Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06767436Recruiting
Real-world study of Enhertu for advanced gastric cancer
This study looks at how well the drug Trastuzumab Deruxtecan works and how safe it is in real-world patients with advanced stomach or gastroesophageal cancer whose tumors are HER2-positive. The goal is to gather more information beyond what was learned in clinical trials.
Seoul, SeoulAges 19 years+ - NCT06757192Recruiting
Colorectal cancer screening study for adults 45-54
This study is looking for people aged 45 to 54 who have not been screened for colorectal cancer (CRC) yet. It aims to understand and improve screening rates. You may be eligible if you are a patient at the health center and have no personal or family history of colorectal cancer.
Boston, MassachusettsAges 45–54 - NCT05686785Recruiting
Test how reliable a liver scan is in chronic hepatitis
This study checks whether a “liver stiffness” scan (called transient elastography) gives consistent, dependable results in adults with long-term viral hepatitis. It may help improve how doctors monitor liver changes over time.
Helsingborg, Skåne CountyAges 18 years+ - NCT07382167RecruitingPhase 3
Study of Tenapanor for Chronic Constipation in Adults
This study tests an investigational drug called tenapanor for people with chronic idiopathic constipation (constipation with no clear cause). It aims to see if the drug can safely improve bowel movements in adults.
Foley, AlabamaAges 18–80 - NCT07413068Recruiting
Comparing treatments for gallstones and bile duct stones
This trial looks at three different ways to treat people who have both gallstones and stones in the bile duct. It aims to find which approach works best and with the fewest complications.
Jinan, ShandongAges 18 years+ - NCT06738004Recruiting
Emergency bariatric surgery national audit
This trial is collecting information about people who have emergency complications after weight loss (bariatric) surgery. It aims to understand how these emergencies are managed and how care can be improved.
LutonAges 18 years+ - NCT05045482RecruitingPhase 1
Study drug in people with cirrhosis from blocked bile flow
This Phase 1 trial studies how saroglitazar magnesium works in people with liver scarring (cirrhosis) caused by a bile-flow problem. It helps doctors understand safety and how the body handles the medicine in this specific liver condition.
Indianapolis, IndianaAges 18–80 - NCT07289997RecruitingPhase 2
Combination therapy for advanced AFP-producing gastric cancer
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus a targeted therapy (apatinib) and a chemotherapy drug (irinotecan hydrochloride) for people with a rare type of advanced stomach cancer called AFP-producing gastric cancer. It is for patients whose cancer did not respond to previous immunotherapy combined with chemotherapy.
Shijiazhuang, HebeiAges 18 years+ - NCT06727981Recruiting
Immunotherapy as first treatment for stomach cancer
This trial tests immunotherapy as the first treatment for people with advanced or locally advanced stomach cancer. It may help if you haven't had any prior anti-cancer therapy and are starting treatment soon.
Jinan, ShandongAges 18–100 - NCT06725433Recruiting
Nissen vs Dor repair for hiatal hernia
This trial compares two types of hiatal hernia repair: Nissen and Dor fundoplication. It aims to see which one works better for patients having keyhole surgery for a large hiatal hernia.
KuopioAges 18 years+ - NCT06721195Recruiting
Study of Euphoria from Remimazolam During GI Scopes
This trial studies a sedative called remimazolam and how it makes people feel during routine upper and lower GI scope procedures. It may help doctors understand which patients are more likely to feel a sense of euphoria (a feeling of intense happiness) from the medicine.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT05214222RecruitingPhase 2
New treatment for advanced esophageal cancer after past therapy
This Phase 2 trial tests penpulimab plus chemotherapy (with or without an added targeted pill called anlotinib) in people with advanced esophageal squamous cell carcinoma. It aims to slow tumor growth and improve outcomes, especially for patients who can’t have curative surgery or radiation.
Guangzhou, GuangdongAges 18–75 - NCT06717542Recruiting
Liver tissue analysis to predict transplant success
This study looks at liver tissue before transplantation to find ways to predict how well the transplant will work. It involves a special treatment called HOPE to help preserve the liver.
BolognaAges 18 years+ - NCT06718725Recruiting
AI for quick slide review during endoscopic biopsy
This trial tests an artificial intelligence system that helps doctors immediately examine biopsy samples taken during an endoscopic ultrasound. It may provide faster, more accurate results for patients with suspicious lesions.
Jinan, ShandongAges 18 years+ - NCT07728292Recruiting
Underwater removal of small gastric neuroendocrine tumors
This trial tests a special underwater technique to remove small type I gastric neuroendocrine tumors (5-9 mm) during an endoscopy. The goal is to see if it is safe and effective, which could offer a less invasive treatment option.
Hyderabad, TelanganaAges 18–65 - NCT05919680RecruitingPhase 2
NST-6179 for liver disease from intestinal failure in adults
This Phase 2 study tests NST-6179 in people who have intestinal failure–associated liver disease (IFALD). It aims to improve liver function and overall outcomes for people whose liver inflammation and lab tests have been abnormal for at least 6 months.
Scottsdale, ArizonaAges 16 years+ - NCT06697691Recruiting
Predicting rebleeding risk after upper gut bleeding
This study aims to create a tool that helps doctors predict if a patient with upper gut bleeding (not from veins) will rebleed while still in the hospital. It uses information from your hospital stay to better understand your risk and improve care.
Wuhan, HubeiAges 18 years+ - NCT06703008Recruiting
Monitoring blood flow during liver transplant surgery
This study is testing a way to closely monitor blood flow and pressure during liver transplant surgery to help improve safety and outcomes. It may help patients undergoing a liver transplant.
Bologna, Emilia-RomagnaAges 18 years+ - NCT06702891Recruiting
Exosome study of gastric cardia cancer
This study looks at tiny particles called exosomes from your cancer cells to better understand gastric cardia cancer. It may help doctors find new ways to diagnose or treat this type of stomach cancer.
Jinan, ShandongAges 18 years+ - NCT06696677Recruiting
Measuring small bowel length in repeat weight-loss surgery
This study compares two ways to measure the length of your small intestine during a second weight-loss surgery. One method uses a 3D CT scan before surgery, and the other uses a special tool during surgery. The goal is to see which method is more accurate and safer.
Cairo, Old CairoAges 16–70 - NCT07614542Recruiting
Understanding Gut Health and Hormones in Aging Women
This study explores how your gut bacteria and hormones change as you age. Researchers will collect stool and blood samples and ask about your health to better understand women's aging.
LisbonAges 40–64 - NCT06688383Recruiting
Leak after right colon cancer surgery: a study on outcomes
This study looks at how often a leak happens at the connection site after right colon cancer surgery. It includes both emergency and planned surgeries, and all types of surgical approaches. The goal is to learn more about this complication so doctors can prevent it better.
Orbassano, PiedmontAges 18 years+ - NCT06648785Enrolling by invitationPhase 2
Modified chemo for GI cancers with non-curative intent
This trial tests a modified version of a common chemotherapy combination (capecitabine and oxaliplatin) for people with gastrointestinal cancers who are not expected to be cured. It aims to see if a simpler treatment schedule can be just as effective while reducing side effects.
Burlington, VermontAges 18 years+ - NCT06688955Recruiting
Using clean water during colonoscopy to reduce infection risk
This trial tests whether using water that is tested for bacteria during a colonoscopy can reduce the risk of infection. It may help make the procedure safer for you.
PessacAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.