear during a shot in the emergency department. It compares using a vibration device or a ShotBlocker device against standard care.
BurdurAges 5–10 - NCT07749170Recruiting
Stroke treatment for blockages in smaller brain arteries
This study looks at how well a special catheter system works to remove blood clots from smaller arteries in the brain after a stroke. It aims to see if this treatment helps people recover better.
Knoxville, TennesseeAges 18 years+ - NCT07750496RecruitingPhase 4
Stopping seizure medications in adults with epilepsy
This study looks at what happens when people with epilepsy stop their seizure medications. The goal is to see if it's safe to stop after being seizure-free for a while, and to help patients and doctors make better decisions.
Ann Arbor, MichiganAges 18 years+ - NCT07555171Enrolling by invitation
Brain Wave Changes During Fenfluramine Treatment in Lennox-Gastaut Syndrome
This study tracks how brain wave patterns change when children and young adults with Lennox-Gastaut Syndrome (a severe seizure disorder) take fenfluramine, a medication that helps reduce drop seizures. Researchers will use EEG (brain wave recordings) to understand how this treatment affects the brain.
Chicago, IllinoisAges 2–35 - NCT06752356RecruitingPhase 3
A study of a new IVIG treatment for CIDP
This study tests a new intravenous immunoglobulin (IVIG) treatment called KIg10 (QIVIGY) for people with chronic inflammatory demyelinating polyneuropathy (CIDP). It aims to see if this treatment can help manage symptoms and maintain stability.
Tampa, FloridaAges 18 years+ - NCT07248228RecruitingPhase 2
Memory-sparing vs standard whole brain radiation for brain metastases
This trial compares two types of whole brain radiation for people with many brain tumors. One method tries to protect parts of the brain important for memory, while the other does not. It aims to see which approach helps maintain thinking and memory better.
Cleveland, OhioAges 18 years+ - NCT05879211Enrolling by invitation
Care learning lab for Duke Health patients
This trial is a “learning laboratory” that studies how best to provide goal-focused care. It may help improve care experiences for Duke Health patients, based on what the study learns.
Durham, North CarolinaAges 18 years+ - NCT07369011RecruitingPhase 3
Study of eloralintide for sleep apnea with obesity
This study tests an investigational medication called eloralintide to see if it can improve sleep apnea in people who are overweight or have obesity. You will receive either the study drug or a placebo (inactive shot), and your sleep and weight will be monitored over time.
Cullman, AlabamaAges 18 years+ - NCT07293494Recruiting
Spaceflight stress and brain changes study
This study looks at how the stress of spaceflight affects the brain and behavior. You will complete tasks and have MRI scans while staying in a controlled environment, including some sleep disruption and alcohol consumption.
Philadelphia, PennsylvaniaAges 21–60 - NCT07005180RecruitingPhase 2
Carbon monoxide gas for Parkinson's disease
This trial tests if a low dose of carbon monoxide (HBI-002) is safe and helpful for people with Parkinson's disease. It requires specific health criteria and stable Parkinson's medication.
Fountain Valley, CaliforniaAges 40–80 - NCT05812755RecruitingPhase 4
Study drug effects on blood vessels and organs in heart surgery
This Phase 4 trial studies vericiguat-like stimulation (a type of medicine that affects blood-vessel signaling) around the time of planned open-heart surgery. It aims to see whether this can change blood-vessel “reactivity” and reduce injury to organs during and after surgery.
Nashville, TennesseeAges 18 years+ - NCT06147843Recruiting
Study on weight loss in ALS patients from France and Germany
This study looks at why some people with ALS lose weight and what factors are involved. It follows patients in France and Germany to better understand weight changes and help improve care.
LilleAges 18 years+ - NCT07216716Recruiting
Health app recommendation tool for Alzheimer's caregivers
This study tests a tool that helps find health apps for people caring for a loved one with Alzheimer's or a related dementia. It aims to see if the tool makes it easier to choose useful apps for your caregiving journey.
Pittsburgh, PennsylvaniaAges 18–65 - NCT07606742Recruiting
Exercise Training for Hispanics With Multiple Sclerosis
This study tests a culturally tailored exercise program designed specifically for Hispanic people with multiple sclerosis (MS) who have walking difficulties. The goal is to help improve walking ability and overall quality of life through a personalized exercise plan.
Houston, TexasAges 18 years+ - NCT07643493Enrolling by invitationPhase 4
Saline vs. clot-busting drug for brain bleeding drainage
This study compares two methods to clear blood from the fluid chambers in your brain after a bleed. Researchers want to see if a clot-dissolving medication (TPA) works better than standard salt solution when delivered through a drainage tube.
Lexington, KentuckyAges 18–99 - NCT07483528Enrolling by invitation
Ways to help people with chronic brain injury manage health
This study compares different ways to help people with long-term traumatic brain injury (TBI) manage their health care. If you have had a TBI for at least a year and see a brain injury doctor, you may be able to join—especially if you also have other health conditions or use multiple medications.
Indianapolis, IndianaAges 18 years+ - NCT05086497Recruiting
Personal TTFields device guided by imaging for brain tumor
This trial tests whether using a personalized TTFields device—placed based on imaging—can help treat adults with glioblastoma (GBM) after surgery and radiation. It’s designed for specific GBM genetic types and may help deliver therapy more precisely.
Philadelphia, PennsylvaniaAges 22 years+ - NCT07700225Recruiting
Long-term study of myotonic dystrophy type 1
This study is a long-term follow-up for people with myotonic dystrophy type 1. It aims to find better ways to measure how the disease progresses, which could help develop future treatments.
Richmond, VirginiaAges 18–70 - NCT07640191Recruiting
New Nerve Stimulation Device for Hard-to-Treat Epilepsy
This study tests a new implanted device that stimulates the vagus nerve (a major nerve in your neck) to help reduce seizures in people whose epilepsy doesn't respond well to medications. The device is surgically placed under the skin and may help lower how often you have seizures.
South Brisbane, QueenslandAges 4–75 - NCT04298723Recruiting
Left atrial appendage closure vs blood thinners after brain bleed
This trial compares a procedure that blocks a heart blood-choke point (the left atrial appendage) versus taking blood thinners by mouth. It is for people with atrial fibrillation who have had a brain bleed and may be safer avoiding long-term blood thinners.
Mannheim, Baden-WurttembergAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,407 recruiting neurology studies from the U.S. registry right now, out of 19,276 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.