Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,772
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07523399Recruiting
Joint Health and Balance in Adults with Hemophilia A
This study looks at how hemophilia A affects joint health, balance, and quality of life in adults. Researchers will assess your joints and balance to understand the relationship between joint damage and everyday function.
VanAges 18–65 - NCT07524998Recruiting
Surgery outcomes for complex heart defects across ages
This study tracks how children and adults with complex heart defects fare after surgery. Researchers want to understand what surgical techniques work best at different ages and how patients recover long-term.
BeijingAges Any age - NCT07525505Recruiting
Nigella Sativa Oil for Itchy, Inflamed Ear Canal
This trial tests whether Nigella sativa (black seed) oil can safely treat eczematous otitis externa—a condition causing itching, discomfort, and drainage in the ear canal. Researchers want to see if this natural oil works as well as standard treatments.
Istanbul, FatihAges 18 years+ - NCT07526909Recruiting
Meal Types and Exercise Effects in Phenylketonuria
This study looks at how different meals eaten before exercise affect amino acid levels and metabolic health in adults with classic phenylketonuria (PKU)—a genetic condition affecting how your body processes protein. The research involves eating test meals, exercising, and providing blood samples to help understand the best nutritional approach for PKU patients.
Ankara, AnkaraAges 18 years+ - NCT07527715Recruiting
Heart MRI Study for Dilated Heart Muscle Disease
This research uses cardiac MRI scans and patient data to better predict outcomes in people with dilated cardiomyopathy—a condition where the heart's main pumping chamber becomes enlarged and weakened. Participating could help doctors improve how they care for similar patients in the future.
Jinan, ShandongAges 18 years+ - NCT07527923RecruitingPhase 1
Testing REGN20423 for healthy people and atopic dermatitis
This early-stage trial tests a new experimental medicine called REGN20423 in two groups: healthy volunteers and people with atopic dermatitis (a chronic skin condition causing itching and inflammation). The trial aims to assess whether the medicine is safe and well-tolerated.
Leuven, Vlaams-BrabantAges 18–65 - NCT07530354Recruiting
Understanding Body Changes After Bile Duct Surgery in Children
This study follows children who have had bile duct (biliary tract) surgery to understand how their bodies change and adapt afterward. Researchers compare them with healthy children to learn what is normal and help improve care.
Wuhan, HubeiAges Up to 16 years - NCT07535203Recruiting
Heart Surgery Outcomes in Single-Ventricle Disease
This study follows children with a rare heart condition (univentricular heart) who need multiple surgeries, including a procedure called Fontan. Researchers want to understand how different blood-flow patterns after surgery affect long-term health and outcomes.
Jakarta, DKI JakartaAges Any age - NCT07535385Recruiting
Kidney Artery Blocking Treatment for Polycystic Kidney Disease
This study follows patients with a genetic kidney disease (autosomal dominant polycystic kidney disease) who are on dialysis and receive a procedure to block blood flow to their enlarged kidneys. Researchers will track how well the procedure works and how it affects patients over time using imaging scans.
Pavia, LombardyAges 18–75 - NCT07538583RecruitingPhase 2/Phase 3
QRX003 Lotion for Netherton Syndrome
This study tests a new lotion (QRX003) designed to treat Netherton Syndrome, a rare genetic skin condition. The lotion is applied to affected skin areas to see if it can reduce symptoms and improve skin health.
Fremont, CaliforniaAges 4 years+ - NCT07539012Recruiting
Corneal Membrane Polishing for Fuchs Eye Disease
This trial tests a surgical technique called Descemet membrane polishing during corneal transplant surgery for Fuchs endothelial corneal dystrophy, a condition that clouds the cornea (the clear front part of your eye). The study aims to see if this polishing step improves healing and vision after surgery.
Saint-Etienne, FranceAges 18 years+ - NCT07540572RecruitingPhase 1
Testing IDE574 safety and effectiveness in advanced solid tumors
This early-stage trial tests a new drug called IDE574 to see if it is safe and effective in treating advanced cancers that have spread or stopped responding to standard treatments. The trial focuses mainly on hormone-receptor positive breast cancer, but also includes lung, prostate, and colorectal cancers.
