Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,973 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2481
- Phase 4480
- Phase 3447
- Phase 1360
- Phase 1/Phase 2162
- Phase 2/Phase 386
Top conditions
- Stroke843
- Heart Failure565
- Hypertension399
- Cardiovascular Diseases390
- Coronary Artery Disease373
- Multiple Myeloma333
- Atrial Fibrillation268
- Ischemic Stroke200
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke138
- Myocardial Infarction101
- Pulmonary Hypertension100
- Stroke, Ischemic86
- Congenital Heart Disease85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California461
- Alabama197
- Massachusetts183
- Arizona173
- New York161
- Florida145
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,970 total
- NCT04755387RecruitingPhase 4
Lower-dose blood thinner after heart attack stent
This trial looks at whether switching to a “lower-intensity” blood thinner plan after a heart attack and stent is safer and still works well. It may help reduce bleeding risk compared with a stronger approach, while protecting the stent from clots.
BusanAges 19–80 - NCT05432778RecruitingPhase 2
Letermovir to prevent CMV in new heart transplant patients
This Phase 2 trial tests whether the medicine letermovir can prevent a common viral infection (CMV) after a new heart transplant. It may help reduce CMV infection or illness in people who are at moderate to high CMV risk.
LjubljanaAges 18–70 - NCT01130545Recruiting
MRI testing of different scan methods in older adults
This study tests different MRI imaging techniques to improve how scans look and measure targets. You may be able to join with or without a contrast dye, and you’ll need to travel to the NIH for follow-up visits.
Bethesda, MarylandAges 18–100 - NCT05174351Recruiting
Stopping beta-blockers in heart failure with preserved pumping
This study checks whether safely stopping beta-blocker medicine is possible in some people with heart failure with preserved pumping (EF ≥50%). It may help by testing whether reducing the medication is safe and workable for certain patients.
Farmington, ConnecticutAges 50–80 - NCT05138575RecruitingPhase 2
Testing SGLT2 pill and potassium nitrate for heart failure with preserved EF
This trial studies whether two medicines—an SGLT2 inhibitor and potassium nitrate—can improve symptoms and heart function in people with heart failure with preserved ejection fraction (HFpEF). It focuses on people who still have signs of “stiff” or high filling pressure in the heart despite a normal-ish ejection fraction.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04914468Recruiting
Study registry for mitral valve replacement by catheter
This study keeps a registry of adults who have a mitral valve problem and are being evaluated for a catheter-based mitral valve replacement. It helps doctors understand what treatments are used and how patients do.
HamburgAges 18–110 - NCT04026776RecruitingEarly Phase 1
Study hormones and salt sensitivity in adults born preterm
This early-phase study looks at natural body chemicals (uric acid and klotho) and how sensitive your blood pressure may be to salt. It may help researchers understand long-term health risks in people born very early.
Winston-Salem, North CarolinaAges 22–33 - NCT04206852Recruiting
Balloon treatment for chronic blood-clot lung vessel disease
This trial tests whether a procedure called balloon pulmonary angioplasty is safe and effective for people with chronic thromboembolic disease in the lungs, especially when surgery isn’t an option. If you have CTEPH, it may help improve lung blood flow and symptoms.
BeijingAges 18 years+ - NCT04457544Recruiting
Registry for people with newly diagnosed SCAD
This is a national Swiss registry that collects information about people who have been newly diagnosed with spontaneous coronary artery dissection (SCAD) or diagnosed within the last 5 years. Your participation can help doctors better understand SCAD and improve future care.
GenevaAges 18 years+ - NCT04619355Recruiting
People who had a special heart scan during stent placement
This study follows people who already had a stent put in (PCI) using a special imaging test (NIRS-IVUS) to look at heart outcomes over time. If you agreed and can attend follow-up visits, this registry may help doctors better understand how this imaging-guided approach performs.
SeoulAges 19 years+ - NCT04484675RecruitingPhase 4
Milrinone during heart surgery for severe pulmonary hypertension
This trial tests whether giving milrinone through a vein and inhaled during mitral valve surgery helps people with severe pulmonary hypertension. The goal is to improve heart and lung blood-flow stability around the time of surgery.
