Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2283
- Phase 1235
- Phase 3216
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona78
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07110987Recruiting
Adding a Medicine to Light Therapy for Newborn Jaundice
This study tests whether adding a medicine called Ursodeoxycholic Acid (UDCA) to standard light therapy (phototherapy) helps treat newborn jaundice more quickly. Jaundice causes yellow skin and eyes, and this trial looks at babies whose jaundice is severe enough to need light treatment.
LatakiaAges Up to 1 month - NCT07111598Recruiting
Iron supplements and the immune system in HHT
This study looks at how iron supplements affect the immune system in people with HHT (a genetic condition that causes bleeding from abnormal blood vessels). You may be placed in one of three groups depending on your iron and ferritin levels.
Bron, RhoneAges 18–99 - NCT07111858Recruiting
Pavlik harness vs monitoring for hip dysplasia in babies
This trial compares using a soft brace (Pavlik harness) versus simply monitoring for babies diagnosed with a certain type of hip condition (Graf type 2b or 2c). Researchers want to see which approach leads to better hip development and avoids the need for more intensive treatment.
Royal Tunbridge WellsAges birth–4 months - NCT07112066Recruiting
Heart imaging study for ATTR amyloidosis patients
This study uses heart imaging to track disease progression in people with ATTR cardiac amyloidosis who are about to start tafamidis treatment. It aims to understand how the disease changes over time.
Zurich, Canton of ZurichAges Any age - NCT07112703Recruiting
Breathing exercise study for children with thalassemia
This study tests if a breathing exercise device (incentive spirometer) can improve lung function and daily activity in children with thalassemia who receive regular blood transfusions. It aims to help them breathe easier and be more active.
ZagazigAges 6–10 - NCT07113262RecruitingPhase 3
Study of IBI311 for people with inactive thyroid eye disease
This trial tests a new medication called IBI311 for people whose thyroid eye disease is no longer active but still causes bulging eyes. It aims to see if the drug can reduce eye bulging safely.
Shenyang, LiaoningAges 18–80 - NCT07115004RecruitingPhase 3
Testing an injectable drug for von Willebrand disease
This trial tests a new drug called VGA039 that is injected under the skin to prevent bleeding episodes in people with von Willebrand disease. It is for those who bleed frequently and are not currently using regular preventive treatments.
Little Rock, ArkansasAges 12–75 - NCT07115108Recruiting
High-energy feeding for growth and brain development in infants with heart disease
This study tests a special high-energy formula for babies with congenital heart disease who are at nutritional risk. It aims to see if this feeding helps them grow and develop better before and after heart surgery.
Shanghai, Shanghai MunicipalityAges birth–6 months - NCT07116772Recruiting
Fertility experiences in sickle cell anemia
This study looks at fertility in people with sickle cell anemia. It aims to understand how the disease and its treatments affect fertility over time.
Santo DomingoAges 8 years+ - NCT07118280Recruiting
Oral health and saliva study in OPMD patients and families
This study looks at the mouth health and saliva of people with OPMD and their household members. By understanding saliva changes, researchers hope to learn more about the disease and find ways to help manage symptoms.
Ramat GanAges 18 years+ - NCT07118631Recruiting
Emergency surgery for bleeding brain blood vessel malformation
This study tests emergency surgery for patients with bleeding from a brain blood vessel malformation (AVM). It aims to see if urgent surgery can help people with this type of stroke.
BeijingAges 18–70 - NCT07120971RecruitingEarly Phase 1
Metformin study for premature babies with lung disease
This study tests whether metformin, a medicine used for diabetes, can help premature babies with chronic lung disease (bronchopulmonary dysplasia, or BPD) breathe better. It may reduce the need for breathing machines.
Milwaukee, WisconsinAges 1 week–6 months - NCT07122505Recruiting
Mouth muscle therapy for sleep apnea in kids with Down or Prader-Willi syndrome
This study tests a therapy that strengthens mouth and tongue muscles to help children with Down or Prader-Willi syndrome who have mild obstructive sleep apnea. It aims to improve breathing during sleep without surgery or machines.
GhentAges 4–18 - NCT07123155RecruitingPhase 2
Testing a new add-on treatment for late-onset Pompe disease
This trial tests a new medication, S-606001, given alongside your current enzyme replacement therapy (ERT) for late-onset Pompe disease. It may help improve your breathing and walking ability.
Irvine, CaliforniaAges 18 years+ - NCT07124572Recruiting
Building a Better Diagnosis System for Thyroid Eye Disease
This study aims to build a better system for diagnosing and treating thyroid-associated ophthalmopathy (a thyroid eye condition). It may help improve care for people with this disease, and also involves healthy volunteers as a comparison group.
Hangzhou, ZhejiangAges 7–90 - NCT07125963Recruiting
Custom vs. standard jaw positioning for jaw surgery
This study compares two ways of positioning your jaw during surgery to correct jaw alignment. The goal is to see if using a custom-made guide based on your own CT scans leads to better results than the standard method.
Istanbul, BağcılarAges 18 years+ - NCT07126470Recruiting
Ring for better lens placement in RP cataract surgery
This trial tests whether using a capsular tension ring (a small support ring) during cataract surgery helps keep the artificial lens more stable in people with retinitis pigmentosa (RP) and cataracts. It may reduce lens shifting after surgery.
Guangzhou, GuangdongAges 18 years+ - NCT07129343RecruitingPhase 3
Study of a new VWF treatment for von Willebrand disease in China
This Phase 3 trial tests an recombinant version of the von Willebrand factor (rVWF) for people with severe von Willebrand disease (VWD) living in China. It aims to see if the drug can safely control bleeding and help those who need regular clotting factor treatments.
BeijingAges 18 years+ - NCT07129538Recruiting
Breathing exercise for teens with FMF
This trial tests whether a special breathing exercise can help teens with FMF breathe better and feel stronger. It is for adolescents aged 13 to 17 who have FMF and are otherwise healthy.
Giza, DokkiAges 13–17 - NCT07129954Recruiting
Fear of Falling in Muscular Dystrophy Trial
This trial tests a treatment to help people with certain types of muscular dystrophy who are afraid of falling. It aims to improve confidence and walking safety.
Verona, veronaAges 16–65 - NCT07130305Recruiting
Vibration therapy and vitamin D for FMF in teens
This trial tests if adding whole-body vibration to vitamin D supplements can improve symptoms in adolescent girls with Familial Mediterranean Fever (FMF). It aims to find a simple, non-drug way to help manage the condition.
Giza, DokkiAges 13–17 - NCT07130318Recruiting
Mediterranean diet and exercise for fatty liver in FMF
This trial tests if a Mediterranean diet plus aerobic exercise can improve fatty liver in women with Familial Mediterranean Fever (FMF) who are also obese. It aims to see if these lifestyle changes help liver health.
Dokki, Giza GovernorateAges 30–55 - NCT07130565Recruiting
Pan-Amyloid PET/CT Scan for Amyloid Heart Disease
This trial is testing a special PET/CT scan (Pan-Amyloid) that finds abnormal protein deposits (amyloid) in the heart and body. It is for people who have or may have cardiac amyloidosis and are already planning to get this scan.
Hefei, AnhuiAges 18–80 - NCT07131293Recruiting
European registry study on lymphatic treatments
This study is for people of any age with a confirmed central lymphatic disorder (a problem in the main lymphatic vessels, often linked to heart conditions or occurring on its own). Researchers want to collect information from different hospitals to learn more about these disorders and the best ways to treat them.
CopenhagenAges Any age
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,779 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.