Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT05890183Recruiting
Telehealth exercise and brain training after a first psychosis episode
This trial tests whether a combination of at-home (telehealth) aerobic exercise and computer-based cognitive training can improve thinking and day-to-day function after a first episode of schizophrenia-spectrum illness. It may help by strengthening attention and learning skills after the initial psychotic episode.
Los Angeles, CaliforniaAges 18–45 - NCT05901233Enrolling by invitation
Remote brain stimulation and speech therapy for primary progressive aphasia
This study tests whether combining speech-language treatment with remotely supervised brain stimulation (a mild current to the scalp) can improve communication in people with primary progressive aphasia. You and a study partner would also join online training and regular video check-ins.
San Francisco, CaliforniaAges Any age - NCT05884073Recruiting
Exercise training for cancer care professionals
This trial is about using low- to moderate-intensity exercise to support people who professionally care for patients with cancer. It aims to see whether building this exercise approach is practical and safe for oncology care teams, starting with care professionals in Halifax.
Halifax, Nova ScotiaAges 18 years+ - NCT05892744RecruitingPhase 4
Testing brain scans to help choose depression treatment
This trial studies how brain signals measured by MRI and EEG may help doctors choose the best treatment for depression. It focuses on people with early-onset, long-lasting or recurring major depression, and tests whether these “brain biomarkers” track with treatment choice and response.
Austin, TexasAges 18–65 - NCT05909267Recruiting
Testing dopamine-targeted treatment for depression and body inflammation
This study looks at how changing dopamine signaling may affect motivation and movement in people with major depression, and it also involves healthy volunteers. It may help researchers understand whether dopamine changes can improve symptoms and how inflammation may relate to brain function.
SteglitzAges 18–65 - NCT05897086Enrolling by invitationPhase 2/Phase 3
PEG-based help during phalloplasty nerve repair
This trial tests whether adding a substance called polyethylene glycol (PEG) helps nerves heal better during phalloplasty. It may improve how well the repaired nerves work after surgery for some people.
Nashville, TennesseeAges 18 years+ - NCT05900271Recruiting
Trial for depression using new brain-stimulation sessions
This study tests whether a specific type of brain stimulation (theta burst delivered over several days) works better than standard rTMS given over 6 weeks for people with treatment-resistant depression. It may help improve depressive symptoms, measured with multiple depression rating scales.
Nijmegen, GLAges 18–99 - NCT05897164Recruiting
Mobile app to help teens cut back on substance use
This study tests a mobile app designed to help teens who use alcohol or drugs cut back or stop. You and your teen would use the app together and get support from the study team by text.
Baltimore, MarylandAges 13 years+ - NCT02434393Recruiting
Studying brain changes in late-life depression and memory decline
This study looks at how thinking and memory change in people with depression later in life, using brain imaging and related assessments. Your past participation and whether your treatments are stable enough around the time of the brain scan may determine whether you can join.
San Francisco, CaliforniaAges 65 years+ - NCT05403086RecruitingPhase 2
Psilocybin for distress in people with serious, life-limiting illness
This Phase 2 study tests whether psilocybin therapy can reduce deep distress (“demoralization”) in people receiving palliative (comfort-focused) care. It may help with mood and well-being, but you must meet safety and medication requirements to join.
Greenbrae, CaliforniaAges 18 years+ - NCT05858346Recruiting
Therapy for social anxiety in Veterans with trauma symptoms
This study compares two kinds of treatment for social anxiety disorder to see which one works better for Veterans. It focuses on people who also have significant posttraumatic stress symptoms (trauma-related symptoms).
Charleston, South CarolinaAges 18–80 - NCT05861752Recruiting
Study of sexual risk behaviors and mental health patterns
This case-control study looks at people with specific sexual behavior-related conditions (like certain paraphilias, compulsive sexual behavior, or sex during sleep) to understand factors linked with risk for sexual violence. The goal is to learn what patterns may be involved so better help and prevention strategies can be developed.
