Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,407 recruiting studies in this area right now.
By phase
- Not applicable9,740
- Phase 2781
- Phase 1578
- Phase 3536
- Phase 4343
- Phase 1/Phase 2306
- Phase 2/Phase 3123
Top conditions
- Stroke841
- Parkinson Disease429
- Multiple Sclerosis345
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke201
- Epilepsy197
- Obstructive Sleep Apnea156
- Spinal Cord Injuries154
- Insomnia152
- Traumatic Brain Injury150
- Sarcopenia149
- Acute Ischemic Stroke137
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Migraine114
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California681
- Massachusetts299
- New York292
- Florida273
- Texas268
- Maryland246
- Arizona214
- Alabama210
- Illinois189
- Pennsylvania175
Recruiting studies12,405 total
- NCT07130136Recruiting
Switching from Baha Connect to Osia for bone conduction implant users
This study is for people who already have a Baha Connect bone conduction hearing implant but are having problems with it, like skin irritation. It tests switching to a newer device called Osia, which may work better for them.
LondonAges 18 years+ - NCT07675135RecruitingPhase 3
Testing a new narcolepsy drug for excessive daytime sleepiness
This study tests a new medicine, HBS-301, for people with narcolepsy type 1 or type 2 who still have excessive daytime sleepiness. If you take other medications for sleepiness or mood, they must be stable for at least 3 months, and you cannot take some as-needed sleepiness medicines.
Birmingham, AlabamaAges 18 years+ - NCT07785492Recruiting
AI-assisted care for acute ischemic stroke
This trial tests whether an artificial intelligence system can help doctors make better treatment decisions for people who have had an acute ischemic stroke within the last 24 hours. The goal is to see if this AI support improves outcomes compared to standard care.
Changsha, HunanAges 18 years+ - NCT07447284Recruiting
Improving sleep for African American couples with OSA
This study tests whether a couple-based approach helps African American patients with moderate to severe sleep apnea stick with CPAP therapy better. It is designed for patients and their bed partners who want to improve sleep health together.
Cleveland, OhioAges 30 years+ - NCT06881277Recruiting
Smartphone app for healthy eating and activity after pregnancy
This trial tests a smartphone app called PRIMI to help new mothers who have moved to Sweden eat well and stay active. If you are a first-generation migrant woman who gave birth within the last 6 months, you may be able to join.
Linköping, Östergötland CountyAges 18 years+ - NCT07431320Recruiting
Green-light test for concussion in football players
This trial tests a new way to check for concussions in football players. If you are a professional or youth football player in France, you may help standardize a quick sideline test to see if you are okay after a head hit.
PloemeurAges 16 years+ - NCT06782230Recruiting
A biobank for rare disease samples and data
This study creates a collection of biological samples and health information from people with rare diseases and their family members. It aims to build a shared resource that can help future research on rare conditions.
San Donato Milanese, MilanAges Any age - NCT06916507Recruiting
Early Use of a Parkinson's Pump in Advanced Stages
This study tests a new pump-delivered combination of Parkinson's medications (foslevodopa/foscarbidopa) in adults who have recently started having motor fluctuations but are not yet using other device therapies. It aims to see how well it works in real life and may offer better symptom control.
Allensbach, Baden-WurttembergAges 18–64 - NCT05471960Recruiting
Brain training study in people with REM sleep behavior disorder
This study looks at how the brain changes (“neuroplasticity”) in people diagnosed with isolated REM sleep behavior disorder (iRBD) using brain stimulation and other testing. Results may help researchers understand brain differences in iRBD and guide future treatments.
Minneapolis, MinnesotaAges 21–75 - NCT05898074Recruiting
Testing a new gel during endoscopic skull base surgery
This trial looks at a new RADA16 hydrogel to see if it can help during an endoscopic surgery through the nose for a skull base tumor or a cerebrospinal fluid (CSF) leak. You might be a candidate if you are already planned for this specific type of nasal surgery and meet key safety requirements.
Indianapolis, IndianaAges 18 years+ - NCT06570824Recruiting
Can repetitive TMS help with levodopa-induced dyskinesia?
This study tests whether a non-invasive brain stimulation technique called repetitive TMS can reduce the involuntary movements (dyskinesia) that some people with Parkinson's disease experience as a side effect of their levodopa medication. If you have Parkinson's and bothersome dyskinesia when your medication is working, this trial may be an option.
