Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT06422793Recruiting
Does a stomach tube reduce nausea after jaw surgery?
This study tests whether using a thin tube through the nose into the stomach during jaw surgery helps reduce nausea and vomiting after the operation. It's for people having certain types of jaw surgery to correct bite or facial problems.
Halifax, Nova ScotiaAges 16 years+ - NCT06751628Recruiting
Reinjecting digestive fluids after small bowel surgery
This study tests a method called chyme reinfusion, where digestive fluids that are lost through a stoma or fistula are collected and put back into the intestine. It aims to help people with high fluid loss from the gut maintain better hydration and nutrition.
Nantes, NantesAges 18 years+ - NCT07134790RecruitingPhase 2
Probiotics to improve gut health during pregnancy
This trial tests whether taking probiotics during pregnancy can improve gut health in mothers living in areas where gut infections are common. It is for women who are in their first or early second trimester and who have certain bacteria in their stool.
Bobo-DioulassoAges 18 years+ - NCT07067697Recruiting
Exercise and nutrition for older adults in the hospital
This study tests whether a supervised exercise program, combined with oral nutritional supplements, helps hospitalized older adults who are malnourished or at risk. It aims to improve strength and recovery during their hospital stay.
Pamplona, NavarreAges 75 years+ - NCT07065461Recruiting
Chocolate and almonds: Chewing, fullness, and blood sugar
This study looks at how chewing whole almonds and chocolate affects how full you feel and your body's response after eating. You'll eat different chocolate-almond snacks and give a finger prick blood sample.
Guelph, OntarioAges 18–45 - NCT06614114Recruiting
Albumin-Bilirubin Score to Predict Variceal Bleeding Outcome
This study looks at a simple blood test score called the Albumin-Bilirubin (ALBI) index to see how well it predicts recovery in people with bleeding from enlarged veins in the esophagus (varices). It may help doctors better understand your risk and guide treatment.
AsyutAges 18–80 - NCT06613113Recruiting
Fruquintinib, adebrelimab, and radiation for advanced colorectal cancer
This trial tests a combination of two drugs (fruquintinib and adebrelimab) plus low or high dose radiation for people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if this combination can shrink tumors or slow the disease.
Ningbo, ZhejiangAges 18 years+ - NCT07127393Recruiting
Seaweed in a meal: effects on comfort, fullness, and eating
This study tests how adding a type of seaweed (Irish moss) to a meal affects how you feel, how full you are, and how much you eat. It looks for healthy young men to join.
Halifax, Nova ScotiaAges 19–35 - NCT07127822RecruitingPhase 2
Testing a new immunotherapy combo for MSI-H gastric cancer
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) for people with advanced gastric cancer that has a specific DNA repair problem (MSI-H/dMMR). It is for those who have not yet had any treatment for their advanced cancer.
Shijiazhuang, HebeiAges 18 years+ - NCT06958952Recruiting
Digestive aid for new stomach upset
This study tests whether a natural digestive supplement can help people with new-onset dyspepsia (stomach upset). It's for people who haven't taken other medications and don't have other stomach problems.
TehranAges 18–75 - NCT06998758RecruitingPhase 3
Megestrol Acetate for weight loss during chemo in advanced colorectal cancer
This trial tests if taking megestrol acetate (a medicine used to stimulate appetite and help gain weight) can reduce weight loss caused by chemotherapy in people with locally advanced colorectal cancer. It may help you maintain strength and energy during treatment.
Guangzhou, GuangdongAges 18–75 - NCT06736301Recruiting
Stent fixation for benign duodenal strictures
This trial tests a method to keep a metal stent in place using a plastic stent for people with non-cancerous narrowing in the first part of the small intestine. It may help if you have symptoms like nausea or vomiting and other treatments have not worked.
