Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,772
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07488091Recruiting
Sickle cell pregnancy care program in Ghana
This trial tests a team-based care program for pregnant women with sickle cell disease. It aims to improve health for both mothers and babies through regular checkups and support.
AccraAges 18–45 - NCT07489209RecruitingPhase 2
Study of EDP167 for homozygous familial hypercholesterolemia
This trial tests a new drug, EDP167, for people with homozygous familial hypercholesterolemia (HoFH), a genetic condition that causes very high cholesterol. The goal is to see if EDP167 can lower 'bad' cholesterol (LDL-C).
BeijingAges 18 years+ - NCT07490522Recruiting
Remote monitoring for gout in primary care
This study tests whether a smartphone app can help your doctor monitor your gout and adjust your urate-lowering medication. It is a feasibility study, meaning it checks if the approach works well for patients.
OsloAges 18 years+ - NCT07493096Recruiting
Intensive therapy program for children with brain-based conditions
This trial tests an intensive therapy program designed to help children with brain-based conditions like cerebral palsy or autism improve their skills in movement, thinking, and daily activities. The program runs for 2 weeks with daily sessions, and researchers will check for changes in your child's abilities.
The Woodlands, TexasAges 4–12 - NCT07497867Recruiting
Long-term study of Korean CADASIL patients
This study follows people with CADASIL over time to learn more about the condition. It may help researchers understand how CADASIL progresses and improve care for patients.
Jeju City, Jeju-doAges 19 years+ - NCT07498829Recruiting
Cancer risk genetic testing for people with female organs
This study offers free genetic testing to women, trans men, and non-binary people (with female reproductive organs) who have not had previous testing for certain cancer-related genes. It aims to find people at higher risk for cancer so they can take steps to prevent it or catch it early.
LondonAges 18 years+ - NCT07502664Recruiting
A study on vision and navigation in inherited retinal disease
This study is looking at how people with inherited retinal disease that affects peripheral vision see and move around. It will test a new way to measure vision and navigation to see if it can help doctors understand how the disease affects daily life.
Irvine, CaliforniaAges 18 years+ - NCT07502989Recruiting
Study of Muscle Health Using Electrical Impedance Myography
This study uses a simple electrical test (EIM) and an MRI scan to check muscle health in people with muscle diseases. It may help researchers learn how to measure muscle changes without a biopsy.
Boston, MassachusettsAges 18–89 - NCT07504146Recruiting
The Orienting study: imaging in CPPD, gout, and OA
This study looks at imaging findings (ultrasound and X-rays) in people with CPPD, gout, or osteoarthritis. It aims to help doctors better identify these conditions early.
Milan, MilanoAges 18 years+ - NCT07505342Recruiting
Remote study for myotonic dystrophy type 1
This study tests whether remote assessments can track myotonic dystrophy type 1 (DM1) and looks at genetic factors. It aims to find better ways to monitor the disease from home.
Rochester, New YorkAges 18–88 - NCT07505797Recruiting
Ultrasound imaging study for suspicious breast lesions
This study is testing a new ultrasound device (ATUSA) to see how well it can image breast lesions that have been classified as suspicious (BI-RADS 4 or 5). If you have a recent finding that needs further evaluation, this research might help improve detection methods.
Sacramento, CaliforniaAges 18–94 - NCT07506109RecruitingPhase 2
Study of sintilimab, ipilimumab, cetuximab, and dabrafenib for advanced colorectal cancer
This trial tests a combination of four drugs for people with a specific type of advanced colorectal cancer that has a BRAF V600E mutation and is microsatellite stable. The goal is to see if this combination can shrink tumors or slow the cancer's growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07508631Recruiting
Friedreich Ataxia Nerve Ultrasound Study
This trial uses an ultrasound to look at nerves in people with Friedreich's Ataxia. It may help doctors better understand how the condition affects the nervous system.
Nice, Alpes MaritimesAges 18–70 - NCT07508904Recruiting
Exercise effects in children with cystic fibrosis
This study tests whether a specific exercise program can improve muscle strength, breathing, and fitness in children with cystic fibrosis who are stable and able to exercise.
LahoreAges 6–18 - NCT07512934Recruiting
Pancreatic Function Study in Early Type 2 Diabetes
This study examines how the pancreas works in people newly diagnosed with type 2 diabetes. Researchers will assess pancreatic function to better understand early diabetes and potentially improve treatment.
Aktobe, AktobeAges 18–74 - NCT07513038RecruitingPhase 1/Phase 2
Using dye imaging to diagnose bile duct blockage in infants
This trial tests whether a special fluorescent dye called indocyanine green (ICG) can help doctors better diagnose biliary atresia—a rare condition where a baby's bile ducts don't form properly. The dye is used during an imaging scan to light up the bile system so doctors can see it more clearly.
Boston, MassachusettsAges birth–3 months - NCT07513844Recruiting
Ultrasound Treatment for Huntington's Disease Movement Symptoms
This trial tests a new focused ultrasound technique aimed at reducing involuntary movements (chorea) in people with Huntington's disease. The treatment targets a specific brain region and may help improve movement control and quality of life.
Fuzhou, FujianAges 18–75 - NCT07514481Recruiting
Lung ultrasound comparison of two surfactant delivery methods in preterm babies
This study compares two ways of giving surfactant (a lung-coating medicine) to newborns with breathing trouble: LISA (a gentler, less invasive method) versus traditional breathing tube delivery. Researchers will use ultrasound to see how the medicine spreads in each baby's lungs to find the best approach.
DohaAges 6 months–10 months - NCT07515235Recruiting
DMD Gene Variants and Heart Function in Young Males
This study examines how different genetic changes in the DMD gene affect heart function in boys with dystrophinopathy (a muscle-weakening condition). Understanding this connection may help doctors better monitor and treat heart problems in affected boys.
ThessalonikiAges 2–24 - NCT07516496Recruiting
Understanding Body Chemistry in Vascular Ehlers-Danlos Syndrome
This study looks at how bodies with vascular Ehlers-Danlos syndrome (vEDS) process nutrients and energy differently. By comparing people with vEDS to healthy volunteers, researchers hope to find new ways to manage the condition better.
CambridgeAges 18–85 - NCT07517250Recruiting
Study of Canakinumab for Fever and Joint Disease
This is a study looking back at patients who were already treated with a medicine called canakinumab for familial Mediterranean fever or Still's disease (rare conditions that cause fevers and joint pain). Researchers want to understand how well this medicine worked over time and what happened to patients who took it.
BaselAges 1 year+ - NCT07519876Recruiting
Blood Clots in the Lungs and Heart Shunts Study
This study looks at whether people with blood clots in their lungs have hidden holes in their hearts that let blood bypass normal circulation. Researchers will use imaging tests to understand this connection and see if it affects how patients do.
Boston, MassachusettsAges 18 years+ - NCT07519915Recruiting
Understanding Nerve Stimulation for Bowel Problems in Children
This research study looks at using sacral neuromodulation—a treatment that uses mild electrical stimulation of nerves in the lower spine—to help children with bowel movement problems. Researchers want to understand how well this treatment works and what improvements matter most to patients and families.
ErlangenAges 3–18 - NCT07520656Recruiting
Heart Valve Surgery and Sleep Breathing Problems
This study looks at whether fixing heart valve problems with minimally invasive procedures (TAVI or MTEER) can improve sleep-related breathing issues. Researchers will monitor your sleep patterns before and after your scheduled heart valve procedure.
Athens, AtticaAges 18 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,795 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.