Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,772
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07280468RecruitingPhase 4
Personalized sleep apnea treatment for Down syndrome
This study tests if a treatment chosen based on your specific type of sleep apnea works better for people with Down syndrome. It looks for participants who have sleep apnea but are not already using a CPAP machine regularly.
Tucson, ArizonaAges 6 years+ - NCT07280585RecruitingPhase 3
Testing a diabetes drug to slow kidney disease progression
This study tests whether a common diabetes medication (SGLT2 inhibitor) can help people with autosomal dominant polycystic kidney disease (ADPKD) maintain kidney function longer. If you have fast-growing kidney cysts and are between 18 and 60 years old, this trial may be an option.
FeldkirchAges 18–60 - NCT07284641RecruitingPhase 2
Stem cell transplant for immune disorders
This trial tests a stem cell transplant to treat common variable immunodeficiency (CVID) and other immune problems. It aims to replace a faulty immune system with a healthy one from a donor.
Pittsburgh, PennsylvaniaAges 5–40 - NCT07285460RecruitingPhase 3
Fitusiran for young boys with hemophilia A or B
This trial tests if fitusiran, given as a shot, can help prevent bleeding in boys ages 1 to 12 with severe hemophilia (factor VIII under 1% or factor IX at 2% or lower). It includes boys with or without inhibitors and aims to understand safety and how well it works.
Los Angeles, CaliforniaAges 1–11 - NCT07285720Recruiting
Language Development in Williams Syndrome
This study looks at how children and adults with Williams syndrome learn language. Researchers want to understand how sounds and word patterns affect language skills in this condition.
AmiensAges 6 years+ - NCT07286565Recruiting
Remote motor development study for early-diagnosed DMD or SMA
This study remotely tracks motor development in children with Duchenne muscular dystrophy or spinal muscular atrophy who were diagnosed at birth or before symptoms started. It aims to see if early monitoring helps improve long-term care and outcomes.
LiègeAges 4 months+ - NCT07286773Recruiting
Biofeedback exercises for flexible flat feet
This study tests if special exercises with biofeedback (a tool that helps you see muscle activity) can improve flexible flat feet. It may help you if you have flat feet that are not fixed in position.
Istanbul, BüyükçekmeceAges 18–45 - NCT07287189RecruitingPhase 2
SAT-3247 for boys with Duchenne muscular dystrophy
This trial tests a new daily pill called SAT-3247 for boys with Duchenne muscular dystrophy (DMD) who are still able to walk. The goal is to see if it can help slow muscle decline.
Los Angeles, CaliforniaAges 7–9 - NCT07287241Recruiting
Heart health study for people with osteogenesis imperfecta
This study looks at heart structure and function in children and adults with osteogenesis imperfecta (OI), a condition that affects bones. Researchers want to understand how OI may impact the heart.
Bologna, Emilia-RomagnaAges 5–80 - NCT07288827Recruiting
Study of airway sensitivity in primary ciliary dyskinesia
This study looks at how the airways in people with primary ciliary dyskinesia (PCD) react to certain triggers. It aims to understand if these airways are more sensitive, which could help improve treatment for breathing problems.
Indianapolis, IndianaAges 6 years+ - NCT07289100Recruiting
Smart home monitoring for lung flare-ups in CF and bronchiectasis
This trial tests if a smart home monitoring system (using sensors and AI) can detect sudden lung flare-ups early in people with cystic fibrosis or bronchiectasis. It may help you get treatment sooner when you are admitted to the hospital for IV antibiotics.
Cambridge, CambridgeshireAges 18 years+ - NCT07290114Recruiting
Surgery with or without mesh for stress incontinence
This study compares two types of surgery for female stress urinary incontinence: one using a small piece of mesh tape (TOT) and another that tightens natural tissues without mesh (PLP). It aims to see which works better and has fewer side effects.