Stockholm, Stockholm CountyAges 18 years+ - NCT05850689RecruitingPhase 3
Lumateperone add-on for major depression that didn’t improve
This study tests whether adding lumateperone to an antidepressant helps adults with major depressive disorder (MDD) who haven’t improved enough after trying at least two different antidepressants. It may help reduce depressive symptoms more than antidepressants alone.
Huntsville, AlabamaAges 18–65 - NCT02832193Recruiting
Uses past anesthesia test data to study memory after surgery
This study looks back at information already collected around elective surgery to understand how anesthesia and surgery may affect thinking and memory (sometimes called POCD). It mainly uses records and questionnaires rather than adding a new treatment.
BerlinAges 18–100 - NCT05871411Recruiting
Test a work wellbeing questionnaire for adults
This trial checks whether a simple work questionnaire (a “visual scale”) reliably measures job satisfaction and wellbeing. If you choose to take part, you’ll likely complete survey questions to help validate the tool.
Clermont-FerrandAges 18–80 - NCT05865470RecruitingPhase 1
How age affects smoked and oral THC effects
This early-stage study compares how people in different age groups respond to THC taken by smoking versus by mouth. It aims to understand age-related differences in effects and safety, which could help guide safer use in the future.
Los Angeles, CaliforniaAges 18–65 - NCT05856552Recruiting
Study on how depression affects older women’s health
This study looks at how depression impacts the health and social life of older women. It aims to understand the effects of depression so care and support can improve.
Chennai, Tamil NaduAges 55 years+ - NCT05847504Enrolling by invitation
Phone-based skills training for suicide risk related to alcohol
This study tests a skills-training program delivered with a smartphone to help reduce suicidal thoughts or crises in people who have been drinking heavily. It focuses on people who were recently hospitalized for a suicide crisis and who also have hazardous alcohol use.
Durham, North CarolinaAges 18 years+ - NCT05853666Recruiting
Support program for parents of babies in the NICU
This study tests a program that connects parents with support to help them feel more confident and less stressed while their baby is in the neonatal intensive care unit (NICU). It aims to improve both parent well-being and baby health outcomes.
Halifax, Nova ScotiaAges Any age - NCT05854836Recruiting
Pre-pregnancy support for incarcerated women with substance use
This study tests a preconception (before pregnancy) support program for incarcerated women who have used substances and could become pregnant. It may help improve health and planning before a future pregnancy.
St Louis, MissouriAges 18–49 - NCT05868668Recruiting
Low-intensity shockwave versus wave therapy for erectile and pelvic pain
This trial compares two types of low-intensity wave therapy to see which works better for erectile dysfunction and/or chronic pelvic pain. Participants may benefit if these therapies improve erection quality and reduce pelvic pain.
Cleveland, OhioAges 40 years+ - NCT05851898RecruitingPhase 4
Tested medicine to prevent depression after hip or leg fractures
This trial studies whether a type of antidepressant medicine (a serotonin–norepinephrine reuptake inhibitor) can prevent depression after a lower-extremity fragility fracture that was treated with surgery. It’s mainly for older adults, and aims to see if starting this medicine early reduces later depression symptoms.
Winston-Salem, North CarolinaAges 65 years+ - NCT05852860Enrolling by invitation
Mentoring program for HIV clinicians on tobacco cessation
This study tests a mentoring program to help clinicians who care for HIV patients learn more about helping patients quit smoking. It aims to improve how doctors and nurses support tobacco cessation in HIV care.
Philadelphia, PennsylvaniaAges Any age - NCT05855668Recruiting
Study how brain and behavior differ in alcohol and cannabis use
This study looks at how people’s thoughts, brain-related measures, and behaviors differ between alcohol use disorder and cannabis use disorder. You may be asked to join group psychotherapy and complete assessments, which could help improve how care is planned for people like you.
Toronto, OntarioAges 18 years+
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.