Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,976 recruiting studies in this area right now.
By phase
- Not applicable7,959
- Phase 2483
- Phase 4479
- Phase 3447
- Phase 1361
- Phase 1/Phase 2161
- Phase 2/Phase 386
Top conditions
- Stroke841
- Heart Failure567
- Hypertension401
- Cardiovascular Diseases390
- Coronary Artery Disease372
- Multiple Myeloma334
- Atrial Fibrillation268
- Ischemic Stroke201
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke137
- Myocardial Infarction102
- Pulmonary Hypertension100
- Congenital Heart Disease85
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California460
- Alabama197
- Massachusetts183
- Arizona174
- New York161
- Florida145
- Maryland120
- Illinois119
- Minnesota119
- Texas118
Recruiting studies9,973 total
- NCT07464093Recruiting
Pilates for joint hypermobility pain
This trial tests if a special Pilates program can reduce pain in people with hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorder. You must have had pain for at least 3 months and be able to get on and off the floor on your own.
Chestnut Hill, MassachusettsAges 18 years+ - NCT04674969Recruiting
Register patients receiving a drug-eluting device for leg arteries
This study is a real-world registry that follows adults who receive a drug-eluting device for narrowed or blocked blood vessels in the legs (peripheral vasculature). It helps researchers understand how these devices perform in everyday care.
Jonesboro, ArkansasAges 18 years+ - NCT07764510Enrolling by invitation
Heart-to-heart support for teens with congenital heart disease
This study tests a support program designed to help teens with congenital heart disease feel better and manage their health. It may improve emotional well-being and heart health.
Columbus, OhioAges 12–18 - NCT07318597RecruitingPhase 2
A study of an experimental drug for pulmonary arterial hypertension
This trial tests a new medication called REGN13335 for people with pulmonary arterial hypertension (PAH). It aims to see if the drug can improve symptoms and function compared to standard care alone.
Aurora, ColoradoAges 18 years+ - NCT07485647RecruitingPhase 2
Finding the best dose of daratumumab for multiple myeloma patients after transplant
This trial tests different dosing schedules of daratumumab to find a more cost-effective option for patients with multiple myeloma who have already had a stem cell transplant and achieved at least a partial response. It aims to see if a lower dose can work just as well.
Nashville, TennesseeAges 18–70 - NCT05545501Recruiting
Testing a ketone drink and salt in healthy young adults
This study tests how a ketone ester plus salt affects the body in young adults. It likely looks at safety and what changes you can measure after taking it.
Bloomington, IndianaAges 19–39 - NCT05723926Recruiting
Carotid implants to help prevent stroke repeat in atrial fibrillation
This trial tests whether placing a carotid implant can reduce the chance of having another stroke in people with atrial fibrillation who are already taking blood thinners. It aims to prevent stroke recurrence while you continue prescribed anticoagulation.
Rockford, IllinoisAges 18 years+ - NCT06868719Recruiting
Ketone Drink Study in Older Adults
This study tests a special drink made from ketones (a type of energy source) to see how it affects blood pressure and overall health in older adults. It is for people aged 60–85 who are in generally good health.
Bloomington, IndianaAges 50–85 - NCT07181109RecruitingPhase 3
Study of zilebesiran for high-risk hypertension patients
This trial tests a new medicine called zilebesiran for people with high blood pressure that isn't well controlled. It may be an option if you have heart or blood vessel disease, or are at high risk for it.
Birmingham, AlabamaAges 18 years+ - NCT07769008Recruiting
CT scan versus angiogram before heart bypass surgery
This trial compares two imaging methods used before coronary artery bypass grafting (CABG) to check for blocked heart vessels. The goal is to see if a CT scan is as good as the standard angiogram and equally helpful for planning surgery.
ShanghaiAges 18 years+ - NCT07132788Recruiting
How PAH affects muscle mass
This study looks at how pulmonary arterial hypertension (PAH) impacts lean muscle mass. It may help researchers understand changes in your body and find new ways to support your health.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07332468Recruiting
Smartphone-based heart health program versus usual care
This study tests whether a digital remote management program (using a smartphone) helps people at high risk for heart disease or stroke make healthier lifestyle choices and better manage their medications, compared to usual care. It is for adults 35+ who are not already on advanced heart treatments.
