Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease84
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California325
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York85
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT07583823Recruiting
Higher-Rate Pacing for Heart Amyloid Disease
This study tests whether pacing your heart at a faster rate helps people with cardiac amyloidosis (a condition where abnormal protein builds up in the heart). If you have a pacemaker and cardiac amyloidosis, this research might help doctors understand the best pacing settings for you.
Minneapolis, MinnesotaAges 18 years+ - NCT07580365Recruiting
Virtual Reality Training for Kids With Muscle Diseases
This study tests whether a virtual reality-based exercise program can help children and teens with diagnosed muscle diseases improve their strength and function. Participants use a special exercise bike while wearing a VR headset to make training more engaging.
Bosisio Parini, LCAges 6–18 - NCT07577414Recruiting
Fetal Treatment for Congenital Diaphragmatic Hernia
This trial tests a procedure called FETO (fetoscopic endoluminal tracheal occlusion) performed during pregnancy to help babies with congenital diaphragmatic hernia—a birth defect where part of the diaphragm (breathing muscle) has a hole and organs from the belly move into the chest. The procedure temporarily blocks the baby's windpipe to help the lungs grow bigger before birth.
Ann Arbor, MichiganAges 18 years+ - NCT07585175Recruiting
Moving from pediatric to adult heart disease care
This study helps doctors understand how to smoothly transition young people with heart problems they were born with from pediatric (children's) hospitals to adult care. It may help improve care coordination and outcomes as patients grow up.
Ottawa, OntarioAges 18 years+ - NCT07584499RecruitingPhase 1
New drug test for children with EGFR-positive solid tumors
This study tests a new cancer drug called Becotatug Vedotin in children ages 2–18 with certain types of solid tumors (cancers that form in organs or tissues) that have an EGFR protein. The drug is designed to find tumors with this protein and attack cancer cells while sparing healthy ones.
Guangzhou, GuangdongAges 2–18 - NCT07582848Recruiting
Breastfeeding Support for Babies with Heart Disease
This study helps mothers of babies born with heart defects learn to breastfeed directly, even when the baby needs heart surgery in the first month of life. Researchers want to see if direct breastfeeding improves health outcomes for both mother and baby during this critical time.
Phoenix, ArizonaAges 18 years+ - NCT07581717Recruiting
Hip Socket Surgery Imaging Study for Children
This study uses MRI scans before and after hip socket surgery to measure how the surgery changes the shape and size of the hip joint. It helps doctors understand which surgical technique works best for children with hip dysplasia (a condition where the hip socket doesn't fully cover the thighbone).
IstanbulAges 2–18 - NCT07582276Recruiting
Bone health in men with severe hemophilia a on two treatments
This study looks at how two different hemophilia A treatments affect bone health over time. It tests if one medicine is better at keeping bones strong than the other.
Little Rock, ArkansasAges 30–50 - NCT07582861Recruiting
Support for Mothers Expecting Babies With Heart Disease
This study offers psychological support to pregnant mothers who have learned their baby has congenital heart disease (a heart condition present at birth). The research tests whether counseling and coping strategies provided before and after birth can help mothers manage stress and anxiety during this challenging time.
Phoenix, ArizonaAges 18 years+ - NCT06723704Recruiting
Long-term outlook in adults with congenital heart disease
This study looks at how adults with congenital heart disease (a heart problem you were born with) do over time. By reviewing medical records, doctors hope to learn what affects long-term health and help improve care for patients like you.
Rome, RMAges 18 years+ - NCT03988764Recruiting
Checking monogenic diabetes wrongly labeled as type 1
This trial looks at people who were diagnosed with diabetes before age 25 as either type 1 or “not sure which type.” It may help confirm whether the cause is genetic (monogenic) rather than type 1, which can change treatment choices.
Montreal, QuebecAges 1 day–25 years - NCT05698277Recruiting
Ultrasound to track baby heart function in heart disease
This study uses automated ultrasound measurements to track how a baby’s heart is working during pregnancy. It compares babies who have a specific congenital heart problem with babies without it, to understand what ultrasound can detect.
