Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT07181876Recruiting
Study of robotic hernia repair with Dexter system
This study tests a robotic system for fixing groin hernias (inguinal hernias) using small incisions. It is for adults scheduled for hernia repair surgery who want to see how well the robot helps.
Buffalo, New YorkAges 22 years+ - NCT04699201Recruiting
Preventing abdominal hernias after gallbladder surgery
This trial tests a method (using a special mesh) to help prevent an abdominal wall hernia after planned laparoscopic gallbladder surgery. If you’re at risk of developing a hernia where the surgery cuts are made, this study may help reduce that risk.
Tarragona, TarragonaAges 18–99 - NCT07488078RecruitingPhase 1
IV fluids for recovery after gallbladder surgery
This trial compares giving more or less IV fluids during gallbladder removal surgery to see which helps patients recover faster. It may help you heal better after your operation.
Lahore, Punjab ProvinceAges 18–60 - NCT07521111Recruiting
Stomach Blood Flow and Feeding Tolerance in Critical Illness
This study examines whether measuring blood flow in the stomach using ultrasound can predict which hospitalized patients will struggle to tolerate tube feeding. Researchers hope this simple test might help doctors adjust feeding plans earlier and improve patient outcomes.
ShanghaiAges 18 years+ - NCT06692673RecruitingPhase 1/Phase 2
Linaclotide for Colonoscopy Bowel Preparation
This trial tests if a medication called linaclotide (a pill that helps with constipation) can improve the bowel-cleaning process before a colonoscopy. It may make the preparation easier and more effective.
Gainesville, FloridaAges 18–65 - NCT06470997Recruiting
Biomarkers for hepatitis from immunotherapy
This study looks for certain markers in the blood that can help diagnose liver inflammation caused by immunotherapy. It aims to better understand this side effect and how to treat it.
Montpellier, FranceAges 18 years+ - NCT06978114RecruitingPhase 2
Study of a new drug for advanced bile duct cancer
This trial tests a new drug called BL-B01D1 combined with an immunotherapy for people with advanced bile duct cancer. It aims to see if this combination can help shrink tumors or slow the disease.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07186738Recruiting
Monitoring after digestive surgery with a care coordination platform
This trial tests a new home monitoring and coordination system for patients after colorectal or weight-loss surgery. It aims to see if the platform helps manage recovery and reduce hospital visits.
Nantes, NantesAges 18 years+ - NCT06482333Recruiting
When to restart blood thinners after polyp removal
This trial looks at the best time to restart direct oral anticoagulants (blood thinners) after having polyps removed during a colonoscopy. It aims to find a balance between preventing bleeding and reducing the risk of blood clots.
Hong KongAges 40 years+ - NCT06767800RecruitingPhase 2
Study of TQB2102 with immunotherapy for HER2-positive gastroesophageal cancer
This trial tests a new combination of drugs (TQB2102, benmelstobart, and pembrolizumab) with or without chemotherapy for people with HER2-positive gastroesophageal cancer that cannot be removed by surgery or has spread. It aims to see if this combination is more effective than current treatments.
Fuyang, AnhuiAges 18–75 - NCT05640830RecruitingPhase 1/Phase 2
Trastuzumab, bevacizumab, and paclitaxel for HER2-positive stomach cancer
This trial tests a combination of anti-cancer medicines for HER2-positive advanced stomach cancer that has already been treated once. It may help shrink tumors and slow the disease by targeting HER2 and blocking tumor blood supply.
SeoulAges Any age - NCT07518238Enrolling by invitationPhase 2
Pain Relief Methods for Abdominal Wall Surgery
This study compares two different pain-relief injection techniques (BDE and Exparel) given during abdominal wall reconstruction surgery to see which works better at reducing pain and opioid use after surgery. You would receive one of these injections as part of your anesthesia care.
Dallas, TexasAges 18 years+ - NCT07665710Recruiting
Predicting diabetes risk after partial pancreas removal
This trial studies how to predict if someone will develop diabetes after having part of their pancreas removed. It may help people who are scheduled for this surgery understand their risk and get earlier care.
LjubljanaAges 18 years+ - NCT07665528Recruiting
Botox vs Botox with surgery for chronic anal fissure
This trial compares two treatments for a long-lasting anal fissure: Botox injections alone versus Botox combined with a small surgery (fissurectomy and anoplasty). It aims to see which works better and may help patients who have not healed with standard care.
Islamabad, FederalAges 18–65 - NCT06485466RecruitingPhase 3
TACE plus Camrelizumab and Apatinib for liver cancer that can't be removed by surgery
This trial tests combining a liver-directed treatment (TACE) with two medications (Camrelizumab and Apatinib) to see if it works better for people with liver cancer that cannot be surgically removed. It is for people who have not had any previous treatment for their cancer.
Chengdu, SichuanAges 18–80 - NCT07529483RecruitingPhase 2
EUS-Guided Chemoablation for Pancreatic Cysts
This trial tests a new procedure using an ultrasound camera passed through your mouth to inject medicine directly into pancreatic cysts. It may help shrink cysts in people who cannot have surgery.
Columbus, OhioAges 18 years+ - NCT06604156Recruiting
Anesthesia based on pain monitoring for painless GI endoscopy
This study tests a new way to give anesthesia during painless upper and lower GI exams by using a special monitor that tracks your body's response to pain. The goal is to make the procedure more comfortable and safer for you.
Chongqing, Chongqing MunicipalityAges 18–60 - NCT06065150Recruiting
Early surgery vs 3-day waiting for bowel blockage
This trial compares two approaches for a sudden blockage in the small intestine caused by scar tissue: having surgery right away versus waiting up to three days with non-surgical care. It aims to see which approach leads to better outcomes, so you and your doctor can make a more informed choice.
AmiensAges 18 years+ - NCT06063577Recruiting
A study to see if a special stitch can prevent hernia after belly surgery
This trial tests whether using a special type of suture (called Stratafix Symmetric) during surgery can help prevent an incisional hernia from forming after abdominal or gastrointestinal cancer surgery. If you are having certain types of major abdominal surgery, this study might be an option for you at the West Michigan Cancer Center.
Kalamazoo, MichiganAges 18 years+ - NCT07660445Recruiting
Endoscopic stomach reshaping and duodenal procedure for obese type 2 diabetes
This trial tests a procedure that reshapes the stomach and treats the upper intestine to help control blood sugar and weight in people with obesity and type 2 diabetes. It may be an option if you have a moderate to high need for metabolic surgery.
ShatinAges 18–70 - NCT06669806Recruiting
TIPS Stent Graft for Cirrhosis Complications
This study tests a TIPS stent graft (a tiny mesh tube placed in the liver to relieve pressure) for people with cirrhosis and complications like bleeding or fluid buildup. It aims to see how well it works and if it's safe.
Changsha, HunanAges 18–75 - NCT06478394Recruiting
Blood test for hidden stomach cancer spread
This study tests a new blood test that uses machine learning to find hidden stomach cancer spread (peritoneal metastases) early. It could help people with locally advanced stomach cancer avoid unnecessary surgery.
Shijiazhuang, HebeiAges 18 years+ - NCT07480057Recruiting
Bone health changes after liver transplant
This study tracks how liver transplantation affects your bone density and mineral metabolism. It aims to find changes early, which can help prevent fractures later.
New Delhi, National Capital Territory of DelhiAges 18 years+ - NCT06060769Recruiting
MRI risk assessment for liver cancer in chronic liver disease
This study uses special MRI scans to better predict liver cancer risk in people with chronic liver disease. It may help doctors identify high-risk patients earlier and improve monitoring.
Zhuhai, GuangdongAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.