Zagazig, Sharqia ProvinceAges 18 years+ - NCT04475289Recruiting
Registry tracking test results for coronary artery anomalies
This study follows adults who have a coronary artery anomaly and are getting a medically needed heart test at the study hospital. Researchers collect information from those tests to better understand outcomes and what different findings mean.
BernAges 18 years+ - NCT04234724Recruiting
Study of how ANGPTL3 gene variants affect body functions
This study looks at how different ANGPTL3 gene versions may change normal body measurements (such as blood and metabolism). It may help researchers understand why these genetic differences affect health, especially related to fats (lipids) in the body.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04212468Recruiting
Home blood pressure tracking for older adults
This study looks at whether recording blood pressure at home is feasible and useful for people age 65 and older. It may help improve how blood pressure is monitored in everyday life.
Guangzhou, GuangdongAges 65 years+ - NCT04619277Recruiting
Drug-coated balloon for a new coronary artery blockage
This trial studies whether a drug-coated balloon can treat a brand-new (de novo) blockage in the coronary arteries. If you may qualify, it could offer a way to reduce problems from this blockage using a device that delivers medicine during treatment.
UlsanAges Any age - NCT04432220RecruitingPhase 4
Taking blood thinners one year after atrial fibrillation ablation
This study looks at whether people who have stayed in normal rhythm one year after atrial fibrillation ablation should continue blood thinning treatment. It may help guide safer, more personalized choices about long-term blood thinners after a successful procedure.
SeoulAges 19–80 - NCT04284839RecruitingPhase 3
Blood thinner pills vs warfarin after heart surgery
This trial compares two ways to prevent blood clots after open heart surgery: a “direct oral” blood thinner pill versus warfarin (a vitamin K antagonist). It may help find the safest and most effective option for people who develop atrial fibrillation after surgery.
Fitzroy, VictoriaAges 18 years+ - NCT03916302Recruiting
Pulmonary embolism registry study in Warsaw
This study keeps a registry (record) of people with a confirmed pulmonary embolism. Your information helps doctors better understand the condition and improve care.
WarsawAges 18 years+ - NCT04558723Recruiting
MRI-guided heart defibrillator placement for non-ischemic weakened hearts
This study looks at whether using a heart MRI (CMR) to guide where to place an implanted defibrillator (ICD) improves outcomes for people with a weakened heart muscle caused by non-ischemic dilated cardiomyopathy. It’s for adults who have low pumping strength and evidence of heart scarring on MRI.
Lübeck, Schleswig-HolsteinAges 18 years+ - NCT04343430Recruiting
Hospital study for fluid buildup in heart failure with preserved heart function
This study looks at how well doctors can assess fluid buildup before you leave the hospital if you have a type of heart failure called “preserved ejection fraction.” It may help improve decisions about when and how safely people are discharged.
Vandœuvre-lès-NancyAges 18 years+ - NCT03876847Enrolling by invitation
Study genetics in people with spontaneous artery tears
This study looks for genetic (inherited) reasons some people develop SCAD, a sudden tear in a heart artery. It compares people with SCAD to people without it and may help doctors recognize risk and causes.
Ages Any age - NCT04549896Recruiting
CT scan study for complex blocked heart artery procedures
This trial studies how a CT scan may help plan a procedure to open a long-standing blocked coronary artery (a chronic total occlusion). It is aimed at people with complex, difficult blockages and symptoms or heart test results showing parts of the heart may still be alive.
OllioulesAges 18–90 - NCT04014647Recruiting
Blood test to predict heart risk during planned surgery
This trial checks a blood test called NT-proBNP (a marker related to heart stress) to help predict outcomes after planned surgery. It may help doctors identify which patients are at higher risk so they can tailor monitoring and care.
Norwich, NorfolkAges 18 years+ - NCT03868150RecruitingPhase 4
Preventing an abnormal heart rhythm after heart surgery
This trial studies whether giving a medication (amiodarone) during and after certain heart surgeries can help prevent atrial fibrillation, an irregular heartbeat that can happen after surgery. It may help by aiming to stop this rhythm problem before it starts.
Stanford, CaliforniaAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,973 recruiting cardiology studies from the U.S. registry right now, out of 15,205 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.