Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT07636798RecruitingPhase 1/Phase 2
Chemotherapy and immunotherapy combination for advanced bile duct cancer
This trial tests a combination of three treatments—chemotherapy delivered directly to the liver, plus two immunotherapy drugs—for advanced bile duct cancer that cannot be surgically removed. The goal is to see if this combination works better than standard treatment and is safe for patients.
Chengdu, SichuanAges 18–75 - NCT07632196Recruiting
Nerve Stimulation to Improve Bowel Control After Rectal Cancer Surgery
This trial tests whether a small electrical device placed on the skin behind your ankle can help improve bowel control after surgery to remove rectal cancer. Many patients experience changes in bowel function after this surgery, and this treatment may help restore normal continence.
Manresa, BarcelonaAges 18 years+ - NCT07629609RecruitingPhase 2
New PET scan imaging for pancreatic and stomach cancers
This study tests a new type of PET scan (a detailed imaging test) called [68Ga]Ga-FAPI that may help doctors see cancer better and faster than standard scans. You'll receive this experimental scan to see if it improves cancer detection before surgery.
CopenhagenAges 18 years+ - NCT07635576Recruiting
How Stomach Stimulation Affects Insulin Levels
This study looks at how a surgically implanted device that stimulates the stomach (called a GES device) affects your body's insulin levels. Researchers will collect blood samples over several hours to understand if and how the device influences insulin production.
Indianapolis, IndianaAges 18 years+ - NCT07632118RecruitingPhase 3
Radiation and chemotherapy after pancreatic cancer surgery
This trial tests whether combining radiation therapy with chemotherapy (called the GX regimen) after pancreatic cancer surgery helps prevent cancer from returning in patients with high-risk features. The study aims to see if this combination treatment improves outcomes compared to standard care.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07631000RecruitingPhase 2
Cadonilimab with chemotherapy for stomach cancer surgery
This trial tests a new immunotherapy drug called cadonilimab combined with chemotherapy before surgery for stomach or gastroesophageal junction cancer. The goal is to shrink the tumor and improve outcomes for patients who are candidates for surgery.
Basking Ridge, New JerseyAges 18 years+ - NCT07635394Recruiting
Pregabalin for Irritable Bowel Syndrome Relief
This study tests whether pregabalin, a nerve-pain medication, can help reduce irritable bowel syndrome (IBS) symptoms like abdominal pain and irregular bowel habits. Researchers want to see if it's safe and effective for people with mild-to-moderate IBS.
Beijing, Beijing MunicipalityAges 18–70 - NCT07631663Recruiting
How Okra Flour Biscuits Affect Fullness and Appetite
This study tests whether biscuits made with okra flour help people feel fuller longer. Researchers want to understand how this food affects appetite and satiety (the feeling of fullness) in healthy young adults.
Serdang, SelangorAges 18–39 - NCT07636382Recruiting
Radiation to relieve cancer-related belly pain from celiac plexus involvement
This trial tests a focused radiation treatment called stereotactic body radiotherapy (SBRT) to target pain from cancer affecting the celiac plexus—a bundle of nerves in the upper abdomen. The goal is to relieve severe, persistent pain without surgery.
Toronto, OntarioAges 18 years+ - NCT07636824RecruitingPhase 2
Chemotherapy plus radiation after bile duct cancer surgery
This study tests whether combining chemotherapy and radiation therapy after surgery improves outcomes for patients with bile duct or gallbladder cancer. It's designed for patients whose surgery showed signs the cancer might come back.
BeijingAges 18–80 - NCT07636148Recruiting
Registry of minimally invasive cancer treatment with advanced imaging
This study collects information from patients undergoing minimally invasive procedures to treat solid tumors (cancers) using advanced CT imaging guidance. Researchers want to understand how well this imaging technique helps doctors perform these procedures safely and effectively.
Lyon, Auvergne-Rhône-AlpesAges 18 years+ - NCT07634159Recruiting
Health effects of ultra-processed food intake
This study compares the health effects of a diet high in ultra-processed foods (like packaged snacks and sugary drinks) with a diet of less processed foods, to see how they affect your body. If you qualify, you'll eat these diets for a period of time, and researchers will monitor your health.