Sydney, New South WalesAges 18 years+ - NCT06456827Recruiting
Bite force and bone changes after braces in different face types
This trial compares how bite force and bone turnover markers change during the retention phase (after braces) in people with high-angle and low-angle face types. It may help understand why some people have more relapse after braces.
Rohtak, HaryanaAges 18–45 - NCT06633003Recruiting
Testing an oral extract for spinocerebellar ataxia
This trial tests whether an oral extract from a mushroom called Antrodia cinnamomea can help improve symptoms in people with spinocerebellar ataxia (a condition that affects coordination and balance). Participants must be able to communicate in Chinese.
TaipeiAges 30–70 - NCT06721234Recruiting
Vein thickness and inflammation in Behcet disease
This study looks at how the thickness of the femoral vein wall and certain markers of inflammation relate to Behcet disease. It may help doctors better understand and monitor the condition.
SohagAges 19–80 - NCT06725940Recruiting
PET scan to check treatment response in breast cancer
This trial uses a special PET scan to see how well your breast cancer is responding to neoadjuvant therapy (treatment given before surgery). The goal is to help doctors personalize your care by checking if the cancer is shrinking.
ShanghaiAges 18–65 - NCT07573631Enrolling by invitationPhase 2
Long-term Safety Study of BMN 351 for Duchenne Muscular Dystrophy
This study continues treatment with an investigational medicine called BMN 351 for people with Duchenne muscular dystrophy (a genetic muscle-weakening condition). It checks whether the medicine remains safe and effective when used over a longer period, building on results from an earlier trial.
Milan, ItalyAges 4 years+ - NCT07573059Recruiting
Safety study of a test system for Loargys-treated patients
This study evaluates whether a new test system is safe to use in patients who are already taking Loargys (a medicine for a rare condition called ARG1-D, which affects how the body processes a protein building block called arginine). The study simply observes how the test system works in people already on this treatment.
Atlanta, GeorgiaAges birth–100 years - NCT07575308RecruitingPhase 2
ALN-6400 for Heavy Bleeding in von Willebrand Disease
This trial tests a new medicine called ALN-6400 in teenage and adult women with von Willebrand disease (a blood clotting condition) who experience heavy menstrual bleeding. The goal is to see if this treatment can reduce bleeding and improve quality of life.
Orange, CaliforniaAges 16–45 - NCT06728007Recruiting
Horseshoe kidney study in children
This study follows children with a horseshoe kidney to understand how the condition affects kidney health and to identify any related birth defects. It may help researchers learn more about this condition and improve care.
Bologna, BolognaAges Up to 18 years - NCT07569835Recruiting
Long-Term Outcomes of Childhood Flatfoot Surgery
This study follows up with patients who had surgery to correct flat feet in childhood using special implants. Researchers want to see how well the surgery worked over 10 years and whether any changes occurred in the foot structure.
BolognaAges Any age - NCT07572227Enrolling by invitation
Fetal Surgery for Blocked Bladder in Male Babies
This trial tests a minimally invasive surgery (fetal cystoscopy) performed during pregnancy to help male babies with severe bladder obstruction. The goal is to prevent kidney damage and improve outcomes after birth.
Rochester, MinnesotaAges 18 years+ - NCT07569419RecruitingEarly Phase 1
Testing Linaclotide for Cystic Fibrosis Bowel Function
This early-stage study tests whether a medication called linaclotide can help improve bowel function in people with cystic fibrosis. Researchers will use MRI scans and other tests to see how the medication affects your digestive system.
NottinghamAges 18–65 - NCT07572435Recruiting
Remote Heart Exercise Program for Kids With Heart Surgery
This study tests whether kids aged 8–18 who had complex heart surgery can safely improve their fitness and well-being using exercise activities at home through a mobile app or video. The goal is to help them become more active after surgery.
SeoulAges 8–18
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,456 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.