Plantation, FloridaAges 18–99 - NCT07543016Recruiting
Amino Acids and Exercise for FSHD Muscle Weakness
This study tests whether amino acid supplements combined with exercise can help people with FSHD (a genetic muscle disease) build strength and reduce fatigue. Researchers will compare participants who receive amino acids plus exercise training to a control group.
Voghera, PaviaAges 18–50 - NCT07543991RecruitingPhase 1
Gene therapy for giant axonal neuropathy via vagus nerve
This is a follow-up study for patients who previously received an experimental gene therapy (scAAV9/JeT-GAN) for giant axonal neuropathy (GAN), a rare genetic nerve disorder. The new treatment delivers the therapy directly into the vagus nerve—a major nerve in the neck—to help manage nerve damage and related symptoms.
Dallas, TexasAges 10–25 - NCT07544862Recruiting
Stapokibart injection for atopic dermatitis in adults
This study tests a new injection medicine called Stapokibart for treating atopic dermatitis (a chronic skin condition causing itching and inflammation). Your doctor has already decided this medicine might help you before you joined the study.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07545395RecruitingPhase 3
Safety study of KN057 blood clot prevention in hemophilia
This study tests whether KN057, a new preventive medicine, is safe for males with hemophilia A or B. It aims to help prevent bleeding episodes without causing unwanted blood clots.
Tianjin, Tianjin MunicipalityAges 12–65 - NCT07545473Recruiting
Eye Imaging to Detect Brain Disease Markers
This study uses a special camera to photograph the back of your eye in detail. Researchers believe changes in the eye may reflect brain diseases like Alzheimer's or Parkinson's, and this imaging could help detect these conditions earlier.
Melbourne, VictoriaAges 30 years+ - NCT07547696Recruiting
Preventing Alcohol-Related Pregnancy Risks for Native American Women
This study tests a smartphone-based program designed to help Native American women reduce risks related to alcohol use and unintended pregnancy. The program aims to provide personalized support and information through a mobile app you can access daily.
Charlottesville, VirginiaAges 18–44 - NCT07547930RecruitingPhase 2
Tofacitinib for Steroid-Resistant Thyroid Eye Disease
This study tests whether tofacitinib, a new type of immune-modulating medication, can help people with moderate-to-severe thyroid eye disease (Graves' orbitopathy) whose eyes haven't improved with standard steroid treatments. The goal is to reduce eye swelling, bulging, and inflammation that affects daily life.
Xiamen, FujianAges 18–75 - NCT07548944Recruiting
How Electrical Stimulation Affects Your Vision
This study watches how a treatment called transcorneal electrical stimulation (TES)—which uses gentle electrical pulses on your eye—affects your vision in the short term. You'll be observed while using the OkuStim device, and researchers will ask about any improvements you notice in your sight.
Frankfurt am MainAges 18 years+ - NCT07554092Recruiting
Fast vs. Standard Casting for Baby Club Foot Treatment
This study compares two ways of treating club foot (a condition where a baby's foot is twisted inward at birth) using casts: a faster method and the traditional method. It will measure which approach works better using X-rays to see how well the foot straightens.
Peshawar, KPKAges 1 day–5 months - NCT07556185Recruiting
Testing a home heart health monitoring app for kids
This study tests whether young people with heart conditions can use a home monitoring app called Medly to track their symptoms and weight. The app may help doctors catch problems earlier and keep kids healthier at home.
Toronto, OntarioAges 8–18 - NCT07556874Recruiting
Study of Surgeries for Multiple Bone Tumors
This research looks at surgery records from patients who had multiple osteochondromas (benign bone tumors) treated at a major orthopedic hospital. The study aims to understand what surgical approaches work best for this condition.
Bologna, BolognaAges Any age - NCT07557225Recruiting
New PET Scan for Detecting Multiple Cancer Types
This study tests a new type of PET scan (a specialized imaging test) that may better detect certain cancers by looking for a specific marker found on many tumor types. The scan uses a new tracer called 18F-T2 to help doctors see cancer more clearly.
Beijing, Beijing MunicipalityAges 18 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,795 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.