Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT07741435Recruiting
Simple blood, urine, and saliva test to find cancer early
This study tests a new way to find cancer by looking at DNA in blood, urine, and saliva. It may help detect cancer earlier and monitor how well treatment works.
Bogotá, Bogota D.C.Ages 18 years+ - NCT07744672Recruiting
Comparing two surgeries for high anal fistula
This trial compares two surgical techniques to treat a complex type of anal fistula (an abnormal tunnel between the anal canal and skin). It aims to find which approach offers better healing and fewer risks.
CairoAges 16 years+ - NCT04972799Recruiting
Fat injection for severe bowel leakage using a placebo comparison
This study tests whether injecting your own body fat around the anal muscle area can reduce severe fecal (bowel) leakage compared with a placebo (fake) treatment. It’s designed to be safe and more effective than doing nothing, with participants getting both treatments in a cross-over design.
AngersAges 18 years+ - NCT06613113Recruiting
Fruquintinib, adebrelimab, and radiation for advanced colorectal cancer
This trial tests a combination of two drugs (fruquintinib and adebrelimab) plus low or high dose radiation for people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if this combination can shrink tumors or slow the disease.
Ningbo, ZhejiangAges 18 years+ - NCT06613945Recruiting
Comparing two ways to open blocked bile ducts in liver cancer
This study compares two procedures to drain bile from the liver in people with blocked bile ducts caused by cancer that cannot be removed. It looks at whether using an ultrasound-guided approach along with standard ERCP works better than ERCP alone.
Al Mansurah, Dakahlia GovernorateAges 18 years+ - NCT06613581Recruiting
Home-based follow-up after colorectal cancer surgery
This trial tests whether patients can do their follow-up from home after surgery for colorectal cancer. It uses a smartphone app instead of hospital visits, aiming to make surveillance easier and less stressful.
Breda, North BrabantAges 21 years+ - NCT04010526RecruitingPhase 2
Local treatment for Crohn’s fistulas using your own fat cells
This Phase 2 trial studies whether a local injection of fat-derived cells (made from your own tissue) can improve difficult Crohn’s disease fistulas around the anus. It’s designed for people whose Crohn’s fistulas have not responded to usual treatments.
Marseille, PACAAges 18 years+ - NCT05994521Recruiting
Preventing stomach blockage in advanced periampullary cancer
This study tests a new procedure (EUS-guided gastroenterostomy) to prevent stomach blockage in people with advanced cancers near the pancreas. It may help you avoid future vomiting and eating problems by placing a small tube between your stomach and intestine using a thin, flexible scope.
MontrealAges 18–85 - NCT04926103Recruiting
Fecal transplant program for active ulcerative colitis donors
This trial screens people as potential donors for a fecal microbiota transplant program used for ulcerative colitis. It checks safety and eligibility so the transplant process is as safe as possible for people with active disease.
Hamilton, OntarioAges 18 years+ - NCT06616714Recruiting
Weight loss procedure for people with obesity and IBD
This study tests a weight-loss procedure called endoscopic sleeve gastroplasty (a stomach-reducing procedure done through a scope) in people with both obesity and inflammatory bowel disease (IBD). It aims to see if the procedure is safe and helpful for this group.
RomaAges 18–70 - NCT05477212Recruiting
Study gut leakiness in obesity and fatty liver with a ketogenic diet
This study looks at “gut permeability,” sometimes called intestinal leakiness, in people with obesity and fatty liver disease. It tests whether a ketogenic (very low-carb) diet changes gut leakiness and fatty liver measurements.
Castellana Grotte, BARIAges 18–65 - NCT02328131Recruiting
Registry study for adults with H. pylori infection
This study is a registry that follows adults who have Helicobacter pylori (a common stomach bacteria) to learn how it’s managed in real life. It may help improve care by tracking treatments and outcomes over time.
