Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,635
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania21
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT07779564Recruiting
Electric flosser study for plaque and gum health
This study tests whether an electric flosser is better than a manual toothbrush for reducing plaque and gum inflammation. Participants will use the electric flosser for 30 days while having regular checkups. This could help you learn a new way to improve your oral health.
Fort Wayne, IndianaAges 18–70 - NCT07778199Recruiting
Implant denture fitting: digital vs traditional dental impressions
This trial compares two ways of taking dental impressions (molds) for making a full-arch implant-supported denture. One method uses a digital scanner, the other uses traditional dental putty. The goal is to see if one results in a more comfortable and precise fit.
Al Mansurah, Dakahlia GovernorateAges 35–70 - NCT07779148Recruiting
Comparing irrigation methods for repeat root canal treatment
This study compares different ways of cleaning the root canal during a repeat root canal treatment. You may qualify if you have a single-rooted tooth with a failed root canal and are generally healthy.
MinyaAges 13–60 - NCT07780760Recruiting
Numbing throat spray to ease pain after tonsil removal in children
This study tests whether a numbing mist sprayed into the throat before surgery can reduce sore throat pain children feel after having their tonsils removed. It compares two numbing medicines to see if one works better than the other.
Al FayyumAges 3–15 - NCT07779421Recruiting
Healing bone after wisdom tooth removal
This study tests whether using a patient's own blood products can help bone heal better after removing a wisdom tooth. It may help reduce the gap left behind and protect the nearby molar.
Fuzhou, FujianAges 18–60 - NCT06563362RecruitingPhase 2
Personalized radiation for oropharyngeal cancer
This trial tests a personalized approach to radiation therapy for oropharyngeal cancer. The goal is to safely reduce the amount of radiation to healthy lymph nodes, which may lower side effects while still effectively treating the cancer.
Zurich, Canton of ZurichAges 18 years+ - NCT07433322Recruiting
Preserving gum and bone after back tooth removal
This study tests a procedure to preserve the bone and gum after removing upper back teeth, which may help prepare the area for future dental implants.
Richmond, VirginiaAges 18 years+ - NCT07622043Recruiting
Testing two varnishes to reduce tooth sensitivity
This study compares two special varnish coatings applied to teeth to see which works better at reducing tooth sensitivity and pain. If you have teeth that hurt when exposed to cold or touch, this trial might help you find relief.
SchaanAges 18–65 - NCT07306026Recruiting
Testing a toothbrush's bristles on plaque and gums
This trial compares how well different toothbrush bristles remove plaque and affect gum health. It may help find the best toothbrush design for everyday oral care.
Buffalo, New YorkAges 18–70 - NCT07508839Recruiting
Probiotic lozenge study for healthy adults
This trial tests a probiotic lozenge (a dissolvable tablet) to see if it's safe and works well. It's for healthy adults who don't smoke and are between 18 and 70 years old.
Hamilton, OntarioAges 18–70 - NCT07773389Recruiting
Early vs late premolar removal for braces
This study compares removing two back teeth early versus later during braces treatment to see which timing leads to better tooth movement. It may help teens and young adults needing braces for crowded teeth or overbite.
IslamabadAges 13–25 - NCT02734537RecruitingPhase 2
Radiation with or without cisplatin after head and neck surgery
This trial studies whether adding cisplatin (a chemotherapy medicine) to radiation therapy helps people with stage III–IVA squamous cell cancer of the head and neck after they’ve had surgery. It’s meant to lower the risk of the cancer coming back.
Birmingham, AlabamaAges 18 years+ - NCT07770256Recruiting
Bone regeneration surgery for lower molar gum disease
This study looks at the shape of lower molar teeth with a certain type of gum disease and tests a surgical treatment to help regrow the bone around those teeth. If you have advanced gum disease and a lower molar with a specific type of bone loss, this treatment might help save the tooth.