GothenburgAges 20–60 - NCT07636304Enrolling by invitationEarly Phase 1
Brain stimulation for inflammatory bowel disease remission
This study tests whether a non-invasive device that stimulates the vagus nerve (a major nerve in your neck) can affect brain function in people whose IBD is in remission. Researchers want to understand if this stimulation might help reduce inflammation or improve symptoms in the future.
Gdansk, Pomeranian VoivodeshipAges 18 years+ - NCT07629986Recruiting
How antibiotics work in cystic fibrosis patients on ETI therapy
This study measures how antibiotics are processed by the body in people with cystic fibrosis who are taking a combination drug called elexacaftor/tezacaftor/ivacaftor (ETI). Understanding this helps doctors prescribe the right antibiotic doses for patients on this newer treatment.
RoscoffAges 12 years+ - NCT07631442Enrolling by invitation
Digital Health Monitoring for Primary Biliary Cholangitis
This study uses a smartphone app or digital platform to track how you're feeling day-to-day if you have primary biliary cholangitis (PBC), a liver condition where your immune system damages bile ducts. Researchers want to see if this digital monitoring helps them better understand and manage PBC symptoms.
Redwood City, CaliforniaAges 18 years+ - NCT07634562RecruitingPhase 1/Phase 2
Reducing immune-suppressing drugs after liver transplant
This study tests a new way to lower the amount of immune-suppressing medicine needed after a liver transplant. It uses special treatments before or during the transplant to help your body accept the new liver with fewer drugs, which may reduce side effects.
Stanford, CaliforniaAges 18–55 - NCT06695455Recruiting
Can music help people with Parkinson's swallow better?
This trial tests if a rhythmic sound cue can reduce rolling (a swallowing problem) in people with Parkinson's. If you have trouble with solid foods but not severe liquid aspiration, you may qualify.
Saint-Sébastien-de-Morsent, NormandyAges 18 years+ - NCT06694636Recruiting
RF Ablation of Nerve for Advanced Liver Cancer
This trial tests whether using radiofrequency ablation (using heat energy) to target specific nerves can help treat advanced liver cancer (HCC) that has spread or grown despite standard treatments.
Nanjing, JiangsuAges 25–75 - NCT06694883Recruiting
Ulcerative colitis remission-recurrence study
This trial studies people with ulcerative colitis who are in a 'remission-recurrence' state, meaning their symptoms come and go. It aims to better understand this pattern and may help guide future treatments.
Dongcheng, Beijing MunicipalityAges Any age - NCT03480971RecruitingPhase 2
Tempol to reduce mouth and other side effects from radiation and cisplatin
This Phase 2 trial tests tempol to lessen harmful side effects caused by head-and-neck radiation and the chemotherapy drug cisplatin. If you qualify, you may receive tempol during treatment to help protect normal tissues and reduce toxicity.
La Jolla, CaliforniaAges 18 years+ - NCT06126419Recruiting
High-dose insulin for liver function after surgery
This trial tests if high-dose insulin can help your liver work better and heal faster after a major liver surgery for colorectal cancer that has spread to the liver.
Montreal, QuebecAges 18 years+ - NCT06631443Recruiting
Asian Watch-and-Wait Study for Rectal Cancer
This study is for people with rectal cancer who have had treatment like radiation or chemo and their tumor has disappeared or nearly disappeared. Instead of surgery right away, doctors will closely monitor the cancer with regular check-ups to make sure it stays gone.
Mumbai, MaharashtraAges 18 years+ - NCT06610799RecruitingPhase 1
Study of IBI363 for first-line advanced gastric cancer
This trial tests a new drug called IBI363 in patients with advanced gastric or gastroesophageal junction cancer who have not yet received any treatment. The goal is to see if the drug can help shrink tumors or slow the cancer's growth.
Hangzhou, ZhejiangAges 18–75 - NCT07624383Recruiting
New topical treatment for nonerosive acid reflux disease
This study tests a new topical treatment for people with chronic heartburn and acid regurgitation who don't have erosions (damage) in their esophagus. The treatment is applied directly to the affected area and may help relieve symptoms without taking daily pills.
Warsaw, Masovian VoivodeshipAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.