Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT04994847Enrolling by invitation
Study APOE-related brain changes to help prevent Alzheimer’s
This study looks at how a person’s APOE gene relates to early brain and health changes that could lead to Alzheimer’s. If you are not currently having memory or thinking problems, you may be asked to do brain scans, cognitive testing, and blood plus a spinal fluid sample to support research.
Phoenix, ArizonaAges 50–90 - NCT04938349Recruiting
Dual-task training for memory and balance in older adults
This trial tests a type of training that challenges you to do two tasks at once to help with thinking and movement. It is for people over 55 who may have mild memory problems but do not have major brain, heart, or lung conditions.
Chicago, IllinoisAges 55 years+ - NCT04939012Recruiting
MyPath tool to help postpartum women plan next pregnancy
This study tests a patient-centered tool (MyPath) that supports reproductive planning for women with substance use disorder during late pregnancy and right after delivery. The goal is to improve how you get guidance about future pregnancy choices and care.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04957537Recruiting
Speech and meaning therapy for primary progressive semantic aphasia
This study tests a “semantic rehabilitation” program—therapy focused on improving word meaning and understanding—for people with primary progressive semantic aphasia. If you qualify, it may help slow or improve language difficulties and daily communication.
ToulouseAges 18–100 - NCT04959838Recruiting
Study of job stress in eye doctors and trainees
This study looks at job stress among ophthalmologists (eye doctors) and ophthalmology residents. It may help improve working conditions and support for people in eye care.
Clermont-FerrandAges 18–65 - NCT04956016Recruiting
Compare two rTMS treatments for moderate to severe depression
This study tests whether a classic type of brain stimulation (rTMS) works better or the same as a deeper version for depression that keeps coming back or is ongoing. You may be offered one of the two stimulation options to see which helps reduce depressive symptoms.
PoitiersAges 18 years+ - NCT04952870Recruiting
Study breathing treatment and early immunity in newborns after COVID
This study looks at how newborns’ bodies are affected by COVID-19 around birth and whether a breathing support treatment (inhaled nitric oxide) changes outcomes. It also compares COVID-exposed babies and a similar group of babies without COVID who are not receiving the breathing treatment.
LilleAges Up to 3 months - NCT04946253Recruiting
Help in teams to improve care for kids with behavior problems
This study tests a program to help pediatric practice teams work together better, led by clinic leadership and managers, to support children’s behavioral health. Caregivers of children ages 5–12 with behavior problems may also be involved to connect care at home and in the clinic.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04961450Enrolling by invitation
Study tracking brain illness markers in motor neuron and frontotemporal disease
This study looks for “biomarkers” (measurable signs in blood or other samples) in people with motor neuron disease and frontotemporal dementia spectrum conditions. It also compares those findings with matched caregivers, to understand what might be happening in these diseases.
Beijing, Beijing MunicipalityAges 18–80 - NCT04964206Recruiting
Epidural pain relief in labor and baby brain development
This trial studies how epidural pain relief during vaginal labor may affect a child’s early brain and development. It’s for first-time, term pregnancies where you plan a vaginal birth.
Beijing, Beijing MunicipalityAges 18–35 - NCT04940585Recruiting
Study for pregnant women with stress or depression symptoms
This study supports pregnant people who are in their second trimester and have signs of stress, trauma, or depression. The goal is to learn whether the program can help improve emotional well-being during pregnancy.
New York, New YorkAges 18–100 - NCT04936009Recruiting
Brain stimulation study for adults with autism
This study tests whether transcranial magnetic stimulation (a non-surgical brain stimulation) can affect brain activity and learning in adults, including some autistic adults. You may also do EEG and eye-tracking tasks during the study.
New Haven, ConnecticutAges 18–40 - NCT04945278Recruiting
Brain study of self-recognition in teens at mental risk
This study looks at how people recognize themselves and understand the difference between self and others. It may help researchers better understand brain processes in teens who are at higher risk for certain mental health problems, using special tasks that involve seeing light and images.
