Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT07448077RecruitingPhase 2
Short radiation with immunotherapy for rectal cancer
This trial tests a combination of short-course radiation, chemotherapy, and an immunotherapy drug (Enlonstobart) for patients with a specific type of rectal cancer called pMMR. It aims to see if this approach can shrink tumors before surgery and improve outcomes.
Shijiazhuang, HebeiAges 18 years+ - NCT06871150Recruiting
Fluid management during major abdominal cancer surgery
This trial compares three different approaches to guiding fluid management during major abdominal cancer surgery. The goal is to find the best way to maintain stable blood pressure and organ function during the procedure.
Bergamo, ItalyAges 65 years+ - NCT06988150Recruiting
SIBO and weight loss in pancreatic cancer
This study looks at whether a condition called SIBO (too many bacteria in the small intestine) is linked to weight loss in people with pancreatic cancer. You might join if you have pancreatic cancer and have lost weight recently.
Los Angeles, CaliforniaAges 18 years+ - NCT06994429Enrolling by invitation
New MRI to check liver function after transplant
This study uses a new MRI technique to check how well your new liver is working after transplant, without any needles or biopsy. If you have had a liver transplant and are scheduled for an MRI, you may be able to join.
Wuhan, HubeiAges 18–80 - NCT07607873Recruiting
Transplant vs surgery after chemo for liver-only colorectal cancer
This trial compares liver transplant versus liver surgery for people whose colorectal cancer has spread only to the liver and cannot be removed initially. You would first receive chemotherapy to shrink the tumors, and if they become removable, you may be randomly assigned to have a liver transplant or standard liver surgery.
MilanAges 18 years+ - NCT06991049Recruiting
Early vs late stenting for benign esophageal narrowing
This study compares placing a stent early versus waiting longer in people with non-cancerous narrowing of the esophagus that makes swallowing difficult. The goal is to find out which timing works best to improve swallowing and quality of life.
Milwaukee, WisconsinAges 18 years+ - NCT06985524Enrolling by invitation
Chinese medicine formula for stomach fullness and discomfort
This trial tests a traditional Chinese medicine formula (Weipi Formula) for people with a feeling of fullness or discomfort in the upper stomach after eating, known as epigastric stuffiness or functional dyspepsia. It aims to see if the herbal mix can improve symptoms.
Nanchang, JiangxiAges 18–80 - NCT07198386RecruitingPhase 2
Study of CS060380 tablets for NASH (fatty liver disease)
This trial tests an experimental pill called CS060380 for people with NASH (a type of fatty liver disease that can cause liver damage). You may qualify if you have a liver biopsy showing NASH with early-to-moderate scarring, or an MRI showing at least 10% liver fat, and your liver enzymes are stable.
Fuzhou, FujianAges 18–70 - NCT06982872Recruiting
AI-assisted scope test for colorectal growths
This trial tests how well different artificial intelligence tools can help doctors see and diagnose growths in the colon during a special type of scope exam. It may help find better ways to detect polyps and other lesions.
Changchun, JilinAges Any age - NCT06982885Recruiting
AI-assisted imaging study for colorectal lesions
This study tests whether artificial intelligence can help doctors see colorectal lesions more clearly using special advanced imaging. If you have a colorectal lesion, this trial may help improve diagnosis.
Changchun, JilinAges Any age - NCT06982703Enrolling by invitation
Butyrate for antibiotic-related diarrhea
This trial tests if a supplement called butyrate can prevent or reduce diarrhea caused by antibiotics. If you're starting antibiotics, you may be able to join.
PadovaAges 18–80 - NCT04964869Recruiting
Epinephrine injection to prevent delayed bleeding after sphincterotomy
This trial tests whether a one-time epinephrine medicine injection can help prevent delayed bleeding after an ERCP procedure called sphincterotomy. You may be considered if you had only brief bleeding right after the procedure and you don’t have certain bleeding-risk conditions.
