Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06876532Recruiting
Inflammation score and Lu-177 treatment for midgut NET
This study looks at whether a simple blood test (inflammation score) can predict how well the drug Lu-177 oxodotreotide (Lutathera) will work for people with midgut neuroendocrine tumors that have grown or spread. It may help doctors understand who benefits most from this treatment.
AngersAges 18 years+ - NCT06878378Recruiting
Why some people have poor colonoscopy prep
This study looks at what factors might make it harder to clean out your bowel before a colonoscopy. Understanding these reasons could help doctors give better instructions and improve success rates.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06954935Recruiting
Eye massage for nausea after gallbladder surgery
This study tests if a gentle massage around the eyes can help reduce nausea and vomiting after laparoscopic gallbladder removal. If you often feel sick after surgery, this might offer a drug-free way to feel better.
GaziantepAges 18–70 - NCT06820151Enrolling by invitation
Exploring injury and repair in the human esophagus
This study looks at how the esophagus heals after injury or surgery. It may help doctors find better ways to prevent or treat leaks that can happen after certain upper gastrointestinal procedures.
CambridgeAges 18–99 - NCT05843877RecruitingPhase 3
Surgery choice and insulin islet transplant to prevent leaks
This Phase 3 trial studies a pancreatic surgery approach (pylorus-preserving Whipple or similar) and, in some cases, moving your insulin-making cells into your body to help prevent a dangerous post-surgery leak from the pancreas. It may help people who are considered high risk for this complication based on pancreas texture and duct size.
DresdenAges 18 years+ - NCT07299110Recruiting
Whey vs. egg protein for ammonia levels in liver cirrhosis
This trial compares how whey protein and egg white protein affect ammonia levels in people with cirrhosis caused by alcohol. The goal is to see which protein source is safer for your liver.
New DelhiAges 18–70 - NCT07283367RecruitingPhase 1/Phase 2
New drug combo for advanced colorectal cancer
This trial tests a new combination of targeted therapies for people with advanced colorectal cancer that has a certain genetic pattern (non-MSI-H, no BRAF V600E mutation). It aims to see if the combination can shrink tumors or slow the cancer's growth.
GuangzhouAges 18 years+ - NCT06881537RecruitingPhase 2
Chemo and targeted therapy before surgery for recurrent colorectal cancer
This trial tests a combination of chemotherapy (CapeOX), a targeted drug (bevacizumab), and an immunotherapy (anti-PD1) given before surgery for colorectal cancer that has come back locally (in the same area). The goal is to shrink the tumor and improve surgical outcomes.
ShanghaiAges 18–75 - NCT06941545Recruiting
Stomach mapping study for functional dyspepsia
This study uses a special stomach mapping technique and a tube to measure stomach activity in people with functional dyspepsia (long-term stomach discomfort or pain). The goal is to better understand how the stomach works, which could help improve future treatments.
Rochester, MinnesotaAges 18–80 - NCT06941415RecruitingPhase 3
Comparing Two Water Pills for Fluid Buildup in Cirrhosis
This trial compares two water pills (bumetanide and furosemide) in people with liver cirrhosis who need treatment for swelling from fluid buildup. It aims to see which medicine works better and is safer when started right after coming to the hospital.
Salt Lake City, UtahAges 18 years+ - NCT06941090Recruiting
Stool sample collection for nutrition gut health study
This study asks participants of the NutriNet-Santé health study to provide a stool sample. Researchers want to understand how diet and gut bacteria affect health.
BobignyAges 18 years+ - NCT06937749RecruitingPhase 2
Study of IBI362 for liver scarring from MASH
This trial tests an investigational drug called IBI362 for people with MASH, a type of fatty liver disease that has caused liver scarring (stage F2 or F3). The study aims to see if the drug can improve the liver's health.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06937671Recruiting
Comparing two ways to remove large flat polyps
This trial tests two methods for removing large, flat polyps from the colon to see which works better. It uses a cold snare (a wire loop that doesn't use heat) with or without an extra fluid lift to make removal safer and more effective.
Weston, FloridaAges 18 years+ - NCT06939231Recruiting
Supporting UCD students toward healthier eating
This trial tests ways to help UCD students build healthier and more sustainable eating habits. It uses a 'living lab' approach, meaning you'll help shape and test real-world changes on campus.
DublinAges 18–30 - NCT06015607Recruiting
Testing a new tool for colon polyp removal
This trial tests a new device to help doctors remove larger, non-cancerous polyps from the colon during a colonoscopy. It may make the procedure easier and more effective for eligible patients.
Cleveland, OhioAges 21 years+ - NCT06935994RecruitingPhase 2
Aspirin for Fatty Liver Disease (MASLD)
This study tests whether aspirin can help people with MASLD, a type of fatty liver disease linked to conditions like diabetes and obesity. It aims to see if aspirin can improve liver health without causing harm.
Taichung, TaiwanAges 18 years+ - NCT07249112Recruiting
Genomic study of metabolic fatty liver disease
This study aims to understand the genetic factors behind metabolic fatty liver disease (MASLD) by comparing patients with advanced liver scarring or liver cancer to healthy blood donors. It may help doctors better predict and treat the disease in the future.
Milan, MilanoAges 18–90 - NCT06935448Recruiting
Recovery program for pancreatic cancer surgery
This trial tests a special recovery program called Enhanced Recovery After Surgery (ERAS) for people having planned open surgery for pancreatic cancer. The goal is to see if this program helps patients recover faster and with fewer complications after their operation.
LarissaAges 18 years+ - NCT06011980Recruiting
Study for treating esophageal variceal bleeding in cirrhosis
This trial tests a treatment for patients with liver cirrhosis who have bleeding from their esophagus or stomach but are currently stable. It aims to help manage bleeding and improve outcomes.
Hanzhou, ZhejiangAges 18–70 - NCT06934564Recruiting
Cutting unnecessary tests before low-risk surgeries
This study helps surgical teams cut down on unnecessary tests before common low-risk surgeries, like breast lump removal, gallbladder removal, or hernia repair. It aims to improve patient care by reducing extra, unneeded procedures.
Ann Arbor, MichiganAges 18 years+ - NCT07744087Recruiting
Comparing two surgical methods for removing tumors near the pancreas
This trial compares two types of surgery to remove tumors that start near the pancreas but not in it. The goal is to see if a newer, less invasive method works as well as the standard approach, which may mean fewer cuts and a faster recovery.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT06932068RecruitingPhase 2
Study of new drug combo for advanced stomach cancer
This trial tests a combination of two immunotherapy drugs (iparomlimab/tuvonralimab) plus chemotherapy (XELOX) in people with advanced stomach or gastroesophageal junction cancer that is HER2-negative and has low PD-L1 levels. It aims to see if this treatment can help shrink tumors or slow the disease.
Zhengzhou, HenanAges 18–75 - NCT06931808Enrolling by invitationPhase 4
Fecal transplant with chemo, radiation, and immunotherapy for advanced colon cancer
This study tests a combination of fecal microbiota transplant, chemotherapy, radiation, and immunotherapy (sintilimab) for people with locally advanced rectal cancer. The goal is to see if this approach improves treatment outcomes.
Ningbo, ZhejiangAges 18–75 - NCT06930079Recruiting
Fat injection for chronic fistulas of the gut and pelvis
This trial tests a new technique where a small amount of your own fat is taken, processed, and injected through an endoscope to help heal long-lasting fistulas (abnormal connections between organs) that haven't healed with other treatments. It's for people with fistulas that affect quality of life.
RomeAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.