Ho Chi Minh CityAges 18 years+ - NCT06980038RecruitingPhase 2
Testing two immunotherapy drugs before surgery for advanced head and neck cancer
This trial tests whether adding a second immunotherapy drug (CDX-1140) to the standard immunotherapy cemiplimab before surgery is better than cemiplimab alone for people with stage III-IV head and neck cancer that can be removed with surgery.
Irvine, CaliforniaAges 18 years+ - NCT07597213Recruiting
Hyaluronic acid to help gum disease treatment in smokers
This study tests whether adding hyaluronic acid (a natural substance) to standard gum disease treatment helps smokers recover better. Gum disease is serious in smokers, and this treatment might improve healing.
IstanbulAges 18–65 - NCT07621809RecruitingPhase 3
Ianalumab versus placebo for Sjögren's disease with high symptom burden
This study tests whether a new drug called ianalumab can reduce dry mouth and other symptoms in people with Sjögren's disease—a condition where the immune system attacks moisture-producing glands. Participants will receive either ianalumab or a placebo (inactive injection) over 52 weeks to see if the drug helps.
Peoria, ArizonaAges 18 years+ - NCT05136196RecruitingPhase 2
Cabozantinib plus nivolumab for advanced melanoma or head-neck cancer
This trial tests whether combining two immunotherapy medicines—cabozantinib and nivolumab—can shrink advanced melanoma or certain head-and-neck squamous cell cancers. It is mainly for people whose cancer has grown after prior PD-1 treatment.
Phoenix, ArizonaAges 18 years+ - NCT06457373Recruiting
Donated vs. your own tooth graft for bone preservation
This trial tests whether a special bone graft made from donated teeth works as well as a graft made from your own teeth to preserve the bone after wisdom tooth removal. It may help you keep more bone in your jaw for future dental work.
Damietta, New-DamiettaAges 25–35 - NCT06064097RecruitingPhase 2
Nivolumab plus chemo for young people with nasopharyngeal cancer
This trial tests combining the immunotherapy drug nivolumab with standard chemotherapy to treat newly diagnosed nasopharyngeal cancer in children and young adults. The goal is to see if adding this immune-boosting medicine can help shrink tumors and prevent the cancer from coming back.
Birmingham, AlabamaAges Up to 21 years - NCT07441681RecruitingPhase 3
Comparing radiation plus targeted therapy vs standard chemo for head and neck cancer
This trial compares two treatments for advanced head and neck cancer in patients who cannot take the drug cisplatin. One group gets radiation plus a targeted drug called cetuximab, the other gets radiation plus standard chemotherapy. The goal is to see which approach works better and is safer for people who are not candidates for cisplatin.
Beverly Hills, CaliforniaAges 18 years+ - NCT07075276Recruiting
Comparing a new growth factor treatment to standard care for jaw joint pain
This study tests a new treatment for a common jaw joint problem called disc displacement. It compares a concentrated growth factor from your own blood to standard care to see which helps more with pain and jaw movement.
Damietta, New DamiettaAges 18–45 - NCT06574152Recruiting
Light therapy for pain relief after dental root surgery
This trial tests whether a special light treatment, called photobiomodulation, can help reduce pain and speed up healing after a specific type of dental surgery on the root of a tooth. The surgery involves a small cut in the gum, and the light may help the gum recover faster.
Houston, TexasAges 18 years+ - NCT07739498Recruiting
Bite turbos with palate expander for teenagers
This trial tests whether adding small plastic bumps, called bite turbos, to a palate expander helps widen the upper jaw better than the expander alone in early teens. This may correct a crossbite, where upper teeth sit inside lower teeth when biting down.
Al MansurahAges 10–14 - NCT06891261Recruiting
Ridge splitting in the upper jaw for dental implants
This trial tests two ways of splitting a narrow upper jawbone to make room for dental implants. It may help you if your jawbone is too narrow for implants but tall enough.
CairoAges 20–48
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,948 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.