Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT05240924Recruiting
Exposure therapy program for veterans with OCD and PTSD
This study tests whether a structured therapy approach called Exposure and Response Prevention (ERP) can improve functioning in veterans with OCD, with or without PTSD. You may be eligible if you’re receiving care through certain VA clinics or telehealth hubs and are willing to take part in ERP.
East Orange, New JerseyAges 18 years+ - NCT05236803Recruiting
Assessing motor problems in autistic children
This study aims to better understand how motor skills (movement and coordination) work in children with autism spectrum disorder. It uses an assessment approach to help researchers understand what motor difficulties look like, which may improve future evaluations and support.
BordeauxAges 6–11 - NCT05200182Recruiting
Brain training to improve control over emotional eating
This study tests a brain training technique (neurofeedback) that may help improve self-control related to emotional eating. If you tend to eat more when stressed or upset, this could help you manage those urges.
RennesAges 18–50 - NCT05197309Recruiting
Metabolic diet to help prevent relapse in anorexia
This study tests whether a specific diet can help people with anorexia nervosa stay well and avoid relapse after weight restoration. It focuses on “metabolic” (energy and blood sugar-related) effects, checked with blood work and regular visits.
New York, New YorkAges 18–40 - NCT05205980Recruiting
Training practice to help prevent falls in Alzheimer’s
This trial tests whether a specific “training practice” can reduce falls in people with probable Alzheimer’s disease. It may help by improving safe walking and balance after doing the training.
Valdosta, GeorgiaAges 65–90 - NCT05254015Enrolling by invitation
Therapy for hoarding symptoms in adults 50+
This trial tests a combined therapy approach (cognitive rehabilitation plus exposure therapy) to reduce hoarding behaviors in older adults. You may benefit if your hoarding is your main diagnosis and your symptoms and medications are stable.
San Diego, CaliforniaAges 50 years+ - NCT05216328RecruitingPhase 4
Preventing opioid-related constipation in advanced cancer
This trial tests whether starting a laxative right away can prevent constipation caused by pain medications called opioids. It's for people with advanced cancer who are beginning opioid pain treatment and aims to improve comfort and quality of life.
Almere Stad, FlevolandAges 18 years+ - NCT05224414Recruiting
Study of how thinking styles may affect OCD treatment response
This study looks at how your interpretation of unclear situations may influence how well OCD treatment works. You’ll likely complete a computer task to understand thinking patterns and response to the main OCD study protocol.
Belmont, MassachusettsAges 18 years+ - NCT05201534Recruiting
Math and thinking skills training for school-age children
This trial studies interventions to improve math and cognitive (thinking) skills in elementary school children. It includes both children with math learning difficulties and typically developing children, using tests and MRI brain scans for those who can participate.
Palo Alto, CaliforniaAges 6–12 - NCT05240352Recruiting
Personalized brain stimulation help for bipolar depression anhedonia
This study looks at using brain scans to better tailor transcranial direct current stimulation (a noninvasive brain stimulation) for people with bipolar depression who feel little pleasure. It aims to see whether matching the stimulation to your brain signals can improve symptoms like anhedonia.
Houston, TexasAges 18–50 - NCT05230758RecruitingPhase 3
Metformin trial for brain tumor survivors’ brain and behavior
This Phase 3 study tests whether metformin can improve brain function, behavior, and thinking in children and teens who were treated for certain brain tumors. You may be able to join if you meet age, time-since-treatment, language, and health/lab safety requirements.
New Lambton Heights, New South WalesAges 7–21 - NCT05235867Recruiting
Secretin to help teens with anorexia during refeeding
This trial studies whether secretin can help the body during “refeeding,” the careful process of restarting nutrition in people hospitalized for restrictive-type anorexia nervosa. It compares participants with very high vs very low urine output during refeeding to see if responses differ.