BeijingAges 35 years+ - NCT07620808Enrolling by invitation
Medically-Tailored Meals and Heart Health Study
This study tests whether personalized meal plans designed by doctors can help people with type 2 diabetes and high blood pressure improve their heart health. You'll receive specially prepared meals for 8 months and answer questions about your health.
New York, New YorkAges 20 years+ - NCT07073352Recruiting
Childhood stress and blood vessel aging in young adults
This study looks at how childhood stress might affect blood vessels and aging in young adults. It tests if a certain protein (SIRT1) is linked to early blood vessel aging.
Iowa City, IowaAges 18–30 - NCT07318610RecruitingPhase 3
Study of a new blood thinner in people with leg artery disease
This trial tests if a new blood-thinning drug (factor XI inhibitor) can prevent serious heart and leg problems in people who recently had a leg artery procedure. It compares the new drug to standard care for up to 3 years.
Alexander City, AlabamaAges 18 years+ - NCT07353710Recruiting
Testing a new imaging system during heart ablation
This study tests a new imaging system (CHORUS IDx) that uses 2D ultrasound pictures to help doctors during a heart ablation procedure. It may help guide the procedure more safely.
MerewetherAges 18 years+ - NCT07221851RecruitingPhase 3
Weekly vs daily growth hormone for short stature in children
This trial tests a weekly growth hormone injection (lonapegsomatropin) compared to the standard daily growth hormone shot in children with short stature due to certain conditions. It aims to see if the weekly shot works as well or better and is safe.
Palo Alto, CaliforniaAges 2–17 - NCT06800716Recruiting
Impella temporary pump for end-stage heart failure
This study tests whether using a temporary heart pump called Impella 5.5 can help strengthen a very weak and enlarged heart (dilated cardiomyopathy) in people who are waiting for a heart transplant. If you qualify, the pump is placed to support your heart temporarily, and the research team will check how your heart responds.
New York, New YorkAges 18 years+ - NCT04077762Recruiting
Radial vs femoral access to reduce bleeding in heart procedures
This study compares two ways doctors can reach the heart during a catheter procedure: through the wrist (radial) or the groin (femoral). It aims to reduce bleeding and access-site complications, especially when patients may need a balloon/stent (PCI).
San Francisco, CaliforniaAges 18 years+ - NCT07770269Recruiting
Heart function and anesthesia depth during heart surgery
This study checks how well the heart works and how deep the anesthesia is during planned heart surgery where a heart-lung machine is used. It aims to improve safety and outcomes for patients.
ThessalonikiAges 18 years+ - NCT07213778RecruitingPhase 3
Comparing a new drug to aspirin for blood clot prevention after knee replacement
This trial tests a new medicine called REGN7508 against aspirin to prevent blood clots after total knee replacement surgery. It may help if you are having a planned knee replacement and are in good health.
La Mesa, CaliforniaAges 18 years+ - NCT07741305Recruiting
Comparing heart ultrasound imaging methods for heart failure
This study tests whether a 3D ultrasound of the heart gives better information than a standard 2D ultrasound in people with heart failure. It aims to improve how doctors measure heart function, which could help guide treatment.
Bari, BAAges 18 years+ - NCT07444567RecruitingPhase 3
Continuing benralizumab treatment after a previous study
This trial lets people who completed an earlier benralizumab study and are benefiting from the medicine keep receiving it. The goal is to provide ongoing access while we continue to monitor safety and effectiveness.
Aurora, ColoradoAges 6 years+ - NCT04566328RecruitingPhase 3
Newly diagnosed multiple myeloma test of combination therapy
This Phase 3 trial tests a combination treatment approach for adults with newly diagnosed multiple myeloma, focusing on response and deeper remission. It may help by improving how well the disease is controlled early and measuring results beyond standard tests.
Anchorage, AlaskaAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,976 recruiting cardiology studies from the U.S. registry right now, out of 15,179 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Pain
- Injuries & trauma
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.