Taichung, North Dist.Ages 20 years+ - NCT06738329Recruiting
How seaweed additive carrageenan affects gut bacteria
This study tests whether carrageenan, a seaweed-based food ingredient, changes the balance of bacteria in your gut. It could help us understand how common food additives affect digestion and overall health.
Reading, ReadingAges 18–55 - NCT06978231Recruiting
EUS during ERCP for pancreatic and bile duct diseases
This trial looks at whether doing an endoscopic ultrasound (EUS) in the same session as an ERCP (a procedure to open blocked bile or pancreatic ducts) is helpful. It is for adults who need an ERCP for the first time and have not had a pancreatic or bile duct EUS in the last 3 months.
Jinan, ShandongAges 18 years+ - NCT03891251Recruiting
Recorded videos during your colonoscopy
This study collects recorded video from routine colonoscopies. It may help researchers by providing real-world footage while you receive standard care.
JerusalemAges 18 years+ - NCT07441369Enrolling by invitationPhase 2
Abemaciclib with chemotherapy for advanced colorectal liver metastases
This trial tests combining the targeted drug abemaciclib with standard chemotherapy (FOLFOX or FOLFIRI) for people whose colorectal cancer has spread to the liver and cannot be removed surgically. It may be an option if you've already tried two or three prior treatments without success.
ShanghaiAges 18–75 - NCT06717061Enrolling by invitation
Studying the normal abdominal wall in gallbladder surgery
This study collects tissue and blood samples from people having gallbladder surgery to better understand what a normal abdominal wall looks like. If you are scheduled for gallbladder removal due to gallstones and do not have certain health conditions, you may be able to help.
SkellefteåAges 18 years+ - NCT06943781Recruiting
Gastric cancer screening using high-risk gene detection
This trial is testing a new way to identify people at higher risk for stomach cancer using a gene test for Helicobacter pylori. It may help detect cancer early in people aged 40 and older.
TonglingAges 40 years+ - NCT07240766RecruitingPhase 2
New drug combo for KRAS G12D pancreatic cancer
This trial tests a new targeted drug (HRS-4642) combined with another drug (Nimotuzumab) and two chemotherapy drugs for people with a specific type of pancreatic cancer that has a KRAS G12D mutation. The goal is to see if this combination can help make the tumor smaller and possibly removable by surgery.
Hangzhou, ZhejiangAges 18–75 - NCT05836597Recruiting
Virtual reality therapy for functional stomach pain
This trial studies whether virtual reality can help people with functional dyspepsia, a type of stomach discomfort that isn’t caused by a specific disease. You may be a good candidate if tests have ruled out other stomach problems like ulcers or an active H. pylori infection.
Jacksonville, FloridaAges 18–75 - NCT02653001Enrolling by invitation
Testing samples in healthy people near Norwich Research Park
This study collects bowel-related samples from healthy people to help researchers test a “colon model” in the lab. You may be eligible if you live or work close by and you don’t have ongoing stomach/bowel conditions or recent major changes.
Norwich, NorfolkAges 18 years+ - NCT03125980RecruitingPhase 3
Chemo timing before vs after colon cancer surgery
This Phase 3 study compares two schedules of a colon cancer chemo combination: starting before surgery or starting after surgery. It aims to see which timing helps people live longer and lowers cancer coming back.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05838300Recruiting
Compare special air flow methods during gastric bypass surgery
This trial compares two ways of delivering and removing carbon dioxide gas during minimally invasive gastric bypass and related hiatal hernia repair surgery. It looks at whether one method is safer or more comfortable by changing how the gas is warmed, humidified, and controlled.
Houston, TexasAges 18–65 - NCT05953948Enrolling by invitation
Smartphone case management program for liver transplant patients
This trial studies whether an “intelligent” phone-based case management program can help people after a liver transplant. You may be able to participate if you’re a liver transplant recipient and can use a smartphone, but not if you have liver-related confusion.
Taoyuan, TYAges 20 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.