Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT06938100Recruiting
CADASIL Study: Genes, Brain Scans and Symptoms
This study looks at how genetic and brain imaging changes relate to symptoms in people with CADASIL, a genetic condition that affects small blood vessels in the brain and can cause strokes. It aims to better understand the disease to improve future care.
MilanAges 18 years+ - NCT06935019Enrolling by invitation
Genome sequencing for kids with undiagnosed rare diseases
This study offers genome sequencing (a complete look at your child's DNA) to help diagnose a suspected rare disease faster. It's for children who are newly referred to the genetics clinic at SickKids or CHEO and haven't had this type of testing before.
Ottawa, OntarioAges Up to 18 years - NCT04106479Recruiting
Baby heart ultrasound study in newborn congenital heart defects
This study records newborn heart measurements (using medical imaging) to compare babies with certain congenital heart defects to healthy-term babies. The goal is to see how well one test matches another, which may help doctors better understand heart conditions in newborns.
Montreal, QuebecAges birth–1 week - NCT04644094Recruiting
Dexamethasone for heart function after very early birth
This study looks at how giving a steroid medicine (dexamethasone) after very early birth affects the baby’s heart function. It may help doctors better understand risks and benefits for babies who need treatment for serious lung problems.
Montreal, QuebecAges 1 minute+ - NCT06448546Recruiting
Gut bacteria in Huntington's disease
This study looks at how gut bacteria are different in people with Huntington's disease who have unusual weight changes. You'll provide stool and blood samples to help researchers understand gut health in HD.
Orlando, FloridaAges 18 years+ - NCT05564689Recruiting
Tests coronary blood flow in heart failure patients with CRT
This study measures how well blood flows in the heart (coronary flow) in people with heart failure with reduced pumping strength and a specific heart rhythm problem called left bundle branch block. It focuses on people who already have a cardiac resynchronization therapy (CRT) device and have stable treatment, to see how coronary flow relates to their heart condition.
AalborgAges 18 years+ - NCT06930417Recruiting
Williams syndrome and related 7q11.23 changes study
This study follows people with Williams syndrome, 7q11.23 duplication, or related genetic changes over time to understand how these conditions affect health and development. It also includes close family members to learn about the genetics.
Philadelphia, PennsylvaniaAges Any age - NCT06928727Recruiting
Eye health in craniosynostosis study
This study looks at eye features in people with craniosynostosis (a condition where skull bones fuse too early). It may help doctors better understand eye problems that can occur with this condition.
AmiensAges Any age - NCT06924658RecruitingPhase 2
Metformin for gout patients study
This trial tests if metformin, a common diabetes drug, can help people with gout. It aims to see if the drug is safe and effective for reducing gout symptoms.
TantaAges 18–60 - NCT06929572Recruiting
Umbilical cord patch for closing spine birth defects after birth
This trial tests using a patch made from a newborn's own umbilical cord to help close an open spine defect (myelomeningocele or myeloschisis) shortly after birth. The goal is to protect the spinal cord and improve healing.
Houston, TexasAges Up to 1 day - NCT06924086Recruiting
Adaptive deep brain stimulation for children with epilepsy
This trial tests a new type of brain stimulation (adaptive deep brain stimulation) that adjusts in real time to stop seizures in children with Lennox-Gastaut syndrome. It's for children who haven't gotten enough help from medications and have frequent drop seizures.
LondonAges 5–14 - NCT06925360RecruitingPhase 2
IVIG for lung disease in premature babies
This trial tests if intravenous immunoglobulin (IVIG) can help prevent or treat bronchopulmonary dysplasia (BPD), a lung condition in premature babies. It is for very preterm infants born between 25 and 29 weeks who show early signs of BPD and are enrolled in the first day of life.
Shanghai, Shanghai MunicipalityAges Up to 2 months - NCT06930703RecruitingPhase 1/Phase 2
CBD for sickle cell pain
This trial tests if cannabidiol (CBD) can help reduce pain interference in adults with sickle cell disease. You will take CBD daily for 4 weeks and report your pain levels.
Manhattan, New YorkAges 18 years+ - NCT06927947Recruiting
Helping families learn about inherited cancer risk
This study tests different ways to help family members of people with inherited cancer syndromes get genetic testing. It aims to improve cancer prevention and early detection.
Ann Arbor, MichiganAges 18 years+ - NCT06926621Enrolling by invitationPhase 2
Long-term safety and effectiveness of VX-670 for myotonic dystrophy
This study is for people who already received VX-670 in a previous trial and want to continue treatment. It will check the drug's long-term safety and how well it works for myotonic dystrophy type 1.
St Louis, MissouriAges 18 years+ - NCT06923111Recruiting
Xromi safety study for children under 2 with sickle cell disease
This study is checking how safe and effective Xromi is for babies and toddlers (under 2 years old) with sickle cell disease. It compares kids who take Xromi to those who don't, to see if it helps prevent problems.
HamburgAges 9 months–1.9 years - NCT02852031Recruiting
Care program for newborns needing the Norwood procedure
This trial focuses on improving care for babies born with certain complex heart conditions where only one pumping chamber works. It is meant for babies (including unborn babies) who are planned to have the Norwood procedure, which is a common early surgery.
Birmingham, AlabamaAges Up to 1.3 years - NCT06364449Recruiting
Study on choices for first-time dialysis access
This study looks at how doctors decide which type of hemodialysis access (fistula or graft) to create for patients who need it for the first time. It gathers information from multiple hospitals to help improve future decision-making.
TaipeiAges 18–100 - NCT06385886Recruiting
Study to improve sickle cell care for adults not seeing a specialist
This study helps connect adults with sickle cell disease who haven't seen a specialist in over a year back into care. It tests a program designed to make it easier to get regular medical support and improve your health.
Birmingham, AlabamaAges 18 years+ - NCT06338891Recruiting
Can gluten or wheat trigger FMF attacks?
This trial looks at whether foods like gluten or wheat might cause attacks in people with Familial Mediterranean Fever (FMF). If you have FMF, joining could help understand if changing your diet can prevent attacks.
Palermo, SicilyAges 6 months–80 years - NCT06919003RecruitingPhase 2
Improving kidney transplant with a single injection of a protective protein
This trial tests whether a single injection of C1 esterase inhibitor into a donated kidney during preservation can improve transplant outcomes. It is for adults on dialysis waiting for a deceased-donor kidney who meet specific blood and tissue matching requirements.
Los Angeles, CaliforniaAges 18–75 - NCT06920030Recruiting
Testing a new heart device for heart failure
This trial tests a new device that delivers a gentle electrical current to the heart to improve its pumping strength. It is for people with a certain type of heart failure caused by weak heart muscle, not a blocked artery.
Banja Luka, Republic of SrbskaAges 18–75 - NCT06917690RecruitingPhase 3
Testing oleogel-S10 for epidermolysis bullosa in Japanese patients
This trial tests a gel called oleogel-S10 on wounds caused by a rare skin condition called epidermolysis bullosa (EB). It is only for people of Japanese descent who have a specific type of EB called junctional or dystrophic EB. The gel is put on the wound to help it heal.
FukuokaAges 3 weeks+ - NCT06918119Recruiting
Spinal cord stimulation for children with spina bifida
This study tests whether a special type of electrical stimulation applied to the skin over the lower spine can help improve function in children and teenagers with spina bifida. It aims to see if this treatment can make daily activities easier.
Rochester, MinnesotaAges 5–18
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.