Los Angeles, CaliforniaAges 13–24 - NCT05209438Recruiting
Caregiver stress support with brief weekly sessions
This trial tests a 4-week support program designed for caregivers who are feeling stressed, anxious, or not sleeping well. It aims to see whether the sessions and technology help improve these symptoms while you keep caregiving.
Winston-Salem, North CarolinaAges 18 years+ - NCT05234866Recruiting
Test for “paradoxical lucidity” in severe late-stage dementia
This trial studies whether “paradoxical lucidity” can happen in people with very advanced dementia. It may help doctors understand changes in awareness in late-stage illness and improve how care is provided.
New York, New YorkAges 18 years+ - NCT05219175RecruitingPhase 2
MDMA therapy for PTSD and opioid addiction after childbirth
This Phase 2 study tests whether MDMA-assisted therapy can reduce symptoms of PTSD and help with opioid use disorder in people after childbirth. You must be on a stable, low enough dose of methadone or buprenorphine and be able to follow study rules, including therapy sessions and safety monitoring.
Albuquerque, New MexicoAges 18 years+ - NCT05231798RecruitingPhase 2
PET and brain scans in adults with Down syndrome
This study looks at how well a brain chemical system works in adults with Down syndrome as they age, including how it relates to Alzheimer’s-type brain changes and thinking skills. It uses brain scans and memory/thinking tests to see whether these measures can help track risk or changes over time.
Nashville, TennesseeAges 18–55 - NCT05208190RecruitingPhase 4
Clozapine to prevent violence in schizophrenia
This trial tests whether clozapine can reduce repeat violent behavior in people with schizophrenia or schizoaffective disorder. Participants are randomly assigned to clozapine or usual care to see which approach works better for preventing violence.
Los Angeles, CaliforniaAges 18–65 - NCT05219955Recruiting
Study of caregiver stress and sleep in older adults
This study looks at how caregiver stress affects sleep problems—especially trouble getting going in the morning. If you are a caregiver for someone with dementia and have specific morning sleep/energy difficulties, you may be able to join and help researchers better understand what helps.
Pittsburgh, PennsylvaniaAges 55 years+ - NCT05218993Enrolling by invitation
Testing a new balance and reaction method for football players
This trial tests a new “dual task” training or testing method for professional football players. It may help coaches and players measure balance and reaction under real game-like conditions.
AnkaraAges 14 years+ - NCT05232032RecruitingPhase 2
Brain scan and medication study for avoiding versus approaching
This Phase 2 study looks at how a medication affects brain activity and real-life mood or anxiety behaviors. It includes people with major depression or several anxiety disorders and also healthy volunteers, using questionnaires, a smartphone, and brain imaging.
Belmont, MassachusettsAges 18–45 - NCT05234125Recruiting
Lifestyle counseling during pregnancy for African American women
This trial tests a better lifestyle counseling program during pregnancy to help improve health—especially for women who started pregnancy at a higher weight. It may help you learn practical changes for a healthier pregnancy and outcomes.
Chicago, IllinoisAges 18–40 - NCT05215353RecruitingPhase 4
Music therapy or talk therapy for anxiety after cancer
This study compares music therapy and cognitive behavioral therapy (CBT) to see which better reduces anxiety in people who have had cancer. You may be randomly assigned to one of the two therapy programs and will join sessions by video call.
Miami, FloridaAges 18 years+ - NCT05207085RecruitingPhase 2
Testing valbenazine for adult hair-pulling disorder symptoms
This Phase 2 study tests whether valbenazine can reduce symptoms of trichotillomania (a hair-pulling disorder) in adults. You may be able to join if your symptoms cause major distress or interfere with daily life.
New Haven, ConnecticutAges 18–65 - NCT05240976RecruitingPhase 2
Testing add-on treatments for very treatment-resistant schizophrenia
This trial tests a combination of an NMDA-targeting medicine and an anti-inflammatory treatment for people with schizophrenia that has not responded well to several standard treatments, including clozapine. If you qualify, the goal is to see whether this combination improves symptoms more than usual care.
TaichungAges 18–65
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.