Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,984 recruiting studies in this area right now.
By phase
- Not applicable7,964
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California465
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,981 total
- NCT04410003RecruitingPhase 1
Stool-sample capsules to study gut microbiome in unexplained atherosclerosis
This early-phase study tests whether taking stool-based capsules can change gut bacteria in people with severe atherosclerosis that can’t be explained by usual risk factors. Researchers also measure related metabolic (body chemistry) and microbiome (gut bacteria) changes to see how this approach might help.
London, OntarioAges 18 years+ - NCT04415203Recruiting
Treatment for frequent extra heartbeats using a simple patch
This trial tests a non-surgery treatment (using a skin patch) for people who have frequent extra heartbeats coming from the heart’s lower chambers. It’s meant to see whether the patch reduces symptoms or abnormal heart rhythm compared with usual care.
Beijing, Beijing MunicipalityAges 18–75 - NCT04414878Recruiting
Transcatheter aortic valve replacement for older, high-risk patients
This trial tests a new heart valve replacement done through a catheter (not open-heart surgery) in older adults with severe aortic valve narrowing. It’s mainly for people who are high-risk or not good candidates for standard surgery, to see if the new valve improves outcomes.
Beijing, Beijing MunicipalityAges 70 years+ - NCT04414475RecruitingPhase 2
Selinexor plus low-dose steroid for hard-to-treat myeloma
This Phase 2 trial tests selinexor (a targeted anti-cancer medicine) plus low-dose dexamethasone to treat multiple myeloma that has not responded to many prior treatments. It compares selinexor combinations depending on what medicines you’ve already had, aiming to reduce myeloma activity and improve outcomes.
Pátrai, AchaiaAges 18 years+ - NCT04414865Recruiting
Check a new heart valve treatment for older, high-risk patients
This study follows how the VitaFlow heart valve works in people age 70+ who have severe, narrowed aortic valves and cannot safely get open-heart valve surgery. It’s meant to see whether the device improves outcomes and is safe over time.
Shanghai, Shanghai MunicipalityAges 70 years+ - NCT04416581RecruitingPhase 4
Compare two stomach-protecting medicines to prevent bleeding
This trial compares a potassium-competitive acid blocker to a proton pump inhibitor to help prevent stomach or intestinal bleeding in people at high risk who take blood-thinning medicines. It may help reduce dangerous GI bleeding while you stay on heart/stroke medicines.
AnyangAges 19 years+ - NCT04417387Recruiting
Check genetics to improve heart disease risk prediction
This study looks at whether adding genetic information to a standard NHS Health Check can better predict a person’s risk of coronary artery disease (CAD). If you qualify, you may be asked to provide genetic information to help refine future risk estimates.
LeicesterAges 40–74 - NCT04416958Recruiting
Pacemaker or defibrillator pacing strategy to reduce heart timing issues
This study looks at a pacing approach for people with a pacemaker or ICD (defibrillator) to help prevent the heartbeats from becoming out of sync. It may be useful if your implant team is trying to reduce pacing-related “timing” problems in the heart.
Fürth, BavariaAges 18 years+ - NCT04419480Recruiting
Monitoring to help prevent complications after cardiogenic shock
This study tests a special monitoring approach (likely using an implanted device) to help prevent serious complications after you survive cardiogenic shock in the hospital. It may help the care team detect problems earlier so treatments can start sooner.
Falls Church, VirginiaAges 18 years+ - NCT04427241RecruitingPhase 4
Testing Cerebrolysin for prolonged brain injury after bleeding stroke
This study tests whether Cerebrolysin can improve recovery in people who remain in a vegetative or minimally conscious state more than 4 weeks after a bleeding stroke. It also tracks safety, to make sure the treatment is not causing harmful side effects.
SeoulAges 19–120 - NCT04431609Recruiting
Study for carotid web-related stroke or TIA
This study looks at people who have had a stroke (cerebral infarction) or a warning episode (TIA) caused by a specific shape in a neck artery called a carotid web. The trial uses expert review of your imaging to confirm the cause and asks for your consent to be followed in a study group.
