Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,772
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07156578Enrolling by invitationPhase 2
Long-term bivamelagon for hypothalamic obesity
This long-term study tests a new drug, bivamelagon, for people with hypothalamic obesity. It's for those who already completed a similar study and tolerated the drug well.
Aurora, ColoradoAges 12 years+ - NCT07142629Enrolling by invitation
Cavity removal methods for MIH-affected molars
This trial compares two ways of removing tooth decay in children with a condition called MIH (which makes enamel weak and spotted). It tests whether selective or non-selective drilling works better for deep cavities, aiming to save the tooth and keep the nerve healthy.
IrbidAges 6–13 - NCT07142135Enrolling by invitation
Long-term follow-up for Klinefelter syndrome patients
This study follows patients with Klinefelter syndrome over time to learn more about their health. It may help doctors better understand and care for people with this condition.
CopenhagenAges Any age - NCT07134621Enrolling by invitation
Blood vessel damage in repaired aortic narrowing with exercise-related high blood pressure
This study checks if people with repaired coarctation of the aorta who develop high blood pressure only during exercise have any damage to their blood vessels or organs. It aims to understand how exercise affects long-term health after aortic repair.
LjubljanaAges 18 years+ - NCT07110220Enrolling by invitation
How well do ceramic dental restorations hold up over time?
This study looks at how well ceramic dental restorations (like crowns and bridges) have lasted over time. If you've had one placed at the University Hospital of Liège, your experience could help dentists understand how to improve future treatments.
LiègeAges Any age - NCT07103863Enrolling by invitation
Imaging test for predicting AL cardiac amyloidosis outcomes
This study uses two types of imaging (PET/CT and MRI) to see if they can better predict outcomes for people with AL cardiac amyloidosis. The goal is to improve how doctors understand and manage the disease.
Beijing, Beijing MunicipalityAges Any age - NCT07095374Enrolling by invitation
How jaw widening affects premolar tilt
This study looks at how widening the upper jaw with a special device (rapid palatal expander) affects the tilt of certain teeth (premolars). It may help doctors understand how to plan better orthodontic treatments.
Pavia, LombardyAges 6–14 - NCT07088705Enrolling by invitation
Subthreshold laser for retinitis pigmentosa
This trial tests a gentle laser treatment (SML) for people with retinitis pigmentosa (RP), an inherited eye disease that slowly causes vision loss. The goal is to see if the laser can help slow or improve vision problems like night blindness and tunnel vision.
SzczecinAges 18–70 - NCT07083713Enrolling by invitation
Group coaching for life goals with chronic conditions
This study tests if group coaching helps people with certain chronic conditions set and achieve life goals. You would join phone or video sessions with a coach and others like you.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07072676Enrolling by invitation
Can a walker help prevent falls in neuromuscular disease?
This study tests if using assistive walking devices, after a short training period, can lower the risk of falls in people with neuromuscular diseases. It aims to help you stay steady and safe on your feet.
Bad FeilnbachAges 65–65 - NCT07062757Enrolling by invitation
Massage and melatonin for jaw surgery recovery
This study tests whether combining gentle lymphatic drainage massage with melatonin can reduce pain and swelling after jaw surgery. If you are scheduled for jaw surgery for the first time and are otherwise healthy, you may be able to join.
Istanbul, FatihAges 16–55 - NCT07057284Enrolling by invitation
Dentofacial effects of proton therapy for childhood head and neck cancer
This study looks at how proton beam therapy (a precise type of radiation) affects the teeth and face in children and teens who had head or neck cancer. The goal is to understand these long-term effects and help improve future care.
ManchesterAges 2–32 - NCT07056738Enrolling by invitation
Ganglion Cell Loss Study in Retinitis Pigmentosa
This study looks at whether a type of retinal cell (ganglion cells) degenerates in people with retinitis pigmentosa. The goal is to learn more about the progression of the disease over time.
GöttingenAges 18 years+ - NCT07053813Enrolling by invitation
Preventive genetic medicine trial for cancer risk
This trial tests whether a special program can help people with cancer-related genetic changes get the right screening and prevention care. It aims to improve how doctors manage your health based on your genes.
Denver, ColoradoAges 18–75 - NCT07050810Enrolling by invitationEarly Phase 1
Bath system for chronic skin conditions
This study tests a special bath system (Thera-Clean Microbubbles) to see if it helps people with certain skin conditions like psoriasis, eczema, epidermolysis bullosa, or ichthyosis. It's designed for people whose skin is stable and who can follow a home bathing routine.
Chicago, IllinoisAges 2 years+ - NCT07050160Enrolling by invitation
Long-term follow-up after gene therapy for arrhythmogenic cardiomyopathy
This study follows participants who have already received the gene therapy LX2020 for a genetic heart condition called arrhythmogenic cardiomyopathy. It tracks their long-term safety and health outcomes, with no new treatment given.
Ann Arbor, MichiganAges 18–67 - NCT07045545Enrolling by invitation
Comparing two layers in hypospadias repair for young boys
This trial tests two ways to add an extra layer during hypospadias repair surgery in young boys. One method uses a material made from your child's own blood (platelet-rich fibrin), and the other uses a small flap of tissue from the penis. The goal is to see which method helps the healing better.
Tashkent, CityAges Any age - NCT07013045Enrolling by invitation
Exercise and video games for teens with FMF
This study compares two types of exercise programs for teenagers with Familial Mediterranean Fever (FMF). One program uses structured muscle-strengthening moves, and the other uses fun video games that get you moving. The goal is to see which helps teens feel better and stay active.
IstanbulAges 12–18 - NCT07004283Enrolling by invitation
Fetal MRI reference ranges for normal brain development
This study uses fetal MRI scans from a large group of healthy pregnancies to create standard growth charts for brain measurements. This helps doctors better understand normal fetal brain development.
Guangzhou, GuangdongAges 18 years+ - NCT06979024Enrolling by invitation
Observational study of myotonic dystrophy type 1
This study follows people with myotonic dystrophy type 1 over time to learn more about the condition. It is for people of any age who have genetic confirmation of DM1, whether or not they have symptoms.
Fuzhou, FujianAges Any age - NCT06969586Enrolling by invitation
Eye drops study for Fuchs corneal disease and glaucoma
This study tests whether special eye drops (Rho-kinase inhibitors) can improve the health of the cornea in people who have both Fuchs endothelial corneal dystrophy and glaucoma. The drops may help reduce corneal swelling and preserve your vision.
ZagrebAges 40–90 - NCT06954909Enrolling by invitation
Hydration self-assessment for firefighters
This study looks at how well firefighters can check their own hydration using urine color. You may help by providing urine and blood samples over a few days.
Phoenix, ArizonaAges 18–65 - NCT06953284Enrolling by invitation
Tape or electrical stimulation for ankle stiffness in CP
This trial compares kinesiotaping (a special stretchy tape) to functional electrical stimulation (mild electrical pulses to muscles) for treating equinus deformity (walking on tiptoes) in children with cerebral palsy. It aims to see which method helps improve ankle movement and walking better.
TantaAges 4–10 - NCT06947252Enrolling by invitation
Food allergy test for kids with eczema avoiding certain foods
This trial tests if children with eczema who avoid certain foods actually have a food allergy. It uses a supervised oral food challenge to confirm.
BangkokAges Up to 6 years
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,795 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.