Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT05486637RecruitingEarly Phase 1
Hearing aid and implant study using voice emotion prompts
This early-phase study checks how well people understand emotions in voices when they have a cochlear implant (or normal hearing). It may help improve communication training and support for patients and families.
Tempe, ArizonaAges 6–80 - NCT06375278Recruiting
Cooling device to protect hearing during cochlear implant
This trial tests a special cooling device used during cochlear implant surgery to help protect any remaining hearing you have. It may be a good option if you are already planning to get a cochlear implant at the University of Miami.
Miami, FloridaAges 18 years+ - NCT06370468Recruiting
Chronic Rhinitis study in Chinese adults
This study looks at chronic rhinitis (long-term stuffy or runny nose) in Chinese adults. It aims to understand how common it is and what causes it.
Wuhan, HubeiAges 18–70 - NCT06375369Recruiting
Digital Health Program for Children with a New Tracheostomy
This study tests a digital health program for children with complex medical needs who have a tracheostomy. The program helps families and doctors manage care at home.
Calgary, AlbertaAges Up to 18 years - NCT06377215Recruiting
How well do you hear speech in noise?
This study tests how well people understand speech in noisy settings, comparing younger and older adults with normal hearing and older adults with hearing loss. It aims to improve our understanding of hearing aid benefits.
Tampa, FloridaAges 18–80 - NCT00900419Recruiting
Check biomarkers during bronchoscopy in breathing and throat pre-cancer
This study looks at “biomarkers” (measurable signals in samples) taken during bronchoscopy or related procedures in people with severe airway pre-cancer or certain lung/throat cancers, and in healthy volunteers. The goal is to better understand what these biomarkers mean and how they might help with diagnosis, staging, or monitoring.
Aurora, ColoradoAges 21–90 - NCT03396718Recruiting
De-escalating radiation after HPV head and neck cancer surgery
This study looks at whether some people with HPV-positive throat/oropharynx cancer can safely receive a less intense form of radiation (and sometimes chemo) after surgery. It aims to reduce treatment burden while keeping the cancer under control, based on how high-risk the pathology looks.
Tübingen, Baden-WurttembergAges 18 years+ - NCT06340633RecruitingPhase 2
Testing SPI-1005 with cochlear implant surgery
This trial tests an oral medication, SPI-1005, given to adults receiving a cochlear implant to see if it improves hearing outcomes. It may help people with moderate to profound hearing loss who are scheduled for implant surgery.
Iowa City, IowaAges 18 years+ - NCT06354010Recruiting
Study of Early-Onset Hearing Loss Related to GJB2 Gene
This study looks at hearing loss that starts in early adulthood (after age 16) and is linked to a specific gene change (GJB2). Researchers want to understand how this type of hearing loss changes over time.
Tampa, FloridaAges 30–55 - NCT06355102Enrolling by invitation
Study of tinnitus after sudden hearing loss using brain scans
This study uses brain imaging (fMRI) and blood tests to understand why some people with sudden hearing loss develop tinnitus (ringing in the ears) while others do not. It may help researchers find better ways to prevent or treat tinnitus.
Nanjing, JiangsuAges 18–65 - NCT06348264RecruitingPhase 2
Rezvilutamide with hormone therapy for high-risk salivary duct cancer
This trial tests a new drug, Rezvilutamide, combined with standard hormone therapy for people with a rare and aggressive type of salivary gland cancer that has a high risk of coming back. The treatment aims to reduce the chance of cancer returning after surgery.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06356272Recruiting
Oropharynx cancer biomarker study
This study looks at certain markers (called p16 and HPV) in tumor samples to better understand oropharynx cancer. It may help doctors learn more about the disease and guide future treatments.
Rochester, MinnesotaAges 18 years+ - NCT06319963RecruitingPhase 1/Phase 2
Lenti-HPV-07 immunotherapy for HPV throat or cervical cancer
This trial tests a new immunotherapy called Lenti-HPV-07 for people with HPV-related throat or cervical cancer. It aims to help your immune system fight the cancer more effectively.
Orlando, FloridaAges 18 years+ - NCT05305131RecruitingPhase 2
Testing chemotherapy with or without extra cancer medicines for nasopharyngeal cancer
This Phase 2 study compares standard chemotherapy (gemcitabine plus cisplatin) against the same chemotherapy plus pembrolizumab and bevacizumab. It aims to see which combination works better for EBV-positive nasopharyngeal cancer before any prior treatment.
SingaporeAges 1.8 years–99 years - NCT06323460RecruitingPhase 2
Less Radiation for HPV Throat Cancer Guided by a Blood Test
This study tests a way to use less radiation for HPV-related throat cancer. Doctors will adjust your treatment based on a simple blood test that tracks cancer DNA, so you may get only the treatment you need.
Columbus, OhioAges 18 years+ - NCT06323239RecruitingPhase 2
Radiation plus chemo and immunotherapy for advanced nasopharyngeal cancer
This trial tests a combination of two types of radiation therapy (standard SBRT and low-dose radiation) along with chemotherapy and an immunotherapy drug (PD-1 antibody) for people whose nasopharyngeal cancer has come back or spread. The goal is to see if this combination can better control the cancer.
Guangzhou, GuangdongAges 18–75 - NCT06331351Recruiting
Herbal tea for chronic throat irritation
This trial tests whether a special herbal tea (Jing Si Herbal Tea) can help people with chronic pharyngitis (long-term throat irritation). It aims to see if the tea packets can soothe symptoms and improve throat health.
Chiayi CityAges 20–70 - NCT05539391Recruiting
Planning the best way to do emergency breathing tubes
This study tests an approach to improve how clinicians place an emergency breathing tube quickly and safely when someone is in serious breathing or life-threatening distress. It may help by standardizing care and optimizing medications and backup steps during urgent situations.
AngersAges 18 years+ - NCT04506853Recruiting
Cochlear implant study for one-sided severe hearing loss
This trial is studying whether a cochlear implant can help people who have very poor hearing in one ear but normal or mild hearing loss in the other ear. It uses hearing tests and speech understanding to see who may benefit and how well the device works.
Chicago, IllinoisAges 5 years+ - NCT06303180Recruiting
Storing tissue samples for hearing and balance studies
This study collects and stores tissue and blood samples from people with hearing, balance, smell, taste, voice, speech, or language conditions, as well as from healthy volunteers. The samples help researchers better understand these conditions and may lead to improved treatments.
Bethesda, MarylandAges 3–99 - NCT06309264Recruiting
Comparing ways to fit hearing aids for blast-exposed Veterans
This study compares two different ways of fitting hearing aids for Veterans who were exposed to blasts and now have hearing difficulties. The goal is to see which method works better for improving hearing and understanding speech.
Loma Linda, CaliforniaAges 18–60 - NCT06305949Recruiting
Brain stimulation to improve swallowing after stroke
This trial tests a gentle electrical brain stimulation (tDCS) to see if it helps improve swallowing after a first-time stroke. It is designed for people who are at least 3 weeks post-stroke and still have swallowing problems.
Bucheon-siAges 19 years+ - NCT06305039Enrolling by invitation
Better hearing with two cochlear implants
This study tests how well people with two cochlear implants (or one cochlear implant and one hearing ear) can hear in complex, noisy settings. It aims to improve how these devices help in everyday listening situations.
Bethesda, MarylandAges 18–85 - NCT06296420Recruiting
Swallowing problems after thyroid surgery
This study looks at swallowing problems after thyroid surgery. It aims to understand how common these issues are and help patients recover better.
Milan, MIAges 18 years+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.