Şanliurfa, HALİLİYEAges 18–80 - NCT07290257RecruitingPhase 4
Long-term safety study of Livmarli for Alagille syndrome or PFIC
This study looks at the long-term safety and effects of Livmarli (maralixibat) in children with Alagille syndrome or progressive familial intrahepatic cholestasis (PFIC). It may help understand how well the medicine works over time for itching and other symptoms.
BrusselsAges 2 months+ - NCT07290556Recruiting
New standing wheelchair for kids and teens
This study tests a new kind of manual wheelchair for kids and teens that lets you stand up while moving around. It’s for people who already use a manual wheelchair and are part of a standing program.
Saint Paul, MinnesotaAges 8–17 - NCT07290582Recruiting
Nerve Pain Relief During Chest Wall Surgery Recovery
This trial tests a freezing technique applied to a nerve during minimally invasive chest wall surgery (Nuss procedure) to help reduce pain after the operation. The goal is to see if this approach helps children recover with less pain medication.
Bergamo, BGAges 14 years+ - NCT07291258Recruiting
Long-term health study of children born to transplant mothers
This study follows children born to mothers who had a solid organ transplant (like kidney, liver, or heart) to learn about their long-term health. It may help doctors understand how to better care for these families.
Groningen, Provincie GroningenAges Any age - NCT07292168RecruitingPhase 1/Phase 2
Study of a new antibody for advanced tumors with FGFR1 protein
This trial tests an experimental antibody, OM-RCA-01, in people with advanced solid tumors that have high levels of a protein called FGFR1. It aims to see if the drug is safe and effective for those who have already tried other treatments.
Kazan'Ages 18 years+ - NCT07292987Recruiting
Support program for people newly diagnosed with retinitis pigmentosa
This study is testing a new way to support people who have just been told they have retinitis pigmentosa (RP) at the Quinze-Vingts hospital in Paris. It aims to help you understand your diagnosis and get the care you need.
Paris, Île-de-France RegionAges 18–65 - NCT07293338Recruiting
Heart muscle blood flow study for dilated cardiomyopathy
This study looks at how small blood vessels in the heart affect outcomes in people with dilated cardiomyopathy (an enlarged, weak heart). You may qualify if you have heart failure with a weak pump and no significant blockages in your main heart arteries.
Hangzhou, ZhejiangAges 18 years+ - NCT07293364Recruiting
Study of C1-inhibitor test for hereditary angioedema diagnosis
This study checks if a blood test measuring C1-inhibitor function can help diagnose hereditary angioedema (HAE), a rare condition that causes painful swelling episodes. If you or a close family member have had swelling without rash or itching that lasts 1-5 days and doesn't get better with allergy meds, this trial may be for you.
AlgiersAges 12 years+ - NCT07293897Recruiting
Study of Livmarli for Alagille Syndrome and PFIC
This study looks at how well Livmarli works for people with Alagille syndrome or a liver disease called PFIC. It uses data from prescriptions to understand the treatment's effects.
Tokyo, TokyoAges Any age - NCT07294014Recruiting
Foot Arch Study in Women With Lipedema
This study looks at the arch of the foot and how the foot works in women with lipedema, a condition where fat builds up unevenly, usually in the legs. Participants will have their existing foot X-rays reviewed to compare foot structure between those with and without lipedema.
IstanbulAges 18–65 - NCT07296419Recruiting
Fetal oxygen monitor study for laboring mothers
This study tests a new device that measures oxygen levels in babies during labor. It may help doctors monitor your baby's health more closely if you are in labor and have an epidural.
Shreveport, LouisianaAges 18 years+ - NCT07297602RecruitingPhase 2
Oral roflumilast for moderate to severe eczema in teens and adults
This study tests an oral medicine called roflumilast to see if it helps treat moderate to severe eczema in people aged 12 and up who haven't used other systemic treatments recently. It's a pilot study to check both safety and how well it works.
Al Mansurah, Dakahlia GovernorateAges 12 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,795 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.