HvidovreAges 18–80 - NCT04675749Recruiting
Quality of life study in adult women with X-ALD
This study looks at quality of life in adult women who have X-linked adrenoleukodystrophy (X-ALD). It may help researchers understand how this condition affects daily life and well-being.
Leipzig, SaxonyAges 18 years+ - NCT01855633Recruiting
Brain stimulation therapy for arm or leg weakness after stroke
This trial studies whether repeated magnetic pulses to the brain can improve movement in people with weakness after a stroke. It may help if your stroke happened more than 2 weeks ago and you can safely receive the magnetic treatment.
Hwaseong-si, Gyeonggi-doAges 18 years+ - NCT07456722Recruiting
Heart health in spinal cord injury with autonomic dysreflexia
This study looks at how the heart is built and works in people with long-term spinal cord injury, especially those who have autonomic dysreflexia. It might help doctors understand heart risks and improve care.
NottwilAges 18 years+ - NCT07287982RecruitingPhase 2
ARGX-119 for children with SMA who can walk
This study tests a new medicine called ARGX-119 in children with SMA. It is given through an IV and aims to help kids who can already walk get stronger and stay healthy.
Little Rock, ArkansasAges 5–17 - NCT06193252Recruiting
Exercising to slow Parkinson's in iRBD
This study tests whether a specific amount of exercise can slow the development of Parkinson's disease in people who have a sleep condition called iRBD. If you have iRBD and are not very active, researchers will help you start a personalized exercise program and track your progress with a smartphone app.
Nijmegen, GelderlandAges 50 years+ - NCT06192342Recruiting
Breathing machine settings for brain injury patients
This study looks at how different breathing machine settings affect people with new brain or spinal cord injuries who need help breathing. It only includes people with healthy lungs to see which ventilator settings work best.
Ciudad Autonoma de Buenos Aires, Buenos AiresAges 16 years+ - NCT07627971RecruitingPhase 1/Phase 2
Gene therapy for GJB2-related hearing loss in young children
This study tests an experimental gene therapy (SKY-GJB2) designed to treat hearing loss caused by mutations in the GJB2 gene. The therapy is given directly to children ages 9 months to 7 years who have significant bilateral hearing loss, and researchers will monitor safety and whether hearing improves.
Bethesda, MarylandAges 9 months–7 years - NCT05077904RecruitingPhase 3
Staccato alprazolam study for prolonged seizures in teens and adults
This Phase 3 trial tests whether staccato alprazolam can reduce and manage “prolonged seizures” that happen repeatedly in people with epilepsy. It also checks safety—especially breathing and heart-related side effects—while participants continue their usual seizure medicines.
Phoenix, ArizonaAges 12 years+ - NCT06887192RecruitingPhase 2
Testing ML-007C-MA for Alzheimer's Psychosis
This trial tests a study drug called ML-007C-MA to see if it can safely reduce hallucinations and delusions in people with Alzheimer's disease who also have psychosis. If you or your loved one has Alzheimer's and has been experiencing false beliefs or seeing/hearing things that aren't there for at least two months, this study may be an option.
Phoenix, ArizonaAges 55–90 - NCT02852213RecruitingPhase 1
Dose-check study for children with AADC deficiency using brain surgery
This Phase 1 trial tests how safe different treatment doses are for children with AADC deficiency, using MRI-guided brain surgery. It may help improve movement and developmental progress after standard medicines did not work well enough.
San Francisco, CaliforniaAges 2 years+ - NCT06696001Recruiting
Brain Study of Talk Therapy for Depression
This study looks at how your brain works during talk therapy for depression. It aims to find out how therapy helps you feel better so that future treatments can be more personalized.
Chapel Hill, North CarolinaAges 18–30 - NCT07395609Recruiting
Brain stimulation to boost memory, movement, and mood in older adults
This study tests whether high-frequency electrical stimulation of the brain can help improve thinking, movement, and mood in older adults who may or may not have early signs of memory decline. Participants will get sessions of stimulation and complete thinking and walking tasks.
Gainesville, FloridaAges 65–89 - NCT07787793Recruiting
Effects of non-invasive brain stimulation on hand movement after stroke
This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help improve hand movement in people who have had a stroke and have severe arm weakness. It uses a special device to stimulate the brain and may help with motor recovery.
Palma, Balearic IslandsAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,407 recruiting neurology studies from the U.S. registry right now, out of 19,231 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.