Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,772
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07298564Recruiting
Magnesium and levocarnitine for PCOS symptoms
This trial tests whether taking magnesium and levocarnitine (a natural substance that helps cells make energy) can improve metabolism and reduce symptoms like irregular periods or weight gain in women with polycystic ovary syndrome (PCOS). If you have PCOS, you may be able to join.
Tehran, Tehran ProvinceAges 19–65 - NCT07301216Recruiting
Copper in urine after stopping Wilson disease therapy
This study is looking at what happens to copper levels in the urine when people with Wilson disease briefly stop their medicine. It may help doctors understand how well your body controls copper without treatment.
New Haven, ConnecticutAges 18 years+ - NCT07301463Recruiting
Study of a new drug for children with achondroplasia
This trial tests a new medicine for children with achondroplasia (a common form of dwarfism). It aims to see if the drug can improve growth. The study is for children aged 2.5 to under 11 years old who have not started puberty and can walk without help.
Beijing, Beijing MunicipalityAges 2.5 years–11 years - NCT07301918Recruiting
Comparing two expanders for crossbite in children
This trial compares two types of expanders (Leaf Expander vs. Hyrax Expander) to fix crossbites in children who still have some baby teeth. The goal is to see which device works better and is more comfortable.
CairoAges 6–12 - NCT07303140Recruiting
Liver stiffness in young people with glycogen storage disease type III
This study looks at liver stiffness (a sign of scarring, called fibrosis) in children and young adults with type III glycogen storage disease. Researchers want to see how common liver fibrosis is in this group and how it changes over time, using a non-invasive ultrasound-like test called elastography.
StrasbourgAges 1 month–21 years - NCT07303296RecruitingPhase 2
Gene therapy study for vision loss from LHON
This trial tests a gene therapy called GS010 given as an injection into the eye for people with vision loss from LHON. It aims to see if it can help improve vision in both eyes.
ParisAges 15 years+ - NCT07303621Recruiting
Study of Trikafta in children with cystic fibrosis
This study looks at how the drug Trikafta (also called Kaftrio) works in children aged 2 to 17 with cystic fibrosis. The goal is to learn how the body processes the medicine so doctors can find the best dose.
BronAges 2–17 - NCT07305168Recruiting
Breathing after tonsil surgery in children with sleep apnea
This study looks at breathing problems that can happen after tonsil or adenoid surgery in children who have sleep apnea. Researchers want to learn more so they can make surgery safer for kids.
Edegem, AntwerpAges 1–18 - NCT07308704Recruiting
Using AI to spot heart muscle disease on echocardiograms
This study at Mayo Clinic is testing an artificial intelligence (AI) tool that analyzes echocardiograms (ultrasound of the heart) to find early signs of four types of heart muscle disease. If the AI flags a high-risk pattern, doctors can learn whether acting on that alert helps catch the condition sooner.
Rochester, MinnesotaAges 18 years+ - NCT07312227Recruiting
Pregnancy at high altitude study
This study follows pregnant women living at high altitude in Bolivia to understand how pregnancy differs from those at sea level. It may help improve care for mothers and babies in high-altitude regions.
Boston, MassachusettsAges 18–45 - NCT07312448Recruiting
Comparing two ways to fix a sunken chest in teens
This trial looks at two surgical methods for correcting pectus excavatum (a sunken chest) in teens. It compares the modified Nuss technique with the classic one to see which works best.
StrasbourgAges 11–18 - NCT07313618RecruitingEarly Phase 1
Gene therapy for children with oculocutaneous albinism type 1
This trial tests a single injection of JWK010 gene therapy for children aged 5 to 12 with OCA1A albinism. The therapy is given into the eye to try to improve vision, and is meant for those who have not had gene therapy before.
Chengdu, SichuanAges 5–12 - NCT07314047Recruiting
A study of a liquid gel for brain AVM treatment
This trial tests a liquid embolic agent (a gel-like material) injected into the blood vessels of a brain arteriovenous malformation (AVM) to block abnormal blood flow. It’s for people aged 18 to 80 with certain types of AVMs that doctors think can be treated this way.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07314229Recruiting
Breathing limits during exercise in cystic fibrosis patients on ETI
This study measures how often people with cystic fibrosis who take elexacaftor-tezacaftor-ivacaftor (ETI) experience breathing limitations during exercise and what factors are linked to this.
LilleAges 18 years+ - NCT07314268Recruiting
Study of tiny blood particles in heart amyloidosis
This study looks at tiny particles called extracellular vesicles in the blood of people with a specific type of heart amyloidosis. It aims to find better ways to track the disease and predict outcomes.
São Paulo, São PauloAges 18 years+ - NCT07314983Recruiting
Long-term blood thinning in severe hemophilia A
This study looks at using long-term blood thinners (anticoagulants) in adults with severe hemophilia A, a bleeding disorder. It aims to understand if this treatment can be safe and effective for patients who may need it.
StrasbourgAges 18 years+ - NCT07316426Recruiting
Preparing for ventral hernia surgery
This trial tests a pre-surgery optimization program for people with ventral hernias. It aims to improve outcomes before and after the operation.
Gällivare, Norrbotten CountyAges 18 years+ - NCT07316465Recruiting
Tracking immune markers in newborns at risk for eczema
This study follows newborns for two years to see how their immune system develops, especially if they have a family history of eczema, asthma, or hay fever. Researchers want to learn if certain immune markers appear early in babies who later develop eczema.
Jette, Brussels CapitalAges 1 hour–2 years - NCT07316478Recruiting
Stress Management and Mindfulness for Sickle Cell Disease
This study tests a stress management and mindfulness program designed to help people with sickle cell disease cope better. It aims to see if these techniques can reduce pain and improve your quality of life.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07316855Recruiting
Iron-based covered stent for aortic narrowing
This trial tests a new type of stent made from iron that slowly dissolves in the body. It is designed to treat narrowing of the aorta (CoA) or narrowing that happens after CoA surgery. The goal is to see if the stent is safe and works well over one year.
Zhengzhou, HenanAges 1–60 - NCT07319780Recruiting
Comparing two surgical methods for hypospadias repair
This trial compares two surgical techniques to fix a common birth defect where the opening of the urethra is on the underside of the penis. It tests whether a new method using a special glue is better than the standard method.
Jakarta, DKI JakartaAges 6 months–7 years - NCT07321977Recruiting
Walking test with a portable device for neuromuscular disease
This study tests a portable device that analyzes walking without markers. It aims to see if it can help assess walking in people with neuromuscular diseases and healthy volunteers, which could lead to simpler check-ups.
ParisAges 18–65 - NCT07323082Recruiting
Testing purine-related compounds for PXE
This trial tests a compound that affects certain chemicals in your body (purines) to see if it helps people with pseudoxanthoma elasticum (PXE), a rare genetic condition affecting skin, eyes, and blood vessels.
AngersAges 18 years+ - NCT07324863Recruiting
Ultrasound block for stress reduction in hernia surgery
This trial tests whether a specific ultrasound-guided nerve block (EXORA) can lower stress during umbilical hernia surgery. If you are having this surgery and are generally healthy, you may be able to join.
TantaAges 21–65
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,795 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.