Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2283
- Phase 1235
- Phase 3216
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona78
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07090057Recruiting
Targeting the plantaris muscle in ankle surgery for children
This study tests if removing the plantaris muscle during surgery improves ankle movement in children with tight heel cords. It aims to see if this extra step leads to better outcomes.
Edmonton, AlbertaAges 4–17 - NCT07090668Recruiting
Ear stimulation for pain in sickle cell disease
This trial tests a safe, non-drug device that gently stimulates the ear to help reduce pain in children with sickle cell disease who are in the hospital for a pain crisis. It may offer a new way to manage pain without extra medication.
Atlanta, GeorgiaAges 7–18 - NCT07092358Recruiting
Hereditary ataxia study in the Yangtze Delta region
This study looks at genetic ataxia (a condition that affects coordination) and uses advanced testing to learn more about it. It aims to help understand the disease better and find new ways to treat it.
Hangzhou, ZhejiangAges Any age - NCT07092644Recruiting
Preeclampsia and baby heart defects: mother's heart study
This study looks at the link between preeclampsia (a pregnancy complication with high blood pressure) and a mother's heart health when her baby has a heart problem. The goal is to understand how the mother's heart adapts during pregnancy in these cases.
RomaAges 18 years+ - NCT07093255RecruitingPhase 1
Testing FLQ-101 in premature newborns
This study tests an experimental medicine called FLQ-101 in very premature newborns to see how safe it is and how the body processes it. It may help babies who are born at 26 to 27 weeks of pregnancy.
Austin, TexasAges 4 days–5 days - NCT07094035Recruiting
Green tea and probiotics for constipation-predominant IBS
This study tests whether a supplement containing green tea extract and probiotics can improve bowel function in people with irritable bowel syndrome (IBS) that mainly causes constipation. If you have chronic constipation and abdominal pain, this could help.
NaplesAges 18–70 - NCT07094971Recruiting
Muscle toning and strengthening for abs, thighs, and glutes
This trial tests a device treatment to strengthen and tone your abdomen, quadriceps, and glutes. It is for people who want to improve muscle definition without surgery or major lifestyle changes.
Eugene, OregonAges 25–60 - NCT07095062Recruiting
EEG brain mapping study for Friedreich's ataxia
This study uses an EEG (a painless test that records your brain's electrical activity) to map the brain connections in people with Friedreich's ataxia. It aims to better understand how the condition affects the brain.
Conegliano, TrevisoAges 8–60 - NCT07095829Recruiting
Predicting circulation after birth for severe pulmonary valve blockage
This study looks at babies with a severe heart defect where the pulmonary valve is blocked and the wall between the heart's lower chambers is intact. It aims to predict how well blood will flow after birth using ultrasound images taken during pregnancy.
MadridAges 4 months–6 months - NCT07095881Recruiting
Gum healing with a custom zirconia healing cap
This study tests how well the gum tissue heals around a special custom healing cap made from a strong white material (zirconia composite) placed on a dental implant. It may be a good option if you need a single tooth replaced and have healthy gums and bone.
Cairo, AbaseyaAges 20–50 - NCT07096349Recruiting
Chronic pain study in severe hemophilia A
This study looks at chronic pain in people with severe hemophilia A. It aims to understand pain better through questionnaires and joint health checks.
Oviedo, Principality of AsturiasAges 18 years+ - NCT07096622Recruiting
Visual training for kids after lens surgery
This study tests whether special visual and perceptual training exercises can help improve eyesight in children who have had surgery for a naturally dislocated lens (congenital ectopia lentis). It is for kids aged 4–12 whose vision is still below normal after their second eye surgery.
Guangzhou, GuangdongAges 4–12 - NCT07097337Recruiting
Quick fibrinogen test for trauma patients with heavy bleeding
This trial checks if a fast bedside test for fibrinogen (a protein that helps blood clot) can help guide treatment for trauma patients who are actively bleeding. It may lead to better care in the emergency department.
Rotterdam, South HollandAges 16 years+ - NCT07098975RecruitingPhase 2
Statin for severe early-onset placental insufficiency
This trial tests if taking pravastatin (a statin) can improve blood flow to the placenta in pregnant people with either severe early-onset preeclampsia (high blood pressure) or a baby not growing well. The goal is to help the pregnancy last longer and improve outcomes.
BarcelonaAges 18 years+ - NCT07099313Recruiting
Hemophilia treatment burden and daily life study
This study looks at how prophylactic treatment for hemophilia affects your daily life, sleep, and feelings about your health. It compares different types of clotting factor concentrates to see if one is easier to manage than the other.
Oviedo, Principality of AsturiasAges 18 years+ - NCT07099456Recruiting
Fertility and sexual health in adrenal gland disorder
This study looks at fertility and sexual function in people with congenital adrenal hyperplasia (CAH), a condition affecting hormone production. It aims to understand how CAH impacts these areas.
Rome, ItalyAges 18–65 - NCT07099560Recruiting
Comparing two numbing blocks for hypospadias repair in children
This study compares two ways to numb the lower belly and groin area for children having hypospadias repair. It tests if a newer injection method (sacral erector spinae block) works as well as the standard method (caudal block) to control pain during and after surgery.
Tanta, El-Gharbia GovenorateAges 1–5 - NCT07099651Recruiting
Social understanding in spinocerebellar ataxia
This study looks at how people with certain genetic types of spinocerebellar ataxia (a condition that affects movement and coordination) understand social situations. It aims to see if there are differences in social thinking compared to people without the condition.
AngersAges 18–100 - NCT07100379Recruiting
Balloon time study for esophageal narrowing after surgery
This study compares two balloon inflation times (30 seconds vs 60 seconds) to see which works better for treating narrow spots in the esophagus that form after esophageal atresia repair.
Boston, MassachusettsAges Up to 18 years - NCT07101523Recruiting
Using technology to promote healthy lifestyles
This trial uses technology to help adolescents with intellectual disabilities adopt healthier habits like exercise and good nutrition. It aims to find out if using smartphones can make it easier to stay active and eat well.
Seville, SpainAges 4–30 - NCT07101926Recruiting
Monitoring anti-TFPI in severe hemophilia patients on Marstacimab
This study looks at how a medicine called Marstacimab affects your body's natural anti-clotting protein (TFPI) in people with severe hemophilia A or B who are already taking it. It involves blood tests to see how well the treatment works.
BronAges 18 years+ - NCT07102394RecruitingPhase 1
Testing talimogene laherparepvec for skin bumps in adults with NF1
This trial tests a drug called IMLYGIC (talimogene laherparepvec) to see if it is safe and tolerable for treating skin bumps (cutaneous neurofibromas) in adults with NF1. The drug is injected directly into the bumps, and the study will check if it can shrink them or improve symptoms.
Baltimore, MarylandAges 18 years+ - NCT07104812RecruitingPhase 2
Testing low-dose osilodrostat for mild cortisol excess
This study tests whether a low dose of the drug osilodrostat can help people with mild cortisol excess (MACS) caused by benign adrenal tumors. It may improve related health problems like high blood pressure, diabetes, or bone thinning.
Rochester, MinnesotaAges 18 years+ - NCT07109856Recruiting
A new tool to predict infection in newborns
This study tests a simple non-invasive score that uses blood flow in muscles to predict if a newborn has or will develop high inflammation levels (C-reactive protein). It may help doctors start treatment earlier in babies with breathing problems.
Graz, StyriaAges birth–6 hours
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,779 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.