ViennaAges 18 years+ - NCT07740122Recruiting
Stool photo analysis for colorectal cancer screening
This study tests whether photos of your stool can help predict your risk of colorectal cancer or precancerous growths. It uses a smartphone app to analyze stool images alongside your routine stool test (FIT) results.
Santiago, Santiago MetropolitanAges 18 years+ - NCT05495152RecruitingPhase 3
Sintilimab after esophageal surgery to help prevent cancer return
This trial looks at adding sintilimab (an immunotherapy) after surgery for certain stages of esophageal squamous cell cancer. The goal is to lower the chance the cancer comes back after standard treatment.
Zhengzhou, HenanAges 18–70 - NCT04699201Recruiting
Preventing abdominal hernias after gallbladder surgery
This trial tests a method (using a special mesh) to help prevent an abdominal wall hernia after planned laparoscopic gallbladder surgery. If you’re at risk of developing a hernia where the surgery cuts are made, this study may help reduce that risk.
Tarragona, TarragonaAges 18–99 - NCT07739121Recruiting
Testing AI vs. tumor boards for cancer treatment advice
This trial compares treatment recommendations from large language models (AI) against those from experienced tumor boards for five common cancer types. The goal is to see if AI can help doctors make better decisions.
Boulogne-BillancourtAges 18 years+ - NCT07733830RecruitingPhase 2
Testing immunotherapy before or after chemoradiation for advanced esophageal cancer
This trial compares two treatment sequences for people with locally advanced esophageal cancer that cannot be removed with surgery. One group gets immunotherapy first, then chemoradiation; the other gets chemoradiation first, then immunotherapy. The goal is to find which order works better.
Beijing, Beijing MunicipalityAges 18–75 - NCT07733115RecruitingPhase 2
Drug combo for advanced bile duct cancer
This trial tests a new immunotherapy drug combined with standard chemotherapy as a first treatment for advanced bile duct or gallbladder cancer. It may help your immune system fight the cancer while chemotherapy attacks the tumor directly.
ShanghaiAges 18–75 - NCT07737340Recruiting
Metabolic liver disease in new HIV patients
This study looks at liver health in people newly diagnosed with HIV, before they start HIV treatment. It aims to understand early changes in the liver related to metabolism.
Ankara, AnkaraAges 18 years+ - NCT07736495RecruitingPhase 2/Phase 3
Alpha-lipoic acid for chemo mouth sores in colorectal cancer
This trial tests if a supplement called alpha-lipoic acid (ALA) can protect against painful mouth sores caused by chemotherapy (FOLFOX-6) in people with colorectal cancer. If you are starting FOLFOX-6 for the first time for colorectal cancer, this study may help reduce treatment side effects.
CairoAges 18 years+ - NCT07735624RecruitingPhase 2
Immunotherapy before surgery for early rectal cancer
This trial tests a combination of two immunotherapy drugs (botensilimab and balstilimab) given before surgery for early-stage rectal cancer that is MSS/pMMR. The goal is to see if this treatment can shrink the tumor and improve outcomes compared to standard care.
Boston, MassachusettsAges 18 years+ - NCT07740382Recruiting
Pain block comparison for recovery after liver surgery
This study compares two types of pain-relieving nerve blocks used during liver surgery to see which one helps you breathe better and recover more comfortably after the operation.
Alexandria, Sbein-ElkomAges 18–75 - NCT07732894Recruiting
Exercise and Guided Imagery for Bowel Symptoms After Cancer Surgery
This study tests if combining gentle aerobic exercise with guided imagery (a relaxation technique using your imagination) can help improve bowel control and reduce symptoms after rectal cancer surgery.
IstanbulAges 18–65 - NCT07734298Recruiting
Ultrasound vs. scope for swallowing problems after ICU breathing tube
This study compares two ways to check swallowing after a breathing tube is removed in the ICU: one uses an ultrasound machine, the other uses a small camera through the nose. If you qualify, you may help doctors find the best method to spot swallowing issues early.
Querétaro City, QuerétaroAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.