Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT05910619Recruiting
Noninvasive brain stimulation to support memory and thinking
This study tests a noninvasive way of stimulating the brain to see if it can help older adults with typical age-related changes or mild memory problems. You may be invited if your screening tests and health history fit one of their target groups.
Gainesville, FloridaAges 65–84 - NCT05892744RecruitingPhase 4
Testing brain scans to help choose depression treatment
This trial studies how brain signals measured by MRI and EEG may help doctors choose the best treatment for depression. It focuses on people with early-onset, long-lasting or recurring major depression, and tests whether these “brain biomarkers” track with treatment choice and response.
Austin, TexasAges 18–65 - NCT05878795Recruiting
Therapy sessions to help prevent future suicide attempts
This trial tests a structured talking therapy (“written exposure therapy”) for people who are currently having suicidal thoughts, plans, or an attempt. It may help you learn ways to reduce how overwhelming these thoughts feel and lower the chance of future suicidal behavior.
San Antonio, TexasAges 18 years+ - NCT05882344Enrolling by invitation
Deep brain stimulation for early Alzheimer’s memory problems
This trial tests whether a targeted deep brain stimulation treatment can help people with early Alzheimer’s disease symptoms and memory loss. It also involves brain imaging and a surgery/anesthesia procedure to place the stimulator.
Nashville, TennesseeAges 60–80 - NCT05878730Recruiting
Melatonin study for people stable on long-term lithium
This trial tests whether taking melatonin (a sleep-related hormone) changes how your body responds to lithium in people with bipolar disorder who are currently stable. It may help researchers understand lithium’s effects and how sleep/circadian timing could matter.
Paris, Île-de-France RegionAges 18–70 - NCT05883540RecruitingPhase 2
LSD therapy in palliative care for comfort and well-being
This Phase 2 study tests how LSD may affect comfort and quality of life for people with advanced or end-stage life-limiting illness. It also checks whether the medicine is safe and can be given in a controlled way in palliative care settings.
BaselAges 22 years+ - NCT05907343Recruiting
Brain stimulation study for memory and thinking concerns
This study tests a new brain stimulation method that may help improve memory and thinking in older adults who have memory concerns. It uses a safe, non-invasive technique called transcranial magnetic stimulation (TMS) that sends magnetic pulses to the brain.
Austin, TexasAges 18–90 - NCT05879211Enrolling by invitation
Care learning lab for Duke Health patients
This trial is a “learning laboratory” that studies how best to provide goal-focused care. It may help improve care experiences for Duke Health patients, based on what the study learns.
Durham, North CarolinaAges 18 years+ - NCT05887934Enrolling by invitation
Bone lead levels and mental health in adults
This study looks at whether the amount of lead stored in the body (from old exposures) is linked to brain activity and mental health. It may help researchers understand what kinds of brain/mental health symptoms are related to lead exposure.
Charleston, South CarolinaAges 18–70 - NCT05890183Recruiting
Telehealth exercise and brain training after a first psychosis episode
This trial tests whether a combination of at-home (telehealth) aerobic exercise and computer-based cognitive training can improve thinking and day-to-day function after a first episode of schizophrenia-spectrum illness. It may help by strengthening attention and learning skills after the initial psychotic episode.
Los Angeles, CaliforniaAges 18–45 - NCT05885971Recruiting
Screening for eating disorders during pregnancy
This study looks at ways to detect eating disorders in pregnant women. It may help doctors identify concerns earlier and offer support sooner during pregnancy.
PoitiersAges 18 years+ - NCT05904132Recruiting
Brain stimulation therapy for early Alzheimer’s memory loss
This trial studies a “closed-loop” brain stimulation approach to improve symptoms in people with early Alzheimer’s-related memory problems. It may help by delivering stimulation based on your brain signals, if you meet the safety and diagnosis requirements.
Charlestown, MassachusettsAges 50–80 - NCT05881239Recruiting
Remote smell tests to track early Alzheimer’s health changes
This trial uses remote, at-home (or remote) smell-based testing to help researchers assess health in people with preclinical Alzheimer’s disease and in control participants. It may help by showing how well smell-related changes can signal disease status over time.
Boston, MassachusettsAges 18–100 - NCT05897619Recruiting
CBT skills app for pregnancy and postpartum stress and coping
This study tests whether a new phone app that teaches “cognitive behavioral therapy” (CBT) skills is helpful and easy to use for people who are pregnant or recently gave birth. It also checks safety and whether participants feel the app is acceptable to use over time.
New York, New YorkAges 18 years+ - NCT05884073Recruiting
Exercise training for cancer care professionals
This trial is about using low- to moderate-intensity exercise to support people who professionally care for patients with cancer. It aims to see whether building this exercise approach is practical and safe for oncology care teams, starting with care professionals in Halifax.
Halifax, Nova ScotiaAges 18 years+ - NCT05880719Recruiting
Music-based computer program for memory after first psychosis
This study tests whether using a computer-based music program can help improve memory and thinking in young people who have had their first episode of psychosis. Participants will work in small groups with the program to see if it helps their cognitive skills.
CaenAges 18–30 - NCT05880225Recruiting
Rhythm play training for autistic toddlers
This study tests whether reciprocal play and music rhythm activities can help autistic toddlers better respond to social interaction and timing. It is designed for young children and may offer structured, parent-friendly activities as part of the training.
Nashville, TennesseeAges 1.5 years–3 years - NCT05897177Recruiting
Study about biological factors and behavior in men
This study is looking at possible biological reasons behind certain sexual behaviors in adult men. You might be asked about your health and medications to see whether you fit their study group.
TantaAges 18–60 - NCT05909267Recruiting
Testing dopamine-targeted treatment for depression and body inflammation
This study looks at how changing dopamine signaling may affect motivation and movement in people with major depression, and it also involves healthy volunteers. It may help researchers understand whether dopamine changes can improve symptoms and how inflammation may relate to brain function.
SteglitzAges 18–65 - NCT05905705Recruiting
ECT plus a sleep monitor for treatment-resistant depression
This study looks at how electroconvulsive therapy (ECT) affects brain activity and sleep patterns in people with difficult-to-treat depression. It uses a wearable sleep monitor (the Dreem device) to record sleep while you receive ECT.
St Louis, MissouriAges 21–65 - NCT05887973Recruiting
Youth gun violence prevention program in Washington, DC
This trial is focused on preventing firearm violence by addressing underlying causes among youth taking part in a specific DC grassroots program. If you’re a youth involved with that program in Washington, DC, this study may fit you.
Ann Arbor, MichiganAges 14–24 - NCT05902741Recruiting
Race-based stress program for Black women
This trial studies whether a specific stress-reduction program tailored to race can improve stress and health for Black women after menopause. It may help you learn coping skills that could benefit blood pressure, cholesterol, or diabetes-related outcomes.
Maywood, IllinoisAges 50–75 - NCT05895747RecruitingPhase 2
5-HTP and creatine for adults with depression symptoms
This Phase 2 study tests whether adding 5-HTP and creatine can reduce depression symptoms in adults with major depressive disorder. It may help if your current depression treatment hasn’t been fully effective and you meet the safety and medical criteria.
Salt Lake City, UtahAges 18–65 - NCT05910580Recruiting
Screening and support for alcohol and substance risk in adults
This study aims to improve care access and outcomes for adults who screen positive for risky alcohol or drug use. If you qualify, you may be offered ways to connect to support during your reproductive years.
Boston, MassachusettsAges 18 years+
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.