Nanjing, JiangsuAges Up to 75 years - NCT07495111Recruiting
Using a Pancreatic Stent to Prevent Pancreatitis During Stone Removal
This study tests whether placing a small tube (prosthesis) in the pancreas before removing gallbladder and bile duct stones during ERCP can prevent pancreatitis. It is for people with small gallbladder stones and bile duct stones who are at higher risk for pancreatitis after the procedure.
Jinan, ShandongAges 18 years+ - NCT07708220Recruiting
Laparoscopic treatment for acid reflux in children
This trial tests a minimally invasive surgery to treat gastroesophageal reflux disease (GERD) in children. It aims to reduce symptoms and improve quality of life for kids who have not had prior reflux surgery.
TantaAges 2–18 - NCT06761209Recruiting
Autoantibody negativity and autoimmune hepatitis severity
This trial checks if the absence of certain antibodies in autoimmune hepatitis (AIH) is linked to more severe disease. It may help doctors better understand and treat AIH.
Paris, FranceAges 18 years+ - NCT06673199Recruiting
Japanese diet and gut health in postmenopausal women
This study tests whether a traditional Japanese diet called 'washoku' can change the gut bacteria in postmenopausal women who are overweight. It may help improve health after menopause.
Poznan, WielkopolskaAges 45–65 - NCT07020247RecruitingPhase 3
Personalized radiation plus chemo with or without immunotherapy for rectal cancer
This trial tests adding immunotherapy to standard radiation and chemotherapy for patients with locally advanced rectal cancer. The goal is to see if a personalized approach improves outcomes while sparing more normal tissue.
Chengdu, SichuanAges 18 years+ - NCT07529236Recruiting
How Children's Bowel Disease Responds After Switching IBD Medications
This study follows children who had to stop one type of IBD medicine (anti-TNFα) because it caused a skin condition called psoriasis, and were switched to a different medicine called ustekinumab. Researchers want to see how well their bowel disease is controlled with the new treatment.
Nice, FranceAges 6–17 - NCT05822895Recruiting
Testing a real-time computer to help find colon polyps
This study checks whether a computer tool helps doctors find colon polyps during routine colonoscopy. If the tool improves detection, it could help find growths earlier and guide safer follow-up.
Singapore, SingaporeAges 21–90 - NCT06764680RecruitingPhase 2
Oral drugs and radiation for advanced colorectal cancer after standard therapy
This trial tests a combination of oral chemotherapy, targeted therapy, and immunotherapy, with or without radiation, for people with advanced colorectal cancer that hasn't responded to at least two prior treatments. The goal is to see if this approach can help shrink tumors or slow the disease.
Guangzhou, GuangdongAges 18 years+ - NCT06669663Recruiting
Hypoxia and metabolism in esophageal and stomach cancer
This trial looks at how low oxygen levels (hypoxia) affect the metabolism of esophageal and stomach cancers. It may help doctors understand why some cancers grow or resist treatment, possibly leading to better therapies.
LondonAges 18–90 - NCT06764966RecruitingPhase 2
Statin and beta blocker study for liver disease
This trial tests if adding a statin to beta blocker treatment helps people with advanced liver disease (cirrhosis) who have had complications like fluid buildup, confusion, or bleeding. It is for patients who are already taking a non-selective beta blocker and will be followed for 12 months.
Charleston, West VirginiaAges 18 years+ - NCT07467928Recruiting
AI colonoscopy's long-term effect on advanced polyps
This study looks at how well AI-assisted colonoscopy prevents new advanced polyps from forming over the long term. It's for people who were in our earlier AI colonoscopy study and are healthy enough for a follow-up scope.
Hong KongAges 18 years+ - NCT07263620Recruiting
Gut bacteria and cancer treatment before surgery
This study looks at the bacteria in your gut to see if they can predict how well chemotherapy or radiation works before surgery for certain cancers. If you have pancreatic, stomach, colon, or esophageal cancer that has spread nearby (but not to distant organs), you may be able to join.
TianjinAges Any age
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.