BordeauxAges 18 years+ - NCT04434586Recruiting
Imaging test to guide treatment of blocked thigh arteries
This study tests whether a detailed eye-like scan (optical coherence tomography) helps doctors choose better treatment for blockages in the thigh-to-knee artery. It may help improve healing and outcomes by guiding how the procedure is done.
LilleAges 18 years+ - NCT04433052Recruiting
Personalized heart-protection program for people at high risk
This trial tests whether a tailored prevention plan can improve outcomes and help with costs for people at high risk of coronary heart disease. You may join if you’ve had recent heart events or scans show significant blockage, and if you can follow the visit and app requirements.
HelsinkiAges 30–80 - NCT04432883Recruiting
Brain stimulation to improve speech after stroke aphasia
This trial tests whether targeted mild brain stimulation (tDCS) can improve speech therapy results for people with long-lasting (chronic) aphasia after a stroke. It may help strengthen naming and communication when added to standard speech-language treatment.
Albuquerque, New MexicoAges 25–85 - NCT04433351Recruiting
Rehab training to improve speech after stroke in French speakers
This trial studies a sensory-and-movement training approach to help people relearn speech after stroke-related language difficulties. It may help if your type of post-stroke aphasia is mainly non-fluent and you can safely complete brain scans.
GrenobleAges 55–75 - NCT04433572RecruitingPhase 3
Temsirolimus treatment to improve below-knee artery procedures
This trial studies whether delivering a medicine called temsirolimus directly into the artery during a below-knee revascularization procedure can improve blood flow and outcomes. It may help people with severe leg artery disease who have symptoms like pain while walking or threatened limb tissue loss.
Houma, LouisianaAges 18 years+ - NCT04434807Recruiting
Surgery soon after brain bleed vs standard care
This trial tests whether removing a certain type of brain bleed (intracerebral hemorrhage) very early, using a minimally invasive surgery approach, improves outcomes compared with standard treatment. It may help people whose bleed is large enough and who can have surgery within a strict time window.
Newcastle, New South WalesAges 18 years+ - NCT04436042Recruiting
Hand brace therapy for adults with stroke-related arm weakness
This trial studies an active hand brace (orthosis) that helps improve hand use in daily life after stroke. You may be able to join if you have stroke-related hand weakness and can safely use the device as directed.
New York, New YorkAges 18 years+ - NCT04436978RecruitingPhase 4
Best blood thinner plan for atrial fibrillation after stent
This study compares different blood-thinner (“antithrombotic”) strategies in people with atrial fibrillation or flutter who recently had a stent placed (PCI). It aims to find a plan that lowers clot risk while keeping bleeding risk as low as possible.
AalstAges 18 years+ - NCT04436653Recruiting
New valve procedure for severe right-sided leakage
This trial tests whether a new minimally invasive valve replacement device (put through a catheter) can improve health in people with severe right-sided tricuspid valve leaking. It’s for patients who are considered too high-risk for standard open-heart tricuspid surgery.
Beijing, Beijing MunicipalityAges 50 years+ - NCT04437628Recruiting
Heart failure follow-up blood tests after hospital discharge
This study checks whether short-term follow-up blood test results after you leave the hospital can predict how you do with heart failure. It may help doctors choose better follow-up and treatment plans based on your early test trends.
Wŏnju, GangwondoAges 18 years+ - NCT04437914Recruiting
Tests a smartwatch to spot heart rhythm and wiring problems
This study checks how accurately a smartwatch can detect heart rhythm and electrical “wiring” problems compared with a standard heart test. If it works well, it could help make heart monitoring easier and more accessible.
Teresina, PiauíAges 18 years+ - NCT04439370Recruiting
Blood pressure control study in women with early menopause
This study looks at how the body automatically regulates blood pressure in women who went through menopause earlier than expected. It may help researchers understand whether early menopause affects blood pressure control and related health risks.
Minneapolis, MinnesotaAges 35–70 - NCT04438213RecruitingPhase 2
Ertugliflozin for chronic heart failure with added urine testing
This Phase 2 trial studies whether the medication ertugliflozin can help people with chronic heart failure. You would be asked to follow a set treatment plan and complete repeated urine (and other) testing to see how your body responds.
New Haven, ConnecticutAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,984 recruiting cardiology studies from the U.S. registry right now, out of 15,291 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.