BoharsAges 15–25 - NCT04982757Enrolling by invitation
Accelerated TMS to treat depression or OCD
This trial tests an “accelerated” form of transcranial magnetic stimulation (TMS) to reduce symptoms of depression or obsessive-compulsive disorder (OCD). You may be considered if standard treatments didn’t help (or you couldn’t tolerate them), and if it’s safe for you to receive TMS.
New York, New YorkAges 18–75 - NCT03810794Recruiting
Acupuncture study for people with Alzheimer’s memory problems
This trial tests whether acupuncture can improve symptoms in people with Alzheimer’s disease. You may qualify if you have memory and thinking changes consistent with Alzheimer’s and meet imaging and brain-scan score requirements.
Shanghai, Shanghai MunicipalityAges 50–85 - NCT04099823Recruiting
MRI study of spinal fluid flow in memory or balance problems
This study uses MRI to look at how spinal fluid moves inside and around the brain. It aims to better understand conditions that can affect thinking, memory, balance, and coordination—such as normal pressure hydrocephalus—or compare with healthy people.
Rochester, MinnesotaAges 18 years+ - NCT04877977Recruiting
Long-Term Follow-Up for People With Mood Disorders
This study follows people with mood disorders over a long time to better understand how symptoms and functioning change. You may be able to join if you already agreed to take part in an earlier mood/anxiety study and you meet basic participation needs.
Bethesda, MarylandAges 18–99 - NCT04917419Recruiting
Light therapy and talk therapy for sleep issues in bipolar disorder
This trial tests whether bright light therapy (luminotherapy) and/or structured education and coaching (psychoeducation) can improve sleep and daily body rhythm in people with bipolar disorder. It may help if your bipolar symptoms come with troublesome sleeping patterns.
PoitiersAges 18–65 - NCT04893525RecruitingPhase 2/Phase 3
Buprenorphine-naloxone microdosing versus standard dosing after ED discharge
This study compares a smaller “microdose” starting method versus the usual starting dose of buprenorphine/naloxone for people with opioid use disorder when they are discharged from the emergency department. It may help find a safer, easier way to start treatment right after an ED visit and avoid problems caused by starting too early.
Calgary, AlbertaAges 18 years+ - NCT04887792RecruitingPhase 1/Phase 2
Acetazolamide for schizophrenia that hasn’t improved
This Phase 1/2 study tests whether acetazolamide can help people with treatment-resistant schizophrenia. It aims to see if adding this medication improves symptoms when standard antipsychotics haven’t worked enough.
Pittsburgh, PennsylvaniaAges 18–55 - NCT04871048Recruiting
tDCS training to reduce cannabis use in people with schizophrenia
This trial tests whether a non-painful brain stimulation method (tDCS) can help people with schizophrenia who also have moderate-to-severe cannabis use disorder reduce or quit cannabis. It also involves MRI scanning to help study brain changes.
BronAges 18–60 - NCT04887116RecruitingEarly Phase 1
Virtual reality sessions to treat PTSD in healthcare workers
This early-phase study tests whether guided virtual reality experiences can reduce symptoms of PTSD (post-traumatic stress disorder) or near-PTSD in healthcare workers. It may help people who have stress reactions related to work during the COVID-19 era.
New York, New YorkAges 18 years+ - NCT04916340Recruiting
Exercise program study for heart blood vessel function and anxiety
This study tests whether an exercise training program can improve how well blood vessels work in people with PTSD or generalized anxiety. You may be placed into a PTSD, GAD, or healthy control group based on questionnaire scores.
Richmond, VirginiaAges 18–35 - NCT04875936Recruiting
Neurofeedback therapy to improve reading after recent stroke
This trial studies whether a brain-training approach called neurofeedback can improve reading skills after a stroke that happened recently. It may help if you have clear reading and comprehension problems following a left-side stroke.
West Orange, New JerseyAges 18–80
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.